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- Case Report
- Alveolar rhabdomyosarcoma with massive disseminated intravascular coagulopathy treated with systemic chemotherapy
- Byung Gyu Yoon, Hee Jo Baek, Burm Seok Oh, Dong Kyun Han, Yoo Duk Choi, Hoon Kook
- Clin Exp Pediatr. 2015;58(12):505-508. Published online December 22, 2015
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It is uncommon for pediatric patients with rhabdomyosarcoma to present with clinical and/or laboratory features of disseminated intravascular coagulation (DIC). We report a case of metastatic alveolar rhabdomyosarcoma with severe bleeding because of DIC in a 13-year-old boy. He experienced persistent oozing at the site of a previous operation, gross hematuria, and massive epistaxis. Two weeks after initiating combination chemotherapy...
- Graves disease following rabbit antithymocyte globulin treatment of severe aplastic anemia in a Korean child
- In Su Choi, Han Kyul Kim, Dong Kyun Han, Hee Jo Baek, Hae In Jang, Chan Jong Kim, Hoon Kook
- Clin Exp Pediatr. 2015;58(7):267-269. Published online July 22, 2015
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Antithymocyte globulin (ATG) is used as an immunosuppressive treatment (IST) to deplete clonal suppressor T cells in patients with severe aplastic anemia (SAA). The depletion of suppressor T cells by ATG may affect the activation of B cells, which results in an increased risk for autoimmune conditions. A 12-year-old boy was diagnosed with idiopathic SAA. As he did not have...
- Original Article
- Long-term follow-up of Fanconi anemia: clinical manifestation and treatment outcome
- Byung Gyu Yoon, Hee Na Kim, Ui Joung Han, Hae In Jang, Dong Kyun Han, Hee Jo Baek, Tai Ju Hwang, Hoon Kook
- Clin Exp Pediatr. 2014;57(3):125-134. Published online March 31, 2014
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Purpose The aim of this study was to characterize Korean patients with Fanconi anemia (FA), which is a rare but very challenging genetic disease.
Methods The medical records of 12 FA patients diagnosed at Chonnam National University Hospital from 1991 to 2012 were retrospectively reviewed.
Results The median age at diagnosis was 6.2 years. All patients showed evidence of marrow failure and one or more...
- Selective embolization of the internal iliac arteries for the treatment of intractable hemorrhage in children with malignancies
- Sul Hee Bae, Dong Kyun Han, Hee Jo Baek, Sun Ju Park, Nam Kyu Chang, Hoon Kook, Tai Ju Hwang
- Clin Exp Pediatr. 2011;54(4):169-175. Published online April 30, 2011
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Purpose Acute internal hemorrhage is an occasionally life-threatening complication in pediatric cancer patients. Many therapeutic approaches have been used to control bleeding with various degrees of success. In this study, we evaluated the efficacy of selective internal iliac artery embolization for controlling acute intractable bleeding in children with malignancies.
Methods We retrospectively evaluated the cases of 6 children with various malignancies (acute lymphoblastic...
- Case Report
- Perivascular epithelioid cell tumor (PEComa) of the ascending colon: the implication of IFN-α2b treatment
- Sun Ju Park, Dong Kyun Han, Hee Jo Baek, Sang Young Chung, Jong Hee Nam, Hoon Kook, Tai Ju Hwang
- Clin Exp Pediatr. 2010;53(11):975-978. Published online November 30, 2010
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A 7-year-old boy presented with hematochezia and abdominal pain. A 3.7-cm-sized mass was identified in the ascending colon by abdominal computed tomography and colonoscopy. The patient underwent surgical resection. Pathological examination revealed a low-grade perivascular epithelioid cell tumor (PEComa). PEComa in the colon is very rare. Only a few cases have been reported so far. An effective treatment method for...
- Original Article
- Comparison of total body irradiation-based or non-total body irradiation-based conditioning regimens for allogeneic stem cell transplantation in pediatric leukemia patients
- Sang Jeong Kim, Dong Kyun Han, Hee Jo Baek, Dong Yeon Kim, Taek Keun Nam, Tai Ju Hwang, Hoon Kook
- Clin Exp Pediatr. 2010;53(4):538-547. Published online April 15, 2010
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Purpose : This study aims to compare the outcome of total body irradiation (TBI)- or non-TBI-containing conditioning regimens for leukemia in children. Methods : We retrospectively evaluated 77 children conditioned with TBI (n=40) or non-TBI (n=37) regimens, transplanted at Chonnam National University Hospital between January 1996 and December 2007. The type of transplantation, disease status at the time of transplant, conditioning regimen,... -
- Thrombotic thrombocytopenic purpura with decreased level of ADAMTS-13 activity and increased level of ADAMTS-13 inhibitor in an adolescent
- Eun Mi Yang, Dong Kyun Han, Hee Jo Baek, Young Ok Kim, Myung Geun Shin, Hoon Kook, Tai Ju Hwang
- Clin Exp Pediatr. 2010;53(3):428-431. Published online March 15, 2010
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Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy characterized by endothelial cell damage, resulting in microangiopathic hemolytic anemia, thrombocytopenia, and various degrees of neurological and renal impairment caused by microvascular thrombi. It is rare in children and frequently follows a fatal course. TTP is divided into 2 types: one is inherited and associated with ADAMTS-13 gene mutations and the other... -
- Case Report
- A case of atypical hemolytic uremic syndrome as an early manifestation of acute lymphoblastic leukemia
- Dong Kyun Han, Hee Jo Baek, Young Kuk Cho, Chan Jong Kim, Myung Geun Shin, Hoon Kook, Tai Ju Hwang
- Clin Exp Pediatr. 2010;53(2):253-257. Published online February 15, 2010
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Hemolytic uremic syndrome (HUS) is the most common cause of acute renal failure in children younger than 4 years and is characterized by microangiopathic hemolytic anemia, acute renal failure, and thrombocytopenia. HUS associated with diarrheal prodrome is usually caused by Shiga toxin-producing Escherichia coli O157:H7 or by Shigella dysenteriae, which generally has a better outcome. However, atypical cases show a... -
- Unrelated stem cell transplantation after reduced-intensity conditioning plus rituximab for Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis with CNS involvement
- Hee Jo Baek, Hoon Kook, Dong Kyun Han, Min-Cheol Lee, Tae Woong Jeong, Tai Ju Hwang
- Clin Exp Pediatr. 2009;52(6):725-729. Published online June 15, 2009
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Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) with central nervous system (CNS) involvement is usually fatal unless stem cell transplant (SCT) is offered. However, SCT with conventional intensity conditioning is associated with high transplant-related mortality. We describe our experience with unrelated SCTs after reduced-intensity conditioning (RIC) for patients with EBV-HLH with progressive CNS disease. This approach was associated with minimal toxicities and... -
- Facial palsy as the presenting symptom of acute myeloid leukemia in children: Three cases with stem cell transplantatio
- Hee Jo Baek, Dong Kyun Han, Young Ok Kim, Ic Sun Choi, Tai Ju Hwang, Hoon Kook
- Clin Exp Pediatr. 2009;52(6):713-716. Published online June 15, 2009
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Facial palsy as the presenting symptom of leukemia is very rare, especially in acute myeloid leukemia. A review of the medical literature identified reports on 8 children with AML who had facial paralysis as the presenting sign. Whole brain irradiation (WBI) has been applied in most cases. We present the cases of 3 such children. Achieving a remission without WBI,... -
- Wilms` tumor, aniridia, genitourinary anomalies, and mental retardation (WAGR) syndrome: Successful treatment of the first case with bilateral Wilms` tumors in Korea
- Kyung Sun Min, Hee Jo Baek, Dong Kyun Han, Ju Hee You, Tai Ju Hwang, Dong Deuk Kwon, Hoon Kook
- Clin Exp Pediatr. 2008;51(12):1355-1358. Published online December 15, 2008
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Wilms` tumor, aniridia, genitourinary anomalies, and mental retardation (WAGR) syndrome is caused by deletion of chromosome 11p13, including the Wilms` tumor (WT1) and aniridia gene (PAX6) loci. Here, we report the first case of WAGR syndrome in Korea; the patient was a 2-year-old girl with bilateral aniridia from birth who presented with abdominal distention and mental retardation. Cytogenetically, she had... -
- Original Article
- Diamond-Blackfan anemia: long-term follow-up of six cases
- Young Jun Son, Hee Jo Baek, Hoon Kook
- Clin Exp Pediatr. 2008;51(11):1211-1216. Published online November 15, 2008
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Purpose : Diamond-Blackfan anemia (DBA) is a rare heterogeneous genetic disorder of infancy and early childhood. It is characterized by red cell aplasia, congenital anomalies, and a predisposition to cancer. Corticosteroids and red cell transfusions are the mainstays of therapy. We describe our experience of 6 cases of DBA that were encountered over a period of 16 years. Methods :... -
- Case Report
- Long-term recombinant interferon-γ treatment in 2 cases of osteopetrosis
- Dong-Yun Kim, Dong-Kyun Han, Hee-Jo Baek, Sung-Taek Jung, Hoon Kook, Tai-Ju Hwang
- Clin Exp Pediatr. 2007;50(11):1129-1133. Published online November 15, 2007
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Osteopetrosis, a rare osteosclerotic bone disease characterized by a defect in osteoclast function and the reduced generation of superoxide by leukocytes, can be classified into several types based on their mode of inheritance, age of onset, severity, and associated clinical symptoms. Stem cell transplantation is the only curative therapy for the infantile malignant type, although alternative treatments, such as corticosteroids,... -
- Original Article
- Comparison of growth and neuropsychological function after treatment for hematologic and oncologic diseases in monozygotic twins
- Gi Hwan Kim, Hoon Kook, Hee Jo Baek, Dong Kyun Han, Eun Song Song, Young Kook Jo, Ic Sun Choi, Young Ok Kim, Chan Jong Kim, Young Jong Woo, Soo Jin Yang
- Clin Exp Pediatr. 2007;50(2):182-189. Published online February 15, 2007
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Purpose : The primary purpose of this study was to evaluate the growth and neuropsychologic function following treatments for pediatric hematologic and oncologic diseases. Healthy monozygotic twins served as ideal controls for comparison to exclude possible confounding factors. Methods : Seven children treated with various hematologic and oncologic diseases were included in the study: acute lymphoblastic leukemia (ALL; n=2), Diamond-Blackfan anemia... -
- Second allogeneic hematopoietic stem cell transplantation in children to overcome graft failure or relapse after initial transplant
- Dong-Yeon Kim, Do Kyun Kim, Soo Young Kim, Seok Joo Kim, Dong Gyun Han, Hee Jo Baek, Hoon Kook, Tai-Ju Hwang
- Clin Exp Pediatr. 2006;49(12):1329-1339. Published online December 15, 2006
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Purpose : Failure of hematopoietic stem cell transplantation(HSCT) may be encountered in practice because of either relapse of the malignancy or dysfunction of the graft. Second HSCT may be the only option for some patients whose initial HSCT failed. Methods : From May, 1991 to December, 2004, 115 HSCTs were performed at the Pediatric Blood & Marrow Transplantation Center, Chonnam National... -
- Case Report
- Pyridoxine responsive sideroblastic anemia in a boy with mitral valve prolapse
- June Seung Sung, Ki Hwan Kim, Dong Gyun Han, Mi Jeong Kim, Young Kook Cho, Hae Yul Chung, Hee Jo Baek, Jae Sook Ma, Hoon Kook, Tai Ju Hwang
- Clin Exp Pediatr. 2006;49(11):1223-1226. Published online November 15, 2006
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Sideroblastic anemia is a rare, heterogeneous group of disorders characterized by hyperferremia, microcytic hypochromic anemia, and bone marrow erythroid hyperplasia with the presence of numerous ringed sideroblasts. We describe herewith the case of a rare coincidence of sideroblastic anemia and mitral valve prolapse with resultant regurgitation in a 2-year-old boy. In addition to the inherent propensity for the development of... -
- Review Article
- Giant platelet syndrome
- Hoon Kook
- Clin Exp Pediatr. 2006;49(8):833-838. Published online August 15, 2006
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Giant platelet syndrome is a group of unique disorders characterized by the presence of abnormally large platelets, and usually accompanied by thrombocytopenia. Most cases of giant platelets are encountered in idiopathic thrombocytopenic purpura(ITP). In contrast, inherited giant platelet disorders, a group of heterogeneous diseases, are rare. Bernard-Soulier syndrome and its variants, and MYH9 related diseases have been defined at the... -
- Case Report
- Two Cases of Paragonimiasis in Young Siblings Presenting with Pleural Effusion and Subcutaneous Nodules
- Moon Young Jeong, Hee Jo Baek, Duck Cho, Jin Kim, Chan Kyoo Hwang, Dong Kyun Han, Jae Sook Ma, Hoon Kook
- Clin Exp Pediatr. 2005;48(12):1385-1388. Published online December 15, 2005
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Paragonimiasis is the infestation of lung flukes of the trematode genus Paragonimus. This disease is common in Asia, and the southern part of Korea has been known as one of the endemic areas of Paragonimiasis westermanii in Korea. Human infection is associated with specific dietary habits, such as eating freshwater crawfish or crabs. In a 6 1/2-year-old boy with pleural... -
- Original Article
- Lorenzo's Oil Treatment in X-linked Adrenoleukodystrophy
- Hyo Jung Kim, Eun Young Kim, Young Jong Woo, Hoon Kook
- Clin Exp Pediatr. 2005;48(11):1232-1238. Published online November 15, 2005
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Purpose: Though more than 15 years have passed after introduction of Lorenzo's oil therapy in X- linked adrenoleukodystrophy(ALD), its efficacy is still fully not known. In patients who already have neurologic symptoms, most reports indicate that the neurologic disability continues to increase. We evaluated its efficacy in X-linked ALD patients. Methods: Four patients who were treated with Lorenzo's oil for at... -
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- Case Report
- Isolated Intracranial Granulocytic Sarcoma as a Relapse Following Unrelated Bone Marrow Transplantation for Myelodysplastic Syndrome in a 1 Year-Old Infant
- Kyung Ran Son, Hoon Kook, So Youn Kim, Hee Jo Back, Seok Joo Kim, Ha Young Noh, Mi Jeong Kim, Ic Sun Choi, Shin Jeong, Jong Hee Nam, Tai Ju Hwang
- Clin Exp Pediatr. 2004;47(9):1008-1012. Published online September 15, 2004
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Isolated relapse of myeloid leukemia as a granulocytic sarcoma(GS) following allogeneic bone marrow transplantation(BMT) is very rare manifestation, and usually associated with a poor prognosis. We report a case of isolated intracranial GS in an infant with myelodysplastic syndrome(MDS) following unrelated BMT. A 7 month-old girl was diagnosed with refractory anemia with excess blasts (RAEB). During observation for a couple... -
- Original Article
- Neurologic Complications after Hematopoietic Stem Cell Transplantation in Children
- Moon Young Jeong, Young Kuk Cho, So Youn Kim, Young Ok Kim, Chan Jong Kim, Hoon Kook, Young Jong Woo, Tai Ju Hwang
- Clin Exp Pediatr. 2004;47(9):978-985. Published online September 15, 2004
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Purpose : Neurologic complications(NC) after hematopoietic stem cell transplantation(HSCT) are important because of high mortality and severe sequelae. We analyzed the incidence, manifestation and risk factors of NC in 61 children undergoing HSCT. Methods : We retrospectively analyzed NC in 61 cases(42 male and 19 female, aged one to 16 years) given HSCT between 1996 and 2003 due to hematologic malignacies,... -
- Medical Lecture Course
- Aplastic Anemia : Its Immune Pathophysiology
- Hoon Kook
- Clin Exp Pediatr. 2002;45(8):948-954. Published online August 15, 2002
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- Original Article
- Characterization of Bruton's Tyrosine Kinase Genetic Mutations in One Korean X-linked Agammaglobulinemia Family
- Eun-Kyeong Jo, Chang-Hwa Song, Jeong-Kyu Park, Young-Jong Baek, Hye-Young Rhu, Jae-Ho Lee, Tai-Ju Hwang, Hoon Kook
- Clin Exp Pediatr. 2002;45(2):183-191. Published online February 15, 2002
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Purpose : X-linked agammaglobulinemia(XLA) is an immunodeficiency caused by abnormalities in Bruton's tyrosine kinase(Btk), and is characterized by a deficiency of peripheral blood B cells. We studied the cytoplasmic expression of Btk protein and analyzed the Btk gene in peripheral blood mononuclear cells from two siblings and one cousin with XLA, as well as additional family members. Methods : Btk... -
- Case Report
- Two Cases of Wolman's in Siblings
- Joon Sung Kim, Tai Huyng Cho, Hoon Kook, Seung Hee Choi, Young Youn Choi, Chang Soo Park, Heoung Keun Kang, Dong Kyu Jin, Tai Ju Hwang
- Clin Exp Pediatr. 1998;41(4):529-537. Published online April 15, 1998
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Wolman' disease is a rare autosomal recessive disorder in which a deficiency of lysosomal acid lipase leads to the accumulation of cholesteryl esters and trigycerides in most of the body tissues. Clinically, it is characterized by abdominal distention, hepatosplenomegaly, vomiting, intractable diarrgeam steatorrhea, malabsorption, inanitionm failure to thrive, and bilateral enlargement and calcification of the adrenal glands demonstrated by roentgenographic... -
- Original Article
- High Dose of Amphotericin B in Intralipid Emulsion-based Delivery System in Immunocompromised Children with Invasive Fungal Infections
- Geun Mo Kim, Hoon Kook, Sung Ho Cho, Ji Yong Park, Young Jong Woo, Tai Ju Hwang
- Clin Exp Pediatr. 1998;41(2):216-223. Published online February 15, 1998
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Purpose : Fungal infections are an important cause of morbidity and mortality in patients with hematologic malignancies. The therapy of choice in documented or suspected invasive fungal infections has been intravenous Amphotericin B(AmB). Adverse effects such as fever, chills, thrombophlebitis, nausea or vomiting are common. A more serious adverse effect is potential renal impairment. As AmB administration mixed with Intralipid(AmB/Intralipid)... -
- Immunophenotypic Analysis of Umbilical Cord Blood Stem Cells
- Won Ho Kang, Tai Ju Hwang, Hoon Kook, Byung Ju Kim
- Clin Exp Pediatr. 1997;40(11):1572-1581. Published online November 15, 1997
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Purpose : Since umbilical cord blood (UCB), which used to be discarded, was found to be a source of enriched hematopoietic stem and progenitor cells, basic research to elucidate characteristics of UCB hematopoietic stem cells (HSCs) and its clinical application to bedside transplantation have been attempted. Moreover, stem cell transplantation (SCT) has expanded its role, not only in hematopoietic reconstitution, but in cancer therapy,... -
- Subclavian Catheterization in the Pediatric Patients
- Seung Hee Lee, Sung Ho Cho, Keun Mo Kim, Chan Jong Kim, Hoon Kook, Tai Ju Hwang
- Clin Exp Pediatr. 1997;40(3):368-374. Published online March 15, 1997
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Purpose : Central venous catheters are used to deliver antibiotics, chemotherapeutic agents, and parenteral nutrition for a extended period of time as well as to draw samples in immunocompromised patients to minimize the discomfort with sampling and the risk of introducing infections. Hickman/Broviac catheters or implantable devices have been used in pediatric patients. This study is aimed to evaluate the safety and clinical efficacy of... -
- Medical Lecture Course
- Allogeneic Peripheral Blood Stem Cell Transplantation
- Hoon Kook
- Clin Exp Pediatr. 1997;40(1):1-6. Published online January 15, 1997
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- Erratum
- Pediatric Cancer Patients' Understanding of Their Disease and the Attitudes of Their Parents Towards the Care of the Child with Cancer
- Eun Kyung Bom, Tai Ju Hwang, Hoon Kook
- Accepted January 1, 1970
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Providing pediatric cancer patients with medical information is thought to facilitate realistic coping; however, systematic research into this concept has been lacking. We analyzed the attitudes of nationwide 220 cancer patients, their parents and doctors towards the care of children with cancer, concerning the patients' understanding of their diseases, from whom the patient heard about his(her) disease, whether the patient... -
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- Original Article
- Two Cases of Goitrous Hypothyroidism in Siblings.
- Kwang Ok Lee, Hwa Il Kwag, Hoon Kook, Young Youn Choi, Tai Joo Hwang
- Clin Exp Pediatr. 1990;33(1):129-134. Published online January 31, 1990
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The authors experienced two cases of goitrous hypothyroidism in siblings. The etiology was considered to be defect of iodide organification in steps of thyroxine synthesis. The diagnosis was made on the basis of history, clinical features, thyroid function test, thyroid scanning, ultrasonogram and perchlorate discharge test. We report these cases with a review of related literatres. -
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Impact Factor3.2
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8.02023CiteScore94th percentilePowered by
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