- Review Article
- Allergy
- Prevalence, comorbidities, diagnosis, and treatment of nonallergic rhinitis: real-world comparison with allergic rhinitis
- Hye Yung Yum, Eun Kyo Ha, Yoon Ho Shin, Man Yong Han
- Clin Exp Pediatr. 2021;64(8):373-383. Published online August 10, 2020
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Rhinitis is among the most common respiratory diseases in children. Nonallergic rhinitis, which involves nasal symptoms without evidence of systemic allergic inflammation or infection, is a heterogeneous entity with diverse manifestations and intensities. Nonallergic rhinitis accounts for 16%–89% of the chronic rhinitis cases, affecting 1%–50% (median 10%) of the total pediatric population. The clinical course of nonallergic rhinitis is generally...
- Original Article
- Allergy
- Sex-based differences in factors associated with bronchial hyperresponsiveness in adolescents with childhood asthma
- Young Hwan Kim, Yoon Young Jang, Jieun Jeong, Hai Lee Chung
- Clin Exp Pediatr. 2021;64(5):229-238. Published online January 14, 2021
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Question: What factors are associated with bronchial hyperresponsiveness (BHR) in adolescents with childhood asthma?
Finding: Age, mold sensitization, and increased eosinophil count were associated with BHR in boys versus a reduced forced expiratory volume in 1 second/forced vital capacity ratio in girls. Early mold sensitization was a risk factor for persistent BHR in boys only.
Meaning: Sex-specific differences were observed in the factors associated with BHR in adolescents.
- Editorial
- Allergy
- Targeting eosinophils: another strategy for asthma treatment
- Hye Mi Jee
- Clin Exp Pediatr. 2021;64(5):223-224. Published online March 5, 2021
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Identifying phenotypes and endotypes of asthma patients is challenging, and eosinophilic phenotypes are generally characterized by severe or refractory asthma.
Biologicals targeting eosinophils are promising for the control of severe or refractory asthma symptoms.
To ensure proper treatment, increased understanding of the diverse phenotypes of high Th2 inflammation in pediatric asthma is needed.
- Review Article
- Allergy
- Eosinophils and childhood asthma
- Bong Seok Choi
- Clin Exp Pediatr. 2021;64(2):60-67. Published online January 6, 2021
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•In allergic eosinophilic asthma, eosinophils act as important effector cells and antigen-presenting cells, while in nonallergic eosinophilic asthma, type 2 innate lymphoid cells play an important role in eosinophil activation.
•Sputum eosinophil counts can be helpful for evaluating allergic airway inflammation in asthma.
• Anti-interleukin-5 has broadened the scope of asthma treatment.
- Editorial
- Allergy
- Insights into pediatric pollen food allergy syndrome
- Jeong Hee Kim
- Clin Exp Pediatr. 2020;63(12):483-484. Published online June 1, 2020
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- Review Article
- Allergy
- Pollen-food allergy syndrome in children
- You Hoon Jeon
- Clin Exp Pediatr. 2020;63(12):463-468. Published online May 14, 2020
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The prevalence of pollen-food allergy syndrome (PFAS) in Korean children with pollen allergy was recently reported to be 42.7%. PFAS can cause a wide range of symptoms from mild allergy to severe anaphylaxis depending on the nature of food allergens that share the epitopes with pollen. Cases of anaphylaxis caused by PFAS have recently increased. Treatments for PFAS should be individualized for patients according to the severity of symptoms.
- Clinical Note
- Allergy
- Recurrent urticaria caused by specific cat serum albumin IgE cross-reacting with pork serum albumin
- Cheon Kim, Sung Won Kim, Yoon Ha Hwang
- Clin Exp Pediatr. 2020;63(11):451-453. Published online April 6, 2020
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Question: What should be considered in children who complain of pork allergies?
Finding: History of raising a cat, the onset of symptoms after the ingestion of pork and specific IgE tests to pork, cat, milk, and Alpha-gal are needed.
Meaning: Pork cat syndrome could be the cause of pork allergies.
- Editorial
- Allergy
- Should we prescribe montelukast to allergic pediatric patients?
- Yong Mean Park
- Clin Exp Pediatr. 2020;63(10):389-390. Published online August 24, 2020
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- Review Article
- Allergy
- Montelukast use over the past 20 years: monitoring of its effects and safety issues
- Yong Ju Lee, Chang-Keun Kim
- Clin Exp Pediatr. 2020;63(10):376-381. Published online February 5, 2020
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Although the efficacy of montelukast is inferior to that of ICS, both physicians and parents prefer montelukast to ICSs.
EDN may be a useful biomarker for the treatment and monitoring of preschool children with asthma.
The US FDA requires boxed warning about serious neuropsychiatric events of montelukast, therefore, physicians should consider the benefits and risks of montelukast before prescribing it.
- Original Article
- Allergy
- Ten-year trends and prevalence of asthma, allergic rhinitis, and atopic dermatitis among the Korean population, 2008–2017
- Jihyun Ha, Seung Won Lee, Dong Keon Yon
- Clin Exp Pediatr. 2020;63(7):278-283. Published online January 29, 2020
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Background: Major questions remain regarding the agestratified trends of allergic diseases and asthma in Korea.
Purpose: To identify the estimated recent prevalence and 10- year trends in asthma, allergic rhinitis, and atopic dermatitis among the Korean population from 2008 to 2017. Methods: This nationwide cross-sectional survey (Korean National Health and Nutrition Examination Survey) over 10 years (2008–2017) examined representative samples of the...
- Editorial
- Allergy
- Trends in prevalence of allergic diseases in Korean children: how and why?
- Kyung Suk Lee
- Clin Exp Pediatr. 2020;63(7):263-264. Published online April 13, 2020
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- Are you sure that it is a drug allergy?
- Eun Hee Chung
- Clin Exp Pediatr. 2020;63(6):213-214. Published online June 1, 2020
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- Review Article
- Allergy
- Drug Allergy in Children: What Should We Know?
- Ji Soo Park, Dong In Suh
- Clin Exp Pediatr. 2020;63(6):203-210. Published online November 12, 2019
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The drug allergy “label” may have a lifetime of consequences for a child. Many children with alleged drug allergies are proven to be tolerant to the culprit medication when challenged. The field of drug hypersensitivity is a recently evolving field of research, but studies on its epidemiology and diagnostic tools are lacking in children. Clinical history is significant in the...
- Original Article
- Allergy
- Asthma predictive index as a useful diagnostic tool in preschool children: a cross-sectional study in Korea
- Dong Hyeon Lee, Ji-Won Kwon, Hyung Young Kim, Ju-Hee Seo, Hyo-Bin Kim, So-Yeon Lee, Gwang-Cheon Jang, Dae-Jin Song, Woo Kyung Kim, Young-Ho Jung, Soo-Jong Hong, Jung Yeon Shim
- Clin Exp Pediatr. 2020;63(3):104-109. Published online November 8, 2019
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Question: Is physician-diagnosed current asthma in preschool children associated with the asthma predictive index, atopic sensitization, or pulmonary function test?
Finding: Physician-diagnosed current asthma in preschool children was associated with the asthma predictive index, but not with spirometry, methacholine provocation test, fractional expiratory nitric oxide level, and atopic sensitization.
Meaning: Physician-diagnosed asthma in preschool children may be different from classic atopic asthma in school children or adolescents.
- Editorial
- Allergy
- Is the predictive model for asthma development useful as a tool for diagnosing pediatric asthma?
- Bong-Seong Kim
- Clin Exp Pediatr. 2020;63(3):102-103. Published online February 5, 2020
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- Clinical Note
- Allergy
- Complement 4 levels of a 4-year-old girl with angioedema
- Soyoung Shin, Yoon Tae Lee, Kyung Yil Lee, Joonhong Park, Jae Ho Lee, Eun Ae Yang
- Clin Exp Pediatr. 2020;63(1):30-31. Published online November 8, 2019
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- Editorial
- Allergy
- Hereditary angioedema in childhood
- Young Min Ahn
- Clin Exp Pediatr. 2020;63(1):18-19. Published online January 15, 2020
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- Perspective
- Allergy
- Food allergy and food-induced anaphylaxis in children: an increasing critical public health issue
- Sooyoung Lee
- Clin Exp Pediatr. 2019;62(12):431-432. Published online November 12, 2019
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- Original Article
- Allergy
- Nasal eosinophilia and eosinophil peroxidase in children and adolescents with rhinitis
- Yeonu Choi, Haeun Jeon, Eun Ae Yang, Jong-Seo Yoon, Hyun Hee Kim
- Clin Exp Pediatr. 2019;62(9):353-359. Published online April 24, 2019
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Background: Researchers have shown that eosinophil peroxidase (EPO) is a relatively accurate marker of eosinophilia and eosinophil activity. However, its use as a marker of eosinophilic inflammation in nasal secretions is limited because the diagnostic cutoff values of EPO for use as a one-time test for allergic diseases such as allergic rhinitis have not been established.
Purpose: To identify the correlation...
- Editorial
- Allergy
- Is determining nasal eosinophil count and nasal eosinophil peroxidase concentration clinically useful in children with rhinits?
- Bong Seok Choi
- Clin Exp Pediatr. 2019;62(9):342-343. Published online July 9, 2019
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- Should partially hydrolyzed infant formula be given to the general infant population for the primary prevention of allergic disease?
- Tae Won Song
- Clin Exp Pediatr. 2019;62(9):340-341. Published online May 17, 2019
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- Review Article
- Allergy
- Phenotypes of allergic diseases in children and their application in clinical situations
- Eun Lee, Soo-Jong Hong
- Clin Exp Pediatr. 2019;62(9):325-333. Published online April 23, 2019
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Allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, are common heterogeneous diseases that encompass diverse phenotypes and different pathogeneses. Phenotype studies of allergic diseases can facilitate the identification of risk factors and their underlying pathophysiology, resulting in the application of more effective treatment, selection of better treatment responses, and prediction of prognosis for each phenotype. In the early phase...
- Editorial
- Allergy
- Why should we monitor for hematologic adverse drug reactions to oxcarbazepine?
- Gwang Cheon Jang
- Clin Exp Pediatr. 2019;62(8):299-300. Published online June 24, 2019
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- Case Report
- Allergy
- Drug eruption by antihistamine mistaken for chronic urticaria in a child
- Gun Moo Lee, Shou-Yu Chu, Sung Yeon Kang, Hyo-Bin Kim, Jin-Sung Park, Ja Kyoung Kim
- Clin Exp Pediatr. 2019;62(2):75-78. Published online October 30, 2018
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Although rare, antihistamines can cause adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g., ucerax [hydroxyzine] or leptizine [levocetirizine]), for cholinergic rashes; he did not have pruritus. Skin prick, intradermal, and drug provocation tests were performed to determine the relationship between the antihistamines and...
- Review Article
- Allergy
- Particulate matter and childhood allergic diseases
- Song-I Yang
- Clin Exp Pediatr. 2019;62(1):22-29. Published online November 7, 2018
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Particulate matter (PM) is a ubiquitous air pollutant that is a growing public health concern. Previous studies have suggested that PM is associated with asthma development and exacerbation of asthma symptoms. Although several studies have suggested increased risks of atopic dermatitis, allergic rhinitis, and allergic sensitization in relation to PM exposure, the evidence remains inconsistent. The plausible mechanisms underlying these...
- Original Article
- Allergy
- Common features of atopic dermatitis with hypoproteinemia
- So Yoon Jo, Chan-Ho Lee, Woo-Jin Jung, Sung-Won Kim, Yoon-Ha Hwang
- Clin Exp Pediatr. 2018;61(11):348-354. Published online September 16, 2018
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Purpose: The purpose of this study was to identify the causes, symptoms, and complications of hypoproteinemia to prevent hypoproteinemia and provide appropriate treatment to children with atopic dermatitis. Methods: Children diagnosed with atopic dermatitis with hypoproteinemia and/or hypoalbuminemia were retrospectively reviewed. The patients’ medical records, including family history, weight, symptoms, treatment, complications, and laboratory test results for allergies and skin cultures,...
- Case Report
- Allergy
- Breast abscess caused by
Staphylococcus aureus in 2 adolescent girls with atopic dermatitis - Sung Man Park, Won Sik Choi, YoonSun Yoon, Gee Hae Jung, Chang Kyu Lee, So Hyun Ahn, Yoon Wonsuck, Young Yoo
- Clin Exp Pediatr. 2018;61(6):200-204. Published online June 25, 2018
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Atopic dermatitis (AD) is a chronic inflammatory skin disease in children. Patients with AD experience a high rate of colonization of the skin surface by
Staphylococcus aureus . Because of a skin barrier defect, there is a potential risk of staphylococcal invasive infection in patients with AD. Here, we present 2 cases of breast abscess caused byS. aureus in 2...
- Original Article
- Allergy
- Accuracy of maximal expiratory flow-volume curve curvilinearity and fractional exhaled nitric oxide for detection of children with atopic asthma
- Sang Hoo Park, Min Ji Im, Sang-Yong Eom, Youn-Soo Hahn
- Clin Exp Pediatr. 2017;60(9):290-295. Published online September 21, 2017
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Purpose Airway pathology in children with atopic asthma can be reflected by the concave shape of the maximal expiratory flow-volume (MEFV) curve and high fractional exhaled nitric oxide (FeNO) values. We evaluated the capacity of the curvilinearity of the MEFV curve, FeNO, and their combination to distinguish subjects with atopic asthma from healthy individuals.
Methods FeNO and angle β, which characterizes the general...
Clostridium difficile colonization and/or infection during infancy and the risk of childhood allergic diseases- Sun Hwa Lee, Yun Na Gong, Eell Ryoo
- Clin Exp Pediatr. 2017;60(5):145-150. Published online May 31, 2017
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Purpose The gut microbiota can influence several diseases through immune modulation; however, the exact role of microbes such as
Clostridium difficile and the relationship between microbiota colonization and allergic diseases are not well known. This study aimed to determine the relationship betweenC. difficile colonization and/or infection (CDCI) during infancy and allergic diseases during early childhood.Methods Infants 1–12 months of age presenting changes in...
- Review Article
- Allergy
- IgE-mediated food allergies in children: prevalence, triggers, and management
- Sooyoung Lee
- Clin Exp Pediatr. 2017;60(4):99-105. Published online April 25, 2017
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Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending...
