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Review Article
Double-negative T cells in pediatric rheumatic diseases
Dimitri Poddighe, Tilektes Maulenkul, Kuanysh Dossybayeva, Gulsamal Zhubanova, Zaure Mukusheva, Lyudmila Akhmaltdinova
Double-negative (CD4-CD8-) T (DNT) cells have been implicated in Autoimmune Lymphoproliferative Syndrome (ALPS), where their expansion inside the circulating pool of T cells represents a diagnostic criterion. Recent experimental evidence has supported the immunomodulatory roles of DNT cells, and studies in adult patients have suggested that they may be altered in some immune-mediated conditions. This study aimed to retrieve available...
Original Article
CD4+/CD8+ T lymphocytes imbalance in children with severe 2009 pandemic influenza A (H1N1) pneumonia
Ji Eun Kim, Siegfried Bauer, Kyong Suk La, Kee Hyoung Lee, Ji Tae Choung, Kyoung Ho Roh, Chang Kyu Lee, Young Yoo
Clin Exp Pediatr. 2011;54(5):207-211.   Published online May 31, 2011
Purpose

This study was conducted to investigate the immune responses of children with moderate and severe novel influenza A virus (H1N1) pneumonia, and to compare their clinical and immunological findings with those of control subjects.

Methods

Thirty-two admitted patients with H1N1 pneumonia were enrolled in the study. The clinical profiles, humoral and cell-mediated immune responses of the 16 H1N1 pneumonia patients who were...

Immunologic Changes of Peripheral Blood Lymphocytes in Kawasaki Disease after Intravenous Gamma Globulin Therapy
Jung Yeon Shim, Kyung Mo Kim, Young Hwue Kim, Soo-Jong Hong
Clin Exp Pediatr. 1996;39(5):712-721.   Published online May 15, 1996
Purpose : Kawasaki disease(KD) is multi-systemic vasculitis and coronary artery abnormalities can develop up to 30 percent in untreated patients. Several observations suggest that immune activation and the secretion of cytokines from immune effector cells contribute to the pathogenesis of this disease. Though high dose intravenous gamma globulin(IVGG,>1 gm/kg) is effective in reducing the prevalence of coronary artery aneurysms in KD,...
Identification of Human Mononuclear Cell Population by Acid alpha-Naphthyl Acetate Esterase Staining.
S G Lee, B H Choi, K Ch Han, T H Chung
Clin Exp Pediatr. 1982;25(6):547-553.   Published online June 30, 1982
This study was carried out to determine the clinical usage of acid alpha-naphthyl acetate esterase staining technic to define subpopulation of human peripheral blood lymphocytes and monocytes. 18 samples of peripheral blood smear of normal subjects were fixed in the formalin-aceton buffer fixative an stained by alpha-naphthyl acetate esterase techinc to be differentiated into 3 types of mononuclear cells; granular,...