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Volume 39(11); Nov 1996
Medical Lecture Courses
Molecular Biological Aspects of Neuroblastoma
Hwang Min Kim
J Korean Pediatr Soc. 1996;39(11):1493-1497.   Published online November 15, 1996
Eosinophilic Gastroenteritisin Childhood and Competitive RT-PCR,In vitro Lymphocyte Proliferation Response to Food Antigens
Jea Won Oh
J Korean Pediatr Soc. 1996;39(11):1498-1503.   Published online November 15, 1996
Clinical Lecture
Surgical Emergencies of the Abdomen in Children
Soo-Myung Oh
J Korean Pediatr Soc. 1996;39(11):1504-1511.   Published online November 15, 1996
Original Articles
Changes in MaternalAge and the Incidence of Down Syndrome
Chang Weon Oh, Sung Su Lim, Ki Bok Kim, Won Jin Kee
J Korean Pediatr Soc. 1996;39(11):1512-1519.   Published online November 15, 1996
Purpose : The incidence of Down syndrome, the most common chromosoaml anomaly, increases with the advanced maternal age. Recently, however, the incidence of Down symdrome was reported to have decreased with wide acceptance of prenatal diagnosis and planned parenthood, prompting us to re-evaluate the incidence of Down syndrome in relation to changes in maternal age. Methods : Subjected to study were 296 Down cases: 26...
Relation of Umbilical Cord Blood Insulin/C-peptide to Neonatal Anthropometric Measures in Offspring of Mother with Normal Glucose Metabolism
Sun Young Kho, Hye Kyung Han, Mi Ryung Uhm, Kyung Hoon Kim, Mi Na Lee, Hak Chul Jang, Moon-young Kim
J Korean Pediatr Soc. 1996;39(11):1520-1526.   Published online November 15, 1996
Purpose : We tried to find the relationships between the fetal beta-cell function and neonatal birth weight, anthropometric measures, and maternal characteristics, and to observe role of insulin as fetal growth factor in offsprings of mothers who have normal glucose metabolism. Methods : We measured umbilical cord blood insulin and C-peptide concentrations in 236 neonates delivered at Cheil General Hospital from Jan. 1 to...
Trend of Tuberculous Meningitis since 1970
Jeong A Park, Chang Weon Oh, Kyoung Sim Kim, Yong Wook Kim, Ki Bok Kim
J Korean Pediatr Soc. 1996;39(11):1527-1537.   Published online November 15, 1996
Purpose : The incidence of tuberculous meningitis has reportedly decreased from 4.2% in 1970 to 1.8% in 1990 in Korea; however, tuberculous meningitis, which spreads hematogenously, claiming majority of mortality in childhood tuberculosis, still poses serious problems. This study was performed to evaluate the recent trend of tuberculous meningitis. Methods : We compared with three groups of tuberculous meningitis, two were our previous reports on...
Clinical Course of the Ostium Secundum Atrial Septal Defect(ASD) and Its Rate of Spontaneous Closure
Dae Yong Kim, Myung Chul Hyun, Sang Bum Lee
J Korean Pediatr Soc. 1996;39(11):1538-1543.   Published online November 15, 1996
Purpose : To know the natural course of the ostium secundum ASD including its rate of spontaneous closure. Methods : We studied 259 cases who were diagnosed as ostium secundum ASD by 2D-echocardiography at Department of Pediatrics, Kyungpook National University Hospital between Jan. 1985 and Dec. 1994. According to the age at diagnosis, we divided them into two groups, group I (those diagnosed before 1...
The Diagnostic Value of Liver Biopsy in Children with Fever of Unknown Origin and Hepatosplenomegaly
Sue Mee Park, Yeon Ho Choi, Jong Jae Kim, Hoan Jong Lee, Jeong Kee Seo
J Korean Pediatr Soc. 1996;39(11):1544-1555.   Published online November 15, 1996
Purpose : Although many strides have been made in the radiological and laboratory diagnosis, the liver biopsy is still considered an important tool for the diagnosis of liver disease. We report our experience that histologic investigation of the liver was essential searching for the etiologic diagnosis in eight children with fever of unknowm origin and hepatosplenomegaly, who's diagnosis were not documented by other diagnostic...
Caustic Esophagitis and Gastrofiberoscopy in Children
Hyeon Jeong Kim, Jeong Kee Seo
J Korean Pediatr Soc. 1996;39(11):1556-1564.   Published online November 15, 1996
Purpose : There have been many accidental ingestions of strong acid or alkali in early childhood. If the patient survives the acute effects of caustic ingestion, the reparative response can result in esophageal and gastric stenosis. However there have been few endoscopic studies on caustic esophagitis in children. The aim of this study was to review the contribution of the endoscopy to the diagnosis...
Diagnostic Significance of DMSA Renal Scan and C-Reactive Protein in Urinary Tract Infection of Childhood
Sung Ho Hong, Hyang Mi Kwon, Hye Lim Jung, Dong Hyuck Kuem
J Korean Pediatr Soc. 1996;39(11):1565-1575.   Published online November 15, 1996
Purpose : Renal scar or reflux nephropathy, known as a major cause of end-stage renal failure and hypertension in children and young adults, is frequently detected in pediatric urinary tract infection(UTI) patients at their first infections. So early and accurate diagnosis, and follow up of renal scar are very important. We performed this study to recognize the importance of radiologic examinations for detection of...
The Effect of Allopurinolon the Ischemia-reperfusion RenalInjury in Young Rats
Seung Joo Lee
J Korean Pediatr Soc. 1996;39(11):1576-1585.   Published online November 15, 1996
Objective : Oxygen free radicals has been reported to be the critical cellular mediators of experimental ischemia-reperfusion renal injury. We examined the protective effect of allopurinol (an xanthine oxidase inhibitor) on the renal damage by reperfusion in the ischemic rat kidney. Methods : To induce renal ischemia, the Sprague-Dawley rats(weight 70-80g) were placed in a sealed 5L jar with 8% O2-92% N2 gas mixture...
Diagnostic Value of 99mTc-DMSA Renal Scan for Early Diagnosis of Acute Pyelonephritis in Children with Febrile Urinary Tract Infection
Soo Ja Hwang, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee, Sun Whan Lee
J Korean Pediatr Soc. 1996;39(11):1586-1593.   Published online November 15, 1996
Purpose : For prevention of renal scar, early diagnosis and treatement of acute pyelonephritis are important in children with febrile urinary tract infection. But it has been difficult to differentiate acute pyelonephritis from lower urinary tract infection. We have performed this study to evaluate the diagnostic value of 99mTc-DMSA renal scan and to clarify the relationship among acute pyelonephritis, vesico-ureteral reflux and renal scar. Methods...
The Characteristics of Insulin-like Growth Factor Binding Protein-3(IGFBP-3) in Serum; The Diagnostic Utility of IGFBP-3 in Growth Hormone Deficiency
Ki-Joong Kim, Jeh-Hoon Shin, Young-Ik Lee
J Korean Pediatr Soc. 1996;39(11):1594-1599.   Published online November 15, 1996
Purpose : For diagnosis of growth hormone(GH) deficiency in short stature, peak growth hormone levels after pharmacologic stimulation are usually used. In this study, we measured serum IGFBP-3, which is a major binding protein in serum and is considered to be GH-IGF-I axis dependent, levels by radioimmuno assay(RIA) in sera from normal short stature(NSS) children, and patients with GH deficiency children to clarify the...
Study of Epstein Barr Virus Antibodies in Patients with Kawasaki Disease
Dong Hee Shin, Kyung Hyo Kim, Young Mi Hong, Gyung Hee Kim
J Korean Pediatr Soc. 1996;39(11):1603-1610.   Published online November 15, 1996
Purpose : The etiology of the Kawasaki disease remains unclear, many strong clinical and epidemiologic characteristics suggest an infectious etiology. However, conventional bacterial and viral cultures and extensive serologic studies have not revealed a consistent causative agent. Thus we studied the Epstein Barr virus(EBV), one of the most important pathogens, to access the association between the EBV and Kawasaki disease. Methods : Seventy-two patients with...
Case Reports
Two Cases of Nitric Oxide Inhalation for Treatment of Severe Pulmonary Hypertension after Surgical Repair of Congenital Diaphragmatic Hernia
Yun Sil Chang, I-Seok Kang, Won Soon Park, Suk Koo Lee, Hun Hahk Kim, Heung Jae Lee
J Korean Pediatr Soc. 1996;39(11):1611-1619.   Published online November 15, 1996
Nitric oxide, an endothelium-derived relaxing factor, is a selective pulmonary vasodilator. We have built and settled down the delivery system of nitirc oxide gas inhalation for the first time in Korea. Two newborn babies delvelped near fatal pulmonary hypertension after surgical repair of a congenital diaphragmatic hernia. All conventional therapeutic measures failed. So we decided to attempt to use of nitric oxide gas for...
A Case of Nezelof's Syndrome
Hyeon Tae Kim, Nok Hong Kim, Eun Yeong Seol, Ki Hyun Chun, Kung Ho Lee, Mun Ki Cho, Kung Ran Choi
J Korean Pediatr Soc. 1996;39(11):1620-1626.   Published online November 15, 1996
Nezelof's syndrome(combined immunodeficiency with immunoglobulin) is a hereditary primary immunodeficiency characterized by recurrent chronic pulmonary infections, oral and cutaneous candidiasis, failure to thrive, chronic diarrhea, skin infection, urinary tract infection, gram-negative sepsis, severe progressive varicella infection, lymphopenia, diminished lymphoid tissue, abnormal structure of the thymus, and presence of normal or increased levels of one or more of the major immunoglobulin classes, but with impaired antibody...
A CaseofAdrenal Aplasi
Yoon-Ok Kim, Myoung-Bum Choi, Yun-Kyeong Cho, Jae-Yong Lim, Yang-Suk Jung, Suong-Hwan Kim, Hyang-Ok Woo, Hee-Shang Youn
J Korean Pediatr Soc. 1996;39(11):1627-1630.   Published online November 15, 1996
Major known causes of neonatal adrenal insufficiency are prolonged maternalsteroid use, adrenal hemorrhage from the perinatal stress and adrenogenital syndrome. Theoretically adrenal aplasia might be a cause of neonatal adrenal insufficiency but it has not been reported yet. We had experienced a case of adrenal aplasia in a 5 day-old male neonate whose chief complaint was hyperpigmentation. His laboratory findings were compatible...
Gastric Duplication in the Newborn
Seong Jin Hong, Kyo Sun Kim, Hee Won Ham, Jeong Hee Park
J Korean Pediatr Soc. 1996;39(11):1631-1635.   Published online November 15, 1996
Duplications of the stomach account for only 3.8% of gastrointestinal duplication, mainly discovered during first year of life. Etiopathogenesis is unknown. The most widely accepted theory is recannalization with fusion of longitudinal epithelial fold. The most frequent presented symptoms and signs include gastric outlet obstruction with vomiting, and palpable mass in the epigatric area. An upper gatrointestinal series usually reveals evidence of extrinsic mass...
A Case of Tethered Cord Syndrome
Sook Yeong Jeon, Ki Hyoung Lee, Moon Sung Park, Ok Wha Kim
J Korean Pediatr Soc. 1996;39(11):1636-1640.   Published online November 15, 1996
Tethered cord syndrome is one of the spinal dysraphism with low-lying conus medullaris frequently associated with spinal lipoma, diastematomyelia and thick filum. The clinical manifestation is variable from no overt symptoms for a long time to back pain, scoliosis, progressive neurological deficit of legs and incontinence. Therefore the diagnosis requires a strong clinical suspicion and aggressive investigation. We experienced a case of 1 day-old male...