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Editorial
Allergy
Trends in food allergen immunotherapy in Korea after changed national regulations
Tae Won Song
Clin Exp Pediatr. 2024;67(4):201-202.   Published online November 21, 2023
National regulations, academic guidelines, and clinical trends in food allergen immunotherapies (FA-AIT) differ among countries and have changed rapidly. Current officially approved FA-AIT are oral immunotherapy (OIT) using heated milk/egg in Korea and peanut OIT using standardized products in the United States and Europe. FA-AIT should be administered by specialist physicians with experience administering oral food challenge tests and managing severe allergic reactions inside and outside research settings.
Review Article
Allergy
A practical view of immunotherapy for food allergy
Tae Won Song
Clin Exp Pediatr. 2016;59(2):47-53.   Published online February 29, 2016

Food allergy is common and sometimes life threatening for Korean children. The current standard treatment of allergen avoidance and self-injectable epinephrine does not change the natural course of food allergy. Recently, oral, sublingual, and epicutaneous immunotherapies have been studied for their effectiveness against food allergy. While various rates of desensitization (36% to 100%) and tolerance (28% to 75%) have been...

Case Report
Massive pulmonary hemorrhage in enterovirus 71-infected hand, foot, and mouth disease
Dong Seong Lee, Young Il Lee, Jeong Bae Ahn, Mi Jin Kim, Jae Hyun Kim, Nam Hee Kim, Jong Hee Hwang, Dong Wook Kim, Chong Guk Lee, Tae Won Song
Clin Exp Pediatr. 2015;58(3):112-115.   Published online March 20, 2015

Hand, foot, and mouth disease (HFMD) is an acute, mostly self-limiting infection. Patients usually recover without any sequelae. However, a few cases are life threatening, especially those caused by enterovirus 71 (EV71). A 12-month-old boy was admitted to a primary hospital with high fever and vesicular lesions of the mouth, hands, and feet. After 3 days, he experienced 3 seizure...

Review Article
Oral food challenges in children
Hye Yung Yum, Hyeon Jong Yang, Kyung Won Kim, Tae Won Song, Woo Kyung Kim, Jung Hee Kim, Kang Mo Ahn, Hyun Hee Kim, Soo Young Lee, Bok Yang Pyun
Clin Exp Pediatr. 2011;54(1):6-10.   Published online January 31, 2011

Many patients assume that allergic reactions against foods are responsible for triggering or worsening their allergic symptoms. Therefore, it is important to identify patients who would benefit from an elimination diet, while avoiding unnecessary dietary restrictions. The diagnosis of food allergy depends on the thorough review of the patients's medical history, results of supplemented trials of dietary elimination, and in...

Original Article
Complex febrile convulsions: A clinical study
Jeong Sic Kang, Sa-Ra Kim, Dong Wook Kim, Tae Won Song, Nam Hee Kim, Jong Hee Hwang, Jin Soo Moon, Chong Guk Lee
Clin Exp Pediatr. 2009;52(1):81-86.   Published online January 15, 2009
Purpose : Febrile convulsions are classified into simple or complex types, the latter being characterized by increased risk of recurrence and progression to epilepsy. This study aimed to delineate the clinical characteristics of complex febrile convulsions. Methods : Between January 2003 and December 2006, 550 children were diagnosed with febrile convulsions at the Department of Pediatrics, Ilsan Paik Hospital. Their...
Mycoplasma pneumoniae-induced production of proasthmatic mediators in airway epithelium
Kyung Won Kim, Byung Chul Lee, Kyung Eun Lee, Eun Soo Kim, Tae Won Song, Mi Yeoun Park, Myung Hyun Sohn, Kyu-Earn Kim
Clin Exp Pediatr. 2006;49(9):977-982.   Published online September 15, 2006
Purpose : There has been an increasing amount of literature concerning the association between Mycoplasma pneumoniae and asthma pathogenesis. Interleukin(IL)-6 stimulates the differentiation of monocytes, and can promote Th2 differentiation and simultaneously inhibit Th1 polarization. IL-8 is a potent chemoattractant and, it has been suggested, has a role in asthma pathogenesis. Nitric oxide (NO) synthesized by airway epithelium may be...
Polymorphisms of the CTLA-4 promoter(-318) and exon 1(+49) genes with atopic dermatitis in Korean children
Tae Won Song, Hea Sun Yang, Kyung Eun Lee, Kyung Won Kim, Eun Soo Kim, Myung Hyun Sohn, Kyu-Earn Kim, M.D
Clin Exp Pediatr. 2006;49(5):545-551.   Published online May 15, 2006
Purpose : The gene-encoding cytotoxic T lymphocyte-associated antigen-4(CTLA-4) is one of the candidate genes for conferring susceptibility to atopic dermatitis(AD). The aim of the study was to investigate the association between Korean children with AD and the polymorphisms of CTLA-4 gene promoter(-318) and exon 1(+49). Methods : The CTLA-4 promoter(-318 T/C) and exon 1(+49 A/G) polymorphisms were genotyped via restriction fragment...
Effects of Hyperosmolar Stimuli on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
Byoung Chul Kwon, Eun Soo Kim, Kyung Won Kim, Tae Won Song, Myung Hyun Sohn, Myeong Heon Shin, Kyu-Earn Kim
Clin Exp Pediatr. 2005;48(8):881-885.   Published online August 15, 2005
Purpose : Airway dehydration and subsequent hyperosmolarity of periciliary fluid are considered critical events in exercise-induced bronchoconstriction. The aim of this study was to establish if a hyperosmolar challenge could induce activation of eosinophils. Methods : Human eosinophilic leukaemic cell lines, EoL-1 cells were incubated with hyperosmolar solutions for 15 minutes. Activation of EoL-1 cells was monitored by degranulation and superoxide...