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Original Article

High Dose of Amphotericin B in Intralipid Emulsion-based Delivery System in Immunocompromised Children with Invasive Fungal Infections

Geun Mo Kim, Hoon Kook, Sung Ho Cho, Ji Yong Park, Young Jong Woo, Tai Ju Hwang

Clin Exp Pediatr. 1998;41(2):216-223. Published online February 15, 1998

Purpose : Fungal infections are an important cause of morbidity and mortality in patients with hematologic malignancies. The therapy of choice in documented or suspected invasive fungal infections has been intravenous Amphotericin B(AmB). Adverse effects such as fever, chills, thrombophlebitis, nausea or vomiting are common. A more serious adverse effect is potential renal impairment. As AmB administration mixed with Intralipid(AmB/Intralipid)...

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