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Original Article
A Clinical Study of Childhood Soft Tissue Sarcoma
Hye Lim Jung, Hong Heo Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(9):1258-1270.   Published online September 15, 1993
Medicine, Seoul, Korea Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea To study the clinical characteristics and treatment results of childhood soft tissue sarcoma, the retrospective study was performed on 67 patients with soft tissue sarcoma, experienced at the Department of Pediatrics, Seoul National University Hospital from January, 1982 to July, 1990. The...
High-Dose Intravenous Immune Globulin Therapy for Hyperbilirubinemia Caused by ABO Incompatibility
Dong Sung Kim, Dong Un Kim, Ji Whan Han, Sung Soo Whang, Kyung Yil Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1073-1079.   Published online August 15, 1993
Four newborn infants with hyperbilirubinemia, caused by ABO blood group incompatibility, were treated with high-dose intravenous immune globulin (IVIG). As soon as the diagnosis was clinically suspected, these infants received conventional treatment including phototherapy and were monitored closely for bilirubin levels. When bilirubin concentrations reached the risk point in spite of pjototherapy, IVIG was given at a dose of 1g/kg for...
Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children
Joon Ho Bang, Nak Gyun Chung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1067-1072.   Published online August 15, 1993
Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence...
The Side Effects of Antiepileptic drugs in Epileptic Children Treated withMonotherapy
Kon-Hee Lee, Hae-Sun Yoon
Clin Exp Pediatr. 1993;36(3):320-327.   Published online March 15, 1993
The goal of therapy of epileptic children is to control of seizures with minimal side effects of antiepileptic drug(AED). The relationship between side effects, serum levels and doses of AED were examined prospectively in 72 epileptic children who received monotherapy with phenobarbital, phenytoin, valproate, or carbamazepine for 6 to 26 months. Our results were as follows: 1) Side effects were observed in...
Case Report
Four Cases of Massive Infiltrating Congenital Cystic Hygroma Managed by Bleomycin Sclerosing Therapy
Hyun Kwack, Dong Wook Kim, Kyung Woon No, Jun Heo, Sun Young Kim, Young Pyo Jang, Jung-Hwan Choi, Chong Ku Yun, Seong En Jung, Gui Won Park, Woo Gi Kim, In Won Kim, Kyung Mo Yeon
Clin Exp Pediatr. 1992;35(8):1148-1156.   Published online August 15, 1992
Cystic hygroma is a true, benign, congenital multi-cystic tumor. It is thought to be arised from failure of the lymphatic system to communicate with the venous system. Frequently it occurs at birth, and it is found most commonly in the neck as painless and fluctuant mass. For many years, surgical excision has been considered as the treatment of choice. However, excision...
Three Cases of Brain Tumors with Bone Metastasis
Eun Joo Kim, Kyung Duk Park, Eun Sil Dong, Hye Jung Park, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Je Geun Chi
Clin Exp Pediatr. 1992;35(3):381-389.   Published online March 15, 1992
Medulloblastoma and primitive neuroectodermal tumor(PNET) are relatively common intracranial neoplasms in childhood. Their extracranial metastasis were thought to be rare occurrences. But they are more frequent compared to other intracranial tumors. The most frequent site of metastasis deposits in medulloblastoma is bone, and metastasis to lymph node, peritoneum, liver or lung have been reported infrequently. The authors experienced three cases...
Original Article
Clinical Considerations of the Mediastinal Tumors in Children
Eun Joo Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(1):98-107.   Published online January 15, 1992
Mediastinal tumors of children constitute a heterogeneous group of malignant and benign neoplasms because they originated from a variety of structures. But they show some characteristics in type of tumor according to location, relative frequency of masses, clinical manifestations. Management and long-term reusult. We observed 82 patients less than 16 years of age who were evaluated and treated for a...
The effect of dietary fats of immune response in sublethally irradiated rats.
Soon Hwan Oh, Dong Soo Kim, Hae Won Nam, Juhn Kyu Loh
Clin Exp Pediatr. 1991;34(11):1494-1504.   Published online November 30, 1991
To investigate the effect of dietary fats on cellular immune response in the immunosuppressed rats, different compositions in the quality and quantity of dietary fats were fed to sublethally irradiated male rats. The results are as follows; 1) After 2 weeks of irradiation, the mean body weight of the fat free dietary group was significant- ly lower than the com oil group. The organ weight, especially...
Effect of yeast-derived methionyl recombinant growth hormone on growth hormone deficient dwarf.
Jong Jin Seo
Clin Exp Pediatr. 1991;34(9):1269-1275.   Published online September 30, 1991
Fifteen GH deficient dwarfs were treated with LBD-003, the first year-derived rhGH produced in Korea. The growth promoting effect of LBD-003 was excellent and similar to that of the pituitary extract GH or the previous imported rhGHs. The serum concentrations of IGF-1 at 6th and 12th month of treatment showed significant elevation (p< 0.005, p< 0.001 respectively), but no significant correlation was observed between the...
Clinical effects of recombinant Korean growth hormone (LBD-003).
Duk Hi Kim
Clin Exp Pediatr. 1991;34(8):1110-1115.   Published online August 31, 1991
LBD-003, methionyl GH, has been produced recently in the yeast by the use of recombinant method. The clinical efficacy and immunogenecity of LBD-003 were studied in 20 patients with naive GH deficiency. The subjects of this study were aged 5.1—13.9 years and received GH 1.5IU/kg thrice weekly for 1 year. During treatment, height, body weight & bone age were checked. Blood count, chemistry amd thyroid...
Two cases of nasopharyngeal carcinoma in children.
Tae Sun Ha, Chul Ho Jang, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):587-593.   Published online April 30, 1991
Nasopharyngeal carcinoma is a primary malignancy of nasopharyngeal epithelium, firstly de- scribed as a separate entity by Regaud and Schmincke in 1921. Although it is a rare tumor, reprsent- ing less than 1% of pediatric malignancies, it accounts for 9% of the nasopharyngeal neoplasms of childhood, and has not been reported in Korean child. We experienced two cases of nasopharyngeal carcinoma in a 10...
Clinical study of Kasabach-Merritt syndrome.
Eun Jung Bae, Young Ah Lee, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(3):371-379.   Published online March 31, 1991
A retrospective analysis of clinical findings in 20 patients with Kasabach-Merritt syndrome who visited Department of Pediatrics, Seoul National University Hospital from January, 1979 to June, 1990 was performed. The average age of occurrence was 6.4 month and male to female ratio was 1: 1.2. The mean size of hemangioma was 11.0x8.5 cm and the locations were cutanous in 18 (extrem- ities 5, trunk...
The Effect of Phototherapy on Serum bilirubin Binding Capacity and Affinity in the Neonate.
In Suck Ryu, Chul Lee, Ran Namkung, Dong Gwan Han
Clin Exp Pediatr. 1990;33(10):1319-1325.   Published online October 31, 1990
Since the effect of phototherapy in the treatment of neonatal hyperbilirubinemia has been reported 30 years ago, phototherapy has been used widely for neonatal hyperbilirubinemia, but the exact mechanism and the effect of light on the human body have not been fully determined. Free bilirubin level in the serum is an important indicator for kemicterus, a complication of neonatal hyperbilirubinemia. Free bilirubin level was...
Immunologic Changes in Bronchial Asthma on Immunotherapy.
Joon Sung Lee, Kyung Tai Whang, Sung Hoon Cho
Clin Exp Pediatr. 1990;33(9):1255-1261.   Published online September 30, 1990
The best treatment of allergic disease is to avoid exposure to known allergen. Immunotherapy has been attempted in IgE-mediated allergic patients who didn’t show any responses to pharmacologic therapy or couldn’t avoid allergen. There have been many enthusiastic claims for symptomatic relief of allergic disease by various forms of hyposensitization, first introduced by Noon and Freeman (1911) in the treatment of hay fever. The mechanism of...
Clinical Analysis of Children with Nephrotic Syndrome.
Ki Young Cheong, Keon Su Rhee
Clin Exp Pediatr. 1990;33(7):959-969.   Published online July 31, 1990
A clinical analysis was made on 51 cases with nephrotic syndrome who were admitted to Pediatric Department of Chung Nam National University Hospital from January 1st, 1984 to December 31st, 1988. Clinical manifestation, response to the inital continuous steroid therapy, relapsing patterns, factors affecting response to steroid therapy, pathologic findings and difference in laboratory findings between relapser and nonrelapser were evaluated. Results were as follows; 1) Among...
A Case of Aplastic Anemia Following hepatitis.
Gae Soon Yeo, Doo Kweon Kim, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1990;33(6):864-869.   Published online June 30, 1990
We experienced a case of aplastic anemia following hepatitis in a 4-year-old girl. Pancytopenia was developed during the convalescent period of hepatitis, and it was getting worse, while serial data of liver function test showed improvement. We tried a methylprednisolone pulse therapy, and about 7 months after treatment the CBC findings returned completely normal. She has enjoyed her healthy life during follow-up of over 2...
Therapeutic Effect of Iron Deficiency Anemia.
Dong Suk Lee, Chang Hee Han, Kun Soo Lee
Clin Exp Pediatr. 1990;33(6):799-806.   Published online June 30, 1990
A prospective study was conducted to see the therapeutic effect of iron deficiency anemia on a different oral iron doses. Studied patients consisted of 48 children with iron deficiency anemia who were admitted to our Pediatric Department during January 1988 - September 1989. Three groups were consisted with Group A (element iron dose 3 mg/kg/d, 16 cases), Group B (3 mg/kg/d with vitamin C...
An Experience of High Dose Intravenous Immunoglobulin Therapy in Refractory Evans Syndrome.
Hee Sup Kim, Won Sup Shin, Sang Il Lee, Sang Woo Kim
Clin Exp Pediatr. 1990;33(5):701-707.   Published online May 31, 1990
Evans syndrome, a combination of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura, relapses freguently and is refractory to conventional treatment such as corticosteroid, immunosuppressive agents, splenectomy and plasma exchange. Recently Oda et al applied high dose immunoglobulin (400/kg/day for 4 days repeated 2 weeks later) to 5 month-old infant with refractory Evans syndrome, and was successful in maintaining remission for five years and nine...
Treatment of Self-Injurious Behavior Through Behavior Therapy.
Bo In Chung, Jong Soo Kim, Jae Seung Yang, Bong Sun Kang
Clin Exp Pediatr. 1990;33(5):585-597.   Published online May 31, 1990
Three-step guided compliance training and movement suppression time-out technique were used to treat desruptive, self-injurious, and aggressive behaviors in an 8-years old tuberous sclerosis with severe mental retardation. In compliance training, the child’s compliance behavior to verval and/or gestural demand was reinforced with edible and/or social reinforcers and the noncomplied demand was forcefully carried out through physical prompting. Movement suppression time-out was enforced whenever any...
Exogenous Surfactant Replacement Therapy of Hyaline Membrane Disease: A controlled clinical trial.
Ran Namgung, Chul Lee, Kook In Park, Dong Gwan Han
Clin Exp Pediatr. 1990;33(1):22-34.   Published online January 31, 1990
We conducted a clinical controlled trial of exogenous surfactant replacement therapy in premature infants with hyaline membrane disease at the neonatal intensive care unit of Yonsei University Medical Center form Nov. 1987 to May 1988. Sixteen premature infants with severe HMD were randomly assigned to control group or surfactant-treated group. Eight infants (mean gestational age 29.9±2.8 week, mean birth weight 1, 425±308.9 gm) were given...
A case of bronchopulmonary dysplasia.
Sun A Chun, Byung Jun Choi, Bo Kyung Cho, Chung Sik Chun, Sung Hoon Cho
Clin Exp Pediatr. 1989;32(11):1553-1559.   Published online November 30, 1989
The development of respiratory management of the newborn has improved the survival rates of respiratory distress syndrome in these two decades. But the incidence of complication associated with this management has been increased. Although the pathogenesis of bronchopulmonary dysplasia has not been clearly established yet, bronchopulmonary dysplasia is one of the major complication of the mechanical ventilation. There are several factors in the development of...
A clinical study on histiocytosis X.
Sang Oh Na, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(11):1510-1519.   Published online November 30, 1989
We made a clinical study on 31 cases of histiocytosis X who had been admitted to the Dept, of Ped. of S.N.U.C.H. from Jan. 1981 to Dec. 1987. Among 31 cases, 28 patients received chemotherapy to include prednisolone, vinblastine, methotrex- ate and cyclophosphamide as induction therapy, and 6-mercaptopurine, methotrexate and cyclophos- phamide as maintenance therapy. The results obtained were as follows. 1) The sex incidence revealed male...
Specific Antibody Response in House Dust Mite Asthmatics on Immunotherapy.
Won Sup Shin, Bub Sung Kim, Sang Il Lee
Clin Exp Pediatr. 1989;32(9):1282-1287.   Published online September 30, 1989
The immunotherapy has become a useful and effective method to treat allergic respiratory diseases. It is a logical assumption that immunotherapy produces symptom relief as a result of immunologically specific response. This study was performed to delineate the IgE, IgG and IgG4 responses to immunotherapy, and their relationships. We selected the six asthmatic children on immunotherapy with Dermatophagoides pteronyssinus (Dp). A set of samples from each...
Effect of Oxandrolone Therapy in Short Stature.
Yil Sub Lee, Soo Young Lee, Duk Hi Kim
Clin Exp Pediatr. 1989;32(9):1273-1281.   Published online September 30, 1989
Fifty six boys and 28 girls aged 4 to 15.8 years were treated with oxandrolone during the 4 to 25 months. Measurement of height and bone age were made at the beginning and at 6 months intervals. The daily dose were 0.08 mg to 0.28 mg per kilogram. Predictions for adult height at the beginning of the study were compared with those at...
Methylprednisolone Pulse Therapy in Childhood Nephropathies.
Moon A Kim, Pyung Kil Kim
Clin Exp Pediatr. 1989;32(9):1259-1264.   Published online September 30, 1989
Methylprednisolone “pulse” therapy was performed on 22 patients of childhood nephropathies who showed resistance to conventional therapy. The diseases included steroid-resistant or frequent relaps- ing nephrotic syndrome including minimal change nephrotic syndrome, focal segmental glomer- ulosclerosis, membranous nephropathy, mesangioproliferative glomerulonephritis, Henoch-Schonlein purpura nephritis and SLE nephritis. Methylprednisolone 30 mg/kg/day was administered intravenously over one hour, which was repeated 6 times on every other day. Sixteen of...
A Case of Hypereosinophilic Syndrome.
Byoung Hoon Lee, Jae Wook Ko, Soon Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1989;32(4):561-566.   Published online April 30, 1989
Hypereosinophilic syndrome is a state of severe eosinophilia of unknown cause accomanied by multiple organ-system involvement. The criteria of hypereosinophilic syndrome includes. (1) A persistent eosinophil count of more than 1.5 X 10 9 /L for associated with the signs and symptoms of hypereosinohilic disease; (2) a lack of evidence for parasite, allergic, or other known causes of eosinophila; (3) presumptive signs and...
Treatment of Acute Myelogenous Leukemia in Children: Remission Induction with Adriamycin and Cytosine Arabinoside, and Postremission Maintenance Chemotherapy with Adriamycin, Cytosine Arabinoside and 6-thioguanine.
Soon Ki Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):850-862.   Published online July 31, 1988
The authers assessed the effectiveness of chemotherapy in 40 children with AML, experienced at Seoul National University Children’s Hospital during 8 years 5 months from April 1979 to August 1987. Remission induction treatment included adriamycin 30 mg/m2/day IV on days 1-3 and cytosine arabinoside 75 mg/m2/day continuous IV infusion on days 1-5. This regimen was repeated, if necessary, for one or two more courses. After...
Clinical Characteristics and Pathogenesis of Typhlitis in Childhood Non-Lymphocytic Leukemia-Considerations on Clinical Mangement with Report of Two Cases and Literature Review.
Do Hyun Kim, Sung Oh Kim, Soo Yup Lee, In Joon Seol, Hahng Lee, Chong Moo Park, Poong Man Jung, Seok Chol Jeon, Young Hyeh Ko, Jung Dal Lee
Clin Exp Pediatr. 1988;31(5):607-620.   Published online May 31, 1988
The treatment of acute leukemia in childhood has been increasingly successful due to progression of chemotherapeutics and other supportive care. Improved survival rates in acute childhood leukemia have been associated with an increasing number of complications in the gastrointestinal tract. Typhlitis also known as ileocecal syndrome is a necrotizing inflammation of the cecum in leukemic patients on chemotherapy in the terminal stage of the...
Clinical Study on Growth Hormone Deficient Dwarfs.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(5):597-606.   Published online May 31, 1988
34 patients with growth hormone (GH) deficiency were studied. The affected males outnumber females in a proportion of 1.8 to 1. The chronological ages on diagnosis was average 9.4 years old and bone age was delayed with average 6.6 years old. The major cause of GH deficiency was idiopathic and organic causes such as craniopharyngioma, germinoma & Tb. meningitis were relatively uncommon. Cerebral anoxia seemed...
2 Cases of Infantile Spasms(Cryptogenic Type) Treated with ACTH Therapy.
Shin Heh Kang, Chang Jun Coe
Clin Exp Pediatr. 1987;30(8):928-933.   Published online August 31, 1987
We have experienced 2 cases of infantile spasms treated with ACTH. They were diagnosed as cryptogenic type within relatively short duration after the onset. With the administration of ACTH, flexor spasms and hypsarrhythmia disappeared. They did not demonstrate any intellectual impair- ment on OPD follow up study. A brief review of literatures was made.