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Original Article
Significance of Brain CT in Children with Chief Complaints of Neurological Symptoms and Signs of Intracranial Disorders
Chun Ho Cho, Chung Hyun Yoon, Young Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 1992;35(6):753-761.   Published online June 15, 1992
Because of its accuracy, rapidity as well as non-invasiveness, brain CT (computerized transaxial tomography)is being widely used as the most reliablel diagnostic approach for neurologic disorders in childhood. Brain CT provides good anatomic configuration of the brain and its gross disease processes that have as a manifestation alteration in brain density, disturbance in blood-brain barrior, or mass effect etc. We evaluated...
MIC and MBC of Oral Antimicrobial Agents Against Staphylococcus aureus
Min Hang Kim, Jin Won Park, Yun Joo Chung, Kyung Sik Ryoo, Myung Woong Chang
Clin Exp Pediatr. 1992;35(5):659-666.   Published online May 15, 1992
Antimicrobial susceptibility for 25 stranis of methicillin senitive Staphylococcus (MSSA) and 25 strains of methicillin resistant Staphylococcus aureus (MRSA), isolated from in-patients at Kosin Medical Center from January, 1989 to July, 1990, were tested by the tube dilution method. 1) For MSSA, sensitivity tests showed 21% was sensitive to cefadroxil. Seventy one percent was intermediate and 8% was resistant. 2) 96% of...
Clinical Significance of Rheumatoid Factor in Juvenile Rheumatoid Arthritis
Ki Joong Kim, Bo Young Yun, Joong Gon Kim
Clin Exp Pediatr. 1992;35(5):639-645.   Published online May 15, 1992
Rheumatoid factor is a commonly used laboratory test by clinicians to assess the children with possible juvenile rheumatoid arthritis. To assess its diagnositc value and clinical significance we reviewed the case histories of the patients in whom latex agglutinating rheumatoid factor was tested during November 1988 to April 1991 at Seoul National University Children's Hospital. There were 61 patients with...
Hepaplastin Test for Screen of Vitamin K Deficiency in Term and Preterm Neonates
Eun Mi Kim, Gyung Og Yu, Dong Rak Choi, Chong Young Park, Hae Ran Lee, Choon Myung Ro
Clin Exp Pediatr. 1992;35(5):614-620.   Published online May 15, 1992
To screen vitamin K deficiency in term and preterm neonates, the authors conducted Hepaplastin test based on 40 term and 40 preterm neonates who were delivered at Han Gang Sacred Heart Hospital. Also we compared Hepaplastin activity of term neonates with that of preterm neonates. 0.5mg or 1mg of vitamin K1 was injected intramuscularly immediately after birth according to the...
Color Doppler Echocardiographic Evaluation of Residual Ductal Flow After Surgical Ligation
I Seok Kang, Hyun Kwack, Chung Il Noh, Jung Yun Choi, Yong Soo Yun
Clin Exp Pediatr. 1992;35(5):602-606.   Published online May 15, 1992
We evaluated the incidence of residual ductal flow with color Doppler echocardiography and associated clinical findings in 63 patients who had undergone surgical ligation for isolated PDA, The interval between surgery and color Doppler echocardiographic evaluation ranged from 2 days to6.6 years(mean 7 months). In 40 patients, color Doppler echocardiographic studies were done within 1month after surgery. In 8 of...
Case Report
A Case of Chronic Recurrent Obstructive Bronchitis Associated with Gastro-Esophageal Reflux
Myung Hee Min, Sang Soo Roh, Sang Il Lee, Sang Woo Kim
Clin Exp Pediatr. 1992;35(4):556-562.   Published online April 15, 1992
It has been well established that the gastroesophageal reflux and chronic respiratory problem were closely related. Several reports in pediatric literature have implicated the aspiration of gasrtric contents as a trigger factor of cough, wheezing, and recurrent pulmonary disease. Several possible mechanisms have been proposed whereby acidic gastric content can trigger bronchospasm and, in turn, bronchospams can trigger gastroesopohageal reflux. Several tests,...
Original Article
Polymicrobial Bacteremia in Children
Hyun Seung Park, Myung Ik Lee, Soon Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1992;35(4):499-507.   Published online April 15, 1992
A clinical observation was made on 212 cases of bacteremia in children, who were hospitalized at department of pediatrics, National Medical Center from Jan. 1981 to Dec.1988 The results were as follows; 1) Blood culture proven bacteremia were 212 cases in children. Among them polymicrobial bacteremia were 22 cases(10.4%) and monomicrobial bacteremia were 190 cases(89.6%). The same species of bacteria was cultured...
Clinical Observation of Meconium Aspiration Syndrome: Prognostic Implication of Early Meconium Suctioning
Dae Hyun Kim, Dong Hoon Ko, Young Jong Woo, Young Youn Choi, Tae Ju Hwang
Clin Exp Pediatr. 1992;35(4):484-491.   Published online April 15, 1992
The authors observed the clinical findings of 36 patients with meconium aspiration syndrome(MAS) to evaluate the effect of early appropriated meconium suctioning on the morbidity and mortality of the syndrome. Patients in the study group, 20 babies born in Chonnam university Hospital, received appropriate meconium suction through endotracheal tube during and rig-ht after the delivery, while the patients in the...
Brain CT Findings According to Seizure Type in Children with Seizure Disorder
Sung-Yoon Cho, Byoung-Kee Yeo, Sa-Jun Chung, Chang-Il Ahn
Clin Exp Pediatr. 1992;35(4):470-475.   Published online April 15, 1992
Detection of the organic lesion in convulsive disorder is very important for the therapeutic p-lan and the prognostic aspects. The results of brain CT in 204 children with seizure were evalu-ated in relation to the age of onset, according to seizure type, and final diagnosis of abnormal fi ndings by CT scan. The following results were obtained. 1) Out of 204 cases,...
A Clinical Study on Infantile Spasms with ACTH Therapy
Se Hee Hwang, Yong Seung Hwang
Clin Exp Pediatr. 1992;35(4):459-469.   Published online April 15, 1992
Infantile spasms is a disease, causes or treatments of which are not clearly delineated. Pri-mary objectives of treatment are complete control of seizure attack and prevention of further brain damage. Forty-one patients were managed with ACTH, who were diagnosed as infantile spasms and admitted to the Department of Pediatrics, Seoul National University Hospital from July 1985 till June 1990. The results...
The Effect of Prostaglandin E1 Infusion for Palliation of Ductus Dependent Cyanotic Congenital Heart Disease in Neonates
Ji Hee Park, Chang Sung Son, Joo Won Lee, Young Chang Tockgo
Clin Exp Pediatr. 1992;35(3):364-370.   Published online March 15, 1992
Prostaglandin E1 (PGE1) was administered to 12 neonates with cyanotic congenital heart disease in whom pulmonary or systemic blood flow were entirely or significantly dependent on persistent patency of the ductus arteriosus. 10 neonates responded favorably to PGE1, by showing significant increase of PaO2 after PGE1 infusion but remaining 2 neonates with hypoplastic left heart syndrome failed to respond. The...
Case Report
A Case of Beals Syndrome
Sung Kee Park, Tae Woo Kim, Young Soo Baik, Chang Yeon Lee, Suk Kang, Moon Jib Yoo, Jae Hwy Lee, Moon Whan Im
Clin Exp Pediatr. 1992;35(2):282-285.   Published online February 15, 1992
Beals syndrome, congenital contractural arachnodactyly (CCA), is an autosomal dominant disorder of connective tissue sharing many of the clinical manifestations of Marfan's syndrome, characterized by congenital joint contractures, crumpled ears, arachnodactyly (dolichostenomelia), kyphoscoliosis, and autosomal dominant inheritance. Differential diagnosis of CCA includes Marfan syndrome, Achard syndrome, homocystinuria, osteogenesis imperfecta, Stickler syndrome, and arthrogryposis multiplex congenita. Especially, the major consideration is Marfan...
Original Article
A Study on the Diagnostic Value of Cerebrospinal Fluid Adenosine Deaminase Activity in Children with Tuberculous Meningitis
Won Kyu Choi, Mee Kyung Namgoong, Hae Yong Lee, Hwang Min Kim, Jae Seung Yang, Jong Soo Kim
Clin Exp Pediatr. 1992;35(1):88-97.   Published online January 15, 1992
Tuberculous meningitis is still relatively common infectious disease of central nervous system in korea. The prognosis of tuberculous meningitis is closely related to the state at which treatment if started. Adenosine deaminase (ADA) is an enzyme which irreversibly hydrolyzes adenosine into inosine and ammonia. Recent investigations have suggested that the measurement of ADA activities in cerebrospinal fluid is useful in the...
Clinical Study of Group B Streptococcal Infection in Infants Less Than Two Months of Age
Hee Jeong Ahn, Ji Yeon Lim, Sung Hee Oh, In Joon Seol, Soo Jee Moon, Hahng Lee
Clin Exp Pediatr. 1992;35(1):17-25.   Published online January 15, 1992
Since 1970, the group B streptococcus has become significant cause of neonatal septicemia and/or meningitis, in recent years the group B streptococcus and E.coli are most common etiologic agent of septicemia and/or meningitis in infants less than two months of age. We have analized 8 cases of group B streptococcal infection who admitted to the department of Pediatrics, Hanyang University...
The effects of 1800 vGy cranial irradiation on intellectual function of children with acute lymphocytic leukemia.
Soo Ho Ahn, Jeong Ok Hah, Jung Hoon Lee
Clin Exp Pediatr. 1991;34(12):1683-1688.   Published online December 31, 1991
This study was conducted to investigate the effects of CNS prophylaxis with 1800 cGy cranial irradiation and intrathecal methotrexate (MTX) chemotherapy on intellectual function of the chil- dren with acute lymphocytic leukemia (ALL). Thirteen longterm survivors with ALL who were treated with 1800 cGy cranial irradiation and intrathecal MTX for CNS prophylaxis at pediatric department of Yeungnam University Hospital from May, 1983 to November, 1988...
Saline reduction of intussusception under ultrasound guidance.
Min Hyea Kim, Jung Weon Seo, Sung Joo Lee
Clin Exp Pediatr. 1991;34(12):1678-1682.   Published online December 31, 1991
Intussusception is the most common cause of acquired intestinal obstruction and requires emer- gency treatment. Recently, saline reduction under the ultrasound guidance has been successful as a diagnostic and therapeutic tool of intussusception. It is a simple, rapid, noninvasive, painless procedure without risk of radiation. We compared the result of saline reduction in 54 cases with that of barium reduction in 104 cases from January, 1988...
A case of 11q deletion syndrome.
Hye Kyeong Nam, Rhee Choi, Chang Hwi Kim, Sang Jhoo Lee
Clin Exp Pediatr. 1991;34(11):1587-1592.   Published online November 30, 1991
11q-syndrome is a rare chromosomal anomaly. We experienced a case of llq deletion syndrome in a female infant. It was diagnosed by clinical features and chromosomal study. She had multiple anomalies such as flat occiput, hypertelorism, low set malformed ear, anteverted nostril, small carp-shaped mouth, micrognathia, hypertrophic pyloric stenosis and ventricular septal defect. Chromosomal study showed partial terminal deletion of the long arm of chromosome...
A study on the immune reaction to the milk protein antigens in the postpartum mother, newborn baby, and children.
Soo chul Cho, Ju Hyung Kim, Hong Ro Lee, Jong San Lee, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1991;34(11):1547-1558.   Published online November 30, 1991
There is continuing interest in the isotype response of human serum antibodies reactive with dietary proteins. This study was performed to clarify the humoral immune responses against cow’s milk proteins, 分-lactoglobulin and a-lactalbumin. Milk protein specific IgG, IgA, IgM, and IgG subclasses were measured using ELISA in the blood of various groups of age. The results were as follows: 1) Milk protein specific immunoglobulins were higher...
Clinical study on the factors used in the diagnosis of heart failure.
Dong Chul Park, Seok Min Choi, Jun Hee Sul, Sung Kyu Lee, Dong Shik Chin
Clin Exp Pediatr. 1991;34(11):1534-1539.   Published online November 30, 1991
Heart failure is the state in which heart cannot produce the cardiac output required to sustain the metabolic needs of the body without evoking certain compensatory mechanisms. As these mecha- nisms become ineffective, increasingly severe clinical manifestations result. The diagnosis of conges- tive heart failure relies on several sources of clinical findings, including history, physical examination, and chest X-rays. For lack of uniform diagnostic...
The value of computerized axial tomography of the brain in children with central nervous system disorders.
Young Gyun Lee, Dae Sung Hwang, Kwang Soo Oh, Hyang Seuk Yoon, Jong Duck Kim
Clin Exp Pediatr. 1991;34(10):1409-1416.   Published online October 31, 1991
The introduction of computerized tomography (CT), a diagnostic method, has revolutionized the evaluation of neurologic disorders in children. And it provides a noninvasive, safe, and rapid diagnosis of intracranial pathology. CT scanning was performed on 126 children with neurologic symptoms who had admitted to department of pediatrics, Wonkwang University Hospital, from January 1986 to June 1990. Our study was designed to evaluate the usefulness of...
Brain CT and clinical finding in tuberlous meningitis.
Moon Chan Kim, Chan Yung Kim
Clin Exp Pediatr. 1991;34(10):1391-1399.   Published online October 31, 1991
In this study, we evaluated clinical symptoms, neurologic findings, CSF examinations and prognosis of patients who were diagnosed to have tuberculous meningitis at Pusan National University Hospital and Gospel Hospital from march, 1983 to december, 1989. 1) Mean age was 3 years and 8 months and the percentage of patients under 6 years old was 71.9%. The male to female ration was 2.2:1. 2) Fever and vomiting...
Indomethacin therapy in premature infants with patent ductus arteriosus.
Dug Ha Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(10):1381-1390.   Published online October 31, 1991
Patent ductus arteriosus (PDA) is a common disease that occurred in 20 〜 40 percent of premature infants. The incidence of PDA is inversely related to the gestational age and birth weight. Hemodynamically significant PDA increases the morbidity and mortality of premature infants. So, the management of PDA is one of the major problems in neonatal intensive care unit. Based on experimental animal studies,...
Congenital cytomegalovirus infection: incidence and clinical outcome.
Young Mo Sohn, Kook In Park, Chul Lee, Dong Kwan Han, Won Young Lee
Clin Exp Pediatr. 1991;34(10):1365-1372.   Published online October 31, 1991
In order to assess the rate of congenital cytomegalovirus (CMV) infection in newborns, CMV IgG antibody was studies at about 37.5 weeks gestation in 309 mothers and a positive rate of 96.4% was obtained. Virus culture for CMV from urine of 514 neonates less than 1 week after birth resulted in CMV growth in 6 neonates showing a 1.2% congenital infection rate. In...
A case of double compartment hydrocephalus.
Eun Kyung Oh, Hae Young Lee, Jae Seung Yang, Chul Hu, Young Hyuk Lee
Clin Exp Pediatr. 1991;34(9):1305-1310.   Published online September 30, 1991
The double compartment hydrocephalus is now recognized as a clinical entity needing early diagnosis and treatment. By definition, the concept of double compartment hydrocephalus indicates seperate and individually progressing, usually sequential, hydrocephalus of the supratentorial and infratentorial CSF ventricles. In most instances, this entity consists of supratentorial hydrocephalus of the third and lateral ventricles (as a result of aqueductal stenosis) that has been treated...
A case of nephrogenic diabetes insipidus due to vesicoureteral reflux.
Yong Bae Suh, Jong Yul Jeon, Sung Ho Cha, Byoung Soo Cho, Chang Il Ahn
Clin Exp Pediatr. 1991;34(9):1299-1304.   Published online September 30, 1991
Nephrogenic diabetes insipidus is a disorder characterized by polydipsia and polyuria resulting from failure of the renal tubules and collecting ducts to respond to antidiuretic hormone despite elevated blood levels of antidiuretic hormone. We experienced a case of nephrogenic diabetes insipidus in 13 months-old girl probably secondary to vesicoureteral reflux grade IV. The clinical manifestations were extreme thirst, polydipsia and polyuria. Family history was nonspecific and...
The diagnostic significance of APR score in early detection of neonatal bacterial infection.
Ki Won Park, Kyeong Choi, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 1991;34(9):1223-1230.   Published online September 30, 1991
An accurate and rapid diagnostic test is essential in the management of bacterial infection in neonates because they lack specific symptoms and the bacterial infections in neonates tends to have rapid progression and poor prognosis. As for the method, APR (acute phase reactants), a score measuring C-reactive protein (CRP), 상racid glycoprotein (이-AG) and Haptoglobin (Hp) by latex agglutination seems to be one of promising methods. In...
Surfactant replacement therapy in neonatal respiratory distress syndrome.
Chan Ok Park, Boung Yul Lim, Byeong Gie Yeo, Ji Ho Song, Eun Kyung Sohn, Chong Woo Bae, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1991;34(9):1211-1222.   Published online September 30, 1991
Respiratory distress syndrome (RDS) in tiny infants remains a major medical challenge as they are less tolerant of supportive care. In 1959, after identification of the pulmonary surfactant (S), S replacement therapy were used to treat RDS. This idea was first successfully tested on RDS infants by Fujiwara, et. al” in 1980. Now the trial and use of S for the treatment in RDS...
Serological study to determine the optimum age for measles vaccination in Korea.
Gum Ja Lee, Kon Hee Lee, Hae Sun Yoon
Clin Exp Pediatr. 1991;34(9):1201-1210.   Published online September 30, 1991
In recent years, measles outbreak has involved a great population of cases in younger children. For this reason, we reevaluated the conventional vaccination schedule by measuring measles antibody level. Two groups totalling 244 children were included in the study. The non-measles group consisted of 133 children who visited or were admitted to our hospital during the 7 month period from Jan. 1990 through July 1990...
A study on current immunization status attending an above-middle from class primary school in Seoul.
Jae Won Oh, Sung Lae Park, Sung Hee Oh, Hahng Lee
Clin Exp Pediatr. 1991;34(9):1187-1200.   Published online September 30, 1991
1. Purpose and Methodology The purpose of this survey was to estimate the current immunization status of Korean children by the information gathered by questionnaire distibuted to the parents of all children attending an above-middle class private primary school in Seoul and thereby analizing various factors closely related to the vaccination program as currently administered in Korea. The survey has been conducted by obtaining written answers...
Tricuspid atresia associated with double orifice mitral valve and coronary sinus septal defect.
In Sook Park, Ki Soo Kim, Young Seo Park, Chang Yee Hong, Shi Joon Yoo, Meong Gun Song
Clin Exp Pediatr. 1991;34(8):1139-1145.   Published online August 31, 1991
Clinical, echocardiographic and angiographic findings of a very rare case of cardiac malformation is presented. The main features were tricuspid atresia, coronary sinus septal defect, and double orifice mitral valve. These defects were correctly diagnosed by echocardiography and were confirmed by angiocardiography. This patient was palliated successfully with blade balloon atrial septostomy and bidirectional cavopulmonary shunt. To the best of our knowledge, this is the...