• Search
  • Advanced Search

Search

  • HOME
  • Search
Original Article
A Study on the Necessity to Revise the Present Growth Data for Height and Weight? -Base on Data from the Circumference and Triceps Thickness-
Gi Dong Hwang, Jae Kyung Choi, Jeh Hoon Shin, Nam Soo Kim, In Joon Seol, Hahng Lee
Clin Exp Pediatr. 1995;38(6):745-751.   Published online June 15, 1995
Purpose : Applying the present growth curve(established in 1985) in practice, we noticed some difference. And so, we performed this study to know that is it necessary to revise the present standard data in Korea. Methods : We checked the height and weight of 208 children of one primary school in Seoul. And also, we measured arm circumference and triceps thickness...
Characteristics of Insulin-Like Growth Factor I in Serum; Pattern of Insulin-Like Growth Factor Binding Protein (Large Complex) in Short Stature Patients with Complete Growth Hormone Deficiency
Jin Nyoung Park, Byung Deok Seo, Jeh Hoon Shin, Soo Ji Moon, Sung Yeoul Chang
Clin Exp Pediatr. 1994;37(11):1548-1559.   Published online November 15, 1994
To elucidate the complex of insulin-like growth factor binding proteins (IGF-BPs) in short stature patients, we carried out a prospective study on three patients who were diagnosed as complete GH deficiency at the department of pediatrics form July 1992 to June 1993. The results were summarized as follows: 1) Two circulating IGFs complexed to specific binding protein existed in normal serum. Binding...
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
Mechanism of Impaired Growth Hormone Response in Children with Simple Obesity
Moon Sung Park, Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1994;37(4):457-463.   Published online April 15, 1994
Obesity is associated with an impairment of the hormone secretion elicited by all stimuli known to date, but the basic mechanism of this alteration is unknown, To determine whether obesity is associated with a chronic state of tonic somatostatin, several tests with growth hormone stimuli such as GHRH (1㎍/kg), clonidine (150㎍/m2) and Resular insulin (0.1U/kg, subcutaneously), to obese subjects and...
The Effect of Testosterone on the Response of Grow Hormone Secretion in Cultured Rat Pituitary Cells
Ho Seong Kim, Duk Hi Kim, Deok Bae Park
Clin Exp Pediatr. 1993;36(11):1578-1582.   Published online November 15, 1993
The effects of testosterone on the pituitary growth hormone(GH) response directly and to hypothalamic growth hormone-releasing hormone(GHRH) were evaluated in vitro using a male pituitary cell monolayer culture system. Wistar male rats were gonadectomized at 22 days of age, and 21 days later their anterior pituitaries were removed and trypsinized for cell dispersion. Testosterone 0.01, 1.0, 10.0nM was added to...
Growth Pattern and Final Height in Congeital Adrenal Hyperplasia
Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(10):1359-1365.   Published online October 15, 1993
Clinical characteristics and growth pattern were evaluated in 42 patients with classical congenital adrenal hyperplasia treated since diagnosis. And final height was evaluated in 16 patients who had reached final adult height with regard to clinical form, degree of hormonal control, and age of initial treatment. The results were as follows; 1) Among 42 patients with classical congenital adrenal hyperplasia, the male...
Growth Outcome in Congenital Hypothyroidism
Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(5):713-720.   Published online May 15, 1993
Congenital hypothyroidism is one of the most common endocrine disease in childhood and it causes not only mental retardation but also growth retardation. There were many papers about evaluation of developmental outcome in congenital hypothyroidism, The aim of this study was to evaluate growth outcome in congenital hypothyroidism. We evaluated 65 patients with congenital hypothyroidism diagnosed at yonsei University College...
Clinical Significance of Urinary Growth Hormone Measurement in patients with Growth Hormone Deficien
Ho Seong Kim, Duk Hi Kim, Min-Seok Cheon
Clin Exp Pediatr. 1993;36(4):478-484.   Published online April 15, 1993
Urinary growth hormone (GH) excretion was quantitated in 12-hr overniaght urine collections obtained from 13 children with complete growth hormone deficiency(CGHD), 6 children with partial growth hormone deficiency(PGHD), 5 children with short stature and normal GH provocation tests(NSC), and 5 normal control children (NC) to investigate whether the measurement of urinary GH can clearly separate the PGHD and CGHD groups...
Plasma Somatomedin C Levels in Normal Children
Bo Young Yun, Hoan Jong Lee
Clin Exp Pediatr. 1992;35(11):1493-1500.   Published online November 15, 1992
Somatomedin C, the insulin-like growth factor I is suggested to mediate the growth-promoting effect of growth hormone. Sm-C, mostly bound to plasma protein forming an IGF-I protein complex, is slowly cleared from plasma and thus its plasma concentration is quite constant. A single sampling of blood for Sm-C is sufficient for the measurement of its concentration. For the evaluation of...
Growth Promoting Effect of Recombinant methionyl-Growth Hormone in Children with Chronic Renal Failure
Heon Seok Han, Yong Choi, Hyung Ro Moon
Clin Exp Pediatr. 1992;35(10):1355-1360.   Published online October 15, 1992
The authors studied the growth-promoting effect of yeast-derived methionyl-hGH in short statured children with uremic chronic renal failure. The subjects were prepubertal chronic renal insufficient patients whose height standard deviation scores were below -2.0. Two boys and two girls participated in this study. Chronic renal insufficiency was the only cause for the short stature. HGH was given to the subjects in dose...
Quantification of Human Urinary Growth Hormone and Its Clinical Significance in the Diagnosis of Growth Hormone Deficiency
Seung Ryul Lee, Ho Seong Kim, Duk Hi Kim, Chang Mi Kim
Clin Exp Pediatr. 1992;35(5):595-601.   Published online May 15, 1992
Twelve-hour nocturnal urine was collecte in 5 patients diagnosed of having complete GH deficiency, 6 of having partial GH deficiency and 7 persons as normal control group. The GH levels in urine collections were evaluated, and the results are as follows. 1) The GH level of normal control group was 16.76¡¾1.91ng/12hr, 59.00¡¾6.92ng/gCr, 16.24¡¾2.52ng/m2, 0.58¡¾0.12ng/kg. 2) The GH level of complete GH deficiency...
The Pharmacokinetics and Biological Effects of Yeat Dervied Recombinant Methionyl Growth Hormone in growth Hormone Deficient Children
Byung Churl Lee
Clin Exp Pediatr. 1992;35(3):349-354.   Published online March 15, 1992
The parmacokinetics and biological effects of an recombinant methionyl growth hormone(LBD-003) produced by the expression of genomic hGH in a yeast cell line, were studied in growth hormone deficient children. Twelve patients were randomly assigned to two age-matched subcutaneous and intramuscular groups. Each group consists of 6 patients. Each subject received an dosage of 0.1 U hGH(LBD-003)/kg, BW, Blood was drawn before...
The Effects of Testosterone on the Pituitary Growth Hormone Secretion
Ho Seong Kim, Duk Hi Kim, Kyung Za Ryu, Chang Mee Kim, Deok Bae Park
Clin Exp Pediatr. 1992;35(2):174-181.   Published online February 15, 1992
The effects of testosterone on growth hormone secretion and somatic growth have been reported in several previous studies. In order to investigate the role of testosterone in growth hormone secretion, we have studied the effect of testosterone on somatic growth, basal growth hormone concentration, and growth hormone response to growth hormone-releasing hormone (GHRH) in orchiectomized rats. In experiment 1, four groups...
Effects of sex hormone on secretion of growth hormone.
Bo Young Lee, Duk Hi Kim
Clin Exp Pediatr. 1991;34(12):1621-1628.   Published online December 31, 1991
Sex honnone had been thought to influence in the serum level of growth honnone (GH) since 1944 year. After it became known that the exogenous administration of sex honnone to growth-retarded children increase serum GH level, sex honnone-especially testosterone-was thought to induce GH release. Testosterone is thought to act on the hypothalamo-pituitary axis to stimulate GH secretion and estradi이 is also thought...
Effect of yeast-derived methionyl recombinant growth hormone on growth hormone deficient dwarf.
Jong Jin Seo
Clin Exp Pediatr. 1991;34(9):1269-1275.   Published online September 30, 1991
Fifteen GH deficient dwarfs were treated with LBD-003, the first year-derived rhGH produced in Korea. The growth promoting effect of LBD-003 was excellent and similar to that of the pituitary extract GH or the previous imported rhGHs. The serum concentrations of IGF-1 at 6th and 12th month of treatment showed significant elevation (p< 0.005, p< 0.001 respectively), but no significant correlation was observed between the...
Study on the antibody formation in patinets treated with recombinant human growth hormone(rhGH).
Hye Jung Joo, Duk Hi Kim, Dong Soo Kim
Clin Exp Pediatr. 1991;34(9):1261-1268.   Published online September 30, 1991
Patients with short stature admitted to the Pediatrics Endocrinology Clinic, Yonsei University College of Medicine during a six-year period from August, 1983 to August, 1989 were divided into three groups. The group 1 received rhGH, group 2 received Oxandrolone and group 3 did not receive any treatment. These patients were tested for presence of antibodies to rhGH with ELISA and effect of rhGH was evaluated. 1) Among 53...
Clinical effects of recombinant Korean growth hormone (LBD-003).
Duk Hi Kim
Clin Exp Pediatr. 1991;34(8):1110-1115.   Published online August 31, 1991
LBD-003, methionyl GH, has been produced recently in the yeast by the use of recombinant method. The clinical efficacy and immunogenecity of LBD-003 were studied in 20 patients with naive GH deficiency. The subjects of this study were aged 5.1—13.9 years and received GH 1.5IU/kg thrice weekly for 1 year. During treatment, height, body weight & bone age were checked. Blood count, chemistry amd thyroid...
The effects of human growth hormone on short stature.
Sang Mi Ha, Duk Hi Kim
Clin Exp Pediatr. 1991;34(7):999-1008.   Published online July 31, 1991
Since Raben’s original report that human growth hormone promoted growth in a boy with pituitary dwarfism, the hormone’s efficacy in children with growth hormone deficiency has been amply confirmed. However the scarcity of growth hormone prepared human pituitaries has limited studies of its usefulness in short stature. The availability of a biologically active human growth hormone produced by recombinant-DNA technology has dramatically changed the...
The mechanism of Arginine-stimulated growth hormone secretion.
Wan Kyu Lee, Dong Goo Lee, Duk Hi Kim
Clin Exp Pediatr. 1991;34(4):544-552.   Published online April 30, 1991
Although Arginine is widely used in the evaluation of growth hormone (GH) secretion in short stature patient, the mechanism of action is unclear, yet. To elucidate how Arginine stimulate GH secretion, we studied the interaction of Arginine with growth homrone releasing hormone (GHRH) on GH secretion in GH deficient short stature patient and constitutional growth delay. The results of the studies were as follows: 1) Peak...
Clinical effects of yeast derived recombinant methionyl growth hormone in growth hormone deficiency.
Byung Churl Lee
Clin Exp Pediatr. 1991;34(3):334-339.   Published online March 31, 1991
Since the success of human growth hormone (hGH) synthesis by recombinant DNA technology, these GH products are used in the treatment of growth hormone deficiency. Recently, methionyl-GH has been produced in the yeast, Saccharomyces cerevisiae 2150 by the use of a recombinant method. In this paper, the clinical efficacy and. immunogenicity of this GH was studied during therapy of 1 year in 20 children...
The Pharmacokinetics, Acute Biological Effects and Safety of Recombinant Human Growth Hormones.
Jong Jin Seo
Clin Exp Pediatr. 1990;33(8):1104-1110.   Published online August 31, 1990
The pharmacokinetics, acute biological성fccts and safety of yeast-derived recombinant methionyl- hGH (LBD-003), the first biosynthetic hGH in Korea, were studied in 10 healthy young adults who were administered 8 IU/day intramuscularly for four consecutive days. 1) GH levels reached a mean (±SD) peak of 27.5±10.7 ng/ml at 3.4±0.8 hours following the first dose, and other pharmacokinetic parameters of LBD-003 were similar to those reported for pituitary...
Intrauterine Growth of Korean Infants from 25 Weeks to 44 Weeks Gestation.
Ghee Young Jung, Keun Lee
Clin Exp Pediatr. 1990;33(7):887-900.   Published online July 31, 1990
It is very important to reduce the perinatal morbidity or mortality by early recognition of abnor- mally overgrown or undergrown neonates. To achieve this, it is necessary to establish the standards of intrauterine fetal growth of Korean infants. Though there were some previous reports, we intended to make more appropriate fetal growth curve standards by retrospective cross-sectional study using the data obtained from measurements...
A Study on the Growth Pattern, History of Respiratory Illness and Family History in Acute Bronchiolitis.
Dong Won Choi, Byung Ju Jung, Kyu Earn Kim, Ki Young Lee
Clin Exp Pediatr. 1990;33(5):623-631.   Published online May 31, 1990
The authors evaluated the growth pattern, history of frequent respiratory illness and family history in 111 infants who were admitted to the Department of Pediatrics, Yonsei University Hospital with the diagnosis of acute bronchiolitis from Sept. 1986 to Jun. 1988. The results of the study were as follows: 1) The sex incidence of bronchiolitis was higher in males compared with the sex incidence of the total...
A Study on the Pre-and Post-operative Growth Status of Children with Ventricular Septal Defect.
Kyung Hwan Kim, Chan Yung Kim
Clin Exp Pediatr. 1990;33(4):463-471.   Published online April 30, 1990
To evaluate the growth status of Congenital Heart Disease, we analyzed the 69 children with Ventricular Septal Defect who were admitted to Pediatric department and Chest Surgery department, Pusan National University Hospital from January, 1986 to June, 1987. The result of study were as follows: 1) This group was composed of 69 consecutive operation on children with ventricular septal defect. The sex distribution chanced to be...
Bone Age Determination and Hand Radiographic Findings in Children With Russell-Silver Syndrome.
Hun Kyu Lim, Sei Won Yang, Hyung Ro Moon
Clin Exp Pediatr. 1989;32(6):823-833.   Published online June 30, 1989
Russell.Silver syndrome is a disease of unknown etiology characterized by prenatal onset dwarfism irrespective of full term gestation, growth retardation, body asymmetry, craniofacial dysproportion with a triangular face, short and incurved little finger, etc. Forty.two children were diagnosed as Russell.Silver syndrome by Silver’s criteria at SNU Children' s Hospital from Apr. 1981 till Aug. 1988, and we reviewed clinical data and hand radiographs of...
Clinical Study on Growth Hormone Deficient Dwarfs.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(5):597-606.   Published online May 31, 1988
34 patients with growth hormone (GH) deficiency were studied. The affected males outnumber females in a proportion of 1.8 to 1. The chronological ages on diagnosis was average 9.4 years old and bone age was delayed with average 6.6 years old. The major cause of GH deficiency was idiopathic and organic causes such as craniopharyngioma, germinoma & Tb. meningitis were relatively uncommon. Cerebral anoxia seemed...
The Effect of Thyroid Hormone Deficiensy on Growth Hormone Levels.
Duk Hi Kim, Chan Il Park
Clin Exp Pediatr. 1988;31(1):64-71.   Published online January 31, 1988
Growth hormone and thyroid hormone are known to affect growth and development. The present experiment was undertaken to assess GH levels in the serum and pituitary gland of prophylthiouracil (PTU) treated rats. The serum concentration of T4 were decreased during PTU treatment. Serum GH concentration and pituitary GH content were decresed with severity of hypothyroid status. After withdrawl of PTU, their levels were recovered gradually. Acidophil...
Pheochromocytoma in Two 10-year Old Children.
Young Soo Kim, Young Hoon Kim, Se Won Yang, Yong Choi, Hyung Ro Moon
Clin Exp Pediatr. 1987;30(2):207-211.   Published online February 28, 1987
We experienced two cases of pheochromocytoma in 10 year-old boy and girl. Boy had bilateral and girl had unilateral pheochromocytoma. Both patients who were severely retarded in height growth had hypertension and one patient had cardiomyopathy. In both patients, vanillylmandelic acid in urine was increased, and phentolamine test was positive. Adrenal mass was visualized by C.T. in each ease. Successful surgical removal was done,...
A Study on Serum Growth Hormone in DM of Childhood.
Duk Hi Kim
Clin Exp Pediatr. 1987;30(2):175-180.   Published online February 28, 1987
The human growth hormone (hGH) levels were evaluated in 13 diabetes mellitus, 11 patients were insulin dependent diabetes (ages 2 yr 10 mo to 13 yr 14 mo), 2 patients were noninsulin dependent diabetes (age 12 yr & 12 yr 5 mo). No difference in hGH level was observed in relation to duration of diabetes. The hGH responses to glucagon 1 mg injection in...
Russell-Silver Syndrome.
Sei Won Yang, Hyung Ro Moon
Clin Exp Pediatr. 1986;29(7):715-722.   Published online July 31, 1986
Seventeen cases(12 boys and 4 girls) with Russell-Silver syndrome were evaluated for weight, height and bone age at initial presentation and during follow up. 1) Distribution of patient` s age at initial presentation was between 1 day and 75/12 year of age. 2) In 14 cases, the birth weight was below 3 percentile except for one case(3 percentile). In 15 cases, the...