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Original Article
Neurology
Intravenous levetiracetam versus phenobarbital in children with status epilepticus or acute repetitive seizures
Yun-Jeong Lee, Mi-Sun Yum, Eun-Hee Kim, Tae-Sung Ko
Clin Exp Pediatr. 2016;59(1):35-39.   Published online January 22, 2016
Purpose

This study compared the efficacy and tolerability of intravenous (i.v.) phenobarbital (PHB) and i.v. levetiracetam (LEV) in children with status epilepticus (SE) or acute repetitive seizure (ARS).

Methods

The medical records of children (age range, 1 month to 15 years) treated with i.v. PHB or LEV for SE or ARS at our single tertiary center were retrospectively reviewed. Seizure termination was defined...

Clinical Characteristics and Prognosis of Neonatal Seizures
Chang Wu Kim, Chang Hwan Jang, Heng Mi Kim, Byung Ho Choe, Soon Hak Kwon
Clin Exp Pediatr. 2003;46(12):1253-1259.   Published online December 15, 2003
Backgroud : Seizures in the neonate are relatively common and their clinical features are different from those in children and adults. The study aimed to provide the clinical profiles of neonatal seizure in our hospital. Methods : A total of 41 newborns with seizures were enrolled in this study over a period of three years. They were evaluated with special reference...
Study on Serum Level of Phenobarbital after Intravenous Administration of Loading Dose
Eun Young Park, In Joon Seol
Clin Exp Pediatr. 1998;41(10):1403-1410.   Published online October 15, 1998
Purpose : To learn the changes of phenobarbital serum level after intravenous administration of loading dose and to determine the optimal time of maintenance therapy to support therapeutic concentration. Methods : A total of 24 patients, who were admitted to the pediatric ward for treatment of ongoing and recurrent seizure, were enrolled in this study from November, 1994 to August,...
The Effect of Long-term Phenobarbital Administration on the Bone Mineral Density of Children
Yoon Suck Suh, Young Guk Kim, Jung Hwa Lee, Kee Hwan Yoo, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1994;37(3):368-375.   Published online March 15, 1994
The long term administration of anti-convulsants on children with convulsive disorders may cause osteomalacia, depending on the dosage, duration, type and combination of anti-convulsants administred. Fifteen children, comprising 10 male and 5 female, dignosed with convulsive disorders and administered with phenobarbital for a long term period of more than 9 months but less than 84 months and 15 healthy children...
Phenobarbital Dosage and Blood Level for Control of Neonatal Seizure
Hye Soon Kim, Keun Lee, Young Sook Ko
Clin Exp Pediatr. 1993;36(12):1641-1646.   Published online December 15, 1993
Twenty-five neonates was observe for the relationship between phenobrbital loading dose, plasma concentrations and control of seizures. Nineteen neonates (76%) had seizures controlled by phenobarbital alone, Effective plasma concentration were 10.0~31.3㎍/ml. Although 14 neonates had seizures controlled by phenobarbital concentration below 20㎍/ml, neonate required level above 30㎍/ml. We foound that continued benefit was obtained until phenobarbital plasma concentrations reached 40㎍/ml...
Blood Level of Phenobarbital in Treatment of Seizure After Neonatal Asphyxia.
Ji Yean Lee, Heng Mi Kim, Doo Hong Ahn
Clin Exp Pediatr. 1989;32(9):1265-1272.   Published online September 30, 1989
In this study, we attempted to determine an optimal first dose of phenobarbital for the treatment of seizures in the asphyxiated full term neonates. Blood samples were obtained 2 to 48 hours after the administration of final effective loading dose and plasma levels were determined by the EMIT system. Four groups of neonates were studied. Six neonates (Group 1) received an intravenous loading dose of...