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Case Report
Infliximab treatment for a patient with refractory Kawasaki disease
Hyo-Jung Yu, Soo-Jin Lee, Sejung Sohn
Clin Exp Pediatr. 2006;49(9):987-990.   Published online September 15, 2006
Intravenous immunoglobulin (IVIG) infusion is an effective therapy for acute Kawasaki disease (KD). Nonetheless, approximately 10 percent to 20 percent of patients have persistent or recrudescent fever despite IVIG treatment, leading to a higher risk for coronary artery aneurysms (CAA). This unresponsiveness may pose a challenge to the clinicians. Tumor necrosis factor-α levels are elevated in the acute phase of...
Original Article
Molecular detection of Bartonella henselae DNA from fleas obtained from dogs, Korea
Tae Hee Han, Ju-Young Chung, Hee Kyung Seong, Sang Woo Kim
Clin Exp Pediatr. 2006;49(9):983-986.   Published online September 15, 2006
Purpose : The purpose of this study was to investigate the presence of Bartonella henselae DNA, which is known as an etiologic agent of lymphadenitis, in fleas from dogs. Methods : The Bartonella henselae infection was investigated in 42 fleas from 22 dogs in Korea. By using seminested PCR targeting pap31 gene, B. henselae DNA was amplified from fleas. Results :...
Effect of prophylactic indomethacin in extremely low birth weight infants
Bo Lyun Lee, Su Jin Kim, Soo Hyun Koo, Ga Won Jeon, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2006;49(9):959-965.   Published online September 15, 2006
Purpose : The purpose of this study was to investigate the effect of prophylactic indomethacin on reduction of patent ductus arteriosus(PDA) and intraventricular hemorrhage(IVH) in extremely low birth weight infants(ELBWI). Methods : Retrospective review of 84 ELBWI who were admitted to our neonatal intensive care unit from June 2004 to April 2006 was performed. Patients were divided into prophylactic group(n=28) and...
Effect of combined exercise on metabolic bio-marker in overweight and obese children
Hyun-Jun Kim, Tae-Un Kim, Sangyeoup Lee, Goon-Soo Shin, Young-Joo Kim, Su-Yung Kim
Clin Exp Pediatr. 2006;49(9):946-951.   Published online September 15, 2006
Purpose : The purpose of this study was to demonstrate the effectiveness of combined exercise for 12 weeks on the adiponectin and obesity related variables in overweight and obese children. Methods : Eighteen children in 5th grade in a certain elementary school in Busan were recruited. They were all overweight or obese children(more than 85 percentile in body mass index). Nine...
Case Report
A case of constrictive pericarditis presenting with protein-losing enteropathy
Jeong Mi Hong, Jae Young Lee, Soo Jin Kim, Gi Young Jang, Woo Sup Shim
Clin Exp Pediatr. 2006;49(8):898-901.   Published online August 15, 2006
Constrictive pericarditis represents a rare cause of protein-losing enteropathy in children. Reported is an 11-year-old girl with protein-losing enteropathy (PLE) as the principal manifestations of constrictive pericarditis. After total pericardiectomy, symptoms and signs of PLE disappeared. Doppler echocardiography including tissue Doppler imaging is a useful noninvasive initial diagnostic tool for differential diagnosis of diastolic heart failure.
Anomalous systemic arterial supply to lung without sequestration in an infant who has congenital heart disease : a case report
Yeon Woo Jang, Duck Young Choi
Clin Exp Pediatr. 2006;49(8):895-897.   Published online August 15, 2006
Systemic arterial supply from the aorta to the lung is a rare congenital anomaly within the spectrum of bronchopulmonary sequestration according to Pryce's terminology. We describe our experience of this anomaly in an infant with congenital cardiac disease confirmed by multidetector CT scan. We found a systemic arterial supply from the aorta to the right lower lobe of lung without...
Original Article
Bacteremia in pediatric cancer patients : A single center study
Sun Mi Park, Byung Kyu Choe, Chun Soo Kim, Joon Sik Kim, Heung Sik Kim, Nam-Hee Ryoo
Clin Exp Pediatr. 2006;49(8):882-888.   Published online August 15, 2006
Purpose : Bacteremia is one of the major concerns in the treatment of pediatric cancer patients. This study was to determine the etiologic agents and the pattern of antibiotic susceptibilities in a single tertiary medical center. Methods : We retrospectively reviewed the medical records of the cases of bacteremia in pediatric cancer patients from 1998 to 2005 in Keimyung University Dongsan...
Frequency and clinical characteristics of prenatally diagnosed congenital hydronephrosis and outcomes of ureteropelvic junction stenosis
Hyun Soo Kang, June Seung Sung, Sun Hui Kim, Hee Jo Back, Young Ok Kim, Chan Jong Kim, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 2006;49(8):870-874.   Published online August 15, 2006
Purpose : Popular use of fetal ultrasonography has increased to detect congenital hydronephrosis(CH) which is the most common anomaly prenatally detected. We'd like to determine the frequency and clinical characteristics of prenatally diagnosed CH and outcome of ureteropelvic junction stenosis(UPJS). Methods : The records of births between January 1994 and June 2003 in Chonnam National University Hospital(CNUH), and the records of...
Immunogenicity and safety of enhanced-inactivated poliovaccine(eIPV) in healthy Korean infants
Jung Soo Kim, Young Jin Hong, Jong Duk Kim, Young Taek Jang, Jin Han Kang
Clin Exp Pediatr. 2006;49(8):864-869.   Published online August 15, 2006
Purpose : We evaluated the immunogenicity and safety of eIPV(Imovax PolioⓇ) in a group of healthy Korean infants on a three-dose primary vaccination. Methods : Eighty one healthy infants aged 8-10 weeks were enrolled, and 79(male 42, female 37) completed the study. Three doses of eIPV were injected intramuscularly at 2, 4 and 6 months of age as of primary...
Comparative study of therapeutic effects according to duration of medium-dose aspirin therapy at the acute stage of Kawasaki disease
Jung Hwa Lee, So Hee Lee, Sang Taek Lee, Yong Hyun Park, Seong Jin Hong
Clin Exp Pediatr. 2006;49(7):790-795.   Published online July 15, 2006
Purpose : This study was performed to compare the therapeutic effects according to duration of medium-dose aspirin(50-60 mg/kg/day) therapy at the acute stage of Kawasaki disease(KD). Methods : Total 87 patients with KD were enrolled in this study. We performed retrospective analysis of clinical characteristics and echocardiographic findings based on medical records. Patient were randomly divided into 2 groups according to...
Susceptibility tests of oral antibiotics including cefixime against Escherichia coli, isolated from pediatric patients withcommunity acquired urinary tract infections
Soo Young Lee, Jung Hyun Lee, Jong Hyun Kim, Jae Kyun Hur, Sun Mi Kim, Sang Hyuk Ma, Jin Han Kang
Clin Exp Pediatr. 2006;49(7):777-783.   Published online July 15, 2006
Purpose : Urinary tract infection(UTI) is one of the most frequent infections in children. E. coli is the most frequent etiological micropathogen in pediatric community UTI, and E. coli has developed resistance to many antibiotics, highlighting the need for regular surveys of this organism resistant patterns in the community. The aim of this study was to determine the oral antibiotic...
A study for headaches and backaches occurrence after diagnostic lumbar puncture in children
In Young Choi, Kyong Yun Park, Young Taek Jang
Clin Exp Pediatr. 2006;49(7):751-756.   Published online July 15, 2006
Purpose : Our goals were to determine the frequency of headaches and backaches occurring as a side effect following lumbar puncture in children, and to investigate various factors that might influence the frequency of headaches and backaches. Methods : From October 2004 to February 2006, we enrolled 148 patients aged 2 to 15 years who received diagnostic lumbar puncture at the...
Utility of polymerase chain reaction(PCR) according to sampling time in CSF and stool specimens from patient with aseptic meningitis
Myo Jing Kim, Hye Jin Lee, Jung Mi Choi, Soo Jin Jung, Jae Won Huh
Clin Exp Pediatr. 2006;49(7):745-750.   Published online July 15, 2006
Purpose : Enteroviruses are the most common cause of aseptic meningitis in patients of all ages. A definite diagnosis of enteroviral meningitis can be established by detection of virus directly in CSF specimens. But this is time-consuming and lacks sensitivity, so polymerase chain reaction(PCR) detecting of viral RNA in patient specimens such as CSF, stool has been demonstrated. But little...
Effect of maternal thyroxine treatment on the offspring's brain development with fetal alcohol effects in the rats
Jin Fu, Yoon Young Chung, Sang Kee Park
Clin Exp Pediatr. 2006;49(6):677-685.   Published online June 15, 2006
Purpose : This study aimed to investigate whether exogenous thyroxine(T4) treatment to alcohol-fed dams would ameliorate the detrimental effects of alcohol on the postnatal development of neuropeptide-Y(NPY)-containing neurons of the cerebral cortex and hippocampus of the offspring. Methods : Time-pregnant rats were divided into three groups. An alcohol-fed group A received 35 calories of liquid alcohol diet daily from gestation day...
Clinical characteristics and outcomes of status epilepticus as an initial seizure in children
Mi Jeong Kim, Young Ok Kim, Sun Hee Kim, Woo Yeon Choi, Hyung Suk Byun, Chan Jong Kim, Young Jong Woo
Clin Exp Pediatr. 2006;49(6):659-664.   Published online June 15, 2006
Purpose : To evaluate the morbidity and mortality of children with status epilepticus(SE) as an initial seizure and to compare these according to age groups. Methods : The 78 cases(38 cases <2 years and 38 cases ≥2 years) with SE as an initial seizure admitted to the Chonnam national university hospital from Jan. 2000 to Jan. 2004 were reviewed. Developmental profiles,...
Early and mid-term results of pulmonary valve reconstruction in surgical repair of tetralogy of Fallot; comparison with other techniques of right ventricular outflow reconstruction
Sheng Wen Wang, Young Seok Lee, Si Ho Kim, Tae Hong Kim, Ji Eun Ban, Hyoung Doo Lee, Yun Hee Chang, Si Chan Sung
Clin Exp Pediatr. 2006;49(6):635-642.   Published online June 15, 2006
Purpose : The purpose of this study is to determine whether the new pulmonary valve reconstruction technique prevents short-term postoperative pulmonary regurgitation and improves early and mid-term clinical outcome. Methods : We reviewed postoperative echocardiographic variables and chest X-ray films from 31 patients who had undergone valve reconstruction(pulmonary valve reconstruction group : PVR) for the repair of TOF between April 2000...
Effects of electromagnetic stimulation on neurogenesis and neuronal proliferation in rat hippocampal slice culture
Deok-Soo Kim, Eung Sang Choi, Soo Ahn Chae
Clin Exp Pediatr. 2006;49(5):558-564.   Published online May 15, 2006
Purpose : Transcranial electromagnetic stimulation(TMS) is a noninvasive method which stimulates the central nervous system through pulsed magnetic fields without direct effect on the neurons. Although the neurobiologic mechanisms of magnetic stimulation are unknown, the effects on the brain are variable according to the diverse stimulation protocols. This study aims to observe the effect of the magnetic stimulation with two...
Effect of GnRH analogue on predicted adult height in girls with early puberty
Byung-Hoon Ahn, Heon-Seok Han
Clin Exp Pediatr. 2006;49(5):552-557.   Published online May 15, 2006
Purpose : The recent results observed in precocious puberty and the hope that interrupting puberty might increase adult height have led to an attempt to use GnRH agonist(GnRHa) in children with premature puberty and a poor growth prognosis. We aimed to analyze the growth promoting effect of GnRHa in girls with early puberty and low predicted adult height(PAH). Methods : Thirty...
Polymorphisms of the CTLA-4 promoter(-318) and exon 1(＋49) genes with atopic dermatitis in Korean children
Tae Won Song, Hea Sun Yang, Kyung Eun Lee, Kyung Won Kim, Eun Soo Kim, Myung Hyun Sohn, Kyu-Earn Kim, M.D
Clin Exp Pediatr. 2006;49(5):545-551.   Published online May 15, 2006
Purpose : The gene-encoding cytotoxic T lymphocyte-associated antigen-4(CTLA-4) is one of the candidate genes for conferring susceptibility to atopic dermatitis(AD). The aim of the study was to investigate the association between Korean children with AD and the polymorphisms of CTLA-4 gene promoter(-318) and exon 1(＋49). Methods : The CTLA-4 promoter(-318 T/C) and exon 1(＋49 A/G) polymorphisms were genotyped via restriction fragment...
Neonatal hearing screening in a neonatal intensive care unit using distortion product otoacoustic emissions
Do Young Kim, Sung Shin Kim, Chang Hwi Kim, Shi Chan Kim
Clin Exp Pediatr. 2006;49(5):507-512.   Published online May 15, 2006
Purpose : Early detection and intervention of hearing impairment is believed to improve speech and language development and behavior of children. The aim of this preliminary study was to determine the prevalence of hearing impairments, and to identify the association of risk factors relating to refer response in high risk neonates who were screened using distortion product otoacoustic emissions (DPOAE). Methods...
Outbreak of Acinetobacter septicemia in a neonatal intensive care unit
Myo Jing Kim, Hye Jin Lee, Sang Hee Son, Jae Won Huh
Clin Exp Pediatr. 2006;49(5):494-499.   Published online May 15, 2006
Purpose : Acinetobacter baumannii is increasingly recognized as an important cause of nosocomial infection, especially in neonatal intensive care units. But little is known about the clinical significance and hospital epidemiology of Acinetobacter species other than A. baumannii. The objective of this study is to describe the clinical characteristics and epidemiology of septicemia due to Acinetobacter species other than A....
Case Report
A case of acute respiratory distress syndrome treated with surfactant and low dose methylprednisolone
Bo Yeon Choi, Kyong Mo Kim, Jong Seo Yoon, Joon Sung Lee
Clin Exp Pediatr. 2006;49(4):455-459.   Published online April 15, 2006
The major pathogenesis of acute respiratory distress syndrome (ARDS) is an inflammatory process that results from a diversity of injuries to the body. Due to the various cytokines and vasoactive peptides released from the endothelium, the vascular permeability is increased; the migration of inflammatory cells and the leakage of plasma proteins then occur and edema develops in the alveolus. There...
A case of scalp abscess caused by Achromobacter xylosoxidans after vacuum delivery
Eun-Young Park, Moon-Kyung Kwon, Seon-Jeong Min, Hyung-Sik Hwang
Clin Exp Pediatr. 2006;49(4):451-454.   Published online April 15, 2006
Achromobacter xylosoxidans is an aerobic gram-negative bacillus that may cause opportunistic infections in immunocompromized patients and newborns. Neonatal scalp abscess is generally a complication of fetal scalp monitoring and is typically polymicrobial. We present a case of a newborn, delivered by vacuum extraction, who developed a scalp abscess that yielded growth of Achromobacter xylosoxidans.
Original Article
The study on cytotoxicity of cytokines produced by the activated human NKT cells on neuroblastoma
Jin Young Cho, Young Wook Yoon, Hyang Suk Yoon, Jong Duk Kim, Du Young Choi
Clin Exp Pediatr. 2006;49(4):439-445.   Published online April 15, 2006
Purpose : α-Galactosylceramide (α-GalCer)-stimulated human Vα24 natural killer T (NKT) cells exert antitumor activity against some leukemia in a CD1d dependent and TCR-mediated manner, but could not kill CD1d - negative neuroblastoma (NB) cells. There are few reports about the direct antitumor effect of highly secreted cytokines by these cells on activation. In this study, using a cell-free supernatant (SPN)...
Evaluation of cardiac function by tissue Doppler imaging in children with cancer
Yeo Hyang Kim
Clin Exp Pediatr. 2006;49(4):417-423.   Published online April 15, 2006
Purpose : The objectives of this study were to assess ventricular function by tissue Doppler imaging in children who were receiving chemotherapy or who had received chemotherapy, and to apply repeated tissue Doppler imaging to make an early assessment in cardiac toxicity studies. Methods : This study was conducted on 23 oncology patients on-treatment or off-treatment from April 2005 to July...
Ultrastructure of nasal cilia in children with recurrent or persistent respiratory diseases
Su-A Shin, Seung Yang, Jae-Won Oh, Ha-Baik Lee, Cheol-Eon Park, Jung-Kyun Kwan
Clin Exp Pediatr. 2006;49(4):410-416.   Published online April 15, 2006
Purpose : Ciliary abnormalities of the respiratory system usually accompany recurrent or persistent respiratory diseases such as paranasal sinusitis, bronchiectasis, rhinitis, and/or otitis media, since they cause certain derangements in ciliary cleaning activities. This disease is usually inherited by autosomal recessive trait, but may also be found to be acquired or transient in rare cases after heavy exposure to pollutants,...
Human metapneumovirus infection in Korean children
Hee-Hyun Yeom, Joon-Soo Park, Dong-Jun Jeong, Chang-Jin Kim, Yong-Bae Kim, Dea-Hoon Lee, Kyung-Joong Kim, Jong-Yoon Chun, Chun Kang, Yoon-Seok Chung, Hyang-Min Cheong
Clin Exp Pediatr. 2006;49(4):401-409.   Published online April 15, 2006
목 적 : 호흡기 감염증의 주된 원인 중 하나인 hMPV가 2001년 van den Hoogen 등에 의해 네덜란드에서 처음으로 발견된 후 여러 나라에서 보고되었지만, 국내에서 hMPV의 검출에 대한 보고는 대단히 드물다. 따라서 저자들은 우리나라에서 hMPV의 역학을 연구하고자 하였다. 방 법 : 2004년 10월부터 2005년 5월까지 순천향대학교 천안병원 소아과에 급성 하기도염으로 입원한 218명의 비인두 흡인액을 추출한 뒤 RT-PCR을 시행하고, hMPV가 검출된 환아들의 비인두...
Urinary tract infections in infants under six months of age
Min Joo Kang, Hye Kyung Shin, Hyung Eun Yim, Bo-Kyung Je, So Hee Eun, Byung Min Choi, Jong-Tae Park, Baik Lin Eun, Kee Hwan Yoo
Clin Exp Pediatr. 2006;49(3):278-286.   Published online March 15, 2006
Purpose : Although suprapubic bladder aspiration(SBA) is the most reliable technique for identifying bacteriuria in young infant, no report has been published about the clinical manifestations of urinary tract infection(UTI) diagnosed by aspirated urine in Korea. This study was performed to examine clinical manifestations and related factors of UTI confirmed by a positive urine culture obtained by SBA in young infants. Methods : We reviewed...
Helicobacter pylori reinfection rate by a 13C-urea breath test and endoscopic biopsy tests in Korean children
Jeong Ok Shim, Jeong Kee Seo
Clin Exp Pediatr. 2006;49(3):268-272.   Published online March 15, 2006
Purpose : The reinfection rate of H. pylori reported before 13C-urea breath test(13C-UBT) era was higher than that of the post 13C-UBT era. Children are usually reluctant to receive invasive endoscopic evaluation for the reinfection of H. pylori, particularly when they are asymptomatic. The aim of the study is to discover the reinfection rate by different diagnostic tests, and to...
Organic acidemias in Korea - Eight years experience of organic acid analysis -
Jun Suck Bang, Si Hong Lim, Kyung Hwa Lee, Eun Joo Bae, Won Il Park, Hong Jin Lee
Clin Exp Pediatr. 2006;49(3):258-267.   Published online March 15, 2006
Purpose : We have done this retrospective study to know the relative incidence and clinical manifestations of organic acidopathies in Korea during 8 years(from Jul. 1997 to May 2005). This results of organic acid analysis of 1,787 patients were compared with the results of organic acid analysis that were published three years ago. Methods : The results of quantitative organic acid...