Clinical and Experimental Pediatrics

Original Article

Endocrinology

Thyroid peroxidase gene variants and susceptibility to congenital hypothyroidism and autoimmune thyroid disease among Egyptian pediatric cohort

Hala M. Sakhr, Mohammed H. Hassan, Esraa Abbass Abdallah, Amira Mahmoud Ewis, Mohamed Hesham Mohamed, Shymaa Gaber Rizk

Clin Exp Pediatr. 2026;69(6):486-496. Published online March 26, 2026

Question: Which factors influence pediatric thyroid disorder susceptibility and severity?
Finding: Anemia, selenium deficiency, excess copper, and the thyroid peroxidase (TPO) Arg³⁸⁶His polymorphism, especially with the histidine/histidine genotype, are strongly associated with pediatric thyroid disease and high thyroid-stimulating hormone levels.
Meaning: Pediatric thyroid disorders are multifactorial. The TPO Arg³⁸⁶His variant may help identify children at higher risk of severe thyroid dysfunction, enabling earlier diagnosis, improved risk stratification, and more personalized clinical management.

DOI: https://doi.org/10.3345/cep.2025.02957

Case Report

A case of Kikuchi-Fujimoto disease with autoimmune thyroiditis

Eun Ji Go, You Jin Jung, Seung Beom Han, Byung Kyu Suh, Jin Han Kang

Clin Exp Pediatr. 2012;55(11):445-448. Published online November 23, 2012

Crossref 8

Kikuchi-Fujimoto disease (KFD) is a benign self-limiting disease characterized by fever and lymphadenitis. The etiology and pathogenesis of KFD is unclear. However, two hypotheses have been suggested: a viral infection hypothesis and an autoimmune hypothesis. Several KFD patients with various types of autoimmune diseases have been reported, and these reports support the hypothesis for autoimmune pathogenesis of KFD. Here, we...

DOI: https://doi.org/10.3345/kjp.2012.55.11.445

Autoimmune hepatitis and thyroiditis associated with antituberculous medications : A case report

Seong Keun Yu, Sara Kim, Jin Soo Moon, Han Seong Kim

Clin Exp Pediatr. 2008;51(5):528-532. Published online May 15, 2008

Drug-induced toxic hepatitis is a relatively common hepatic disease in children, and it is usually self-limiting upon cessation of the offending drugs. Antituberculous drugs are well known for inducing hepatitis. Some cases of drug-induced hepatitis with autoimmune features have been reported; in these cases, the offending drugs were usually methyldopa, nitrofurantoin, minocycline, and interferon. The authors report the first case...

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Original Article

Clinical Characteristic of Chronic Autoimmune Thyroiditis in Children

Hye Rim Chung, Choong Ho Shin, Sei Won Yang

Clin Exp Pediatr. 2004;47(1):76-80. Published online January 15, 2004

Purpose : Although chronic autoimmune thyroiditis(AIT) is known to progress into overt hypothyroidism in adults, the outcomes of this disorder in pediatric patients are different from those in adults, so it is hard to predict its course. We reviewed clinical characteristics of chronic AIT in children. Methods : The medical records of 94 children, who were diagnosed as AIT, were analyzed,...

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