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Original Article
Therapeutic Effect of Helicobacter pylori Eradication in Children with Recurrent Abdominal Pain Associated with H. pylori
Ji Hyun Uhm, Ki Sup Chung
Clin Exp Pediatr. 2004;47(5):547-554.   Published online May 15, 2004
Purpose : In order to clarify the role of Helicobacter pylori(H. pylori) in recurrent abdominal pain, we investigated prospectively the effect of eradication of H. pylori based on symptom improvement in children with recurrent abdominal pain. Methods : Children with recurrent abdominal pain were evaluated with diagnostic upper gastrointestinal endoscopy to rule out peptic ulcer disease, etc. During endoscopy, biopsies were...
Natural History of Chronic Hepatitis B in Children
Yuria Kim, Seoung Yeon Baek, Ji Hyun Eom, Ki Sup Chung
Clin Exp Pediatr. 2004;47(3):282-289.   Published online March 15, 2004
Purpose : We investigated the spontaneous seroconversion rate of hepatitis B viral markers and predictive factors affecting seroconversion in children with chronic hepatitis B. Methods : The study population included 214 children diagnosed as chronic hepatitis B, with positive HBsAg, HBeAg and HBVDNA over six months, and all patients had a family history of chronic Hepatitis B. They were followed between...
The Usefulness of MRCP in the Evaluation of Pancreaticobiliary Diseases in Children
Ji Hyun Uhm, Seung Yeon Lee, Ki Sup Chung
Clin Exp Pediatr. 2002;45(11):1381-1388.   Published online November 15, 2002
Purpose : Magnetic resonance cholangiopancreatography(MRCP) is a noninvasive method for imaging the pancreaticobiliary tree. The aim of this study was to evalute the usefulness of MRCP for the diagnosis of pancreaticobiliary diseases in children. Methods : From October 1996 to May 2001, 67 patients with obstructive jaundice and three patients with chronic recurrent pancreatitis were evaluated with abdominal ultrasonography and...
The Diagnostic Usefulness of Endoscopic Findings and Detection Rates of CLO and HpKit Test for Helicobacter pylori Infection in Children
Seung Yeon Lee, Ji Hyung Yoo, Ki Sup Chung
Clin Exp Pediatr. 2002;45(4):482-488.   Published online April 15, 2002
Purpose : We performed this study to evaluate the diagnostic usefulness of endoscopic finding of nodular gastritis, CLO and HpKit test for H. pylori infection in children. Methods : Gastroduodenal endoscopy and mucosal biopsy were performed on 212 children who visited our hospital between Jul. 1999 and May 2000 due to abdominal pain. We performed CLO and HpKit test for H....
The Usefulness of Magnetic Resonance Cholangiography in the Diagnosis of Biliary Atresia
Seok Joo Han, Ki Sup Chung, Myung-Joon Kim, Airi Han, Eui Ho Hwang
Clin Exp Pediatr. 2001;44(8):899-907.   Published online August 15, 2001
Purpose : To evaluate the usefulness of magnetic resonance cholangiography(MRC) for the diagnosis of biliary atresia in infantile cholestatic jaundice. Methods : Fifty consecutive infants with cholestatic jaundice underwent single-shot MRC for 3 years. The radiologic diagnosis of non-biliary atresia with MRC was based on visualization of the common bile duct and common hepatic duct. The diagnosis of biliary atresia was...
Hemorrhagic Shock and Encephalopathy Syndrome as a Cause of Sudden Death in Infants
Jong Won Lee, Chang Han Lee, Ki Sup Chung
Clin Exp Pediatr. 2000;43(6):814-819.   Published online June 15, 2000
Purpose : To evaluate the clinical characteristics, treatments and outcome of patients with hemorrhagic shock and encephalopathy(HSE) syndrome. Methods : We performed a clinical study on 14 patients who were diagnosed as hemorrhagic shock and having encephalopathy syndrome in the Department of Pediatrics, from 1984 to 1998. Age, sex, clinical symptoms and physical findings at admission, the most deranged laboratory findings,...
Red Blood Cell Indices, Serum Iron and Total Iron Binding Capacity in Children with Helicobacter pylori Infection
Soo Joon Park, Chang Han Lee, Ki Sup Chung
Clin Exp Pediatr. 2000;43(6):755-762.   Published online June 15, 2000
Purpose : H. pylori infection was recently reported to be associated with unexplained iron-deficiency anemia(IDA) in children and adolescents. H. pylori-related IDA was thought to occur due to GI blood loss, scavenging of iron by H. pylori and iron malabsorption. The aim of this study was to examine how the status of H. pylori infection and age of children affected...
Serum Pepsinogen Ⅰ, Ⅱ Levels and Upper Gastrointestinal Diseases in Children with H. pylori Infection
Je Woo Kim, Ki Sup Chung
Clin Exp Pediatr. 1998;41(2):200-208.   Published online February 15, 1998
Purpose : In H. pylori infection serum pepsinogen Ⅰ/Ⅱ ratio decreases and pepsinogen Ⅱ level is increased. Increased serum pepsinogen Ⅱ level correlates with pathologic severity of gastritis. We assayed serum pepsinogen Ⅰ, Ⅱ levels and pepsinogen Ⅰ/Ⅱ ratio to evaluate the relationship between the serum pepsinogen level and upper gastrointestinal diseases. Methods : One hundred and sixty-five children who had...
Colonic Transit Time in Children with Recurrent Abdominal Pain
Je Woo Kim, Ki Sup Chung
Clin Exp Pediatr. 1997;40(11):1544-1551.   Published online November 15, 1997
Purpose : Recurrent abdominal pain is defined as the presence of at least three discrete episodes of pain occurring over a period of 3 or more months. The reported prevalence is high up to 15% of school aged children. Mostly the pain results from functional dysmotility of the intestine but not much studies has been done. Thus we studied segmental colonic transit time(CTT)...
Case Report
Ectopic Pancreas of Stomach in a Child with Recurrent Abdominal Pain
Hyun Chul Bae, Je Woo Kim, Ki Sup Chung, Dong Hwan Shin
Clin Exp Pediatr. 1997;40(8):1178-1182.   Published online August 15, 1997
Ectopic pancreas is a rare congenital anomaly defined by the presence of pancreatic tissue that lacks anatomic and vascular continuity with the main body of the pancreas. A 11-year-old girl was admitted to the Department of Pediatrics, Yonsei University College of Medicine with the history of recurrent abdominal pain for 2 years. We performed fiberoptic endoscopy which showed a 1.5¡¿1.5cm sized polypoid mass, and...
A Case of Choledochal Cyst with Anomalous Pancreaticobiliary Ductal Union
Je Woo Kim, Hyun Chul Bae, Ki Sup Chung, Seok Joo Han, Eui Ho Hwang
Clin Exp Pediatr. 1997;40(7):1010-1014.   Published online July 15, 1997
Choledochal cysts are congenital or acquired lesions of the biliary tree with a cystic dilatation of the bile duct. We experienced a choledochal cyst accompanying acute pancreatitis caused by anomalous pancreaticobiliary ductal union(APBDU) in a 2 year old boy. The choledochal cyst associated with APBDU is rarely encountered in the clinical field, and thus we report this case with the presentation of abdominal ultrasonogram, computed...
Original Article
The Therapeutic Effect of Interferon-alpha Treatment in Children with Chronic Hepatitis B
Il Sang Jeong, Ki Sup Chung
Clin Exp Pediatr. 1997;40(7):955-964.   Published online July 15, 1997
Purpose : The prevalance rate of chronic hepatitis B viral infection in children is high in our contry. We performed a prospective study to evaluate the effectiveness of and the factors predictive of response to interferon-alpha therapy in children with chronic hepatitis B. Methods : Thirty-two children with chronic hepatitis B werew admitted to the Department of Pediatrics, Yonsei University College of Medicine from...
Case Report
A Case of Arteriovenous Malformation of Cecum in a Infant
Jung-Eun Lee, Je Woo Kim, Ki Sup Chung, Eui Ho Hwang, Jong In Yook
Clin Exp Pediatr. 1997;40(2):274-278.   Published online February 15, 1997
Arteriovenous malformation in the gastrointestinal tract is very rare in children. However, when present they are frequently a source of either acute and massive, or chronic occult hemorrhage, and may be difficult to diagnosis. In reviewing Korean literature, only 2 cases has been reported in adults. We have experienced a rare case of arteriovenous malformation in a 1 year and 10 month-old female...
Original Article
Serum Gastrin Levels in Relation to Helicobacter pylori Infection and Various Upper Gastrointesting Diseases
Hyun Young Kim, Ki Sup Chung
Clin Exp Pediatr. 1997;40(1):80-87.   Published online January 15, 1997
Prognosis of Congenital Extrahepatic Biliary Atresia After Hepatic Portoenterostomy
Myung Hyun Sohn, Ki Sup Chung, Euh Ho Whang
Clin Exp Pediatr. 1996;39(5):658-664.   Published online May 15, 1996
Purpose : The surgical results for congenital extrahepatic biliary atresia have been improved since Kasai first described hepatic portoenterostomy(Kasai operation) in 1959. This study was conducted to evaluate the postoperative prognosis of congenital extrahepatic biliary atresia after hepatic portoenterostomy. Methods : This clinical study was done by reviewing the medical records of 30 patients who have undergone hepatic portoenterostomy at the Severance Hospital, Yonsei...
Helicobacter pylori Infection and Various Upper Gastrointestinal Diseases in Children with Abdominal Complaint
Hyun Young Kim, Ki Sup Chung
Clin Exp Pediatr. 1996;39(3):361-369.   Published online March 15, 1996
Purpose : The purpose of this study was to research the incidence of H. pylori infection in children with upper gastrointestinal complaints according to age, sex, and diseases diagnosed by endoscopy. This study was also aimed at evaluating the usefullness of diagnostic methods, and to assess the effectiveness of treatment. Methods : Upper gastrointestinal endoscopy and gastric mucosal biopsy were performed...
A Clinical Study on the Liver Cirrhosis in Children: Review of 40 Cases
Je Woo Kim, Ki Sup Chung, Chan Il Park
Clin Exp Pediatr. 1995;38(11):1506-1514.   Published online November 15, 1995
Purpose : Liver cirrhosis is relatively uncommon disease in childhood, but the overall prevalence rate and etiology of the liver cirrhosis in children were uncertain in Korea. This clinical study was undertaken to help pediatricians manage the patients properly by investigating the etiology, clinical findings and the outcome on 40 pediatric patients with liver cirrhosis. Methods : This study was conducted...
Clinical and Histologic Study of Progressive Muscular Dystrophy Which was Considered as Chronic Hepatitis
Jae Kwang Kim, Ki Sup Chung, Tae Seung Kim
Clin Exp Pediatr. 1995;38(2):216-222.   Published online February 15, 1995
Purpose : The authors have experienced thirty three children of progressive muscular dystrophy. 10 children of these(30.3%) were considered as chronic hepatitis because of persistent, u nexplained elevated serum aminotransferase values. We performed this study in order to evaluate the characteristics of age distribution, clinical and histologic features in children considered as chronic hepatitis. Methods : This study was performed on...
Epstein-Barr Viral Hepatitis in Childhood
Soo Kyung Lee, Ki Sup Chung
Clin Exp Pediatr. 1994;37(8):1124-1135.   Published online August 15, 1994
We analysed 58 patients who were admitted to the Department of Pediatrics, yonsei University College of Medicine due to infectious mononucleosis from January 1986 to August 1992. Of 58 patients who had responses to IgM to EBV viral capsid antigen and/or heterophil antibody, 35 patients had hapatitis. Of 35 hepatitis patients, group I consisted of 22 patients who had only...
Chronic Diarrhea In Infancy
Hee Soo Kim, Ki Sup Chung
Clin Exp Pediatr. 1994;37(2):212-220.   Published online February 15, 1994
Diarrhea is an extremely common cause of morbidity in infancy. Occasionally it becomes protracted, leading to a vicious cycle of malabsorption, malnutrition and failure to thrive. Thirty nine infants of chronic diarrhea who had been admitted to the Department of pediatrics, Yonsei University College of Medicine for 3 years between September, 1989 and December 1992, were clinically studied and analogized,...
Case Report
A Case of Childhood Adenocarcinoma
Mi Jung Park, Moon Sung Psrk, Seunng Hwang Oh, Chuhl Joo Lyu, Ki Sup Chung, Byung Soo Kim
Clin Exp Pediatr. 1994;37(1):109-114.   Published online January 15, 1994
Gastric adenocarcinoma in childhood is an extremely rare disease with poor prognosis. We experienced a case in which a 14 year old female patient who was admitted with complaints of abdominal pain, indigestion and obstipation. Her physical examination revealed positive Blumer's rectal shelf, positive ascitic fluid cytology and typical radiologic and endoscopic findings suggesting gartric adenocarcinoma. She showed symptomatic improvement...
Original Article
The Usefulness of Measuring Serum α-fetoprotein and Thyroxine-binding Globulin to Differentiate between Neonatal Hepatitis and Congenital Extrahepatic Biliary Atresia
Soo Kyoung Lee, Ki Sup Chung
Clin Exp Pediatr. 1993;36(4):512-520.   Published online April 15, 1993
Together, neonatal hepatitis and biliary atresia make up approximately 70 to 80% of the causes of neonatal cholestasis. Biliary atresia must be differentiated from neonatal hepatitis as soon as possible in order to institute early surgical intervention. We performed this study to examine whether the measurement of the serum α-fetoprotein(AFP) and thyroxine-binding globulin(TBG) was useful for differentiating these two conditions....
Foreign Body in the Upper Gastrointestinal Tract in Infants and Children
Sang Heui Song, Ki Sup Chung
Clin Exp Pediatr. 1993;36(1):17-24.   Published online January 15, 1993
The accidental swallowing of foreign bodies by infants and children is a common problem. The proper methods of therapy must be carefully selected according to the age of the patient, the type of foreign body, the location of impaction, the duration of ingestion, and the available medical resoruces and skills. This report reviews 41 cases of ingested foreign bodies in...
Portal Hypertension in Children
Young Sook Kim, Ki Sup Chung
Clin Exp Pediatr. 1992;35(11):1528-1536.   Published online November 15, 1992
Portal hypertension assumes special interest in children due to the large variety of causes, the apparent difficulty of performing surgical portal systemic shunts because of the small size of vessels, the doubt still cast on the long term tolerance of portal systemic shunts and the theoretical possibility of spontaneous regression of varices with growth. Thirty cases of portal hypertension under...
Clinical Features of Twelve Coxiellemia Pediatric Patients in Korea
Chuhl-Joo Lyu, Dong Soo Kim, Young Mo Sohn, Ki Sup Chung, Kir-Young Kim, Won Young Lee
Clin Exp Pediatr. 1992;35(9):1220-1225.   Published online September 15, 1992
Coxiella burnetii is a rickettsial organism and extremely infectious for humans animals. The infection caused by this organism is endemic throughout the world. Although it has not been reported in Korea because of the nonspecific clinical manifestations, the difficulties in diagnosis, and the underestimate of this disease. Update this infection has been misdiagnosed as other disease. We experienced twelve cases of...
A case of primary hepatocellular carcinoma following vertical transmission of hepatitis B virus in a child.
Soo Kyoung Lee, Ki Sup Chung, Sun Won Hong, Chan Il Park
Clin Exp Pediatr. 1991;34(11):1573-1580.   Published online November 30, 1991
Authors experienced a case of primary hepatocellular carcinoma in a 7 year 9 month old male patient, who was admitted to our hospital due to abdominal pain on right upper quadrant and anorexia during last two months. On family history, his mother was HBs Ag and HBe Ag carrier. On past history, he was admitted to a hospital due to persistant jaundice at...
Clinical study on metabolic liver diseases in infancy and childhood.
Jeong Lim Kim, Ki Sup Chung
Clin Exp Pediatr. 1991;34(11):1477-1493.   Published online November 30, 1991
The liver plays a central role in synthetic, degradative, and regulatory pathways involving the metabolism of carbohydrates, protein, lipid, mineral, and vitamins. There are many metabolic abnormalities or specific enzyme deficiencies that affect the liver. The clinical manifestations of metabolic diseases of the liver mimic infections, intoxications, and other systemic diseases. The comprehension of the pathogenesis on the inborn metabolic errors and early...
The clinical review of congenital magacolon.
Myung Goo Min, Ki Sup Chung
Clin Exp Pediatr. 1991;34(10):1373-1380.   Published online October 31, 1991
This clinical study presents an anlaysis of 102 patients who underwent definitive surgery for Hirschsprung’s disease from January 1979 to April 1990 at Department of Pediatrics, Yonsei Univer- sity College of Medicine. The results were summarized briefly as follows: 1) The sex ratio was 2.6:1, of male preponderence. 2) The first symptom appeared within 1 month after birth in majority of cases, in 82 cases (80.4%) and diagnosis...
Clinical Characteristics and Prognosis of Fulminant Hepatic Failure in Infants and Children.
Keum Cheon Kim, Ki Sup Chung
Clin Exp Pediatr. 1990;33(10):1362-1373.   Published online October 31, 1990
29 patients admitted into Department of Pediatrics, Severance Hospital, Yonsei University, college of medicine during 16 years period from 1974 to 1989 with the diagnosis of fulminant hepatic failure were divided into 2 groups, live and expired groups. These patients were compared with sex, age distribution and etiology and in order to find the factors responsible for death platelet counts, prothrombin time, SGOT, SGPT,...
A clinical studies on Wilson's disease.
Won Kyu Lee, Ki Sup Chung, Chang Jun Coe
Clin Exp Pediatr. 1989;32(11):1496-1502.   Published online November 30, 1989
The 12 cases of Wilson disease younger than the age of 18 years were observed at Severance hospital between Jan. 1980 and July 1988 and we obtained following results. 1) The mean age was 14 years old and male to female ratio was 2:1 2) The younger the patient, the clinical symptoms predominantly manifested hepatic dysfunction and the older patient manifested neurologic symptoms. 3) Kayser-Fleischer’s ring was the...