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Original Article
Hu.4-1BB-Fc fusion protein inhibits allergic inflammation and airway hyperresponsiveness in a murine model of asthma
Byoung-Ju Kim, Ji-Won Kwon, Ju-Hee Seo, Won-Ah Choi, Young-Jun Kim, Mi-Jin Kang, Jinho Yu, Soo-Jong Hong
Clin Exp Pediatr. 2011;54(9):373-379.   Published online September 30, 2011

4-1BB (CD 137) is a costimulatory molecule expressed on activated T-cells. Repression by 4-1BB is thought to attenuate Th2-mediated allergic reactions. The aim of this study was to investigate the effect of 4-1BB on allergic airway inflammation in a murine asthma model.


BALB/c mice were sensitized to and challenged with ovalbumin (OVA). Hu.4-1BB-Fc was administered 1 day before the first OVA...

Review Article
Environmental tobacco smoke and childhood asthma
Dae Jin Song
Clin Exp Pediatr. 2010;53(2):121-128.   Published online February 15, 2010
In recent years, environmental tobacco smoke (ETS) has become an important worldwide public health issue. Children are particularly vulnerable to ETS because they are still developing. ETS exposure causes a wide range of adverse health effects on childhood asthma. There is convincing evidence that ETS exposure is causally associated with an increased prevalence of asthma, increased severity of asthma and...
Original Article
Relationship of serum IL-13 and eotaxin level with airway hyperresponsiveness in children with asthma
Eun Young Park, Jung Yeon Shim, Myung Hwan Yoo, Deok Soo Kim, Jae Won Shim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2006;49(8):889-894.   Published online August 15, 2006
Purpose : Asthma is characterized by the presence of airway hyperresponsiveness(AHR) and inflammation. The extensive eosinophil infiltration into the lung is the hallmark of asthma and contributes to the damage of respiratory epithelium during late phase airway responses. Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage(BAL) fluid of allergic inflammation. IL-13 has been known to induce the...
Characteristics of Childhood Asthma According to the Onset of Wheezing
Yoon Jeong Kim, Bong Seong Kim, Soo-Jong Hong
Clin Exp Pediatr. 2000;43(5):686-693.   Published online May 15, 2000
Purpose : To understand the characteristics of early childhood asthma, we evaluated and compared the characteristics between early persistent wheezers and late wheezers. Methods : From January, 1998 to December, 1998, 106 children aged six to seven years were divided into three groups according to the onset of wheezing : Early persistent wheezers(n=36) who had wheezing both before three years of...
Characteristics and Follow-Up of Bronchial Hyperresponsiveness in Cough Variant Asthma
Jeong-Ho Kim, Jung-Yeon Shin, Soo-Jong Hong
Clin Exp Pediatr. 1997;40(2):240-248.   Published online February 15, 1997
Purpose : Cough variant asthma is characterized as a persistent, nonproductive cough with minimal or no wheezing and dyspnea. Cough variant asthma can be overlooked or misdiagnosed because it is a common problem amongst all ages that frequently is unrecognized. The patho-physiology of cough variant asthma is still unclear. Methods : To characterize the pathophysiological abnormalities of cough variant asthma, bronchial provocation tests with methacholine...
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