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Review Article
Haploidentical hematopoietic stem cell transplantation in children and adolescents with acquired severe aplastic anemia
Ho Joon Im, Kyung-Nam Koh, Jong Jin Seo
Clin Exp Pediatr. 2015;58(6):199-205.   Published online June 22, 2015

Severe aplastic anemia (SAA) is a life-threatening disorder for which allogeneic hematopoietic stem cell transplantation (HSCT) is the current available curative treatment. HSCT from matched sibling donors (MSDs) is the preferred therapy for children with acquired SAA. For patients who lack MSDs, immunosuppressive therapy (IST) is widely accepted as a first-line treatment before considering HCT from an unrelated donor (URD)....

Case Report
Chronic Epstein-Barr virus infection causing both benign and malignant lymphoproliferative disorders
Yoojin Kwun, Soo-Jong Hong, Jin Seong Lee, Da Hye Son, Jong Jin Seo
Clin Exp Pediatr. 2014;57(9):420-424.   Published online September 30, 2014

The Epstein-Barr virus (EBV) is oncogenic and can transform B cells from a benign to a malignant phenotype. EBV infection is also associated with lymphoid interstitial pneumonia (LIP). Here, we report the case of a 14-year-old boy who was diagnosed with a latent EBV infection and underlying LIP, without any associated immunodeficiency. He had been EBV-seropositive for 8 years. The...

Original Article
Clinical features of infantile hepatic hemangioendothelioma
Eun Hee Kim, Kyung Nam Koh, Meerim Park, Bo Eun Kim, Ho Joon Im, Jong Jin Seo
Clin Exp Pediatr. 2011;54(6):260-266.   Published online June 30, 2011

Infantile hepatic hemangioendothelioma (IHHE) is the most common type of hepatic vascular tumor in infancy. We conducted this study to review our clinical experience of patients with IHHE and to suggest management strategies.


We retrospectively analyzed the medical records of 23 IHHE patients (10 males, 13 females) treated at the Asan Medical Center between 1996 and 2009.


Median age at diagnosis was...

Prognostic significance of minimal residual disease detected by a simplified flow cytometric assay during remission induction chemotherapy in children with acute lymphoblastic leukemia
Kyung Nam Koh, Meerim Park, Bo Eun Kim, Ho Joon Im, Chan-Jeoung Park, Seongsoo Jang, Hyun Sook Chi, Jong Jin Seo
Clin Exp Pediatr. 2010;53(11):957-964.   Published online November 30, 2010

Our study attempted to determine the prognostic significance of minimal residual disease (MRD) detected by a simplified flow cytometric assay during induction chemotherapy in children with B-cell acute lymphoblastic leukemia (B-ALL).


A total of 98 patients were newly diagnosed with precursor B-ALL from June 2004 to December 2008 at the Asan Medical Center (Seoul, Korea). Of those, 37 were eligible for...

Review Article
Psychosocial aspects of childhood cancer survivors
Jong Jin Seo
Clin Exp Pediatr. 2010;53(4):471-476.   Published online April 15, 2010
The majority of childhood cancer survivors and their families will be psychologically healthy, but may desire and benefit from preventive care. A significant portion of the survivor population will be psychosocially distressed in various aspects by their harsh experience of long cancer treatment, and may warrant professional intervention and treatment. Pediatricians should be aware of the late psychological effects that can occur a...
Original Article
Ototoxicity in children receiving cisplatin chemotherapy
Hee Jin Jang, Hyung Rae Cho, Jae Hee Lee, Kun Yuk Bae, Jong Jin Seo, Hyung Nam Moon, Ho Joon Im
Clin Exp Pediatr. 2010;53(2):210-214.   Published online February 15, 2010
Purpose : Cisplatin is highly effective for the treatment of solid tumors in children. However, the clinical use of cisplatin is limited by its ototoxicity. The aim of this study was to evaluate the ototoxicity in children treated with cisplatin. Methods : We performed a single institution retrospective analysis of pediatric oncology patients who received cisplatin therapy between January 2001 and...
Outcome and risk factors of pediatric hemato-oncology patients admitted in pediatric intensive care unit
Bo Eun Kim, Eun Ju Ha, Keun Wook Bae, Seongguk Kim, Ho Joon Im, Jong Jin Seo, Seong Jong Park
Clin Exp Pediatr. 2009;52(10):1153-1160.   Published online October 15, 2009
Purpose : To evaluate the risk factors for mortality and prognostic factors in pediatric hemato-oncology patients admitted to the pediatric intensive care unit (PICU). Methods : We retrospectively reviewed the medical records of pediatric hemato-oncology patients admitted at the PICU of the Asan Medical Center between September 2005 and July 2008. Patients admitted at the PICU for perioperative or terminal...
Review Article
Recent advances in histiocytic disorders
Jong Jin Seo
Clin Exp Pediatr. 2007;50(6):524-530.   Published online June 15, 2007
The recent advances in the basic hematology and immunology have significantly enhanced the understanding of histiocytic disorders. The Histiocyte Society which was established in 1985 enabled the randomized trials for these diseases, and important knowledge regarding pathogenesis, clinical presentation, diagnosis, therapy and late consequences has been obtained. The treatment of Langerhans cell histiocytosis (LCH) has varied greatly over last decades,...
Original Article
The Effects of Echinacea Extract on the Gene Expression of Monocytes and Monocyte-derived Dendritic Cells
Jun Eun Park, Kang Duk Choi, Sung Hwan Kim, Dae-Hyun Hahm, Jong Jin Seo
Clin Exp Pediatr. 2005;48(7):779-788.   Published online July 15, 2005
Purpose : Echinacea, a traditional plant medicine has been used as immune-stimulant. Recent studies have revealed that extract of Echinacea has immunostimulatory effects on human blood mononuclear cells. This study was designed for the purpose of screening the genes associated with immunologic effects of Echinacea on monocytes and dendritic cells using a cDNA microarray chip. Methods : CD14+ monocyte cells...
Clinical Lecture
Recent Advances in the Treatment of Childhood Leukmia
Jong Jin Seo
Clin Exp Pediatr. 2003;46(1):1-5.   Published online January 15, 2003
Original Article
Analysis of Etiology and Prognosis of Pulmonary Complications in Children with Hematological or Oncological Disorders in Pediatric Intensive Care Unit
Jin Young Jung, Soo-Jong Hong, Young Jun An, Ja Hyung Kim, Jong Jin Seo, Hyung Nam Moon, Thad Ghim
Clin Exp Pediatr. 2002;45(8):1000-1006.   Published online August 15, 2002
Purpose : In the course of treatment, patients with hematological or oncological disorders often develop pulmonary complication. The patients who develop a severe pulmonary complication have a poor outlook. The causes of pulmonary complication are either infectious or non-infectious in origin. We have analyzed the etiology and outcome of these patients admitted to the pediatric intensive care unit of Asan...
QT Dispersion after Chemotherapy with Anthracyclines in Children
Jae Kon Ko, Young Hwee Kim, In Sook Park, Jong Jin Seo, Hyung Nam Moon
Clin Exp Pediatr. 2001;44(8):908-915.   Published online August 15, 2001
Purpose : Anthracycline induced cardiotoxicity is well known and its pathology is characterized by localized myocardial cell necrosis and myocardial fibrosis. The variability in QT interval duration amongst the different leads of the standard 12-lead ECG(QT dispersion) is considered to reflect inhomogenous repolarization of the myocardium. The aim of this study was to assess the effects of anthracycline on cardiac...
Medical Lecture Course
Recent Advances in Molecular Genetics of Pediatric Leukemias
Jong Jin Seo
Clin Exp Pediatr. 1993;36(5):605-614.   Published online May 15, 1993
Case Report
A Familial Case of Tricho-Rhino-Phalangeal Syndrome
Kyong Ok Ko, Sang Hyun Byun, Jong Jin Seo, Kun Su Rhee, Young Hun Chung, Yong Bae Sin
Clin Exp Pediatr. 1992;35(8):1135-1140.   Published online August 15, 1992
We experienced a familial case of Tricho-Rhino-Phalangeal syndrome in a 12-year-6-month-old girl, her younger sister and father. The diagnosis was made by family history history, characteristic morphologic clinical features of bulbous nose, sparse thin hair and deformity of hand and radiologic findings of cone shape epiphyses and Legg-perthes like change of right femoral capital epiphysis. A brief review of the...
Non-Hodgkin's Lymphoma of Bone with Multiple Punched-out Lesion on Simple Radiologic Examination
Gye Eun Whoang, Sang Hyun Byun, Jong Jin Seo, Keon Su Rhee, Young Hun Chung, Kwang Seon Seo, Cheol Woo Kim, Seong Hoae Kim
Clin Exp Pediatr. 1992;35(2):269-274.   Published online February 15, 1992
NHL is a malignant tumor that invade in abdominal cavity, mediastinum, cervical lymph node, rarely in peripheral lymph node, skin, and bone. Primary malignant lymphoma of bone with multiple punched-out lesion on simple radiologic examination was not reproted yet. We experienced a case of primary NHL of bone with multiple punched-out lesion on simple radiologic examination, in a 3-year 7-month old boy...
Original Article
Effect of yeast-derived methionyl recombinant growth hormone on growth hormone deficient dwarf.
Jong Jin Seo
Clin Exp Pediatr. 1991;34(9):1269-1275.   Published online September 30, 1991
Fifteen GH deficient dwarfs were treated with LBD-003, the first year-derived rhGH produced in Korea. The growth promoting effect of LBD-003 was excellent and similar to that of the pituitary extract GH or the previous imported rhGHs. The serum concentrations of IGF-1 at 6th and 12th month of treatment showed significant elevation (p< 0.005, p< 0.001 respectively), but no significant correlation was observed between the...
Two cases of Gaucher disease in brother and sister.
Yong Ju Kim, Ki Young Cheong, Jong Jin Seo, Keon Su Rhee, Young Hun Chung, Seon Hoe Koo
Clin Exp Pediatr. 1991;34(8):1151-1156.   Published online August 31, 1991
We experienced two cases of Gaucher disease in brother and sister. The first case of 6 year old female showed hepatosplenomegaly with thrombocytopenia and characteristic Gaucher cells in bone marrow aspiration and biopsy. She is alive without complaints except abdominal distension. The second case of 3 year ~ 7 month old male showed hepatosplenomegaly with anemia and throm- bocytopenia. There were characteristic Gaucher cells...
A clinical study on the thyroid nodule in childhood.
Yong Ju Kim, Ki Young Cheong, Jong Jin Seo, Young Hun Chung
Clin Exp Pediatr. 1991;34(8):1116-1122.   Published online August 31, 1991
A clinical study was carried out in 27 children with thyroid nodule who visited the Dept, of pediatrics, Chungnam National University Hospital during the 4 year period from March 1986 to February 1990. The results are as follows; 1) The most frequent age group was between 10 to 15 year, and the mean age was 10.65 ±3.19 year. The male to female ratio was 1:4.4 2) All patients...
One case of hereditary spherocytosis with aplastic crisis.
Kee Young Park, Ho Kyung Choi, Jong Jin Seo, Keon Su Rhee, Yong Hun Chung
Clin Exp Pediatr. 1991;34(6):843-848.   Published online June 30, 1991
We experienced one case of hereditiary spherocytosis with aplastic crisis who was 3 year-old female. On admission, there were pallor and fever. Diagnosis was made by pressence of spherocytes in peripheral blood smear, osmotic fragility test, and bone marrow examination. A brief review of related literature was made.
A clinical study of Graves' disease in children.
Kee Young Park, Ho Kyung Choi, Jong Jin Seo, Young Hun Chung
Clin Exp Pediatr. 1991;34(6):812-819.   Published online June 30, 1991
The authors analyzed the clinical manifestations, laboratory results, and relationship between the presence of antithyroid autoantibodies and response of short-term antithyroid medication in 20 children with Graves* disease who were diagosed at the Department of Pediatarics, Chungnam National Universtiy Hospital from March 1985 to February 1990. The results were as follows; 1) The ratio of male to female was 1:9. 2) The age distribution of patients ranged from...
The Pharmacokinetics, Acute Biological Effects and Safety of Recombinant Human Growth Hormones.
Jong Jin Seo
Clin Exp Pediatr. 1990;33(8):1104-1110.   Published online August 31, 1990
The pharmacokinetics, acute biological성fccts and safety of yeast-derived recombinant methionyl- hGH (LBD-003), the first biosynthetic hGH in Korea, were studied in 10 healthy young adults who were administered 8 IU/day intramuscularly for four consecutive days. 1) GH levels reached a mean (±SD) peak of 27.5±10.7 ng/ml at 3.4±0.8 hours following the first dose, and other pharmacokinetic parameters of LBD-003 were similar to those reported for pituitary...
A Case of Mediastinal Gastroenteric Cyst.
Hong Ryang kil, Hye Suk Hong, Yang Won Lee, Jong Jin Seo, Young hun Chung, Seung Pyung Lim
Clin Exp Pediatr. 1988;31(7):924-929.   Published online July 31, 1988
Among heterogenous group of developmental anomalies known as enteric duplication, mediastinal gastroenteric cysts are rare and of outstanding diagnostic importance, because without definitive treatment they can be fatal. Unlike other mediastinal cysts they are almost never asymtomatic. The authors experienced a case of mediastinal gastroenteric cyst in 1 year 7 month-old female patient with chief complaint of abnormal mass density in chest X-ray. The...
Case Report
Three Cases of Nephrogenic Diabetes Insipitus.
Hey Sun Lee, Byoung Hai Ahn, Jong Jin Seo, Hyung Ro Moon
Clin Exp Pediatr. 1984;27(9):912-917.   Published online September 30, 1984
From July 1981 to Feb. 1983, we experienced three cases of nephrogenic diabetes insipidus in which the initial diagnostic clues were repeated episodes of unexplained fever in infancy and which were confirmed by water deprivation and pitressin tests and clinical responses to administration of hydrochlorthiazide. So we report this with some review of literatures.
Three Cases of Idiopathic Hypertrophic Subaortic Stenosis.
Sei Weon Yang, Dong Gyoon Kim, Jong Jin Seo, Jung Yun Choi, Yong Soo Yun, Chang Yee Hong
Clin Exp Pediatr. 1984;27(5):493-500.   Published online May 31, 1984
Idiopathic Hypertrophic Subaortic Stenosis is a primary disease of cardiac muscle that is probably congenital, is often genetically transmitted, and is characterized by asymmetric septal hypertrophy, systolic anterior motion of anterior mitral valve and disorganization of cardiac muscle cells. The authors experienced 3 cases of Idiopathic Hypertrophic Subaortic Stenosis which were confirmed by echocardiography, cardiac catheterization and angiocardiography. The literatures...
Adrenal Cortical Carcinoma in a Nineteen Month Old Girl.
Sei Weon Yang, Jong Jin Seo, Hyung Ro Moon
Clin Exp Pediatr. 1984;27(4):413-418.   Published online April 30, 1984
Adrenal carcinoma is a rare disease both in adults and in children. Most of these tumors are functional, especially in children, producing endocrine syndromes such as Cushing syndrome, virilization, feminization or precocious puberty. The authors report a nineteen month old girl who exhibited features of Cushing syndrome and virilization caused by adrenal cortical carcinoma measuring 5.5X5.0X2.8 cm. She was successfully...
Original Article
Clinical Study on the Dilated Cardiomyopathy in Children.
Jong Jin Seo, Byong Gwan Sohn, Jung Yeun Choi, Yong Soo Yoon, Chang Yee Hong
Clin Exp Pediatr. 1983;26(11):1081-1094.   Published online November 30, 1983
Forty five cases of dilated cardiomyopathy who were admitted, to Seoul National University Hospital from June, 1980 to May, 1983 were studied on the clinical features and laboratory findings. 1) Twenty two cases (44.4%) were primary dilated cardiomyopathy, and the other 25 case (55.6%) were secondary. Nineteen cas&s(95.0%) of primary dilated cardiomyopathy were diagnosed within 3 year of age, but sacondary dilated cardiomyopathy did...
Statistical Assessment on Chromosomal Aberrations Observed in Childhood.
Jong Jin Seo, Hyung Ro Moon
Clin Exp Pediatr. 1983;26(3):220-227.   Published online March 31, 1983
A statistical assessment was carried out in two hundreds and eighty three inpatients and outpatients and fifteen mothers who were subjected to chromosomal analysis at Department of Pediatrics, Seoul National University Hospital, from January 1977 to February 1982. The following results were obtained: 1) Age distribution revealed 65.8% of all children subjected to chromosomal analysis to be: under 2 years of age. The number of...
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