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Volume 50(9); Sep 2007
Review Articles
The management and treatment of chronic hepatitis B in Korean children
Byung-Ho Choe
Korean J Pediatr. 2007;50(9):823-834.   Published online September 15, 2007
Interferon (IFN) alpha has been the first line therapy of chronic hepatitis B in children, but HBeAg seroconversion occurred in 26% of treated children compared to 11% of controls in multinational randomized controlled study. Recently, lamivudine was shown to be a potent inhibitor of Hepatitis B virus (HBV) reproduction both in HBeAg positive and in HBeAg negative (the pre-core mutant...
The etiologies of neonatal cholestasis
Jae Sung Ko, Jeong Kee Seo
Korean J Pediatr. 2007;50(9):835-840.   Published online September 15, 2007
Any infant noted to be jaundiced at 2 weeks of age should be evaluated for cholestasis with measurement of total and direct serum bilirubin. With the insight into the clinical phenotype and the genotypephenotype correlations, it is now possible to evaluate more precisely the neonate who presents with conjugated hyperbilirubinemia. Testing should be performed for the specific treatable causes of...
Acute liver failure in children
Kyung Mo Kim
Korean J Pediatr. 2007;50(9):841-847.   Published online September 15, 2007
Acute liver failure (ALF) is a very rare but devastating illness in children. Specific treatment to recovery is often not available, and the underlying cause of the liver failure is often unknown and diverse especially in children. Liver transplantation has increased the chance of survival; however it needs an optimal timing to reach the best result which is not familiar...
Original Articles
Usefulness of auditory brainstem response as early predictor of kernicterus in early breast-feeding jaundice
Jae Won Jang, Gil Sang Lee, Dae Keun Song, Sung Hee Kim, Won Duck Kim, Sang Geel Lee
Korean J Pediatr. 2007;50(9):848-854.   Published online September 15, 2007
Purpose : The present study examined the etiology and risk factors of the early breast-feeding jaundice and the usefulness of auditory brainstem response test as early predictor of kernicterus. Methods : Medical records of neonatal jaundice in newborn admitted to Daegu Fatima Hospital between September 2005 and May 2006 were analyzed prospectively. Infants were grouped according to feeding method : breast...
Isolation rate of 4 type virus of acute gastroenteritis in full-term neonates during neonatal period
Soo Kyoung Moon, Jae In Lee, Hye Sun Yoon, Young Min Ahn
Korean J Pediatr. 2007;50(9):855-861.   Published online September 15, 2007
Purpose : The most common causes of acute viral gastroenteritis in newborn period are rotavirus, astrovirus, norovirus and enteric adenovirus. This study was designed to investigate the clinical characteristics, clinical symptoms, isolation rate and distribution of these viruses in full-term neonates during neonatal period. We also studied the influence on the viral isolation rate by postnatal care place and feeding...
Reference values for respiratory system impedance using impulse oscillometry in school-aged children in Korea
Young Sun Wee, Hyoung Yun Kim, Da Wun Jung, Hye Won Park, Yoon Ho Shin, Man Yong Han
Korean J Pediatr. 2007;50(9):862-867.   Published online September 15, 2007
Purpose : The impulse oscillometry (IOS) is applicable to young children because it requires minimal cooperation and a non-invasive method to measure the mechanics of respiratory system. This study aimed to develop the reference values in school-aged children in Korea, using IOS which is a modification of forced oscillation technique (FOT). Methods : Measurements were performed in 92 previously untrained healthy...
Clinical characteristics of congenital myotonic dystrophy diagnosed by molecular genetic method
Sook Hyun Nam, Young Bae Son, Bo Lyun Lee, Jeehun Lee, Chang-seok Ki, Munhyang Lee
Korean J Pediatr. 2007;50(9):868-874.   Published online September 15, 2007
Purpose : We performed this study to investigate the perinatal and developmental features of the patients with congenital myotonic dystrophy (CDM) confirmed by the molecular genetic method and the clinical characteristics of their mother, and to identify the relation between the number of CTG repeats and the clinical severity. Methods : A retrospective review of the medical records and the results...
Chromosomal analyses of 4,500 cases of the peripheral blood : An experience in a single hospital for 25 years
Hye-Eun Seo, Ji Hye Lee, Ji Yoon Kim, Dong Ha Lee, Heung Kyo Lee, Kun Soo Lee
Korean J Pediatr. 2007;50(9):875-881.   Published online September 15, 2007
Purpose : Chromosome analysis is important in genetic study and genetic counseling. This study was performed to evaluate the type and incidence of chromosome abnormalities in a single hospital for 25 years. Methods : Chromosome analyses were performed on peripheral blood lymphocytes, obtained from 4,856 patients with suspected chromosomal aberrations, referred to cytogenetic laboratory in Department of Pediatrics, Kyungpook National...
A pilot study of neuroprotection with umbilical cord blood cell transplantation for preterm very low birth weight infants
Kyu Young Chae, Kyu Hyung Lee, So-Hee Eun, Byung Min Choi, Baik-Lin Eun, Hoon-Chul Kang, Myung Jae Chey, Nam Keun Kim, Doyeun Oh
Korean J Pediatr. 2007;50(9):882-890.   Published online September 15, 2007
Purpose : Preterm very low birth weight infant have high rate of adverse neurodevelopmental sequale. Recently, there have been lots of reports that human umbilical cord blood transplantation ameliorates functional deficits in animal models as hypoxic ischemic injury. This pilot study was undertaken to determine the clinical efficacy and safety of autologous umbilical cord blood cell transplantation for preventing neurodevelopmental...
Clinical characteristics and prognosis of acute disseminated encephalomyelitis based on the lesions on MRI
Sunghoon Chung, Sungsin Park, Sajun Chung
Korean J Pediatr. 2007;50(9):891-895.   Published online September 15, 2007
Purpose : Acute disseminated encephalomyelitis (ADEM) is a demyelinating disease of the central nervous system and mostly develops after viral illness or vaccinations. We investigated the clinical differences and neurologic outcomes according to the distribution of the lesions on brain MRI. Methods : The study group was composed of 21 patients from January 1995 to August 2003 in Kyunghee University hospital....
Acoustic differences according to the epileptic focus in benign partial epilepsy with centrotemporal spikes patients
Jung Tae Kim, Sang Hoon Choi, Sun Jun Kim
Korean J Pediatr. 2007;50(9):896-900.   Published online September 15, 2007
Purpose : The aim of this study was to investigate the speech problems in benign rolandic epilepsy (BRE) according to the seizure focus in EEG and semiology. Methods : Twenty three patients [right origin (13 patients) or left side (10 patients)] who met the BRE criteria by International League Against Epilepsy (ILAE) were prospectively enrolled. We excluded the patients who...
Clinical and Radiological Analysis of Reversible Posterior Leukoencephalopathy Syndrome in Children
Hae-Ri Lim, Hye-Eun Seo, Sun-Hak Kwon
Korean J Pediatr. 2007;50(9):901-904.   Published online September 15, 2007
Purpose : Reversible posterior leukoencephalopathy syndrome is a complex disorder with characteristic clinical and radiologic findings that mainly involve the white/gray matter of the parieto-occipital lobes. The purpose of this study was to determine its clinical and radiological characteristics. Methods : A total of 15 pateints were involved in the study. Their medical records and radiological features of brain MRI were...
Serum ghrelin and leptin concentrations in children with cancer : comparisons with normal children
So Hyun Park, Min Ho Jung, Nac Gyun Chung, Byung-Kyu Suh, Byung Churl Lee
Korean J Pediatr. 2007;50(9):905-911.   Published online September 15, 2007
Purpose : Ghrelin, being secreted from the stomach, stimulates growth hormone secretion and controls energy homeostasis by increasing appetite. Leptin, being secreted from the adipocytes, controls weight and energy homeostasis by decreasing appetite. Leptin concentration is reported to increase after childhood cancer therapy. This study was aimed to compare ghrelin and leptin concentrations in normal children and children who received...
Case Reports
Effect of cytokines in breast milk on infant during the first two-years of life
Woo Kyung Kim, Hae-Sun Yoon
Korean J Pediatr. 2007;50(9):912-918.   Published online September 15, 2007
Purpose : Breast milk contains several components that provide specific immunity and affect the maturation of the infant's immune system. Allergic disease (AD), including atopic eczema, asthma, allergic rhinitis, and food allergy is characterized by an imbalance between cytokines produced by distinct T-helper cell subtypes. The aim of the study was to investigate the concentrations of cytokines and chemokines that...
Stent implantation to relieve secondary pulmonary venous stenosis in total anomalous pulmonary venous connection: case report
Youn Ho Shin, Ki Eun Kim, Hae Sik Kwon, Byung Won Yoo, Jae Young Choi
Korean J Pediatr. 2007;50(9):919-924.   Published online September 15, 2007
Pulmonary venous stenosis may be congenital or acquired. Regardless of its origin, the prognosis for patients affected with PVS remains poor. There have been many attempts to palliate PVS with little success. This report describes two patients with PVS which became evident after repair of total anomalous pulmonary venous connection. Intravascular stents were successfully implanted, but progressive restenoses in the...
Erratum
Vaccination schedule in 1958
Chang Hwi Kim, M.D.
Korean J Pediatr. 2007;50(9):925-926.   Published online September 15, 2007