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Case Report
A case of thanatophoric dysplasia type I with an R248C mutation in the FGFR3 gene
Eun Jung Noe, Han Wook Yoo, Kwang Nam Kim, So Yeon Lee
Clin Exp Pediatr. 2010;53(12):1022-1025.   Published online December 31, 2010

Thanatophoric dysplasia (TD) is a short-limb neonatal dwarfism syndrome that is usually lethal in the perinatal period. It is characterized by shortening of the limbs, severely small thorax, large head with a prominent forehead, macrocephaly, curved femur, and flattened vertebral bodies. These malformations result from the mutation in fibroblast growth factor receptor 3 (FGFR-3) gene which is located on the...

Review Article
Treatment of juvenile rheumatoid arthritis
Kwang Nam Kim
Clin Exp Pediatr. 2010;53(11):936-941.   Published online November 30, 2010

The systematic approach to pharmacologic treatment is typically to begin with the safest, simplest, and most conservative measures. It has been realized that the more rapidly inflammation is under control, the less likely it is that there will be permanent sequelae. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of initial treatment for inflammation. In addition, the slow-acting antirheumatic drugs (SAARDs)...

Case Report
A Case of Subdural Abscess Caused by Morganella morganii
Eun Young Park, Su Jin Lee, Phil Soo Oh, Kwang Nam Kim, Seung Myung Moon
Clin Exp Pediatr. 2004;47(9):1024-1027.   Published online September 15, 2004
Morganella morganii, a gram-negative bacillus and part of normal faecal flora, is recognised as a common cause of urinary tract infection. We report a rare case of subdural abscess caused by M. morganii in an infant. It was secondary to purulent meningitis. The patient improved with treatment that consisted of surgical excision and systemic antibiotics.
Two Cases of Inhalation Injury Caused by An Explosion of Two Different Chemical Disinfectants(Sodium Dichloroiso Cyanurate & Calcium Hypochlorite) in a Swimming Pool
Su Jin Lee, Eun Young Park, Mi Ran Kim, Kon Hee Lee, Kwang Nam Kim
Clin Exp Pediatr. 2003;46(2):198-202.   Published online February 15, 2003
Of all toxic inhalant exposures, chlorine is one of the most common toxic chemical inhalants. When acutely inhaled, it can be responsible for symptoms ranging from upper air way irritation to more serious respiratory effects. It can also deteriorate lung function and lead to death. Chlorine and its compounds such as chlorinated cyanurates and hypochlorites are commonly used in water...
Original Article
Clinical Analysis of Acute Respiratory Tract Infections by Influenza Virus in Children
Min Kyoung Kwon, Mi Ran Kim, Eun Young Park, Kon Hee Lee, Hae Sun Yoon, Kwang Nam Kim, Kyu Man Lee
Clin Exp Pediatr. 2002;45(12):1519-1527.   Published online December 15, 2002
Purpose : Although influenza virus is one of the most important causes of acute respiratory tract infections(ARTIs) in children, virus isolation is not popular and there are only a few clinical studies on influenza in Korea. We evaluated the epidemiologic and clinical features of ARTIs by influenza virus in children. Methods : From February 1995 to August 2001, nasopharyngeal aspirations were...
Clinical Features of Acute Scrotum in Children
Ja Yun Yun, Mi Ran Kim, Kon Hee Lee, Kwang Nam Kim
Clin Exp Pediatr. 2001;44(12):1424-1431.   Published online December 15, 2001
Purpose : The acute scrotum is a clinical syndrome that is defined as an acute, painful swelling of the scrotum or its contents. The symptoms and signs of acute scrotum are similar and its pathognomonic features are rarely detected. This study was performed to find a proper way to diagnose and treat acute scrotum promptly and correctly. Methods : From January 1990 through December...
Case Report
Three Cases of Acute Scrotal Disorders in the Neonate
Ja Yun Yun, Min Kyoung Kwon, Mi Ran Kim, Kon Hee Lee, Kwang Nam Kim, Ho Hyun Jeong
Clin Exp Pediatr. 2001;44(7):841-846.   Published online July 15, 2001
Acute scrotal disorders(ASD) in neonates-especially the torsion of testes- are rare, and the clinical presentations are quite different from those of adolescents or adults. The neonates with ASD are generally afebrile and do not show typical symptoms. Early diagnosis and proper treatment of ASD are very important but the differentiation of torsion and orchitis is not easy in neonates. The...
A Case of Apert's Syndrome with Encephalocele and Hypogenesis of Corpus Callosum
Min Kyoung Kwon, Ja Yun Yu, Mi Ran Kim, Kon Hee Lee, Hae Ran Lee, Kwang Nam Kim
Clin Exp Pediatr. 2001;44(7):832-836.   Published online July 15, 2001
Apert's syndrome(acrocephalosyndactyly) is a rare congenital anomaly that is characterized by the combination of premature fusion of multiple cranial sutures primarily involving the coronal suture and severe symmetrical syndactyly of fingers and toes. Some patients of this syndrome have various abnormalities of the central nervous system. We experienced a case of Apert's syndrome with craniofacial malformations, symmetric syndactyly, occipital encephalocele...
Original Article
Brain Magnetic Resonance Imaging(MRI) in Neurologic Disorders of Children
Jin Hee Yun, Jae Guk Cha, Ki Sic Min, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo, Ho Chul Kim
Clin Exp Pediatr. 1995;38(8):1132-1140.   Published online August 15, 1995
Purpose : This study was performed to be helpful in early diagnosis and treatment of the children with neurologic disorders. Methods : One hundred and eighty-five pediatric patients with neurologic disorder were studied from May 1991 to March 1994, ranging in age from neonate to 15 years old. All patients were imaged with MRI. We observed age and sex distribution, frequency...
Prophylactic Effect of Diazepam to Prevent Recurrent Febrile Seiz
Seung Eun Choi, Ki Sik Min, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo
Clin Exp Pediatr. 1995;38(5):685-691.   Published online May 15, 1995
Purpose : The purpose of this study was to investigate efficacy of shortterm diazepam prophylaxis in recurrent febrile seizure. Methods : A total of 107 children admitted to the department of pediatrics, Kangdong Sacred Heart Hospital, Ballym University from 1 July 1991 to 31 December 1992, with their first or recurrent febrile seizures(one or two times), were entered in the study,...
Case Report
A Case of Right Lung Agenesis
Seung Hyun Seo, Yu Sub Shin, Ki Sik Min, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo
Clin Exp Pediatr. 1992;35(3):428-433.   Published online March 15, 1992
Lung agenesis is the very rare disease which is defined as total absence of the pulmonary parenchyma, its vascular supporting structure, and bronchi beyond the carina. In many cases, there are coexisting anomalies involving the skeletal, cardiovascular, gastrointestinal, and genitourinary systems. Also, severe respiratory infections are common in infancy and may lead to pneumonia and death. When associated anomalies are...
Original Article
Clincal Observations on Human Rotavirus (HRV) Gastroenteritis
Seung Ryong Han, Seung Hyun Seo, Ki Sik Min, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo
Clin Exp Pediatr. 1992;35(2):226-233.   Published online February 15, 1992
Clinical observations were made on 787 patients who were admitted to pediatric department of Kangdong Sacred Heart hospital because of watery diarrhea and vomiting between Jan. 1987 and Dec, 1989. ELISA study was done to detect HRV antigen for all patients. The results were as follows : 1) HRV antigen was detected in 492 patients (62.5%) by ELISA among 787 patients with watery...
Intracranial hemorrhage in the prematurity and small for gestational age an attempt of clinico-ultrasonographic correlation.
Kwang Sup Kim, You Seop Shin, Jong Wan Kim, Kwang Nam Kim, Ki Yang Ryoo, Hyo Keun Lim
Clin Exp Pediatr. 1991;34(1):49-56.   Published online January 31, 1991
To evaluate the correlation between clinical and ultrasonographic findings, 79 consecutive brain ultrasonographic examinations were performed in the 50 prematurity and 29 SGA. Statistical significance was not detected about sex ratio, hemoglobin and hematocrit, Apgar score and maternal age between the prematurity and SGA. Incidence of ICH was 66% in the prematurity and 48% in the SGA. According to Papile’s grading system, Grade 1 was...
A Study of Ultrasonographic findings in Children with Gastrointestinal Symptoms.
Dong Lag Choi, Kwang Sup Kim, Jong Wang Kim, Duk Kyu Kim, Kwang Nam Kim, Ki Yang Ryoo, Hyo Keun Lim
Clin Exp Pediatr. 1990;33(11):1548-1556.   Published online November 30, 1990
We analyzed retrospectively the sonographic findings in 162 children who accompanied with gastrointes- tinal symptoms and performed the comparative analysis of the clinico-pathologic findings to sonographic findings from Jan. 1988 to July 1989. The most frequent symptom was abdominal pain (79.6%). The clinical impression prior to ultrasonography were acute appendicitis (34%), mesenteric lymphadenitis (10.4%), hyper- trophic pyloric stenosis (5%) in order. Positive cases in...
Case Report
A case of Sacrococcygeal Teratoma.
Seung Jae Yang, Kwang Nam Kim, In Joon Seol, Soo Jee Moon, Keun Soo Lee
Clin Exp Pediatr. 1986;29(5):564-569.   Published online May 31, 1986
We exprienced a case of sacrococcygeal teratoma in newborn girl with massive intraabdominalfextensioii and small caudal mass, which is relative rare.
Original Article
Clinical Studies on Childhood Bronchial Asthma.
Kwang Nam Kim, Soo Yup Lee, Ha Baik Lee, Kyu Hwan Lee, Woo Gill Lee, Keun Soo Lee
Clin Exp Pediatr. 1985;28(10):997-1006.   Published online October 31, 1985
The results of clinical observation and hematologic findings on 120 cases with bronchial asthma who were admitted to the department of pediatrics, Hanyang University Hospital from Mar. 1984 to Feb. 1985 were as followings: 1)As to the age distribution, 80% of total cases were under 7-year-old and the sex ratio was 2.6 . 1 with male predominance. 2)As to the...
Case Report
A case of Congenital Nephrotic Syndrome.
Kwang Nam Kim, Kwang Hyun Kim, In Joo Seol, Ha Baik Lee, Chong Moo Park
Clin Exp Pediatr. 1985;28(9):931-935.   Published online September 30, 1985
The congenital nephrotic syndrome is characterized by large placenta, low birth weight, early clinical findings, delayed growth and development and resistance to treatment. Authors experienced a case of characteristic of congenital nephrotic syndrome in a girl, who was admitted to the Pediatric Department of HUH at 28 days of age because of generalized edema, abdominal distension with vomiting and diarrhea....
Original Article
Clinical Studies of Anaphylactoid Purpura in Childhood.
Kwang Hyun Kim, Kwang Nam Kim, Ha Baik Lee, Hang Lee
Clin Exp Pediatr. 1985;28(6):545-554.   Published online June 30, 1985
Anaphylactoid purpura or Henoch-Schonlein purpura is a common pediatric disease presenting most frequently with purpura, and occasionally with gastrointestinal and joint manifestations, and has been known to present pathologically with diffuse vasculitis involving small blood vessles in many organs. Clinical manifestations and laboratory findings were observed and analyzed in 110 cases with anaphylactoid purpura hospitalized at Hanyang University Hospital during...
Clinical Study of Idiopathic Thrombocytopenic Purpura in Children.
Kwang Nam Kim, Sang Hee Cho, Je Hoon Shin, Woo Gill Lee
Clin Exp Pediatr. 1985;28(3):251-257.   Published online March 31, 1985
The authors studied 26 cases with idiopathic thrombocytopenic purpura who were admitted to Department of Pediatrics Hanyang University Hospital. The results were as follows: 1)The peak incidence of age was 5 to 7 years old. Male to female ratio was 2.7 : 1 which showed: slight male preponderance. 2)lThe most prevalent seasons were spring and summer. In both seasons, the...
Clinical Study of the Paranasal Sinusitis in Childhood.
Young Suk Song, Kwang Nam Kim, Gwi Jong Choi, Chong Moo Park, Hyung Seok Lee
Clin Exp Pediatr. 1984;27(9):877-882.   Published online September 30, 1984
Sinusitis is generally considered to occur frequency to children. However, objective diagnostic procedures to establish the etiology of the disease have not been used ordinarily because of the growth and development of paranasal sinus in childhood. Due to these difficulties, adequate information concerning the incidence of the disease and its optimal therapy has not been available. This retrospective study was...
Case Report
Adrenogenital Syndrome with Congenital Adrenal Hyperplasia.
Myoung Sung Moon, Kwang Nam Kim, Woo Gill Lee
Clin Exp Pediatr. 1984;27(5):511-515.   Published online May 31, 1984
When the adrenogenital syndrome is associated with congenital adrenal hyperplasia, it is caused by an inborn defect in the biosynthesis of adrenal corticoids. Especially, infant with congenital adrenal hyperplasia caused by a 21-hydroxylation. defect in steroidogenesis often present with salt-losing crisis, hyponatremia and dehydration. Vomiting is prominent and disturbances in cardiac rate and rhythm may occur. Without treatment, collapse and death...