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Original Article
Clinical characteristics of severe meconium aspiration syndrome
Chang Won Choi, Beyong Il Kim, Hyun Ju Lee, Kyoung Eun Joung, Gyu Hong Shim, In Suk Lim, Jin-A Lee, Ee-Kyung Kim, Han-Suk Kim, Jung-Hwan Choi
Clin Exp Pediatr. 2008;51(7):713-721.   Published online July 15, 2008
Purpose : This study aims to describe the clinical characteristics of severe meconium aspiration syndrome (MAS) which required mechanical ventilation over 48 h and to delineate the progress of respiratory failure and radiographic findings in severe MAS. Methods : Twelve infants admitted to the Neonatal Intensive Care Unit (NICU) of the Seoul National University Bundang Hospital diagnosed with severe MAS from...
The outcome of surfactant replacement therapy in above nearterm neonates with severe pulmonary disease
Su-Min Shon, Bo-Young Lee, Chun-Soo Kim, Sang-Lak Lee, Tae-Chan Kwon
Clin Exp Pediatr. 2007;50(12):1200-1205.   Published online December 15, 2007
Purpose : We performed this study to investigate the outcome of surfactant replacement therapy (SRT) in above nearterm neonates who were required mechanical ventilatory care due to meconium aspiration pneumonia (MAP), respiratory distress syndrome (RDS) or other severe pneumonia (PN). Methods : 48 patients, gestational period ≥36 weeks, who were admitted in NICU of Dongsan Medical Center, Keimyung University between July...
Comparison of Clinical Progress between Single- and Multiple-dose Surfactant Treatment in Neonatal Respiratory Distress Syndrome
Chang Hee Kil, Ho Sang Jeon, Chong Woo Bae
Clin Exp Pediatr. 2005;48(10):1090-1095.   Published online October 15, 2005
Purpose : In the case of serious respiratory distress syndrome(RDS) or relapse of clinical appearances after single treatment, we obtained more effective results with multiple-dose surfactant replacement therapy. We carried out this investigation for comparing and observing clinical progress between single-dose(group S) and multiple-dose(group M) pulmonary surfactant treatment group of neonatal RDS. Methods : We investigated 48 neonates who were...
Prognostic Factors for Mortality in Neonates with Respiratory Distress Syndrome After Surfactant Replacement Therapy
Nam Soo Kang, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(9):1188-1197.   Published online September 15, 1998
Purpose : To evaluate the association between neonatal mortality and the initial response to surfactant replacement therapy, and to examine the correlation between the response type and other prognostic factors. Methods : Sixty-seven neonates with respiratory distress syndrome(RDS) were divided into two groups; group I(n=51) who survived and group II(n=16) who died within the first 28 days of life after one...
Erratum
Perinatal Factors Influencing Clinical Response to Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome
June Dong Park, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(8):1023-1032.   Published online August 15, 1998
Purpose : Surfactant replacement therapy significantly decreases neonatal complications and mortality in neonates with respiratory distress syndrome(RDS), but clinical responses to the treatment is not consistent. An analysis of the perinatal factors influencing the clinical response to the therapy is important for early detection of high risk and prognosis. The purpose of this study is to analyze the clinical...
Original Article
Diagnostic Value of Stable Microbubble Rating test and Efficacy of Surfactant Replacement Therapy in Neonates with Respiratory Distres syndroems
Jeong Hee Kim, Eun Ae Park, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(6):760-770.   Published online June 15, 1995
Purpose : Stable microbubble rating test(SMR) plays an important role in the clinical course and the prognosis of respiratory distress syndrome(RDS) patients, because SMR can be easily performed and it can predict quickly the neonatal RDS. After the success of the pulmonary surfactant replacement therapy in RDS infants by Fujiwara and co-workers in 1980, many supporting studies were presented and...
Sequential Changes of Chest Radiographic Finding after Exogenous Surfactant Replacement Therapy in Neonates with RDS
Hyeok Choi, Chong-Woo Bae, Sa-Jun Chung, Yong-Mook Choi
Clin Exp Pediatr. 1995;38(2):151-158.   Published online February 15, 1995
Purpose : The chest radiograph is useful and reliable in assessing the severity and progres-sion of neonatal respiratory distress syndrome. To evaluate the effect of exogenous surfactant r eplacement therapy, we performed sequential observation of chest radiogratphic findings in ne-onates with respiratory distress syndrome. Methods : Two groups of infant with RDS in mechanical ventilation therapy were studied. S-urfactant(S-Tx) group(n=36) was...
Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome: A Collective Evaluation of Trials from 16 Hospitals
CW Bae, YD Kwon, SJ Ko, KS Kim, HM Kim, WS Park, SH Byun, CS Son, HS Ahn, SG Lee, YP Chang, YJ Chung, KS Cho, KH Cho, KC Choeh, MJ Chey, JH Choi, JK Yoon, CI Ahn, S Chida, T Fujiwara
Clin Exp Pediatr. 1993;36(2):244-265.   Published online February 15, 1993
Surfactant replacement therapy in neonates with respiratory distress syndrome (RDS) has been introduced in our country since May 1990. The purpose of this study was to assess the effect and short-term outcome of surfactant replacement for neonatal RDS using collective data of uncontrolled trials from different hospitals in Korea. For the period May 1990 to Dec. 1991, a total of 68...
Surfactant replacement therapy in neonatal respiratory distress syndrome.
Chan Ok Park, Boung Yul Lim, Byeong Gie Yeo, Ji Ho Song, Eun Kyung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1991;34(9):1211-1222.   Published online September 30, 1991
Respiratory distress syndrome (RDS) in tiny infants remains a major medical challenge as they are less tolerant of supportive care. In 1959, after identification of the pulmonary surfactant (S), S replacement therapy were used to treat RDS. This idea was first successfully tested on RDS infants by Fujiwara, et. al” in 1980. Now the trial and use of S for the treatment in RDS...
Exogenous Surfactant Replacement Therapy of Hyaline Membrane Disease: A controlled clinical trial.
Ran Namgung, Chul Lee, Kook In Park, Dong Gwan Han
Clin Exp Pediatr. 1990;33(1):22-34.   Published online January 31, 1990
We conducted a clinical controlled trial of exogenous surfactant replacement therapy in premature infants with hyaline membrane disease at the neonatal intensive care unit of Yonsei University Medical Center form Nov. 1987 to May 1988. Sixteen premature infants with severe HMD were randomly assigned to control group or surfactant-treated group. Eight infants (mean gestational age 29.9±2.8 week, mean birth weight 1, 425±308.9 gm) were given...