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Volume 40(7); Jul 1997
Medical Lecture Course
The Role of Proteinases in Tumor Invasion and Metastasis
Young Tak Lim
J Korean Pediatr Soc. 1997;40(7):901-907.   Published online July 15, 1997
Clinical Lecture
Respiratory Infection and Bronchial Asthma
Joon-Sung Lee
J Korean Pediatr Soc. 1997;40(7):908-916.   Published online July 15, 1997
Original Articles
Extrachromosome 21 in Korean with Down Syndrome Using DNA Haplotyping
Jin-Sung Lee, Won Kyu Choi
J Korean Pediatr Soc. 1997;40(7):917-924.   Published online July 15, 1997
Purpose : Down syndrome, the most common single cause of mental retardation, is usually due to meiotic nondisjunction leading to trisomy 21. In order to understand the mechanisms of meiotic nondisjunction including parental origin of an extrachromosome and the meiotic stage of nondisjunction, we have studied DNA polymorphisms at loci on the long arm of chromosome 21 in 36 families with free trisomy 21. Methods...
Analgetic Effect of Chloral Hydrate in Pain Induced by Spinal Tap in Neonates
Eun Jin Choi, Heng Mi Kim
J Korean Pediatr Soc. 1997;40(7):925-930.   Published online July 15, 1997
Purpose : The need for analgesia in neonates during and after surgery has been widely accepted in the past decade. Pain relief and sedation are still rarely used during minor treatment procedures in the neonatal intensive care units. However, many diagnostic and treatment procedures in the neonatal intensive care unit are noxious and often painful, and highly stressful for sick neonates. Methods : A prospective...
Oral Agar and Conventional Phototherapy Combination in the Treament of Neonatal Hyperbilirubinemia
Seong Wha Kim, Ji Hyang Doh, Jin Woo Choi, Min Hyang Kim, Ji Won Lee, Sung Taek Kim
J Korean Pediatr Soc. 1997;40(7):931-938.   Published online July 15, 1997
Purpose : Neonatal jaundice is one of the most common problems in our country leading to hospitalization. Agar is low cost, low risk, and easily fed orally; it can bind bilirubin in the intestine, decreasing its enterohepatic circulation, thereby decreasing serum bilirubin levels. At present, however, the effectiveness of agar in the prevention and treament of neonatal jaundice is quite conflicting and controversy. Recently we...
A Study of Relation between Stable Microbubble Rating and Surfactant Derivatives(SurfactenⓇ : Phospholipid :, ExosurfⓇ : Dipalmitoyl-Phosphatidyl Choline) Concentration in Vitro
Myung Ho Oh, Kee Hyuck Kim, Jae Gun Sim, Min Hee Kim
J Korean Pediatr Soc. 1997;40(7):939-944.   Published online July 15, 1997
Purpose : With the recent advent of surfactant replacement therapy, there is an increasing need for a rapid and reliable test to predict respiratory distress syndrome (RDS) immediately before or at birth. There are many investigations and methods for the detection of RDS in prenatal or postnatal period. The stable microbubble rating test (SMR-test) developed by pattle et al. is rapid and simple test...
A Clinical Study for the Time of Development and Risk Factors of Retinopathy of Prematurity
Eun Ae Park, Gyoung Hee Kim
J Korean Pediatr Soc. 1997;40(7):945-954.   Published online July 15, 1997
The Therapeutic Effect of Interferon-alpha Treatment in Children with Chronic Hepatitis B
Il Sang Jeong, Ki Sup Chung
J Korean Pediatr Soc. 1997;40(7):955-964.   Published online July 15, 1997
Purpose : The prevalance rate of chronic hepatitis B viral infection in children is high in our contry. We performed a prospective study to evaluate the effectiveness of and the factors predictive of response to interferon-alpha therapy in children with chronic hepatitis B. Methods : Thirty-two children with chronic hepatitis B werew admitted to the Department of Pediatrics, Yonsei University College of Medicine from...
Clinical Manifestations of Recurrent Abdominal Pain May Differ with Helicobacter pylori Infection in Children
Nam Seon Beck, I-Seok Kang
J Korean Pediatr Soc. 1997;40(7):965-973.   Published online July 15, 1997
Purpose : The role of H. pylori in the pathogenesis of recurrent abdominal pain in children is uncertain. In order to find a correlation between H. pylori infection and recurrent abdominal pain in children, the present study was designed to compare the clinical manifestations between recurrent abdominal pain children with and without H. pylori infection and to investigate the effects of H. pylori eradication...
Thin Glomerular Basement Membrane Disease Without Glomerular IgA Deposition in Children
ll-Jou Sohn, Yong-Hun Park, Yong-Ho Ahn, Yong-Jin Kim, Woo-Young Chung
J Korean Pediatr Soc. 1997;40(7):974-980.   Published online July 15, 1997
Purpose : Thin glomerular basement membrane (TGBM) disease is now recognized as one of leading causes of isolated microscopic hematuria, regarded as a benign condition and characterized by the presence of familial benign hematuria. But there are few studies of TGBM in Korea. The purpose of this study was to evaluate the clinical and pathological findings in TGBM according to...
Urinary Interleukin-1β Levels in Children with Urinary Tract Infection
Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
J Korean Pediatr Soc. 1997;40(7):981-990.   Published online July 15, 1997
Purpose : IL-1β and TNF-α are important mediators of the inflammatory response in serious bacterial infections. The mucosal and systemic IL-1β and TNF-α responses to urinary tract infection are analyzed in children with acute urinary tract infection. Methods : We studied the levels of these two cytokines in the urine and sera of 21 children at diagnosis and after treatment with sandwich ELISA method. Results...
Seizure Types and EEG Findings of Juvenile Onset Idiopathic Generalized Epilepsy
Hyunmi Kim, Won Seop Kim, Jong Shin Kim, Kangho Cho, Ki Joong Kim, Yong Seung Hwang
J Korean Pediatr Soc. 1997;40(7):991-998.   Published online July 15, 1997
Purpose : Juvenile myoclonic epilepsy, juvenile absence epilepsy, and epilepsy wth generalized tonic clonic seizure(GTCS) on awakening are the three syndromes of idiopathic generalized epilepsy of adolescent onset currently included in the classification of epilepsy syndromes of the International League Against Epilepsy(ILAE). Although they differ in their predominant seizure types, the syndromes share several seizure types. Also, there are no unique electrophysiologic or genetic markers....
Case Reports
A Case of Band Heterotopia
Sung Koo Kim, Young Jun Kim, Young Ah Lee, Ha Joo Choi, Woo Kap Chung
J Korean Pediatr Soc. 1997;40(7):999-1003.   Published online July 15, 1997
The “band heterotopia” or “double cortex” is a brain anomaly that is presumed to result from a premature arrest of neuronal migration. Generalized disorders of neuronal migration to the cerebral cortex have been recognized since the end of the 19th century. Recently, development of neuroimaging technique, such as MRI, have permitted easy diagnosis of generalized neuronal migration disorder. This syndrome is prevalent in females. Most...
A Case of Choledochal Cyst with Anomalous Pancreaticobiliary Ductal Union
Je Woo Kim, Hyun Chul Bae, Ki Sup Chung, Seok Joo Han, Eui Ho Hwang
J Korean Pediatr Soc. 1997;40(7):1010-1014.   Published online July 15, 1997
Choledochal cysts are congenital or acquired lesions of the biliary tree with a cystic dilatation of the bile duct. We experienced a choledochal cyst accompanying acute pancreatitis caused by anomalous pancreaticobiliary ductal union(APBDU) in a 2 year old boy. The choledochal cyst associated with APBDU is rarely encountered in the clinical field, and thus we report this case with the presentation of abdominal ultrasonogram, computed...
Morquio's Syndrome Accompanied by Respiratory Failure
Jun Hur, Hyeon Jeong Lee, Jeong Hwa Whang, Hee Jin Kim, Chan Yung Kim
J Korean Pediatr Soc. 1997;40(7):1015-1020.   Published online July 15, 1997
Authors experienced a case of Morquio’s syndrome accompanied by respiratory failure in a aged fifteen year old boy. Patient showed normal intelligence, but stunted growth with short trunk and unproportionately large head, pectus carinatum, kyposcoliosis, muscular weakness, paralysis and genu valgum. No other member of family was affected with this syndrome. There were radiological findings of subluxation between first and second cervical vertevrae, central beaking with...
A Case of Chronic Granulomatous Disease Which is Improved by Interferon-γ Therapy
Jae Choon Kim, Soon Seong Park, Myung Ja Yun, Dong Hyuk Keum
J Korean Pediatr Soc. 1997;40(7):1021-1025.   Published online July 15, 1997
Chronic granulomatous disease is a group of rare disorders characterized by a disease of oxidative metabolism of phagocytes with deficit of antimicrobial activity. Also, it has clinical features of chronic pyogenic infection, granuloma formation, hypergammaglobulinemia, anemia and leukocytosis. We experienced a case of chronic granulomatous disease with chronic recurrent infection, hypergammaglobulinemia and liver abscess. It was confirmed by modified NBT test. The result of patient' s...
A Case of Infectious Mononucleosis Associated with Pleural Effusion and Ascites
Seung-Kyoo Han, Yun-Jeong Yang, Yon-Ho Choe, Yong-Hoon Jun, Soon-Ki Kim, Byong-Kwan Son
J Korean Pediatr Soc. 1997;40(7):1026-1030.   Published online July 15, 1997
Infectious mononucleosis is an acute infectious disease occurring predominantly in older children and young adults due to primary Epstein-Barr virus infection. The clinical picture is extremely variable in both severity and duration. The disease in children is generally mild. It is characterized clinically by fever, exudative or membranous pharyngitis, generalized lymphadenopathy, and splenomegaly. Rarely, it complicates neurologic involvement such as cranial nerve palsy, meningoencephalitis, and...