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Original Article
High Dose of Amphotericin B in Intralipid Emulsion-based Delivery System in Immunocompromised Children with Invasive Fungal Infections
Geun Mo Kim, Hoon Kook, Sung Ho Cho, Ji Yong Park, Young Jong Woo, Tai Ju Hwang
Clin Exp Pediatr. 1998;41(2):216-223.   Published online February 15, 1998
Purpose : Fungal infections are an important cause of morbidity and mortality in patients with hematologic malignancies. The therapy of choice in documented or suspected invasive fungal infections has been intravenous Amphotericin B(AmB). Adverse effects such as fever, chills, thrombophlebitis, nausea or vomiting are common. A more serious adverse effect is potential renal impairment. As AmB administration mixed with Intralipid(AmB/Intralipid)...
Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia
Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(2):209-215.   Published online February 15, 1998
Purpose : We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG). Methods : BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment. Results...
Congenital Asymptomatic Cytomegalovirus Infection; A Comparison of Specific IgM Antibody Test and pp65 Antigenemia Assay
Jong Hyun Kim, Eun Ah Seo, Ji Hyang Lim, Sang Hee Park, Won Bae Lee, Kyong Su Lee, Sin Ho Jung
Clin Exp Pediatr. 1998;41(2):163-169.   Published online February 15, 1998
Purpose : It is increasingly important to diagnosis asymptomatic infections which make up a majority(90%) of congenital cytomegalovirus(CMV) infections and that they may have sequeles such as sensorineural hearing loss and mental retardation. Recently antigenemia assay has been developed by using monoclonal antibodies against early structural protein pp65 of CMV. This CMV antigenemia assay seems to be more quicker to...
A Study of Homocysteine Metabolism related Neural Tube Defect
Baeck Hee Lee
Clin Exp Pediatr. 1998;41(1):110-114.   Published online January 15, 1998
Purpose : Methylenetetrahydrofolate reductase is an important enzyme in homocysteine metabolism. Since the identification of the gene locus and mutation of methylenetetrahydrofolate reductase, an increasing number of reports have suggested that elevated levels of homocysteine were associated with various kinds of arteriovascular disease and neural tube defect. Our research plans to investigate whether elevated levels of homocysteine are more common with neural tube defect and...
The Relationships of Pretreatment IGF-I SDS, Delay in Bone Age and Response to Recombinant Human Growth Hormone(rhGH) Therapy in Children with Growth Hormone Deficiency
Seon-Young You, Ki-Joong Kim, Jeh-Hoon Shin, Jin-Nyoung Park, Hee-Jeong Ahn, Yong-Joo Kim
Clin Exp Pediatr. 1998;41(1):90-98.   Published online January 15, 1998
Purpose : To assess whether pretreatment IGF-I SDS and pretreatmental bone age are useful indicators in the response of rhGH therapy in children with GH deficiency(GHD), the relationship between pretreatment IGF-I SDS, delay in bone age and the growth response during the first year of rhGH treatment was analyzed. Methods : This study included 12 children with GHD. We measured IGF-I levels by RIA...
Case Report
A Case of Lipoid Pneumonia with Hypercalcemia Caused by SqualelneⓇ Intake by Force
Young Kyoun Kim, Ho Suk Kang, Seung Cheol Lee, Chong Guk Lee, Sang Woo Kim
Clin Exp Pediatr. 1997;40(12):1745-1749.   Published online December 15, 1997
Lipoid pneumonia is a chronic, interstitial, proliferative inflammation resulting from aspiration of lipoid material and occurs principally in debilated infants. We experienced a case of lipoid pneumonia with hypercalcemia in a 15 month-old boy who showed irritability, poor weight gain, cough, dyspnea, fatigue, diarrhea and pale face after ingestion of SqualeneⓇ(shark liver oil : 20-30 cap/day) by force for 2 months. Calcium preparation was also...
Original Article
A Result of Treatment of Malignant Germ Cell Tumors in Childhood
Hyoung Jin Kang, Jun Ah Lee, Hyo Jeong Han, Hyoung Su Choi, Hyeon Jin Park, Ki Woong Sung, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn, Kwi Won Park, Byung Keu Cho, Hwang Choi, Chul Woo Kim
Clin Exp Pediatr. 1997;40(12):1707-1718.   Published online December 15, 1997
Purpose : Germ cell tumors have variable clinical characteristics according to the age, sex, primary site, and pathologic diagnosis. To provide the therapeutic principle, the clinical characteristics, response to the treatment, and prognostic factors were analyzed. Methods : Medical records of 57 children who were diagnosed as malignant germ cell tumor in Seoul National University Children' s Hospital from January 1986 till June 1996 were...
Follow-Up Study of Urinary Tract Infection Associated with Vesicoureteral Reflux
Do Whan Kil, Jea Eun Lee, Wan Seob Kim
Clin Exp Pediatr. 1997;40(12):1692-1700.   Published online December 15, 1997
Purpose : Vesicoureteral reflux(VUR) is the major cause of urinary tract infection (UTI) in children. Prolonged untreated UTI associated with VUR may result in serious complications, such as renal scarring, renal atropy, and decreased renal function. Therefore, follow up must be continued until UTI is cured completely, to prevent of serious complication. The authors conducted this study to evaluate results of the follow-up of...
Postoperative Weight-Gain in Early Infants with Symptomatic Large Ventricular Septal Defect
Chang-Rang Kang, Hyang-Suk Yoon, Jong-Bum Choi, Soon-Ho Choi
Clin Exp Pediatr. 1997;40(12):1675-1680.   Published online December 15, 1997
Purpose : To investigate the postoperative patterns of weight-gain in early infants with ventricular septal defects(VSDs), we analyze 48 patients who received primary surgical closure of the symptomatic VSDs during 6 months of age in the period of 1993 through 1995. Methods : Forty-sixt infants met criteria for inclusion in the study. The mean follow up period was 14 months(3 to 36 months). Weight...
Case Report
Pyomyositis of Pyriformis Muscle Caused by Vigorous Exercise and Acupuncture in a Healthy Boy
Joo Hun Choi, Seo Jeong Kim, Woo Hyun Ahn
Clin Exp Pediatr. 1997;40(11):1608-1611.   Published online November 15, 1997
A case of pyomyositis of right pyriformis and iliacus muscle in a healthy 13 year old male patient is presented and discussed. Pyomyositis is a primary acute bacterial infection of large skeletal muscles, associated with abscess formation. Since pyomyositis has been reported mainly in tropical countries and is rare in temperate climates, the name ' tropical myositis' is often used. Outside the tropics, pyomyositis...
Original Article
Diagnostic Value of 99mTc-DMSA SPECT in Children with Urinary Tract Infection
Jae Won Choi, Sung Ho Cha, Byoung Soo Cho, Duk Yoon Kim
Clin Exp Pediatr. 1997;40(11):1559-1566.   Published online November 15, 1997
Purpose : The accurate identification of renal cortical defects in children with urinary tract infection is essential in reducing subsequent morbidity. Imaging of the kidneys with 99mTc-dimercaptosuccinic acid (DMSA) has been demonstrated as the sensitive method available for identification of renal cortical defects. Single photon emission computerized tomography(SPECT) has been suggested as a method by which the accuracy of identification of renal cortical defects can...
Endoscopic Removal of Foreign Bodies in Upper GI Tract in Children
Hae Jung Han, Sang Gil An, Yong Min Chung, Hee Sup Kim, Hann Tchah, Ho Jin Park
Clin Exp Pediatr. 1997;40(11):1552-1558.   Published online November 15, 1997
Purpose : The foreing bodies in the upper GI tract are chiefly caused by accidental swallowing and rarely provoke symptoms. It is recommended to remove the foreign bodies if they produce symptoms or remain in GI tract for long duration or complications are expected to bring about. Nowadays the development of pediatric therapeutic endoscopy enables the removal of the foreign bodies in upper GI tract...
Comparison of Antimicrobial Susceptibility of Nosocomial and Community-Acquired Pathogens in Children of Medium-Sized Hospital
Kil Soo Joung, Jae Kook Cha, Kon Hee Lee, Hye Sun Yoon, Wonkeun Song
Clin Exp Pediatr. 1997;40(11):1537-1543.   Published online November 15, 1997
Purpose : We evaluated the identification and antimicrobial susceptibility patterns of nosocomial and community-acquired pathogens in children of the medium-sized hospital. Methods : The 357 bacterial strains isolated from Pediatric department of Dongsan Sacred Heart Hospital were examined the species identification and antimicrobial susceptibility test during the period of March to October 1996. Results : Fifty three strains(15%) of 357 strains were nosocomial pathogens. A...
Neonatal Facial and Cry Responses to Invasive and Non-invasive Procedures
Seon Hwa Seo, Young Pyo Chang
Clin Exp Pediatr. 1997;40(11):1520-1528.   Published online November 15, 1997
Purpose : The evaluation of pain in neonates is difficult due to their limited means of communication. The aim of this study was to determine whether the behavioral reactions of facial action and cry provoked by an invasive pain-induced procedure could be discriminated from the reactions to a noninvasive pain-induced procedure in normal full-term neonates. Methods : Thirty-six healthy full-term neonates received three pain-induced...
Influences of the Intrapulmonary R→L Shunt on PaO2 and PaCO2 after Instillation of Exogenous Pulmonary Surfactant to Premature Neonates with Respiratory Distress Syndrome
Yoon Hyung Park, Sei Woo Chung, Seung Baik Han, Young Se Kwon, Ji Youn Kim, Woo Sik Cheong, Dae Hyun Lim, Byong Kwan Son
Clin Exp Pediatr. 1997;40(11):1508-1519.   Published online November 15, 1997
Purpose : We are inclined to analyze the relationship between the intrapulmonary right-to-left shunt and the PaO2/PaCO2 after endotracheal single-dose surfactant instillation to premature neonates with respiratory distress syndrome within 6 hours after birth. Methods : From Jan. 1993 to Jun. 1995, we have conducted a clinical trial of surfactant replacement therapy to the premature neonates with respiratory distress syndrome at the neonatal intensive care unit...
Erratum
A Survey on the Factors Related to the Failure of Breast-feeding
Seung Joo Lee, Jeong Wan Seo, Jae Ock Park, Jae Hoon Shin, Hae Ran Lee, Ji Tae Chung, Hae II Chung
Clin Exp Pediatr. 1997;40(10):1336-1346.   Published online October 15, 1997
Objective : The breast-feeding rate has decreased in Korea despite of the active encouraging effort of breast-feeding for the last 10 years. So we investigated the factors that are related to breast-feeding failure. Method : 1807 specific questionares of mothers who visited the six university hospitals in Seoul from October 1993 to December 1995 were analysed by ANOVA and multiple logistic regression using SAS program. Results...
Original Article
Interim Results of Single Stage Operation for Coarctation of Aorta with Large Ventricular Septal Defect in Infancy
Ho Sung Kim, Chung Il Noh, Yong Soo Yun, Jung Yun Choi, Jeong Ryul Lee, Yong Jin Kim, Joon Ryang Roh
Clin Exp Pediatr. 1997;40(9):1250-1257.   Published online September 15, 1997
Purpose : There are controversies in the operative methods of aorta with ventricular septal defect in infancy. Recent results of single stage operation for coarctation of aorta with intracardiac defects were regarded as comparable to staged operation. We evaluated our interim results after single stage operation for coarctation of aorta with large ventricular septal defect in infancy. Methods : Twenty six infants who had received...
Rapid Identification of Mycoplasma Pneumoniae, Mycobacterium Tuberculosis and Staphylococcus Aureus in Pleural Fluid by PCR
Chang Wan Kim, Byung Moon Ahn, Eun Ryoung Kim, Il Su Kim, Yung Seuk Pak, Sang Chul Sung
Clin Exp Pediatr. 1997;40(9):1232-1241.   Published online September 15, 1997
Purpose : Pleural effusions may develop during the course of bacterial pneumonia. The aim of this study was to evaluate the significance of the polymerase chain reaction(PCR) method for detection of M ycoplasma pneumoniae, M ycobaterium tuberculosis and Staphylococcus aureus from pleural fluid. Methods : Total 12 samples were obtained from pleural fluid; 2 samples from children with Mycoplasma pneumonia, 5 samples from adults with...
Case Report
Ectopic Pancreas of Stomach in a Child with Recurrent Abdominal Pain
Hyun Chul Bae, Je Woo Kim, Ki Sup Chung, Dong Hwan Shin
Clin Exp Pediatr. 1997;40(8):1178-1182.   Published online August 15, 1997
Ectopic pancreas is a rare congenital anomaly defined by the presence of pancreatic tissue that lacks anatomic and vascular continuity with the main body of the pancreas. A 11-year-old girl was admitted to the Department of Pediatrics, Yonsei University College of Medicine with the history of recurrent abdominal pain for 2 years. We performed fiberoptic endoscopy which showed a 1.5¡¿1.5cm sized polypoid mass, and...
Acute Renal Failure(ARF) Associated with Yersinia Pseudotuberculosis Infection Diagnosed by Polymerase Chain Reaction
Hyung Gyu Park, Byung Moon Ahn, Eun Ryoung Kim, Il Soo Kim, Jae Jong Kim, Sung Ok Kang, Han Ho Park, Ki Jeong Kim
Clin Exp Pediatr. 1997;40(8):1162-1168.   Published online August 15, 1997
The clinical significance of Yersinia pseudotuberculosis(Y. pseudotuberculosis) has recently recognized in various part of the world because it can cause a wide range of clinical problems such as mesenteric lymphadenitis, septicemia, reactive arthritis, terminal ileitis, erythema nodosum and acute renal failure. we experienced a case of acute renal failure associated with Y. pseudotuberculosis infection. We applied a nested polymerase chain reaction method for rapid diagnosis...
Original Article
Cardiovascular Effects of Growth Hormone Treatment in Idiopathic Short Stature
Hyang Ok Woo, Dong Wook Kim
Clin Exp Pediatr. 1997;40(8):1149-1155.   Published online August 15, 1997
Purpose : An excess of GH causes various problems within the cardiovascular system including cardiac hypertrophy and abnormalities of left ventricle(LV) function. To evaluate the cardiovascular effects due to GH treatment in idiopathic short stature (ISS), we measured the cardiovascular function. Methods : Twenty-two echocardiographic studies were performed in ISS who were admitted from Jan. 1994 through Jul. 1996, and they were divided into two...
The Clinical Study on Conversion Rate of Mantoux Test, Change of Local Lesion and Complication after Multipuncture BCG Vaccination in Neonates
Myung Ho Oh, Kee Hyuck Kim, Jae Gun Sim
Clin Exp Pediatr. 1997;40(8):1120-1130.   Published online August 15, 1997
Purpose : Ugly ulcer and keloid formation of injection site has sometimes been a problem in Korea from the cosmetic point of view in intradermal vaccination. Since 3 or 4 years ago, multipuncture BCG vaccination has been used in Korea, there are no data and information about multipuncture BCG vaccination. We therefore performed this study to evaluate of conversion rate, complication and to make...
Epidemiologic and Clinical Feature of Acute Lower Respiratory Tract Infections by Respiratory Syncytial Virus and Parainfluenza Virus in Children
Jeoung Jin Lee, Hyeon Seon Park, Mi Ran Kim, Dug Ha Kim, Hae Ran Lee, Chong Young Park, Woo Kap Chung, Kyu Man Lee
Clin Exp Pediatr. 1997;40(8):1071-1080.   Published online August 15, 1997
Purpose : This is to analyze epidemic and clinical features of acute respiratory tract infections(ALRTI) by respiratory syncytial virus(RSV) and parainfluenza virus(PIV), which are considered to be the major respiratory pathogens in children. Methods : Nasopharyngeal aspirates were collected from 515 patients with ALRTI hospitalized at Hangang Sacred Heart Hospital between Apr. ’94 and Oct. ’96. Nasopharyngeal aspirates were inoculated to...
Case Report
A Case of Infectious Mononucleosis Associated with Pleural Effusion and Ascites
Seung-Kyoo Han, Yun-Jeong Yang, Yon-Ho Choe, Yong-Hoon Jun, Soon-Ki Kim, Byong-Kwan Son
Clin Exp Pediatr. 1997;40(7):1026-1030.   Published online July 15, 1997
Infectious mononucleosis is an acute infectious disease occurring predominantly in older children and young adults due to primary Epstein-Barr virus infection. The clinical picture is extremely variable in both severity and duration. The disease in children is generally mild. It is characterized clinically by fever, exudative or membranous pharyngitis, generalized lymphadenopathy, and splenomegaly. Rarely, it complicates neurologic involvement such as cranial nerve palsy, meningoencephalitis, and...
A Case of Choledochal Cyst with Anomalous Pancreaticobiliary Ductal Union
Je Woo Kim, Hyun Chul Bae, Ki Sup Chung, Seok Joo Han, Eui Ho Hwang
Clin Exp Pediatr. 1997;40(7):1010-1014.   Published online July 15, 1997
Choledochal cysts are congenital or acquired lesions of the biliary tree with a cystic dilatation of the bile duct. We experienced a choledochal cyst accompanying acute pancreatitis caused by anomalous pancreaticobiliary ductal union(APBDU) in a 2 year old boy. The choledochal cyst associated with APBDU is rarely encountered in the clinical field, and thus we report this case with the presentation of abdominal ultrasonogram, computed...
Original Article
Urinary Interleukin-1β Levels in Children with Urinary Tract Infection
Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(7):981-990.   Published online July 15, 1997
Purpose : IL-1β and TNF-α are important mediators of the inflammatory response in serious bacterial infections. The mucosal and systemic IL-1β and TNF-α responses to urinary tract infection are analyzed in children with acute urinary tract infection. Methods : We studied the levels of these two cytokines in the urine and sera of 21 children at diagnosis and after treatment with sandwich ELISA method. Results...
Clinical Manifestations of Recurrent Abdominal Pain May Differ with Helicobacter pylori Infection in Children
Nam Seon Beck, I-Seok Kang
Clin Exp Pediatr. 1997;40(7):965-973.   Published online July 15, 1997
Purpose : The role of H. pylori in the pathogenesis of recurrent abdominal pain in children is uncertain. In order to find a correlation between H. pylori infection and recurrent abdominal pain in children, the present study was designed to compare the clinical manifestations between recurrent abdominal pain children with and without H. pylori infection and to investigate the effects of H. pylori eradication...
A Clinical Study for the Time of Development and Risk Factors of Retinopathy of Prematurity
Eun Ae Park, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(7):945-954.   Published online July 15, 1997
A Study of Relation between Stable Microbubble Rating and Surfactant Derivatives(SurfactenⓇ : Phospholipid :, ExosurfⓇ : Dipalmitoyl-Phosphatidyl Choline) Concentration in Vitro
Myung Ho Oh, Kee Hyuck Kim, Jae Gun Sim, Min Hee Kim
Clin Exp Pediatr. 1997;40(7):939-944.   Published online July 15, 1997
Purpose : With the recent advent of surfactant replacement therapy, there is an increasing need for a rapid and reliable test to predict respiratory distress syndrome (RDS) immediately before or at birth. There are many investigations and methods for the detection of RDS in prenatal or postnatal period. The stable microbubble rating test (SMR-test) developed by pattle et al. is rapid and simple test...
Extrachromosome 21 in Korean with Down Syndrome Using DNA Haplotyping
Jin-Sung Lee, Won Kyu Choi
Clin Exp Pediatr. 1997;40(7):917-924.   Published online July 15, 1997
Purpose : Down syndrome, the most common single cause of mental retardation, is usually due to meiotic nondisjunction leading to trisomy 21. In order to understand the mechanisms of meiotic nondisjunction including parental origin of an extrachromosome and the meiotic stage of nondisjunction, we have studied DNA polymorphisms at loci on the long arm of chromosome 21 in 36 families with free trisomy 21. Methods...