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Volume 47(2); Feb 2004
Medical Lecture Courses
Perinatal Hepatitis B Virus Infection - Viral Factors in the Mechanism of Perinatal Immunoprophylaxis Failure -
Jong-Hyun Kim
Korean J Pediatr. 2004;47(2):123-130.   Published online February 15, 2004
Perinatal hepatitis B virus(HBV) infection may occur despite combined immunoprophylaxis with hepatitis B immunoglobulin and vaccines. Although the mechanism of perinatal prophylaxis still has been obscure, it could be due to : in utero infection; host factors as the personal immunological differences of HLA or cytokine gene; viral factors as a high maternal HBV-DNA level or the presence of surface...
Developmental Disabilities in Children
Hee Jung Chung
Korean J Pediatr. 2004;47(2):131-139.   Published online February 15, 2004
Despite the 5-10% prevalence of developmental disability, the early identification for such problems remains difficult. Pediatricians tried to diagnose developmental delay early to promote early intervention and thus to reduce long-term disability in these patients. Identification of a delayed young child by routine pediatric screening mandates a careful search for an underlying etiology. Accurate etiologic determination, despite the fact that...
Original Articles
Alteration of Bone Metabolism Markers According to the Progression of Puberty
Seong Yong Lee, Choong Ho Shin, Sei Won Yang
Korean J Pediatr. 2004;47(2):140-149.   Published online February 15, 2004
Purpose : The object of this study is to evaluate bone metabolism in healthy adolescents according to the progression of puberty. Methods : Forty boys(13.9?.7 years) and 42 girls(12.1?.6 years) were classified by Tanner stage (TS) and bone age. Serum levels of osteocalcin(OC) and bone specific alkaline phosphatase(BALP) were measured as bone formation markers. Serum level of C-terminal telopeptide of type...
The Effect of Histologic Chorioamnionitis on the Development of Respiratory Distress Syndrome and Chronic Lung Disease in Preterm Infants
Heui seung Jo, Beyong Il Kim, Chang Won Choi, Jun Dong Park, Chong Jai Kim, Jung-Hwan Choi
Korean J Pediatr. 2004;47(2):150-156.   Published online February 15, 2004

Purpose: Histologic chorioamnionitis may play a role in the development of respiratory distress syndrome(RDS) and chronic lung disease(CLD) independently or through its association with preterm birth. We investigated the relationship between histologic chorioamnionitis and clinical complications including, RDS and CLD, of preterm infants. Methods: Clinical data were collected retrospectively from 478 preterm infants(gestational period≤34 weeks) who were admitted to the neonatal...
A Clinical Study on Mental Retardation of Preschool Children Diagnosed in Pediatric Developmental Clinic
Young Yeui Kim, In Kyung Sung
Korean J Pediatr. 2004;47(2):157-163.   Published online February 15, 2004
Purpose : Mental retardation, which can be defined as subnormal cognitive ability with markedly decreased ability to adapt to one's environment, is a common developmental disorder. But the diagnosis of mental retardation in young children is frequently missed in pediatric clinics. The purpose of this study is to increase the rate of early diagnosis and intervention by providing clinical information...
Risk Factors of Urinary Tract Infections Due to Extended-spectrum β-lactamase Producing Escherichia coli in Children
Nam Hee Kim, Jin A Lee, Yun Kyung Kim, Eun Hwa Choi, Il Soo Ha, Hoan Jong Lee, Yong Choi
Korean J Pediatr. 2004;47(2):164-169.   Published online February 15, 2004
Purpose : This study was performed to identify risk factors for urinary tract infection(UTI) by extended-spectrum β-lactamase(ESBL)-producing Escherichia coli in children. Methods : We analyzed 125 episodes of UTI which were developed in 112 children at the Seoul National University Children's Hospital from July to December 2002. Medical records of 74 episodes of UTI caused by E. coli were reviewed in...
Serum ECP, RANTES and Eotaxin Levels in Infants with Bronchiolitis
Jong Seo Yoon, Mi Hee Lee, Joon Sung Lee
Korean J Pediatr. 2004;47(2):170-176.   Published online February 15, 2004
Purpose : Viral respiratory infection, especially respiratory syncytial(RS) virus, can predispose sufferers to the development of asthma by mechanisms that are presently undetermined. The role of inflammatory mediators in pathogenesis of asthma and RS virus disease is not well-understood. We investigated the performance of serum eosinophil cationic protein(ECP), regulated on activation normal T-cell expressed and secreted(RANTES) and eotaxin levels on...
An Epidemiological Study on Refractory Enterobiasis
Hyea Sook Ryue, Jo-Won Jung, Ki-Soo Pai
Korean J Pediatr. 2004;47(2):177-182.   Published online February 15, 2004
Purpose : In order to render substantial solutions to control the refractory enterobiasis, factors were evaluated which were associated with treatment failure in Enterobius vermicularis infestation. Methods : An epidemiological study was done in 20 patients with refractory entrobiasis and in 107 preschoolers as a control. The possible symptoms and hygienic habits which may associated with entrobiasis were surveyed by questionnaires. Results...
The Prevalence of Transfusion-Transmitted Virus Infection in Children
Ju Young Chung, Tae Hee Han, Eung Su Hwang
Korean J Pediatr. 2004;47(2):183-186.   Published online February 15, 2004
Purpose : Transfusion-transmitted virus(TTV) is an newly described nonenveloped human virus, with a circular, negative stranded DNA genome. Although a high prevalence of TTV infection in the normal population has been demonstrated, there is a still possibility of association with hepatitis according to the genotype of TTV. The aim of this study is to investigate the prevalence of TTV infection...
Ultrasonographic Bladder Parameters for Successful Suprapubic Bladder Aspiration
Sung Chul Baek, Hoe Kyoung Koo, Cheol Hong Kim, Kyung Bum Kim, Hyun Hee Lee, Byung Min Choi, Kee Hwan Yoo, Young Suk Hong, Dong Gwan Han
Korean J Pediatr. 2004;47(2):187-192.   Published online February 15, 2004
Purpose : Suprapubic bladder aspiration(SBA) is a widely accepted method of obtaining sterile urine for culture in neonates but has a relatively low success rate and a few serious complications during SBA procedure. To improve the chance of obtaining urine, we determined the ultrasonographic bladder parameters(diameters and volume) to confirm that the bladder is adequately distended for successful aspiration of...
Pharmacokinetics of Cyclosporine A and Its Therapeutic Effect in Children with Renal Diseases
Woo Sung Chun, Min-Soo Park, Jae Seung Lee, Juyun Yu, Moon Sung Park, Ki-Soo Pa
Korean J Pediatr. 2004;47(2):193-203.   Published online February 15, 2004
Purpose : To know the body handling properties and anti-proteinuric effect of cyclosporine A(CsA) in children with renal diseases, 34 patients with nephrotic syndrome or glomerular diseases were included to treatment trials and evaluated. Methods : Microemulsion formula CsA, 5 mg/kg/day was administered orally in two divided doses for 9.3?.6 months. Pharmacokinetic studies of CsA were done twice at beginning and...
Effects of 7-Nitroindazole on Brain Cell Membrane Function and Energy Metabolism during Transient Global Cerebral Hypoxia-Ischemia and Reoxygenation-Reperfusion in Newborn Piglets
Chang Won Choi, Jong Hee Hwang, Yun Sil Chang, Won Soon Park
Korean J Pediatr. 2004;47(2):204-209.   Published online February 15, 2004
Purpose : Our study was undertaken to discover whether a selective neuronal nitric oxide synthase inhibitor, 7-nitroindazole, influences brain cell membrane function and energy metabolism during and after transient global hypoxia-ischemia(HI) in newborn piglets. Methods : Cerebral HI was induced by temporary complete occlusion of bilateral common carotid arteries and simultaneous breathing with 8% oxygen for 30 minutes, followed by release...
Case Reports
A Case of G-6-PD Guadalajara
Gi Bum Lee, Sun Ju Lee, Yoo Jung Kim, So Young Kim, Hyun Hee Kim, Bin Cho, Wonbae Lee
Korean J Pediatr. 2004;47(2):210-213.   Published online February 15, 2004
Glucose-6-phosphate dehydrogenase(G-6-PD) deficiency is a disease that shows hemolytic anemia and jaundice caused by injury of erythrocytes. The gene of G-6-PD has 13 exons and locates in Xq28, and over 150 mutations of this gene have been reported. We experienced a G-6-PD deficienct male patient who was suffering hemolytic anemia and jaundice confirmed by measuring low G-6-PD activity in the...
A Case of Systemic Sclerosis in a Child
Ji Yeon Chang, Ja Kyoung Kim, Jeong Hee Kim, Dae Hyun Lim, Byong Kwan Son, Jung Soo Song
Korean J Pediatr. 2004;47(2):214-216.   Published online February 15, 2004
Systemic sclerosis is a connective tissue disease involving primarily the skin and subcutaneous tissue but may involve other organ systems such as the lungs, gastrointestinal tract, and heart. Systemic sclerosis is a rare childhood disease. The age of onset for patients with systemic sclerosis has its peak between 30 and 50 years of age. Only 1 to 2% of all...
Atypical Hemolytic Uremic Syndrome Associated with Streptococcus pneumoniae Infection
Hyun Sug Lee, Ja Wook Koo, Sang Woo Kim, Hyun Soon Lee
Korean J Pediatr. 2004;47(2):217-222.   Published online February 15, 2004
Hemolytic uremic syndrome is the most common cause of acute renal failure in childhood. Atypical hemolytic uremic syndrome which is not usually associated with prodromal symptoms has a higher mortality rate and more tendency to progress to chronic renal failure. Children younger than two years of age are a more susceptible to pneumococcal infection and can develop more serious disease....
A Case of Cutis Verticis Gyrata due to Cerebriform Intradermal Nevus in the Neonate
Hye Ryung Choi, Hyun Joo Lee, Eun Ae Park
Korean J Pediatr. 2004;47(2):223-226.   Published online February 15, 2004
Cutis verticis gyrata(CVG) is a morphologic syndrome of the scalp characterized by folds and furrows resembling the surface of brain. The primary form of cutis verticis gyrata is commonly associated with a neuropsychiatric condition and a secondary form occurs as a response of inflammatory or neoplastic process. The patient was a 1-day-old girl, who had a 15?1 cm sized, convoluted...
A Case of Multiple Juvenile Xanthogranuloma Involving Skin and Systemic Organs
So Yeon Lee, Yong Seok Jang, Min Sun Kim, Yun Jeong Yang, Myoung Ja Jung, Pyoung Han Hwang
Korean J Pediatr. 2004;47(2):227-230.   Published online February 15, 2004
Juvenile xanthogranuloma(JXG) is one of the most common non-Langerhans cell histiocytosis, benign histiocytic proliferative disorder. It typically presents as a solitary, benign, rapidly growing cutaneous tumor that may regress spontaneously. Most cutaneous lesions of JXG occur in the head and neck region of infants and young children. This disease is usually present with cutaneous lesion only; visceral involvement including the...