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Volume 42(8); Aug 1999
Clinical Lecture
The Resolving Management for Problems of Pediatric Field in Korean Medical Insurance
In Ho Kim
J Korean Pediatr Soc. 1999;42(8):1035-1042.   Published online August 15, 1999
Original Articles
Screening Device for Developmental Delay at Well Baby Visit
Keun Lee
J Korean Pediatr Soc. 1999;42(8):1043-1049.   Published online August 15, 1999
Purpose : Developmental delay is a fairly common problem in childhood and its early diagnosis is crucial not only for the child but also for the family and society. If found early and properly managed, the side effects can be minimized and the child with developmental delay will have a better prognosis. However, early diagnosis is difficult due to various...
A Survey on Mothers' Perception of Breastfeeding
Ji Hye Jung, Keun Lee
J Korean Pediatr Soc. 1999;42(8):1050-1055.   Published online August 15, 1999
Purpose : The objective of this investigation was to identify the postpartum change in breastfeeding rate and mothers' perception of breastfeeding. The investigation was carried out to make plans for the education of mothers regarding breastfeeding. Methods : Total of 284 mothers, who delivered healthy full-term babies at Dongdaemun Hospital, Medical College, Ewha Womans University, were interviewed and asked to complete...
The Relation of Food-Specific IgE to Recurrent Wheezing Attack
Yun Jeong Yang, Jeong Hee Kim, Yoo Mee Choi, Dae Hyun Lim, Sei Woo Chung, Jeong Gyu Kim, Byong Kwan Son
J Korean Pediatr Soc. 1999;42(8):1056-1062.   Published online August 15, 1999
Purpose : There were some reports that IgE-mediated food hypersensitivity is associated with subsequent development of atopic disease in wheezy infants. So we carried out this study to show whether the food specific IgE antibodies are useful to predict recurrent wheezing attack in wheezy infants. Methods : A total of 190 children younger than 4-year-old were enrolled in this study. They...
Changes of Left Ventricular Diastolic Function in Normal Children
Jin-Hee Kim, Young-Yoo Kim, Won-Bae Lee, Jong-Wan Kim,, Kyung-Tai Whang
J Korean Pediatr Soc. 1999;42(8):1063-1070.   Published online August 15, 1999
Purpose : Doppler echocardiography provides a noninvasive technique for the evaluation of left ventricular diastolic function. This study was performed to define the normal pattern of left ventricular diastolic filling by real-time Doppler flow mapping, and to determine how this pattern changes with aging in normal children. Methods : The changes in diastolic function in 89 normal subjects less than 15...
Depolarization, Repolarization Inhomogeneity and Late Potential after Surgical Repair of Tetralogy of Fallot
Soo Young Kim, Myung Chul Hyun, Sang Bum Lee, Seung Tae Kim, Jong Soo Lee
J Korean Pediatr Soc. 1999;42(8):1071-1077.   Published online August 15, 1999
Purpose : After repair of tetralogy of Fallot(TOF), ventricular arrhythmia and sudden death remain as serious late complications which are due to right ventricular systolic and diastolic overloading, exposure to hypoxia and surgical scar. Among the various methods for predicting the risk of such complications, we evaluated signal average ECG(SAECG), QRS duration, QT and JT dispersion, cardiothoracic(CT) ratio, age at...
Effect of Antiepileptic Drugs on Bone Metabolism and Growth in Epileptic Children
Woo Suk Juhng, Sun Jun Kim, Soo Chul Cho, Chan Uhng Joo
J Korean Pediatr Soc. 1999;42(8):1078-1085.   Published online August 15, 1999
Purpose : Long-term administration of anticonvulsants for children with convulsive disorder may cause osteomalacia, depending on dosage, duration, types, and combination of anticonvulsants administered. This study was performed to examine the effect of anticonvulsant drugs on bone mineral density in epileptic children. Methods : Forty-eight epileptic children aged 3 to 15 years were enrolled in this study. They were treated with...
Effects of Angiotensin Converting Enzyme Inhibition into Apoptosis and Related Genes in the Neonatal Rat Kidney
Kee Hwan Yoo, Haewon Cheon, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
J Korean Pediatr Soc. 1999;42(8):1086-1095.   Published online August 15, 1999
Purpose : The renin-angiotensin system plays an important role in renal growth and development. Exposuring the neonate to angiotensin converting enzyme(ACE) inhibitor increases mortality and results in growth retardation and abnormal renal development. ACE inhibition in the developing kidney reduces the renal expression of TGF-β1 and EGF, which may account for renal growth impairment. This study was designed to...
The Effects of Glutamate Receptor Antagonists on Cultured Cerebral Cortical Neurons of Neonatal Mouse Damaged by Oxidative Stress
Dae-ho Choi, Yeon-kyun Oh, Seung-taek Park
J Korean Pediatr Soc. 1999;42(8):1096-1103.   Published online August 15, 1999
Purpose : To evaluate neurotoxic effects induced by oxygen-radicals, which were generated by adding xanthine oxidase(XO) and hypoxanthine(HX), and protective effects of glutamate receptor antagonist such as MK-801 and 6-cyano-7-nitroquinoxaline(CNQX). Methods : Dissociated cell cultures were prepared from cerebrum of neonatal mouse. Tissues were dissected and diced into small pieces in phosphate buffered saline and were incubated at 37℃. Isolated cells...
A Comparative Study of Red Blood Cell Indices and Anemia by Feeding Patterns
Pill-Jin Shin, Chong-Woo Bae, Yong-Mook Choi
J Korean Pediatr Soc. 1999;42(8):1104-1110.   Published online August 15, 1999
Purpose : Iron-deficiency anemia is the most common nutritional deficiency in young infants. This study was designed to determine feeding patterns in infants, and determine a correlation between feeding patterns and incidence of anemia. Methods : This study was conducted by taking blood tests (hemoglobin, hematocrit, and red cell indices) by venipuncture with the electronic counters from 221 infants aged 9-12...
Chemosensitivity Test of Childhood Leukemic Cells
Tae Woong Ha, Su Kyung Jung, Heung Sik Kim, Chin Moo Kang
J Korean Pediatr Soc. 1999;42(8):1111-1121.   Published online August 15, 1999
Purpose : The purpose of the present study is to determine the relation between in vitro resistance to 9 drugs, measured with colorimetric methylthiazol tetrazolium(MTT) assay and prognostic factors. Methods : Thirty children with leukemia were evaluated at the pediatric department of Dongsan Medical Center. All samples tested with the MTT assay contained 80% or more leukemic cells, which were isolated...
The Use of Quadruple Blood Bags Transfusion of Low Birth Weight Neonates
Sang Hoon Lee, Jean Yoon, Yang Park, Sung Kyu Lee, Hee Chung Kim, Woo Sup Shim
J Korean Pediatr Soc. 1999;42(8):1122-1129.   Published online August 15, 1999
Purpose : Low-birth-weight(LBW) neonates often need multiple transfusions during their neonatal period. The routine use of the 500ml mono-bag system in Korea, even in neonatal transfusions, results in a great waste of blood and exposes the neonate to multiple blood donors. To reduce the waste of blood and the number of exposures, we used quadruple blood bags in the transfusion...
Comparison between Thyroid Function Test and Radiographic Size of Knee Epiphysis in Neonates with Congenital Hypothyroidism
An Sung Koh, Jae Ock Park, Dong Hwan Lee
J Korean Pediatr Soc. 1999;42(8):1130-1135.   Published online August 15, 1999
Purpose : Biochemical confirmation of congenital hypothyroidism takes about 10 days, which may result in a delay in diagnosis. The delay could be reduced if a faster method of investigation such as knee radiograph is used. The aim of this study is to assess the value of plain radiography of the knee in providing supportive evidence for the diagnosis of...
Serum Leptin Concentrations in Extremely Obese Childen
Yon Ho Choe, In Young Hyun
J Korean Pediatr Soc. 1999;42(8):1136-1140.   Published online August 15, 1999
Purpose : The purpose of this study is to investigate whether there is a difference in leptin concentrations between those of children of normal weight and extremely obese children. Methods : We measured serum concentrations of leptin in 70 extremely obese subjects(7 to 12 years, 20 girls and 50 boys), whose serums had been frozen at -70℃. Height, weight, obesity index,...
Follow up of Infants with Congenital Hypothyroidism Who were Detected by Newborn Screening Test
Kyung Ah Kim, Eun Sil Lee, Son Moon Shin, Han Ku Moon, Yong Hoon Park
J Korean Pediatr Soc. 1999;42(8):1141-1148.   Published online August 15, 1999
Purpose : Developmental delay in congenital hypothyroidism can be prevented by early detection and treatment. We conducted a follow-up study to assess the growth and development of infants with congenital hypothyroidism who were detected by newborn screening test and received thyroid hormone therapy. Methods : Nineteen hypothyroid infants were detected by newborn screening test from April 1995 to May 1997. Measurements...
Case Reports
A Case of Wolf-Hirschhorn Syndrome Resulting from Familial Translocation
So Yeon Yoon, Jae Kyun Hur, Dae Chul Jeong, Won Bae Lee, Chang Kyu Oh
J Korean Pediatr Soc. 1999;42(8):1149-1153.   Published online August 15, 1999
Wolf-Hirschhorn syndrome is caused by a partial loss of the distal short arm of chromosome 4. Characteristic clinical features are severe growth retardation, mental retardation, seizures, congenital cardiac defects, urogenital abnormalities, microcephaly, hypertelorism, prominent glabella, cleft lip and palate and micrognathia. In 87% of cases, chromosome 4 deletion arises as a de novo event, whereas in the remaining cases it...
A Case of Catel Manzke Syndrome
Sang Hyun Oh, Eun Young Kim, Young Bong Park, Sang Kee Park, Jeong Ryoul Yang
J Korean Pediatr Soc. 1999;42(8):1154-1158.   Published online August 15, 1999
Catel Manzke syndrome is characterized by hyperphalangy of the index fingers associated with Robin malformation sequence. The etiology of Catel Manzke syndrome is still uncertain, with the majority of cases being sporadic. Careful observation to recognize upper airway obstruction secondary to the Robin sequence should be made a part of routine care for newborns with this disorder. Failure to thrive...
A Case of Propionic Acidemia
Woo Seop Yeoum, Kwang Wook Lee, Byeong Ho Chae, Baek Keun Lim, Hong Jin Lee
J Korean Pediatr Soc. 1999;42(8):1159-1164.   Published online August 15, 1999
Propionic acidemia is an autosomal-recessive inborn error of branched-chain amino acid metabolism. It is caused by deficient activity of propionyl-coenzyme A carboxylase and is characterized by a spectrum of clinical and biochemical findings. It usually manifests in the neonatal period or early infancy. Since Childs et al first described the propionic acidemia of infants in 1961, it has rarely been...
A Case of Guillain-Barré Syndrome Coinciding with Bronchial Asthma associated with Mycoplasma Pneumonia
Kyung-Yil Lee, Dong-Joon Lee, Ji-Whan Han, Sang-Won Ch, John-Sung Lee, Kyung-Tai Whang
J Korean Pediatr Soc. 1999;42(8):1165-1169.   Published online August 15, 1999
Mycoplasma pneumoniae is the most common etiologic agent of pneumonia in school-aged children and young adults. It involves not only the respiratory system but includes extrapulmonary complications such as exanthem, hemolysis, arthritis, hepatic dysfuction, cardiac disease, and central nervous system disease. The pathogenesis of extrapulmonary involvements may be an autoimmune phenomena. Recent studies suggest that bronchial asthma can be initiated...
A Case of Rheumatic Fever Associated with Acute Poststreptococcal Glomerulonephritis
Jeong Kyung Seo, Un Seok Nho, Eun Jeong Kim, Chur Woo Yoo, Chul Kyu Kim
J Korean Pediatr Soc. 1999;42(8):1170-1174.   Published online August 15, 1999
It is well known that both acute glomerulonephritis and rheumatic fever are a common sequelae of group A streptococcal infection. However, their simultaneous occurrence is uncommon. Only a few cases have been reported because they are different in epidemiologic, clinical, serologic and immunopathogenic characteristics. We experienced a 10-year-old boy who presented the manifestation of acute rheumatic fever and acute poststreptococcal...