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Volume 47(7); Jul 2004
Clinical Lectures
Pathophysiology of Persistent Pulmonary Hypertension of the Newborn
Yong Hoon Jun
Korean J Pediatr. 2004;47(7):707-715.   Published online July 15, 2004
Persistent pulmonary hypertension of the newborn(PPHN) is a disorder characterized by persistence of the pattern of fetal circulation after birth due to a sustained elevation of pulmonary vascular resistance. The two primary events in the pathophysiology of neonatal pulmonary hypertension are hypoxic pulmonary vasoconstriction(HPV) and hypoxic pulmonary vascular remodeling(HPR). Chronic hypoxemia may cause increased muscularity of the pulmonary arteries and...
About the Reformed Medical Terms
In Seok Lim
Korean J Pediatr. 2004;47(7):716-718.   Published online July 15, 2004
Concerning our medical history, the importance of medical terms has been neglected for a long time. In addition, medical terminologies are unaccustomed to the patients including the public. The separation of communications between the public and medical participants has been enlarged more and more. The importance of terms which can be easily recognized, comfortable to the ear, and familiar to...
Original Articles
A Study for Adiponectin in Obese Adolescents with Hypertension
Jee Yoon Park, Su Jin Cho, Kyung Hyo Kim, Young Mi Hong, Keun Lee
Korean J Pediatr. 2004;47(7):719-725.   Published online July 15, 2004
Purpose : The adipocyte has traditionally been known as a reservoir for energy, but currently there is growing evidence that the adipocyte plays an important role in the pathogenesis of energy metabolism and homeostasis. Adipocytokine released from the adipocyte has been known to play a role in diabetes mellitus, coronary artery disease and other diseases related with obesity. The purpose...
Diagnostic Approach of Wiskott-Aldrich Syndrome
Dong Jin Hwang, Jun Won Yang, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Korean J Pediatr. 2004;47(7):726-734.   Published online July 15, 2004
Objective : A probable diagnosis of Wiskott-Aldrich syndrome(WAS) should be considered in any boy presenting with unusual bleeding, congenital thrombocytopenia and small platelets. The definitive diagnosis of WAS is usually made by the detection of WASP gene mutation or a decrease or absence of the WAS protein(WASP) in blood cells using molecular genetic analysis. However, these methods are too time-consuming...
Association between the Human Surfactant Protein-A(SP-A) Gene Locus and Respiratory Distress Syndrome in Korean Neonates
Jae Hoon Choe, Myung Ho Oh, Jung Ho Ko, Sun Young Kim, In Kyu Lee, Chong Woo Bae
Korean J Pediatr. 2004;47(7):735-739.   Published online July 15, 2004
Purpose : Respiratory distress syndrome(RDS) is caused by a deficiency of pulmonary surfactant, which is a lipoprotein complex. Both low levels of surfactant protein A(SP-A) and SP-A alleles have been associated with RDS. However, the genes underlying susceptibility to RDS are insufficiently known. The candidate-gene approach was used to study the association between the SP-A gene locus and RDS in...
Antithrombin III in the Diagnosis and Treatment of Disseminated Intravascular Coagulation in Premature Infants
Su Jin Cho, Hye Ryung Choi, Young Mi Hong, Kyung Hee Kim, Keun Lee, Eun Ae Park
Korean J Pediatr. 2004;47(7):740-745.   Published online July 15, 2004
Purpose : We evaluated the diagnostic implications and therapeutic efficacy of antithrombin III(AT III) in the disseminated intravascular coagulation(DIC) of premature infants. Methods : Ninety-two premature infants diagnosed with DIC and treated with AT III from March, 2000 to May, 2003 were retrospectively reviewed. Clinical manifestations, complete blood counts, coagulation tests, and AT III levels were compared between the two groups...
Evaluation of Intrauterine Growth in Neonates with Congenital Heart Disease
Ji Hyun Yeo, Hee Jung Lee, Eun Sil Lee, Young Hwan Lee
Korean J Pediatr. 2004;47(7):746-750.   Published online July 15, 2004
Purpose : Intrauterine growth retardatation(IUGR) is very important because of high mortality and morbidity in the neonatal period. We studied the intrauterine growth retardation pattern in neonates with congenital heart disease(CHD). Methods : One hundred seventeen cases with CHD(acyanotic, 73 cases; cyanotic, 44 cases) who had no other congenital malformation or maternal diseases that might affect fetal growth were enrolled in...
A Clinical Study of Neurologic Abnormalities Associated with Rotavirus Gastroenteritis
Yoon-Duk Kang, Myung-Kul Yum, Jae-Won Oh, Chang-Ryul Kim, In-Joon Seol, Jung-Oak Kang
Korean J Pediatr. 2004;47(7):751-755.   Published online July 15, 2004
Purpose : Reports of neurologic abnormalities associated with acute diarrhea are increasing recently. It was reported that the incidence of the neurologic abnormalities related to gastroenteritis was higher in rotavirus gastroenteritis than in non-rotavirus gastroenteritis. We investigated the incidence, the manifestations and the prognosis of the neurologic abnormalities associated with rotavirus diarrhea and non-rotavirus diarrhea in Korean children. Methods : Six...
Colonic Polyps; Experience of 34 Cases in Two Hospitals
Seoung Joon Kim, Sun Mi Kim, You Jeong Kim, Dae Chul Jeong, Won Bae Lee, Seung Yun Chung, Jin Han Kang
Korean J Pediatr. 2004;47(7):756-761.   Published online July 15, 2004
Purpose : Colonic polyps are among the most common causes of rectal bleeding in children. We studied the clinical spectrum, histology, malignant potential and treatment of colonic polyps in our cases. Methods : We reviewed hospital charts of all patients with colonic polyps, seen over a 15-year period from January 1988 to November 2002. Colonoscopy and/or barium enema were done for...
CSF Examination in the First Febrile Seizure
Joseph Jo, Sun Hee Yu, Young Taek Jang
Korean J Pediatr. 2004;47(7):762-767.   Published online July 15, 2004
Purpose : This study was launched to classify subjects of the CSF examination and improve early diagnosis of meningitis and its treatment in children who have had a first febrile seizure. Methods : From March 1995 to September 2003, children aged 3 months to 5 years who had had treatment for febrile seizure were analyzed as to their age at first...
Evaluation of Intellectual Development in Patients with Transient Congenital Hypothyroidism at Early School Age
Pil Ju Jeong, Su Yung Kim
Korean J Pediatr. 2004;47(7):768-773.   Published online July 15, 2004
Purpose : Thyroxine is the hormone indispensible to the growth and development of infants. We made this study to confirm the influence of temporary depression of serum thyroxine levels on the development of intelligence. Methods : I adopted as the study group 14 patients diagnosed with depression at the pediatrics department of Pusan National University Hospital from April of 1991 to...
Methylenetetrahydrofolate Reductase(MTHFR) Gene Expression in Kawasaki Disease
Hye Ryung Choi, Ae Ra Joo, Hae Soon Kim, Sejung Sohn, Young Mi Hong
Korean J Pediatr. 2004;47(7):774-778.   Published online July 15, 2004
Purpose : Hyperhomocysteinemia is known as an independent risk factor for cardiovascular diseases such as atherosclesosis and myocardiac infarct. A common mutation in 5, 10-methylenetetrahydrofolate reductase(MTHFR) gene results in a valine for alanine substitution, which makes enzyme thermolabile and reduces enzymal activity. We examined the relation of MTHFR genetic mutation and Kawasaki disease. Methods : We extracted DNA from the peripheral...
Effect of Histone H1 on Collagen Induced Arthritis in Mice
Jae Ho Yang, Kyung Mi Shin, Dong Soo Kim
Korean J Pediatr. 2004;47(7):779-788.   Published online July 15, 2004
Objective : Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule of sea urchin sperm flagella. This microtule assembly function of the histone is similar to that of taxol, which has an effect of controlling joint inflammation. In this study,...
Case Reports
A Case of Neonatal Hydrometrocolpos Accompanying Urinary Tract Obstruction
Kyoung Eun Lee, Ok Yeon Cho, Eun Jung Sim, Do Jun Cho, Dug Ha Kim, Ki Sik Min, Ki Yang Yoo, Guan Sup Lee
Korean J Pediatr. 2004;47(7):789-793.   Published online July 15, 2004
Neonatal hydrometrocolpos is the cystic dilatation of the vagina and uterus, which is caused by the combination of vaginal obstruction such as imperforate hymen, transverse vaginal septum, or vaginal atresia, and glandular secretion by maternal estrogenic stimulation. Although hydrometrocolpos is a rare congenital abnormality unlike pubertal hematocolpos, it is one of the relatively common abdominal masses in neonates. In typical...
A Case of CATCH22 Syndrome with First Attack of Hypocalcemic Seizure at 13 Years of Age
Young Won An, Mi Jin Jung, Jee Suk Yu, Young Seok Lee, Han Wook Yoo
Korean J Pediatr. 2004;47(7):794-798.   Published online July 15, 2004
The acronym 'CATCH22' is characterized by many clinical manifestations such as cardiac defects, abnormal face, thymic and parathyroid hypoplasia, cleft palate and hypocalcaemia. It is now known to arise from chromosome 22q11.2 microdeletion, and it is also called 22q11.2 deletion syndrome. Hypocalcemia occurs in more than 50% cases of this syndrome, most frequently in neonatal periods, with some exceptions. Our...
A Case of Hereditary C7 Deficiency Associated with Meningococcal Meningitis
Hyun Woo We, Won Duck Kim, Sun Ju Lee, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Gyoung Yim Ha
Korean J Pediatr. 2004;47(7):799-802.   Published online July 15, 2004
The complement system is composed of more than 25 different proteins and is usually divided into classical and alternative pathways. Complement component 7(C7) is one of the five terminal complement proteins that, upon activation of either the classical or the alternative pathway, interacts sequentially to form a large protein-protein complex, called membrane attack complex(MAC). Assembly of the MAC on target...
Bronchiolitis Obliterans Associated with Stevens-Johnson Syndrome
Ko Un Chun, Soo Yun, Byung Ho Cha, Hae Yong Lee
Korean J Pediatr. 2004;47(7):803-806.   Published online July 15, 2004
Bronchiolitis Obliterans(BO) is one of the rare inflammatory lung disease that primarily affects bronchi and bronchioles, followed by partial or complete obstruction. In children, the etiology of BO has been under consideration, but infections and toxic inhalation, connective tissue diseases, lung transplantation, congestive pulmonary edema, etc., may be causes of BO. Even though steroid therapy was reported as an effective...