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Original Article
General Pediatrics
Prevalence of hyperuricemia and its association with metabolic syndrome and cardiometabolic risk factors in Korean children and adolescents: analysis based on the 2016–2017 Korea National Health and Nutrition Examination Survey
Jung Hyun Lee
Clin Exp Pediatr. 2019;62(8):317-323.   Published online June 24, 2019

Purpose: Investigating the prevalence of hyperuricemia and its association with metabolic syndrome (MetS) and cardiometabolic risk factors (CMRFs) in Korean children and adolescents. Methods: This cross-sectional survey used data from the 7th Korea National Health and Nutrition Examination Survey (2016–2017); 1,256 males and females aged 10–18 years were included. Hyperuricemia was defined as serum uric acid levels were >6.6 mg/dL at...
Case Report
Severe dapsone hypersensitivity syndrome in a child
So Yoon Choi, Ho Yeon Hwang, Jung Hyun Lee, Jae Sun Park, Min Soo Jang
Clin Exp Pediatr. 2013;56(6):260-264.   Published online June 21, 2013

Dapsone (4,4'-diaminodiphenylsulfone, DDS), a potent anti-inflammatory agent, is widely used in the treatment of leprosy and several chronic inflammatory skin diseases. Dapsone therapy rarely results in development of dapsone hypersensitivity syndrome, which is characterized by fever, hepatitis, generalized exfoliative dermatitis, and lymphadenopathy. Here, we describe the case of an 11-year-old Korean boy who initially presented with high fever, a morbilliform...

Original Article
Recent incidence of congenital heart disease in neonatal care unit of secondary medical center: a single center study
Seon Young Cho, Jin-Hee Oh, Jung Hyun Lee, Jae Young Lee, Soon Ju Lee, Ji Whan Han, Dae Kyun Koh, Chang Kyu Oh
Clin Exp Pediatr. 2012;55(7):232-237.   Published online July 17, 2012
Purpose

With feasibility in the diagnoses of congenital heart disease (CHD) in the antenatal period, we suspect changes have occurred in its incidence. No data have been reported about the current incidence of simple forms of CHD in Korea. We have attempted to assess the recent incidence and characteristics of CHD in the neonatal care unit of a secondary referral medical...

Review Article
Catheter-related bloodstream infections in neonatal intensive care units
Jung Hyun Lee
Clin Exp Pediatr. 2011;54(9):363-367.   Published online September 30, 2011

Central venous catheters (CVCs) are regularly used in intensive care units, and catheter-related bloodstream infection (CRBSI) remains a leading cause of healthcare-associated infections, particularly in preterm infants. Increased survival rate of extremely-low-birth-weight infants can be partly attributed to routine practice of CVC placement. The most common types of CVCs used in neonatal intensive care units (NICUs) include umbilical venous catheters,...

Original Article
Clinical characteristics of children with 2009 pandemic influenza A (H1N1) admitted in a single institution
Sang In Park, Min Ji Kim, Ho Yeon Hwang, Chi Eun Oh, Jung Hyun Lee, Jae Sun Park
Clin Exp Pediatr. 2010;53(10):886-891.   Published online October 31, 2010
Purpose

This study aims to investigate the clinical characteristics of children diagnosed with the novel influenza A (H1N1) in the winter of 2009 at a single medical institution.

Methods

Out of 545 confirmed cases of influenza A (H1N1) in children, using the real time RT-PCR method at Kosin University Gospel Hospital from September to December of 2009, 149 patients and their medical records...

The immunogenicity and safety of three-component DTaP vaccine in Korean infants
Jin Han Kang, Jong Hyun Kim, Jung Hyun Lee, Soo Young Lee, Young Jin Hong, Chang Hwi Kim
Clin Exp Pediatr. 2007;50(4):355-362.   Published online April 15, 2007
Purpose : We conducted the study to evaluate the immunogenicity and safety of three component DTaP vaccine (Infanrix ) in a group of Korean healthy infants on a three-dose primary vaccination. And we compared the immunogenicity of this DTaP vaccine with two component DTaP vaccine which has been widely used in Korea. Methods : We enrolled one hundred fifty one healthy...
Factors affecting hematologic recovery and infection in high-dose chemotherapy and autologous stem cell transplantation in patients with high-risk solid tumor
Jung Hyun Lee, Bo Lyun Lee, Soo Hyun Lee, Keon Hee Yoo, Ki Woong Sung, Hye Lim Jung, Eun Joo Cho, Hong Hoe Koo
Clin Exp Pediatr. 2006;49(10):1079-1085.   Published online October 15, 2006
Purpose : The purpose of this study was to evaluate factors affecting hematologic recovery and infection in high-dose chemotherapy(HDCT) and autologous stem cell transplantation(ASCT) in patients with high-risk solid tumor. Methods : From January 2004 to December 2005, 72 HDCTs and ASCTs were applied to children with high-risk solid tumor at Samsung Medical Center. Medical records of these 72 HDCTs and...
Susceptibility tests of oral antibiotics including cefixime against Escherichia coli, isolated from pediatric patients withcommunity acquired urinary tract infections
Soo Young Lee, Jung Hyun Lee, Jong Hyun Kim, Jae Kyun Hur, Sun Mi Kim, Sang Hyuk Ma, Jin Han Kang
Clin Exp Pediatr. 2006;49(7):777-783.   Published online July 15, 2006
Purpose : Urinary tract infection(UTI) is one of the most frequent infections in children. E. coli is the most frequent etiological micropathogen in pediatric community UTI, and E. coli has developed resistance to many antibiotics, highlighting the need for regular surveys of this organism resistant patterns in the community. The aim of this study was to determine the oral antibiotic...
Case Report
A Case of Rothmund-Thomson Syndrome with Pure Red Cell Aplasia, Autoimmune Hemolytic Anemia and Chronic Respiratory Infection
Jung Hyun Lee, Eun Seok Roh, Yoo Rah Hong, Jae Sun Park, Ghi Seok Seo, Bang Hur, Mi Hyang Kim
Clin Exp Pediatr. 2004;47(12):1351-1355.   Published online December 15, 2004
Rothmund-Thomson syndrome(RTS), or poikiloderma congenita, is a rare, multisystem disorder. It is inherited genetically as an autosomal recessive trait, occurring predominantly in females(1.4 : 1). The RTS is comprised of poikiloderma, short stature, sparse hair, juvenile cataracts, skeletal defects, dystrophic teeth and nails, photosensitivity, and hypogonadism. We report a case of RTS who died of bleeding from esophageal varices, pulmonary...
Original Article
Clinical Utilities of Serum Ferritin as a Marker of Disease Activity and Prognostic Factor in Childhood Tumors
Eun Seok Roh, Jung Hyun Lee, Yu Ra Hong, Jae Sun Park, Jong Shin Kim
Clin Exp Pediatr. 2004;47(12):1319-1324.   Published online December 15, 2004
Purpose : In order to assess the usefulness of serum ferritin as a marker of disease activity and prognostic factor in pediatric malignancy, serum ferritin levels were measured. Methods : Peripheral blood samplings for ferritin level were made at presentation, in remission following therapy, and in relapse in 95 children with malignancy admitted to the Department of Pediatrics, Kosin University Gospel...
Effects of Insulin-like Growth Factor-I and 1,25-(OH)2 Vitamin D3 Concentration on Intrauterine Growth of Newborns from Mothers with Preeclampsia
In Sook Yang, Jung Hyun Lee, Hyung Shin Lee, So Young Kim, Sung Dong Choi, In Kyung Sung, Chung Sik Chun
Clin Exp Pediatr. 2004;47(5):527-531.   Published online May 15, 2004
Purpose : This study was undertaken to observe the blood levels of IGF-I and 1,25-(OH)2 Vit. D3 in maternal and neonatal compartments and the effects of IGF-I concentration on intrauterine fetal growth and 1,25-(OH)2 Vit. D3 metabolism in the presence of preeclampsia. Methods : Thirty-four full-term pregnant women with preeclampsia and their newborns(preeclampsia group) and 10 normotensive full-term pregnant women and...
Detection Limit of Minimal Residual Disease in Leukemia Using Fluorescence in situ Hybridization
Jung Hyun Lee, So Young Kim, Hyun Hee Kim, Byung Kyu Suh, Wonbae Lee, Kyung Tai Whang
Clin Exp Pediatr. 2000;43(10):1364-1371.   Published online October 15, 2000
Purpose : The close relationship between the size of a tumor burden and the curability of acute leukemia is well established. Therefore, it is very important to detect residual leukemia accurately at low levels. Fluorescence in situ hybridization(FISH) techniques rely on chromosome-specific and gene specific DNA probes to identify numerical and structural chromosomal abnormalities. But the detection limit of FISH...