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Neurology

Cerebral organoid research for pediatric patients with neurological disorders

Jin Eun, Jung Eun Lee, Seung Ho Yang

Clin Exp Pediatr. 2025;68(4):269-277. Published online November 28, 2024

Cerebral organoids obtained from human induced pluripotent stem cells are transforming the study of pediatric neurological diseases by providing more accurate models of human brain development and pathology. These advancements have improved pathology modeling and the potential for novel therapeutic approaches despite existing challenges such as reproducibility and vascularization.

DOI: https://doi.org/10.3345/cep.2024.01235

Disease-specific pluripotent stem cells

Hoon-Chul Kang

Clin Exp Pediatr. 2010;53(8):786-789. Published online August 31, 2010

Crossref 3

Induced pluripotent stem (iPS) cells are generated by epigenetic reprogramming of somatic cells through the exogenous expression of transcription factors. Recently, the generation of iPS cells from patients with a variety of genetic diseases was found to likely have a major impact on regenerative medicine, because these cells self-renew indefinitely in culture while retaining the capacity to differentiate into any...

DOI: https://doi.org/10.3345/kjp.2010.53.8.786

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