Clinical and Experimental Pediatrics

Original Article

Longitudinal analysis of gut microbiota dysbiosis and bacterial signatures predictive of postoperative enterocolitis in children with Hirschsprung disease

Sireekarn Chantakhow, Chanon Kunasol, Jiraporn Khorana, Kanokkan Tepmalai, Nipon Chattipakorn, Siriporn C Chattipakorn

Background: We aimed to investigate differences in gut microbiota between patients with Hirschsprung disease (HSCR) and healthy children; assess longitudinal changes in the microbiota of patients with HSCR from diagnosis through postoperative period; and identify microbial markers predictive of postoperative HSCR-associated enterocolitis (HAEC).
Purpose: To investigate alterations in the gut microbiota of patients with HSCR by assessing longitudinal microbiome changes after...

DOI: https://doi.org/10.3345/cep.2025.01886 [Accepted]

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Bifidobacterium animalis subsp. lactis BLa80 for preventing allergic, respiratory, and gastrointestinal diseases in young children in China: a randomized double-blind placebo-controlled trial

ke Chen, xi Zhang, Kaihong Zeng, Jiayi Zhong, Shanshan Jin, Yang Nie, Ping Yang, Nianyang He, Haixia Chen, Yanmei Cao, Yunrong Fu, Ziji Fang, Wei Jiang, Changqi Liu

Background: Respiratory, gastrointestinal, and allergic diseases can significantly affect children’s physical and mental health and quality of life.
Purpose: This study aimed to assess the safety of Bifidobacterium animalis subsp. lactis BLa80, its preventive effects on morbidities related to respiratory, gastrointestinal, and allergic diseases, and its impact on the gut microbiome of children during the study period. Methods: Healthy children aged 0–3...

DOI: https://doi.org/10.3345/cep.2025.01256 [Accepted]

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Neonatology (Perinatology)

Characterization of gut microbiota in very low birth weight infants with versus without bronchopulmonary dysplasia

Anucha Thatrimontrichai, Manapat Praditaukrit, Gunlawadee Maneenil, Supaporn Dissaneevate, Kamonnut Singkhamanan, Komwit Surachat

Clin Exp Pediatr. 2025;68(7):503-511. Published online February 26, 2025

Web of Science 3 Crossref 3

Question: Does the gut microbiota differ between very low birth weight (VLBW) infants with versus without bronchopulmonary dysplasia (BPD)?
Finding: Common respiratory pathogens were notably elevated in the BPD group, whereas anaerobic and butyrate-producing taxa, key components of postbiotics, were dominant in the non-BPD group.
Meaning: In gut-lung communication, the interplay between the intestinal and respiratory systems may implicate pro- and postbiotics in VLBW infants with BPD.

DOI: https://doi.org/10.3345/cep.2024.01718

Review Article

Neonatology (Perinatology)

Influence of infant microbiome on health and development

Noelle Younge

Clin Exp Pediatr. 2024;67(5):224-231. Published online August 21, 2023

Web of Science 3 Crossref 5

· The infant gut microbiome is highly dynamic and individualized.
· Microbes are vertically transmitted from mother to infant during delivery and throughout infancy.
· Delivery mode, gestational age, diet, and antibiotic use influence infant microbiome composition and function.
· In animal studies, the microbiome played critical roles in the structural and functional development of the infant gastrointestinal and immune systems.
· Microbiome-targeted therapies have great potential to reduce infant morbidity and mortality.

DOI: https://doi.org/10.3345/cep.2023.00598

Case Report

Allergy

Breast abscess caused by Staphylococcus aureus in 2 adolescent girls with atopic dermatitis

Sung Man Park, Won Sik Choi, YoonSun Yoon, Gee Hae Jung, Chang Kyu Lee, So Hyun Ahn, Yoon Wonsuck, Young Yoo

Clin Exp Pediatr. 2018;61(6):200-204. Published online June 25, 2018

Crossref 7

Atopic dermatitis (AD) is a chronic inflammatory skin disease in children. Patients with AD experience a high rate of colonization of the skin surface by Staphylococcus aureus. Because of a skin barrier defect, there is a potential risk of staphylococcal invasive infection in patients with AD. Here, we present 2 cases of breast abscess caused by S. aureus in 2...

DOI: https://doi.org/10.3345/kjp.2018.61.6.200

Review Article

Neonatology (Perinatology)

Fetal and preterm infant microbiomes: a new perspective of necrotizing enterocolitis

Yong-Sung Choi, In Gyu Song

Clin Exp Pediatr. 2017;60(10):307-311. Published online October 20, 2017

Crossref 6

Necrotizing enterocolitis (NEC) is a devastating condition of hospitalized preterm infants. Numerous studies have attempted to identify the cause of NEC by examining the immunological features associated with pathogenic microorganisms. No single organism has proven responsible for the disease; however, immunological studies are now focused on the microbiome. Recent research has investigated the numerous bacterial species residing in the body...

DOI: https://doi.org/10.3345/kjp.2017.60.10.307

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