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Volume 34(7); Jul 1991
Original Articles
The effect of pertussis vaccine on streptozotocin induced diabetic rats.
Kyung Rae Moon, Kwang Rhun Koo, Sang Kee Park, Yeong Bong Park, Byoung Rai Lee, Keun Hong Kee
J Korean Pediatr Soc. 1991;34(7):897-906.   Published online July 31, 1991
Streptozotocin produces diabetes in laboratory animals through the destuction of the pancreatic beta cells. The diabetogenic activity of STZ, however, is known to be modified by several agents such as nicotinamide, diazoxide, adrenergic blockers and petussis vaccine (PV). The present study was undertaken to observe the protective effect of PV or boiled pertussis vaccine (bPV; incubating the PV at 80 C for 30 mintues)...
Pi phenotyping in cord blood of 543 newborns.
Mee Na Lee, Jong Su Chun, Soo Kyung Choi, Yong Kyun Paik
J Korean Pediatr Soc. 1991;34(7):907-911.   Published online July 31, 1991
Phenotypes and • gene frequencies in cord blood samples of 543 newborns were studied for Pi phenotypes for the purpose of estimating the risk of diseases associated with genetic deficiency of alpha-1 antitrypsin. Pi phenotypes were performed by polyacrylamide gel separator isoelectric focusing method. The allele frequencies obtained were as follows:'PiM!=0.7670, M2=0.1796 M3=0. 0506, G=0.0018,/P=0.0009. There were no alleles causing severe deficiency such as...
Neonatal hypocalcemia: clinical manifestations and prognosis.
Jeong Lim Kim, Heung Dong Kim, Chang Jun Coe
J Korean Pediatr Soc. 1991;34(7):912-920.   Published online July 31, 1991
Hypocalcemia during the newborn period is relatively common particularly in infants with predis- posing factors, such as prematurity, low birth weight, birth asphyxia and diabetic mothers and it is often manifested by various clinical findings. Some authors have reported that in some cases of the neonatal hypocalcemia, there were neurologic deficits such as irritability and convulsion, and neur- ologic sequelae on follow up. It...
Relationship between underlying disease and time at onset of neonatal pulmonary air leak.
Young Yaek Jang, Kyong Nyong Kim, Jong Lim Choi, Ok Kyung Lee
J Korean Pediatr Soc. 1991;34(7):921-928.   Published online July 31, 1991
We observed 38 cases of neonatal pulmonary air leak who were admitted to the nicu of Presbyter- ian Medical center from July, 1984 to October, 1990. The result was as follows: 1) The overall incidence of neonatal pulmonary air leak was 0.15% of all live birth. Spontaneous pulmonary air leak were 6cases (0.03%) and secondary pulmonary air leak were 21 cases (0.12%). 2) There were no differences...
Clinical charateristics of pregnancy-induced hypertensive mothers and their neonates.
Soo Jeong Ryu, Jin Sook Kim, Kyong Hoon Choi, Myong Jin Kim, Mi Na Lee
J Korean Pediatr Soc. 1991;34(7):929-933.   Published online July 31, 1991
The results were as follows; 1) The mean platelet count of peripheral blood in pergnancy-induced hypertensive mothers was 221, 733±17,357/mm3 which was than control Significant thrombocytopenia was encountered in 8 cases 2) Meanwhile their newborns showed neutropenia and prolongation of prothrombin time. 3) Intrauterine growth retardation could be assesed in 8 out of 30 newborns from these mothers.
Pulsed doppler echocardiographic analysis of pulmonary venous flow in congenital heart diseases with left-to-right shunt.
Kye Hwan Seol, Chang Sung Son, Joo Won Lee, Soon Kyum Kim, Young Chang Tockgo
J Korean Pediatr Soc. 1991;34(7):934-939.   Published online July 31, 1991
Pulsed Doppler echocardiography was performed to evaluate the flow velocity pattern of the pulmonary vein in 28 patients with congenital heart diseases which comprised of 8 atrial septal defect (ASD), 14 ventricular septal defect (VSD) and 6 patent ductus arteriosus (PDA). 20 normal children served as controls. The objective of this study was to ascertain that pulmonary venous flow velocity is dependent on the...
Early detection of gentamicin nephrotoxicity using urinary beta2-microglobulin in neonates.
Mi Kyung Kim, Seung Joo Lee
J Korean Pediatr Soc. 1991;34(7):940-948.   Published online July 31, 1991
Gentamicin, commonly used antibiotics in neonatal care, has a nephrotoxicity, but it is difficulto to assess renal function in early stage. This study evaluated the renal function and urinary β2-microglobulin excretion in 17 gentamicin treated and 11 control neonates. The results are as follows. 1) Urinary 02-M in gentamicin treated neonates were 0.84±0.17mg/L at postnatal day 1 and increased to 5.99±1.15mg/L at day 4, 14.17±2.39mg/L at day...
A study for mass screening of galactosemia using galactitol level by spot urine method among Korean infants.
Jin Tae Kim, Chong Won Bae, Sa Jun Chung, Chang Il Ahn, Suyama I , Isshiki G
J Korean Pediatr Soc. 1991;34(7):949-958.   Published online July 31, 1991
For mass screening of the galactosemia, we used spot urine method using filter paper which was newly developed by Department of Pediatrics, Kyung Hee University Hospital and Department of Pediatrics, Osaka City University in Japan. We used control groups as followed, 7 of normal adults,- one patient of I, II, III types of galactosemia, respectively. The experimental groups were 62 infants of 0 to...
Experimental study on the effect of phenobarbital on Na+, K+-activated adenosine triphosphatase in microsome fractions of mouse brain.
Seo Kyu Kim, Sa Jun Chung, Chang Il Ahn
J Korean Pediatr Soc. 1991;34(7):959-970.   Published online July 31, 1991
Na+, K+-activated adenosine triphosphatase (Na+, K+-ATPase) is known to play a role as a trigger in neurotransmitter release and may also affect the transport of calcium ion (Ca++). By doing so, Na+, K+-ATPase, as an anticonvulsant, can modify the excitability level of cells in epilepsy. In order to elucidate the possible mechanisms of neuropharmacological interaction between Na+, K+.ATPase and phenobarbital, serial experimental studies were...
Clinical significance of mega cisterna magna.
Young Hyuk Lee, Min Hee Kim, Kyo Sun Kim, Hae Jeong Jeon, Jeong Hee Park
J Korean Pediatr Soc. 1991;34(7):971-977.   Published online July 31, 1991
The mega cistema magna is a congenital developmental malformation. The size of the cistema magna and the criterion of the mega cistema is still debatable. A clinical study had been performed on 12 children with mega cistema magna diagnosed by computed tomography scan from January 1980 to December 1990. The results are summarized as follows: 1) Among 4900 consecutive unselected computed tomography scans, twelve cases with...
Sodium and calcium transport in spherocytic red blood cells.
Shin Heh Kang, Kir Young Kim, Young Ho Lee, Bok Soon Kang
J Korean Pediatr Soc. 1991;34(7):978-991.   Published online July 31, 1991
Hereditary spherocytosis (HS) is an autosomal, dominantly inherited hemolytic disorder which shows characteristic spherocytes on peripheral smear. As spherocytes are rounder, more fragile and susceptible to extravascular hemolysis in the spleen, HS patients suffer from variable degrees of anemia, jaundice, splenomegaly and gall stones. However the pathogenesis is heterogenous in HS, such as spectrin deficiency, decreased spectrin-protein 4.1 binding, increased spectrin binding to the RBC...
Clinical observation on tuberous sclerosis.
Yong Seung Hwang, Yong Soo Yun
J Korean Pediatr Soc. 1991;34(7):992-998.   Published online July 31, 1991
Thirty one cases of tuberous sclerosis were seen at the Dept, of Pediatrics, Seoul National University Children’s Hospital. Thirteen cases (41.9%) were diagnosed before 1 year of age and the sex ratio was 2.9:1 with male prefonderance The clinical epileptic manifestations were seen in 28 patients (90.3%), of whom generalized tonic clonic seizures were associated in 12 cases (42.8%) and infantile spasm in 9 cases...
The effects of human growth hormone on short stature.
Sang Mi Ha, Duk Hi Kim
J Korean Pediatr Soc. 1991;34(7):999-1008.   Published online July 31, 1991
Since Raben’s original report that human growth hormone promoted growth in a boy with pituitary dwarfism, the hormone’s efficacy in children with growth hormone deficiency has been amply confirmed. However the scarcity of growth hormone prepared human pituitaries has limited studies of its usefulness in short stature. The availability of a biologically active human growth hormone produced by recombinant-DNA technology has dramatically changed the...
A case of Crohn disease.
Ahn Hong Choi, Hyung Sim Chang, Young Ho Lee, Woo Taek Kim, Woo Won Shin
J Korean Pediatr Soc. 1991;34(7):1009-1014.   Published online July 31, 1991
We experienced a case with chief complaints of abdominal pain and diarrhea in a 12-year-old boy, who was diagnosed as Crohn disease with a result of radiologic, endoscopic, pathologic findings, and therapeutic diagnosis with antituberculous medications. Crohn disease is quite rare in Korea to our knowledge along with collaborative survey in litera- tures, and it is very important that therapeutic diagnosis with antituberculous medications...
A case of Prune Belly syndrome associated with holoprosencephaly.
Myung Hee Youn, Mi Sung Jeong, Hyung Ja Park, Shinna Kim, Keum Min Park, Song Ja Chin
J Korean Pediatr Soc. 1991;34(7):1015-1021.   Published online July 31, 1991
This is brief report of a case of prune belly syndrome associated with holoprosencephaly in one-day old neonate. At birth, physical examination revealed skull bone defect, anophthalmia, severe hypotelorism, arhinia with proboscis, micrognathia, webbed neck, severely dilated abdomen with thin wall, agenesis of external urogenital organs and anus, equinovalgus and genu valgus. Autopsy findings were alobar holoprosencephaly with hydrocephalus, hypoplasia of lung and ribs, markedly dilated...
A case of a variant of Pierre Robin syndrome -cerebrocostomandibular syndrome-.
Hye Jin Lee, Eun Jin Mun, Ock Seung Jeong, Son Sang Seo, Jeong Ja Kang
J Korean Pediatr Soc. 1991;34(7):1022-1028.   Published online July 31, 1991
We experienced a case of cerebrocostomandibular syndrome in newborn consisted of costal deficiency, and micrognathia. It is a variant of Pierre Robin syndrome, and cleft palate and glossoptosis are frequently present. Respiratory difficulty due to rib dysplasia result in poor prognosis for survival. Brief review of literature was made.
A case of tuberous sclerosis developing with subependymal giant-cell astrocytoma.
Young Chul Ahn, Yong Suk Choi, Pyoung Han Hwang, Jung Soo Kim
J Korean Pediatr Soc. 1991;34(7):1027-1033.   Published online July 31, 1991
Subependymal giant-cell astrocytoma is a rare cerebral glioma that characteristically arises in the wall of the lateral ventricle and presents as an intraventricular mass, causing hydrocephalus by obstruction of the foramen of Monro. The tumor mainly occurs in patients with tuberous sclerosis and is slow growing and well circumscribed, so that long survival after total surgical resection is often achieved. We experienced a cas^ of...
A case of atypical neurofibromatosis type 1.
Eun Joo Choi, Young Hyuk Lee, Min Hee Kim, Kyo Sun Kim
J Korean Pediatr Soc. 1991;34(7):1034-1039.   Published online July 31, 1991
Almost of all patients with neurofibromatosis type I show caf6-au-lait macules on their skin. These macules are thought to be early sign of neurofibromatosis in childhood. We experienced a case of neurofibromatosis type I in a 10-year-old-boy who did not have caf6-au-lait macules, but progressive psychomotor retardation, short attention span, hyperactivity and megalencephaly. The brain C-T findings showed diffuse cerebromalacia and ventriculomegaly. We confirmed the...