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- Review Article
- Cardiology
- Heart failure in children and adolescents: an update on diagnostic approaches and management
- Amit Agrawal, Dalwinder Janjua, Abdulrahman Ahmed Alsayed Ali Zeyada, Ahmed Taher Elsheikh
- Clin Exp Pediatr. 2024;67(4):178-190. Published online June 19, 2023
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· Pediatric heart failure (PHF) is a clinical syndrome featuring various symptoms (shortness of breath, ankle swelling, fatigue) and signs (pulmonary crackles, peripheral edema).
· Congenital heart diseases are the most common underlying etiology of PHF, whereas myocarditis and primary cardio-myopathies are common in children without structural ab-normalities.
· PHF pathophysiology is complex and multifactorial and varies by etiology and age.
· PHF management includes decongestive therapy, treatment of underlying causes, preventing progression, and managing pulmonary or systemic obstructions.
· Drugs should be chosen based on pharmacodynamics, clinical manifestations, hemodynamic state, and renal function.
- Environmental changes surrounding congenital heart disease
- Eun-Young Choi
- Clin Exp Pediatr. 2023;66(8):332-338. Published online January 2, 2023
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· As the number of patients with congenital heart disease increases, the medical burden increases.
· Various fusion imaging techniques using percutaneous procedures have been introduced.
· With advances in technology, convenient ambulatory devices have been introduced.
· A well-organized team approach is required to resolve advanced heart failure in patients with congenital heart disease.
- Application of CRISPR-Cas9 gene editing for congenital heart disease
- Heeyoung Seok, Rui Deng, Douglas B. Cowan, Da-Zhi Wang
- Clin Exp Pediatr. 2021;64(6):269-279. Published online March 2, 2021
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Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) system has made a big step in the genome editing which still requires technical developments for the efficient applications in the many fields including congenital heart diseases (CHDs), closely related to the genomic abnormality. In this review, we tried to cover the most updated researches of CRISPR-Cas9 in the CHDs to understand the current technologies, eventually becoming therapeutic bases for the CHD patients.
- Original Article
- Neonatology (Perinatology)
- New modified version of the Risk Adjustment for Congenital Heart Surgery category and mortality in premature infants with critical congenital heart disease
- Young Mi Yoon, Seong Phil Bae, Yoon-Joo Kim, Jae Gun Kwak, Woong-Han Kim, Mi Kyoung Song, Seung Han Shin, Ee-Kyung Kim, Han-Suk Kim
- Clin Exp Pediatr. 2020;63(10):395-401. Published online July 15, 2020
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Questions: This study aimed to describe the survival of premature infants with critical congenital heart disease (CHD) and to identify the risk factors including the new modified version of the Risk Adjustment for Congenital Heart Surgery (M-RACHS) associated with mortality.
Finding: For premature infants with critical CHD, survival rate was 76.9% and very low birth weight (VLBW), persistent pulmonary hypertension of the newborn (PPHN), bronchopulmonary dysplasia (BPD), and M-RACHS 5 or more were associated with in-hospital mortality.
Meaning: VLBW, PPHN and BPD, as well as M-RACHS≥5, were risk factors for mortality among premature infants with critical CHD.
- Cardiology
- Outcomes of transcatheter closure of ductus arteriosus in infants less than 6 months of age: a single-center experience
- Gwang-Jun Choi, Jinyoung Song, Yi-Seul Kim, Heirim Lee, June Huh, I-Seok Kang
- Clin Exp Pediatr. 2018;61(12):397-402. Published online September 19, 2018
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Purpose: Transcatheter device closure of patent ductus arteriosus (PDA) is challenging in early infancy. We evaluated PDA closure in infants less than 6 months old. Methods: We performed a retrospective review of infants less than 6 months of age who underwent attempted transcatheter device closure in our institution since 2004. To compare clinical outcomes between age groups, infants aged 6–12 months...
- The outcome of percutaneous stent implantation in congenital heart disease: experience of a single institute
- Moon Sun Kim, Ja Kyoung Yoon, Seong Ho Kim, Ji Seok Bang, So Ick Jang, Sang Yoon Lee, Eun Young Choi, Su Jin Park, Hye Won Kwon
- Clin Exp Pediatr. 2018;61(6):187-193. Published online June 25, 2018
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Purpose The efficacy of percutaneous stent implantation for congenital heart disease (CHD) in Korea, where stent availability is limited, has not been determined. This study evaluated the acute and midterm results of stent implantation in different CHD subgroups.
Methods Stents were implanted in 75 patients with 81 lesions: (1) pulmonary artery stenosis (PAS) group, 56 lesions in 51 patients; (2) coarctation of the...
- Review Article
- Cardiology
- Recent advances in pediatric interventional cardiology
- Seong-Ho Kim
- Clin Exp Pediatr. 2017;60(8):237-244. Published online August 14, 2017
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During the last 10 years, there have been major technological achievements in pediatric interventional cardiology. In addition, there have been several advances in cardiac imaging, especially in 3-dimensional imaging of echocardiography, computed tomography, magnetic resonance imaging, and cineangiography. Therefore, more types of congenital heart diseases can be treated in the cardiac catheter laboratory today than ever before. Furthermore, lesions previously...
- Original Article
- Cardiology
- Impact of postoperative duration of Aspirin use on longevity of bioprosthetic pulmonary valve in patients who underwent congenital heart disease repair
- Tae-Woong Hwang, Sung-Ook Kim, Sang-Yun Lee, Seong-Ho Kim, Eun-Young Choi, So-Ick Jang, Su-Jin Park, Hye-Won Kwon, Hyo-Bin Lim, Chang-Ha Lee, Eun-Seok Choi
- Clin Exp Pediatr. 2016;59(11):446-450. Published online November 18, 2016
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Purpose Generally, aspirin is used as a protective agent against thrombogenic phenomenon after pulmonary valve replacement (PVR) using a bioprosthetic valve. However, the appropriate duration of aspirin use is unclear. We analyzed the impact of postoperative duration of aspirin use on the longevity of bioprosthetic pulmonary valves in patients who underwent repair for congenital heart diseases.
Methods We retrospectively reviewed the clinical data...
- Review Article
- Psychosocial adjustment and quality of life of adolescents and adults with congenital heart disease
- Gi Beom Kim
- Clin Exp Pediatr. 2014;57(6):257-263. Published online June 30, 2014
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The incidence of people living with congenital heart disease (CHD) has been increasing every year owing to remarkable advances in surgical and catheter intervention techniques and devices, and improved knowledge of critical care for patients with CHD. However, these patients continue to face physical, psychosocial, and environmental challenges, and a number of studies have shown higher rates of depression and...
- Right ventricular failure in congenital heart disease
- Young Kuk Cho, Jae Sook Ma
- Clin Exp Pediatr. 2013;56(3):101-106. Published online March 18, 2013
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Despite developments in surgical techniques and other interventions, right ventricular (RV) failure remains an important clinical problem in several congenital heart diseases (CHD). RV function is one of the most important predictors of mortality and morbidity in patients with CHD. RV failure is a progressive disorder that begins with myocardial injury or stress, neurohormonal activation, cytokine activation, altered gene expression,...
- Respiratory syncytial virus infection in children with congenital heart disease: global data and interim results of Korean RSV-CHD survey
- Jo Won Jung
- Clin Exp Pediatr. 2011;54(5):192-196. Published online May 31, 2011
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Respiratory syncytial virus (RSV) is a main cause of hospitalization for bronchiolitis and pneumonia in infants worldwide. Children with hemodynamically significant congenital heart disease (HS-CHD), as well as premature infants are at high risk for severe RSV diseases. Mortality rates for CHD patients hospitalized with RSV have been reported as about 24 times higher compared with those without RSV infection....
- Congenital heart disease in the newborn requiring early intervention
- Sin Weon Yun
- Clin Exp Pediatr. 2011;54(5):183-191. Published online May 31, 2011
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Although antenatal diagnostic technique has considerably improved, precise detection and proper management of the neonate with congenital heart disease (CHD) is always a great concern to pediatricians. Congenital cardiac malformations vary from benign to serious conditions such as complete transposition of the great arteries (TGA), critical pulmonary and aortic valvular stenosis/atresia, hypoplastic left heart syndrome (HLHS), obstructed total anomalous pulmonary...
- Original Article
- Early postoperative arrhythmias after open heart surgery of pediatric congenital heart diseas
- Hee Joung Choi, Yeo Hyang Kim, Joon Yong Cho, Myung Chul Hyun, Sang Bum Lee, Kyu Tae Kim
- Clin Exp Pediatr. 2010;53(4):532-537. Published online April 15, 2010
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Purpose : Early postoperative arrhythmias are a major cause of mortality and morbidity after open heart surgery in the pediatric population. We evaluated the incidence and risk factors of early postoperative arrhythmias after surgery of congenital heart disease. Methods : From January 2002 to December 2008, we retrospectively reviewed the medical records of the 561 patients who underwent cardiac surgery in Kyungpook National University... -
- Final height of patients with congenital heart disease
- Soon Ju Lee, Young Kuk Cho, Jae Sook Ma
- Clin Exp Pediatr. 2010;53(2):203-209. Published online February 15, 2010
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Purpose : Growth impairment is usually observed in children with congenital heart disease (CHD). Studies on the final height and weight of this population are insufficient. Our aim was to evaluate the final height of children with CHD and to identify the relationship between CHD and growth. Methods : We recorded the values of final height and weights of 105 CHD... -
- Surgical outcome of severe pulmonary arterial hypertension secondary to left-to-right shunt lesions
- Cha Gon Lee, Su In Jeong, June Huh, I-Seok Kang, Heung Jae Lee, Ji-Hyuk Yang, Tae Gook Jun
- Clin Exp Pediatr. 2010;53(2):195-202. Published online February 15, 2010
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Purpose : Despite recent advances in pulmonary hypertension management and surgery, appropriate guidelines remain to be developed for operability in congenital heart disease with pulmonary artery hypertension (PAH). Our aim was to evaluate clinical outcomes of patients with severe PAH who underwent surgical closure of left-to-right shunt lesions (LRSL) on the basis of pulmonary reactivity. Methods : We retrospectively reviewed 21... -
- Acoustic variations associated with congenital heart disease
- Jung Eun Oh, Yoon Mi Choi, Sun Jun Kim, Chan Uhng Joo
- Clin Exp Pediatr. 2010;53(2):190-194. Published online February 15, 2010
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Purpose : To investigate the nature of deviant voice physiology in preoperative children with congenital heart disease. Methods : Ninety-four children with congenital heart disease were enrolled. Their cries and related acoustic variables (fundamental frequency, duration, noise to harmonic ratio, jitter￠￢ and shimmer) were analyzed using a multi-dimensional voice program. Results : The average fundamental frequency showed a significant decrease in patent... -
- The changes in signal-averaged electrocardiogram after surgical correction of congenital heart disease
- Yeo Hyang Kim, Hee Jung Choi, Gun Jik Kim, Joon Yong Cho, Myung Chul Hyun, Sang Bum Lee
- Clin Exp Pediatr. 2009;52(12):1364-1369. Published online December 15, 2009
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Purpose : To analyze abnormal ventricular activation in childhood congenital heart disease induced by postoperative changes in ventricular volume and pressure and ventricular scar formation using signal-averaged electrocardiography (SAECG). Methods : Fifty-two patients who had undergone open heart surgery (OHS) were enrolled. Patients were divided into the following 3 groups: right ventricular volume overload (atrial septal defect, group1), left ventricular... -
- Metabolic syndrome in the overweight and obese adolescents and the impact of obesity on the cardiovascular system
- Yong Mi Hong, Young Young Song, Hae Soon Kim, Hae Sook Park, Jung Hae Min, Jo Won Jung, Nam Soo Park, Chung Il Noh
- Clin Exp Pediatr. 2009;52(10):1109-1118. Published online October 15, 2009
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Purpose : Metabolic syndrome (MS), characterized by obesity and insulin resistance, elicits risk factors such as hyperlipidemia, hypertension, and glucose intolerance with additive effects on atherosclerosis, leading to cardiovascular diseases. The purposes of this study were to evaluate the prevalence of MS among overweight and obese adolescents and to investigate the impact of obesity on the cardiovascular system. Methods : In... -
- Case Report
- Plastic bronchitis in children: 2 cases
- Yeo Hyang Kim, Hee Jung Choi, Jung Ok Kim, Myung Chul Hyun
- Clin Exp Pediatr. 2009;52(7):832-836. Published online July 15, 2009
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Plastic bronchitis is a rare disorder characterized by the formation of extensive, obstructing endobronchial casts. It is associated with asthma and complex cardiac defects such as those requiring the Fontan procedure. The treatment of plastic bronchitis comprises conventional therapy involving spontaneous expectoration and bronchoscopic removal and specific therapy with several new drugs. Herein, we describe the cases of 2 patients... -
- Review Article
- Right-sided heart failure in congenital heart diseases
- Jo Won Jung
- Clin Exp Pediatr. 2007;50(11):1055-1060. Published online November 15, 2007
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Right-sided heart failure is a major problem among patients with congenital heart diseases, due to the prevalence of congenital heart defects and the association of pulmonary hypertension. More attention is focused on the structure of the right heart particularly in association with congenital heart defects and chronic lung disease. The right ventricle (RV) may support the pulmonary circulation, and sometimes... -
- Original Article
- Evaluation of short-term cardiac function by tissue Doppler imaging in pre and postoperative period of congenital heart disease
- Jun-Hwa Lee, Yeo-Hyang Kim, Myung-Chul Hyun, Sang-Bum Lee
- Clin Exp Pediatr. 2007;50(5):476-483. Published online May 15, 2007
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Purpose : The objective of this study was to assess ventricular function by tissue Doppler imaging (TDI) in children with congenital heart disease (CHD) who have been undergoing open heart surgery (OHS) using cardiopulmonary bypass. We tried to compare the parameters of tissue Doppler imaging before and after OHS in patients with congenital heart disease. Methods : This study was conducted... -
- Impact of fetal diagnosis of congenital heart disease on parents
- Eun Young Choi, Chang Hoon Lee, Myung Ja Yoon, Eun Sook Han, Joon Suk Hong, Yun Sook Jung, Jung Yun Choi
- Clin Exp Pediatr. 2006;49(10):1073-1078. Published online October 15, 2006
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Purpose : This study was performed to assess how a fetal diagnosis of congenital heart disease affects parents, as regards pregnancy management and care of infants after birth. Methods : Database search to find out abnormal fetal echocardiography performed at Seoul National University Children's Hospital from July 1988 to June 2003 revealed 370 examinations. After excluding both arrhythmias without structural cardiac... -
- Review Article
- Medical management of adults with congenital heart disease
- I-Seok Kang
- Clin Exp Pediatr. 2006;49(9):937-945. Published online September 15, 2006
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The population of adult patients with congenital heart disease(CHD) has increased dramatically because of improved survival of infants and children with CHD. There are still a substantial number of adults with unrepaired CHD. Many adult patients do not know the possible problems of their disease such as ventricular dysfunction, arrhythmia, and what they should pay attention to. They often consider... -
- Original Article
- Relationship between depression and resilience in adolescents with congenital heart disease
- Ju Ryoung Moon, Yoen Yi Jung, June Huh, I-Seok Kang, Seung Woo Park, Ji-Hyuk Yang, Tae-Gook Jun, Myung Ja Kim, Heung Jae Lee
- Clin Exp Pediatr. 2006;49(5):523-528. Published online May 15, 2006
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Purpose : The purpose of this study was to investigate the relationship between depression and resilience in adolescents with congenital heart disease(CHD) and to identify the variables associated with depression. Methods : The Resilience Scale(cronbach’s α=0.92), Children's Depression Inventory(cronbach’s α= 0.72) and Maternal Behavior Research Instrument(cronbach’s α=0.88) were applied and analyzed to assess depression and resilience among 231 adolescents after... -
- Clinical features and surgical results of ruptured sinus of valsalva aneurysm
- Tae Ho Lee, Dong Won Lee, Joon Yong Cho, Myung Chul Hyun, Sang Bum Lee
- Clin Exp Pediatr. 2006;49(3):287-291. Published online March 15, 2006
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Purpose : Aneurysms of sinus valsalva are rare anormalies thought to be primarily congenital in origin, progressing into death by acute heart failure in cases of rupture. Surgical correction is the only method of treatment. With these clinical implications, we reviewed the clinical characteristics and surgical results of patients with ruptured sinus of valsalva aneurysm. Methods : Between January 1991... -
- Usefulness of Intraoperative Transesophageal Echocardiography
- Dong Won Lee, Byung Mok Kim, Sei Young Kim, Yeo Hyang Kim, Myung Chul Hyun, Sang Bum Lee
- Clin Exp Pediatr. 2004;47(12):1281-1286. Published online December 15, 2004
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Purpose : This study was undertaken to learn the usefulness, cost-effectiveness and safety of intraoperative transesophageal echocardiography(ITEE) during open heart surgery for congenital heart diseases. Methods : The usefulness and safety of ITEE were assessed in 254 patients who underwent open heart surgery for congenital heart diseases from January 1, 2001 to June 30, 2003, with retrospective chart reviews and a... -
- Congenital Heart Disease in Jeju : Postnatal Incidence and Clinical Features
- Jung Ha Lee, Gyu Hong Shim, Kyung Sue Shin, Jung Yun Hong, Yeoun Woo Kim, Seong Ho Kim, Chung Il Noh
- Clin Exp Pediatr. 2004;47(3):294-303. Published online March 15, 2004
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Purpose : This is a retrospective descriptive study to determine the incidence of congenital heart disease(CHD) in Jeju and to estimate the suitability of the Jeju population as the subject for a regional birth cohort study. Methods : All patients with CHD diagnosed by two dimensional echocardiography in Cheju National University Hospital and Halla General Hospital from January 1999 to... -
- Screening Test for Heart Diseases in the First Grade Elementary School Children in Busan
- Jae Min Oh, Hee Ju Park
- Clin Exp Pediatr. 2003;46(5):490-494. Published online May 15, 2003
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Purpose : We'd like to determine the incidence of congenital heart disease and arrhythmia in elementary school children in Busan, and to provide adequate prevention and treatment. Methods : A total of 23,802(male 12,909, female 10,893) 1st grade elementary school children living in Busan were studied. All children were 7-8 years old. We obtained their medical history by questionnaire and checked... -
- Case Report
- A Case of Isolated Right Ventricular Hypoplasia without Tricuspid Atresia or Pulmonary Atresia
- Eui Jun Yang, Sun Young Kim, Sank Ook Nam, Hee Ju Park, Nam Hee Kwak
- Clin Exp Pediatr. 1999;42(7):1026-1030. Published online July 15, 1999
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Isolated right ventricular hypoplasia, unassociated with severe pulmonary or tricuspid valvar malformations, is a rare primary congenital cardiac anomaly in which of the trabecular portion of right ventricle fails to develop. An atrial septal defect or a patent foramen ovale serves as an escape valve. We observed a 2-day-old neonate with this disorder who suffered from cyanosis. The diagnosis was... -
- Original Article
- Assessment of Regional Wall Motion of the Left Ventricle in Children with Congenital Heart Disease
- Chang Hee Han, Jun Ho Huh, Un Seok Nho, Byung Ho Choi, Myung Chul Hyun, Sang Bum Lee
- Clin Exp Pediatr. 1999;42(6):807-816. Published online June 15, 1999
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Purpose : To assess wall motion of the left ventricle in the various forms of congenital heart disease and to select appropriate methods by which to gauge left ventricular wall motion. Methods : We evaluated left ventricular function, including volume, global ejection fraction, and regional wall motion(Centerline method, Local Ejection Fraction, Curved Perimeter method and Radial method). The evaluation was done... -
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Impact Factor4.2
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6.52022CiteScore92nd percentilePowered by
