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Original Article
Effects of Endothelin A Receptor Antagonist to Cellular Proliferation and Apoptosis in Neonatal Rat Heart
Byung Min Choi, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2003;46(7):668-678.   Published online July 15, 2003
Purpose : In order to investigate the role of endothelins in the cardiac development, the present study was designed to examine the effects of endothelin A receptor(ETAR) antagonist to the cellular proliferation and apoptosis in the neonatal rat heart. In addition, the expression of various regulatory genes in protein and mRNA levels by ETAR antagonist were examined. Methods : Neonatal...
Leukoencephalopathy after CNS Prophylactic Therapy in Pediatric Hematologic Malignancy
Jun Hwa Lee, Sun Min Lee, Eun Jin Choi, Kun Soo Lee
Clin Exp Pediatr. 2003;46(6):566-571.   Published online June 15, 2003
Purpose : Leukoencephalopathy(LE) is one of the most serious complications in children with hematologic malignancies during the course of treatment. Early recognition is important to reduce the impact and sequelae from LE. We therefore investigated the clinical features of LE following central nervous system(CNS) prophylaxis in children with hematologic malignancies and evaluated the significance of regular check-ups of brain MRI. Methods...
Differential Excretion of Urinary Eosinophil Protein X after Methacholine Challenge Test in Children with Asthma
Su-A Shin, Jae-Won Oh, Ha-Baik Lee
Clin Exp Pediatr. 2003;46(5):495-499.   Published online May 15, 2003
Purpose : Eosinophil is one of the important inflammatory cell involved in the airway inflammation in childhood asthma. It has been demonstrated that markers of eosinophil activation, including eosinophil cationic protein or eosinophil protein X(EPX), are increased in childhood asthma. Furthermore, they are related to disease activity and are assumed to be helpful in monitoring the treatment effect as urinary...
Clinical Significance of C-reactive Protein in Measles
Sang-Lim Choi, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Kyung-Tai Whang
Clin Exp Pediatr. 2003;46(5):480-483.   Published online May 15, 2003
Purpose : We evaluated clinical manifestations and laboratory findings in patients with measles according to C-reactive protein(CRP) concentration. Methods : A retrospective analysis was performed using the medical records of patients with measles at The Catholic University of Korea, Daejeon St. Mary's Hospital from October 1999 to May 2000. We divided the patients with measles into four groups according to CRP...
Causative Pathogens and Therapeutic Assessment of Cefprozil in Acute Otitis Media
Jin-Han Kang, Jong Hyun Kim, Yong-Soo Park, Young-Chul Choi, Heil Noh, Hoon Shik Yang, Kyu Sung Kim, Yeon Sook Moon, Young Jin Hong
Clin Exp Pediatr. 2003;46(5):459-466.   Published online May 15, 2003
Purpose : AOM is the most common bacterial URI in children. The bacteriology and antibiotic Tx of AOM in children has been studied in many countries. But, there is few study of causative pathogens and antibiotic Tx of AOM in our country. In this aspect, we performed prospective clinical study to confirm the causative pathogens and assess the clinical responses...
Differential Response of Surfactant Protein-A Genetic Variants to Dexamethasone Treatment
Eul Soon Kim, In Kyu Lee, Myung Ho Oh, Chong Woo Bae
Clin Exp Pediatr. 2003;46(4):335-339.   Published online April 15, 2003
Purpose : Surfactant protein A(SP-A) is involved in surfactant physiology and structure, and plays a major role in innate host defense and inflammatory processes in the lung. Steroid therapy is widely used for mothers who threaten to deliver prematurely and also used commonly in the management of preterm infants with chronic lung disease. Two SP-A genes(SP-A1, SP-A2) and several alleles...
Postoperative Progress and Influencing Factors in Patients after Rastelli Procedure
Se Heui Kim, Kyeong Sik Kim, Jong Kyun Lee, Jae Young Choi, Jun Hee Sul, Sung Kyu Lee, Young Whan Park, Bum Koo Cho
Clin Exp Pediatr. 2003;46(3):259-264.   Published online March 15, 2003
Purpose : We have performed an analysis on patients who received Rastelli operation in our institute and reviewed their progress postoperatively. Various factors with suspected relationship to the outcome have been considered to help in future treatment and follow-up. Methods : We analyzed retrospectively 43 patients who either received Rastelli operation in Yonsei University Cardiovascular Center from March 1995 to April...
Effective Screening Test for Obesity in Obese Adolescents and the Correlation Among Obesity Index, Body Mass Index and Serum Lipid Profile
Tae Jung Sung, Dal Hyun Kim, Young Jin Hong, Byong Kwan Son, Kyung Ja Chang, Jun Young Park, Soon Ki Kim
Clin Exp Pediatr. 2003;46(3):217-223.   Published online March 15, 2003
Purpose : Every year, there is a remarkable increase in the prevalence of children with excess body fat. The aim of this study is to find a useful screening method in assessing adolescent, obesity and to specify the predictable risk factors that are related to adult cardiovascular disease according to BMI and obesity index. Methods : From July to November in...
Influence of Prognostic Factors on Survival Rate of Medulloblastoma Patient with Chemotherapy
Kyung Mi Shin, Sung Yeon Choi, Sung Chul Won, Chang Hyun Yang, Chuhl Joo Lyu, Chang Ok Suh, Joong Uhn Choi, Byung Soo Kim
Clin Exp Pediatr. 2003;46(2):178-182.   Published online February 15, 2003
Purpose : Brain tumors are the second most common tumor in childhood, and medulloblastomas comprise 15-25% of brain tumors. The well known prognostic factors are age at diagnosis, stage of disease, and extent of surgical excision. In this study, we analysed the prognostic factors in patients who received chemotherapy after excision. Methods : We reviewed the medical records of 61...
The Usefulness of Spot Urine Protein/Creatinine Ratio in Evaluating Proteinuria in Children and the Correlation between 24-hour Urinary Protein Amount and Spot Urine Protein/Creatinine Ratio
Seon Young Hong, Ji Young Kim, Woo Yeong Chung
Clin Exp Pediatr. 2003;46(2):173-177.   Published online February 15, 2003
Purpose : Recently, different results about factors affecting accurate quantitation of 24-hr urinary protein(24UP) amount using spot urine protein/creatinine ratio(PCR) have been reported. The current study was designed to evaluate correlation between 24UP amounts and PCR in children, and the effect of 24UP amounts, age, sex, and glomerular filtration rate(GFR) on this correlation. Methods : Among 94 patients who visited the...
Repetition of Apoptosis Induced by Amiloride Derivatives in Human Umbilical Vein Endothelial Cells
Kyu Chang Park, Kyu Sang Park, Soo Jee Moon
Clin Exp Pediatr. 2003;46(1):56-66.   Published online January 15, 2003
Purpose : Human umbilical vein endothelial cells(HUVECs) play an important role in regulating blood flow by releasing vasoactive substances. It has been reported that endothelial impairment and dysfunction might be a primary cause of placental vascular disease, which is manifested clinically as preeclampsia in mother and intrauterine growth restriction in fetus. Furthermore, the frequency of apoptotic changes is increased in...
Blood Eosinophil and Serum Eosinophil Cationic Protein as a Marker of Bronchial Hyperresponsiveness in Children with Suspected Asthma
Yang Park, Hee Kang, Eun Kyeong Kang, Young Yull Koh
Clin Exp Pediatr. 2002;45(12):1577-1584.   Published online December 15, 2002
Purpose : Airway inflammation is considered to be a characteristic feature of asthma, and eosinophils are recognized as the most important inflammatory cells. This study aims to assess the importance of blood eosinophil count and serum eosinophil cationic protein(ECP) levels as a non- invasive marker of bronchial hyperresponsiveness(BHR) in children with suspected asthma. Methods : This study used data from 87...
Serological Analysis and Epidemiologic Characteristics of Group A Streptococci in Seoul(1998-2000)
Sun-Hee Choi, Yun-Ho Kim, Sung-Ho Cha, Ki-Sang Kim, Young-Hee Lee
Clin Exp Pediatr. 2002;45(11):1368-1372.   Published online November 15, 2002
Purpose : Group A streptococci have a cell wall which consists of M protein and T protein. T protein is known to be helpful in the understanding of the epidemiology of group A streptococci. To study the epidemiologic characteristics, we serotyped T protein of group A streptococci obtained from patients admitted to hospitals, or who visited OPD in five districts...
Case Report
A Case of Fetal Valproate Syndrome Associated with Both Elbow Joint Contractures
Yun Chang Choi, Eun Young Kim, Kynug Rye Moon, Young Il Rho
Clin Exp Pediatr. 2002;45(10):1288-1292.   Published online October 15, 2002
Fetal valproate syndrome has been described as a distinctive pattern of minor anomalies of the face and digits. This pattern has not been delineated completely but appears to involve brachycephaly with a high forehead, shallow orbit, ocular hypertelorism, small nose, small mouth, low set posteriorly rotated ears, long overlapping fingers and toes, and hyperconvex fingernail. Cleft palate and congenital heart disease have occasionally been...
Original Article
Study on Vaccination State in Children : Jeonbuk Province, 2000
Ju Mi Choung, Jung Chul Kim, So Hee Eun, Pyoung Han Hwang, B. Nyhambat, P. Kilgore, Jung Soo Kim
Clin Exp Pediatr. 2002;45(10):1234-1240.   Published online October 15, 2002
Purpose : This study was carried out to obtain the vaccination rate and age appropriateness of vaccination in children under five years of age in Jeonbuk province. Methods : Eight hundred and fifty infants and children were enrolled in this study. Vaccination rate(Number of vaccinees/Number of subjects), places of vaccination, age appropriateness of vacination were examined by either vaccine record review or interview with...
Case Report
A Case of Stevens-Johnson Syndrome Plus Vanishing Bile Duct Syndrome Associated with Ibuprofen Use
Jee Yee Choi, Su Young Kim, Soon Ok Byun, Jae Hong Park
Clin Exp Pediatr. 2002;45(9):1146-1149.   Published online September 15, 2002
Acute vanishing bile syndrome is a cause of progressive cholestasis. It is most often drug or toxin related. It's pathogenesis is unknown. Stevens-Johnson syndorme is a well-recognized immune complex-mediated hypersensitivity reaction. It is induced by drug or infection. It has classic systemic, mucosal, and dermatologic manifestations. We report a case of a 14 years old female suffering from Stevens-Johnson syndrome...
A Case of Neonatal Atrial Flutter Treated by Propafenone after Fetal Echocardiographic Diagnosis
Kyung Hwa Lee, Chang Woo Ha, Chul Ho Kim, Min Seob Song, Moon Su Sung
Clin Exp Pediatr. 2002;45(7):928-932.   Published online July 15, 2002
Perinatal atrial flutter is a potentially lethal arrhythmia. Management of this disorder is difficult and controversial. Fetal atrial flutter is a serious and life threatening rhythm disorder particulary when it causes hydrops; it may be associated with fetal death or neurological damage. Although the initial episode of flutter may be difficult to control, recurrence of atrial flutter after successful resolution...
Original Article
Effect of Xanthine Oxidase Inhibitor on Cerebral Hypoxia-Ischemia in Neonatal Rats
Dae-Ho Choi, Yeon-Kyun Oh, Seung-Tak Park
Clin Exp Pediatr. 2002;45(6):732-742.   Published online June 15, 2002
Purpose : In order to evaluate the hypoxia-ischemia(H-I) induced neurotoxicity and the protective effect of xanthine oxidase(XO) inhibitor(allopurinol), cell number, cell viability, lactate dehydrogenase(LDH), protein synthesis(PS) and protein kinase C(PKC) activity were measured in cerebral neurons and astrocytes. Methods : Cytotoxic effect was measured by in vitro assay at 12-72 hours after H-I on cerebral neurons and astrocytes derived from 7-day...
Case Report
A Case of Rett Syndrome with MECP2 Gene Mutation
Jin Kyung Kim, Chang Seok Ki, Jong Won Kim
Clin Exp Pediatr. 2002;45(4):540-544.   Published online April 15, 2002
Rett syndrome is an X-linked dominant, progressive neurodevelopmental disorder, with a prevalence estimated to be one in 10,000-15,000 girls, which is thought to be the second most common genetic causes of mental retardation in females after Down syndrome. Patients with classic Rett syndrome show an apparently normal neonatal period, followed by developmental regression and deceleration of head growth, accompanied by...
Original Article
Clinical Study of the Correlation of Tumor Necrosis Factor Alpha and the Proteinuria of Henoch-Schönlein Nephritis and Idiopathic Nephrotic Syndrome
Dong-Ho Jeong, Jeong-Hyun Park, Hye-Cheon Jeong, Hyun-Hoe Koo, Jun-Ho Lee, Tae-Sun Ha
Clin Exp Pediatr. 2002;45(2):240-246.   Published online February 15, 2002
Purpose : It is not clear that the development of glomerular injury and aggravation by tumor necrosis factor alpha(TNF-α) is related to intrarenal or serum concentration of TNF-α. So, we studied the relationship between the concentration of TNF-α and aggravation of glomerular damage in the Henoch-Schönlein nephritis(HSN) and idiopathic nephrotic syndrome(INS). Methods : We collected the sera and urines of...
Conversion of Total Atrio-pulmonary Connection to Total Cavo-pulmonary Connection - Review of Indications and Hemodynamic Characteristics -
Jung Ho Seo, Jong Kyun Lee, Jae Young Choi, Jun Hee Sul, Sung Kyu Lee, Young Whan Park, Bum Koo Cho
Clin Exp Pediatr. 2002;45(2):199-207.   Published online February 15, 2002
Purpose : Since the successful application of total atrio-pulmonary connection(TAPC) to patients with various types of physiologic single ventricles in 1971, post-operative survival rates have reached more than 90%. However some patients have been shown to present with late complications such as right atrial thrombosis, atrial fibrillation and protein losing enteropathy eventually leading to re-operation to control the long-term complications....
Changes of Body Weight and Lipid Profiles According to Apolipoprotein E Polymorphism in Children with Antiepileptics
Seung Hee Jang, Eun Kyoung Choi, So Hee Eun, Sun Jun Kim
Clin Exp Pediatr. 2002;45(1):88-94.   Published online January 15, 2002
Purpose : Weight changes, especially weight gain, is a side effect of antiepileptics(especially valproate and carbamazepine). This may be sufficiently severe to cause noncompliance or to require the withdrawal of effective treatment. Unfortunately, the exact mechanism of weight change is not illustrated. Several reports and our experiment suggested that weight gain highly correlated with a familial tendency of obesity. The genetic makeup is a...
A Study on the Disease Course and Prognosis of Cyclic Vomiting Syndrome
Hye Ran Yang, Jae Sung Ko, Jeong Kee Seo
Clin Exp Pediatr. 2001;44(10):1141-1156.   Published online October 15, 2001
Purpose : To describe clinical features of cyclic vomiting syndrome(CVS), managements during episodes, prophylactic drugs as long term therapy and to investigate the disease course and prognostic factors of CVS. Methods : Thirty two children who fulfilled the diagnostic criteria of CVS and who presented to Seoul National University Children's Hospital from March 1989 to December 2000, were included. Data were...
Case Report
Malignant Ectomesenchymoma in a Two-Month-Old Boy
Ji Young Hwang, Ji Hyoun Seo, Jeum-Su Kim, Young-Suk Kim, Sue-Jin Lee, Chan-Hoo Park, Yoo Kyung Kim, Sun Hoo Park, Jung Hee Lee, In Oak Ahn, Ki Hyun Chung, Byung-Kiu Park
Clin Exp Pediatr. 2001;44(8):959-964.   Published online August 15, 2001
Malignant ectomesenchymoma is a rare tumor originating from remnants of migratory neural crest(ectomesenchyme) and composed of neuroectodermal as well as mesenchymal components. Neuroblasts and ganglion cells constitute the neuroectodermal components and rhabdomyosarcoma is the most frequently encountered mesenchymal components. We report a case of malignant ectomesenchymoma in a two-month-old boy who was presented with abdominal pain and urinary difficulty. The...
Original Article
The Effectiveness of Propofol on Pediatric Cardiac Catheterization and Electrophysiologic Study
Woo Saeng Park, Myung Chul Hyun
Clin Exp Pediatr. 2001;44(7):773-777.   Published online July 15, 2001
Purpose : Our purpose was to evaluate the effectiveness of propofol on pediatric cardiac catheterization or radiofrequency catheter ablation. Methods : We measured the serial changes of arterial oxygen saturation, heart rate, systolic and diastolic blood pressure at 4 stages, a baseline(during normal sleep), stage 1(just after loading of propofol 2 mg/kg over 10 minutes), stage 2(10-15 minutes after propofol continuous...
Clinical Features of Food Protein-Induced Enterocolitis Syndrome
Jeong Sik Seo, Hai Lee Chung
Clin Exp Pediatr. 2001;44(7):758-763.   Published online July 15, 2001
Purpose : Food protein-induced enterocolitis syndrome(FPIES) is a symptom complex of severe vomiting and diarrhea which is known as a food-related gastrointestinal hypersensitivity disorder without evidence of IgE-mediated sensitivity. We described the clinical characteristics of FPIES in young infants. Methods : Twenty-eight patients, aged 7 to 120 days, were included who were diagnosed as FPIES by clinical criteria and food challenges....
Case Report
A Case of Protein-losing Enteropathy in Congestive Heart Failure : Resolution with Prednisolone
Jong-Woon Choi
Clin Exp Pediatr. 2001;44(5):587-591.   Published online May 15, 2001
Protein-losing enteropathy can result from primary or secondary intestinal lymphangiectasia. Secondary intestinal lymphangiectasia develops as a result of lymphatic obstruction or elevated lymphatic pressure. Cardiac lesions such as constrictive pericarditis, post-Fontan procedure state, and chronic congestive heart failure increase lymphatic pressure and may cause intestinal lymphangiectasia and protein-losing enteropathy. An 11-year-old girl who underwent corrective surgery for Tetralogy of Fallot...
Original Article
Identification of Novel Mutations and Three Most Common Mutations in the Human ATP7B Gene of Korean Patients with Wilson Disease
Han-Wook Yoo, Gu-Hwan Kim, Ji-Won Chung, Chang-Yeon Lee, Kyung-Mo Kim
Clin Exp Pediatr. 2001;44(5):569-576.   Published online May 15, 2001
Purpose : Wilson disease is an autosomal recessive disorder of copper transport, which is probably the most common inherited metabolic disorder in Korea. It is characterized by defective biliary excretion of copper and impairment in the corporation of copper into ceruloplasmin. In Wilson disease, synthesis of a defective copper transporting enzyme leads to the accumulation of copper in the liver, brain and kidney. The...
Long-term Clinical Follow-up of Korean Children with Wilson Disease; Twenty Years` Experience
Jin Soo Moon, Jae Sung Ko, Jeong Kee Seo
Clin Exp Pediatr. 2001;44(2):127-138.   Published online February 15, 2001
Purpose : To investigate the clinical features of long-term follow-up, and the treatment responses in Korean children with Wilson disease(WD). Methods : The clinical data from ninety-two children with WD, diagnosed at Seoul National University Hospital from 1976 to 1999, were reviewed. Mean duration of follow-up was 5¡¾4.5 years. We analysed the patient's records based on the clinical manifestations, laboratory findings,...
The Correlation Between the TSH Level in Neonatal Screening Test and the Prognosis of Congenital Hypothyroidism
Hong Sun Park, Kye Shik Shim, Kyuchul Choeh
Clin Exp Pediatr. 2001;44(1):25-31.   Published online January 15, 2001
Purpose : It is important to diagnose and treat newborn patients with congenital hypothyroidism as soon as possible because of neurodevelopmental outcome. If we can detect more severe forms of congenital hypothyroidism with neonatal screening test, the results of treatment will improve. Methods : Sixty-four term infants whose TSH levels in neonatal screening test had been higher than 20μIU were recalled....
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