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- National Research Foundation of Korea (26)
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- Review Article
- Allergy
- Phenotypes of allergic diseases in children and their application in clinical situations
- Eun Lee, Soo-Jong Hong
- Clin Exp Pediatr. 2019;62(9):325-333. Published online April 23, 2019
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Allergic diseases, including allergic rhinitis, asthma, and atopic dermatitis, are common heterogeneous diseases that encompass diverse phenotypes and different pathogeneses. Phenotype studies of allergic diseases can facilitate the identification of risk factors and their underlying pathophysiology, resulting in the application of more effective treatment, selection of better treatment responses, and prediction of prognosis for each phenotype. In the early phase...
- Original Article
- Endocrinology
- Comparison of effectiveness of growth hormone therapy according to disease-causing genes in children with Noonan syndrome
- Kyo Jin Jo, Yoo Mi Kim, Ju Young Yoon, Yeoun Joo Lee, Young Mi Han, Han-Wook Yoo, Hyang-Sook Kim, Chong Kun Cheon
- Clin Exp Pediatr. 2019;62(7):274-280. Published online December 3, 2018
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Purpose: To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations. Methods: Twenty-three patients with prepubertal NS treated at Pusan National University Children’s Hospital between March 2009 and July 2017 were enrolled. According to the disease-causing genes identified, the patients with NS were divided into 4 groups. Three groups were...
- Genetics and Metabolism
- Clinical and molecular characterization of Korean children with infantile and late-onset Pompe disease: 10 years of experience with enzyme replacement therapy at a single center
- Min-Sun Kim, Ari Song, Minji Im, June Huh, I-Seok Kang, Jinyoung Song, Aram Yang, Jinsup Kim, Eun-Kyung Kwon, Eu-Jin Choi, Sun-Ju Han, Hyung-Doo Park, Sung Yoon Cho, Dong-Kyu Jin
- Clin Exp Pediatr. 2019;62(6):224-234. Published online October 4, 2018
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Purpose: Pompe disease (PD) is an autosomal recessive disorder caused by a deficiency of acid alphaglucosidase resulting from pathogenic GAA variants. This study describes the clinical features, genotypes, changes before and after enzyme replacement therapy (ERT), and long-term outcomes in patients with infantile-onset PD (IOPD) and late-onset PD (LOPD) at a tertiary medical center. Methods: The medical records of 5 Korean...
- Developmental and Behavioral Medicine
- Validity of the Korean Developmental Screening Test for very-low-birth-weight infants
- Chae Young Kim, Euiseok Jung, Byong Sop Lee, Ki-Soo Kim, Ellen Ai-Rhan Kim
- Clin Exp Pediatr. 2019;62(5):187-192. Published online March 20, 2019
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Purpose: The importance of the neurodevelopmental outcomes of very-low-birth-weight (VLBW) infants has been emphasized as their mortality rate has markedly improved. This study aimed to assess the validity of the Korean Developmental Screening Test (K-DST), a developmental screening tool approved by the Korean Society of Pediatrics, for the timely diagnosis of neurodevelopmental delay in VLBW infants. Methods: Subjects included VLBW infants...
- Neonatology (Perinatology)
- Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants
- Ian Kim, Sung Shin Kim, Jee In Song, Seock Hwa Yoon, Ga Young Park, Yong-Wha Lee
- Clin Exp Pediatr. 2019;62(5):166-172. Published online October 24, 2018
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Purpose: This study aimed to evaluate vitamin D status at birth in very-low-birth-weight infants (VLBWIs: <1,500 g) and to determine the association between vitamin D level and respiratory morbidity. Methods: A retrospective study was conducted at Soonchunhyang University Bucheon Hospital between November 2013 and November 2017. We collected blood samples and data on respiratory morbidity from 230 VLBWIs on the first...
- Case Report
- Reninoma: a rare cause of curable hypertension
- Ji Hye Kim, Ji Hyun Kim, Myung Hyun Cho, Eujin Park, Hye Sun Hyun, Yo Han Ahn, Hee Gyung Kang, Kyung Chul Moon, Il-Soo Ha, Hae Il Cheong
- Clin Exp Pediatr. 2019;62(4):144-147. Published online October 29, 2018
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The most common type of refractory hypertension found in children is secondary hypertension, which is a potentially curable disease. Reninoma, a renin-secreting juxtaglomerular cell tumor, is a rare cause of severe hypertension that is usually diagnosed in adolescents and young adults. Surgical resection of the tumor completely cures the hypertension of patients with reninoma. The typical clinical presentation of reninoma...
- Original Article
- Respiratory syncytial virus-associated seizures in Korean children, 2011–2016
- Teahyen Cha, Young Jin Choi, Jae-Won Oh, Chang-Ryul Kim, Dong Woo Park, In Joon Seol, Jin-Hwa Moon
- Clin Exp Pediatr. 2019;62(4):131-137. Published online October 23, 2018
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Purpose: Respiratory syncytial virus (RSV) infection can cause various neurological complications. This study aimed to investigate the RSV-associated neurologic manifestations that present with seizures. Methods: We retrospectively reviewed the medical records of patients aged less than 15 years with laboratory-confirmed RSV infections and seizures between January 2011 and December 2016 in a regional hospital in South Korea. Results: During this period, 1,193...
- The association between preeclampsia and autism spectrum disorders among children: a meta-analysis
- Ensiyeh Jenabi, Manoochehr Karami, Salman Khazaei, Saeid Bashirian
- Clin Exp Pediatr. 2019;62(4):126-130. Published online December 24, 2018
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Purpose: In this meta-analysis, relevant case-control and cohort studies were pooled to evaluate the association between preeclampsia and the risk of autism spectrum disorders (ASDs) in children. Methods: A search for relevant studies in major databases, including Web of Science, PubMed, and Scopus, was performed up to May 2018. The odds ratios (ORs) or rate ratios (RRs) with 95% confidence intervals...
- Cardiology
- Changes of Bax, Bcl-2, CCR-2, MCP-1, and TGF-β1 genes in the left ventricle of spontaneously hypertensive rat after losartan treatment
- Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
- Clin Exp Pediatr. 2019;62(3):95-101. Published online October 24, 2018
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Purpose: Increased apoptosis was recently found in the hypertrophied left ventricle of spontaneously hypertensive rats (SHRs). Although the available evidence suggests that apoptosis can be induced in cardiac cells by various insults including pressure overload, cardiac apoptosis appears to result from an exaggerated local production of angiotensin in adult SHRs. Altered expressions of Bcl associated X (Bax), Bcl-2, chemokine receptor...
- Hematology and Oncology
- Lymphocyte-monocyte ratio at day 14 of first cisplatin-doxorubicin chemotherapy is associated with treatment outcome of pediatric patients with localized osteosarcoma
- Jun Ah Lee, Hea Lin Oh, Dong Ho Kim, Jung Sub Lim
- Clin Exp Pediatr. 2019;62(2):62-67. Published online October 1, 2018
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Purpose: We aimed to determine the prognostic significance of lymphocyte counts and the lymphocytemonocyte ratio (LMR) in pediatric patients with osteosarcoma. Methods: We retrospectively reviewed the medical records of 27 pediatric patients with localized extremity osteosarcoma, treated at the Korea Cancer Center Hospital between May 2002 and March 2016. Leukocyte counts and LMR before treatment and on day 14 (LMR14) of...
- Neurology
- Clinical manifestations of headache in children younger than 7 years
- Bu Seon Kang, Jinsun Lee, Jin Hyuk Choi, Hyeok Hee Kwon, Joon Won Kang
- Clin Exp Pediatr. 2018;61(11):355-361. Published online September 16, 2018
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Purpose: Headache is a common symptom during childhood. It is usually persistent and requires special care. This study aimed to identify the characteristics of headache in children <7 years of age. Methods: We reviewed 3 years of clinical files on children <7 years of age with a chief complaint of headache. Results: This study included 146 children (66 males, 80 females; mean...
- Review Article
- Nephrology (Genitourinary)
- Acute kidney injury and continuous renal replacement therapy in children; what pediatricians need to know
- Myung Hyun Cho, Hee Gyung Kang
- Clin Exp Pediatr. 2018;61(11):339-347. Published online October 23, 2018
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Acute kidney injury (AKI) is characterized by abrupt deterioration of renal function, and its diagnosis relies on creatinine measurements and urine output. AKI is associated with higher morbidity and mortality, and is a risk factor for development of chronic kidney disease. There is no proven medication for AKI. Therefore, prevention and early detection are important. Physicians should be aware of...
- Original Article
- Neurology
- Comparison of conservative therapy and steroid therapy for Bell’s palsy in children
- Hye Won Yoo, Lira Yoon, Hye Young Kim, Min Jung Kwak, Kyung Hee Park, Mi Hye Bae, Yunjin Lee, Sang Ook Nam, Young Mi Kim
- Clin Exp Pediatr. 2018;61(10):332-337. Published online September 12, 2018
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Purpose: Bell’s palsy is characterized by sudden onset of unilateral facial weakness. The use of corticosteroids for childhood Bell’s palsy is controversial. This study aimed to identify clinical characteristics, etiology, and laboratory findings in childhood Bell’s palsy, and to evaluate the efficacy of corticosteroid treatment. Methods: We conducted a retrospective analysis of children under 19 years of age treated for Bell’s...
- Neonatology (Perinatology)
- Oral findings and its association with prenatal and perinatal factors in newborns
- Brenda Perez-Aguirre, Uriel Soto-Barreras, Juan Pablo Loyola-Rodriguez, Juan Francisco Reyes-Macias, Miguel Angel Santos-Diaz, Alejandra Loyola-Leyva, Obed Garcia-Cortes
- Clin Exp Pediatr. 2018;61(9):279-284. Published online September 15, 2018
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Purpose: This study aimed to determine the frequency of abnormalities in the newborn oral cavity and to evaluate the association with prenatal and perinatal factors. Methods: This cross-sectional study evaluated 2,216 newborns. Oral findings were assessed in the first 24 hours of life using visual examination. Sex, weight, length, gestational age, and medical disorders at birth were recorded. Maternal demographic and...
- Cardiology
- Change of voltage-gated potassium channel 1.7 expressions in monocrotaline-induced pulmonary arterial hypertension rat model
- Hyeryon Lee, Kwan Chang Kim, Young Mi Hong
- Clin Exp Pediatr. 2018;61(9):271-278. Published online September 15, 2018
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Purpose: Abnormal potassium channels expression affects vessel function, including vascular tone and proliferation rate. Diverse potassium channels, including voltage-gated potassium (Kv) channels, are involved in pathological changes of pulmonary arterial hypertension (PAH). Since the role of the Kv1.7 channel in PAH has not been previously studied, we investigated whether Kv1.7 channel expression changes in the lung tissue of a monocrotaline...
- Endocrinology
- Changes of the growth plate in children: 3-dimensional magnetic resonance imaging analysis
- Hyung Ho Yun, Hyun-Jung Kim, Min-Sun Jeong, Yun-Sun Choi, Ji-Young Seo
- Clin Exp Pediatr. 2018;61(7):226-230. Published online July 15, 2018
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Purpose: This pilot study assessed changes in the growth plate and growth rates in children during a 6-month period. Methods: The study included 31 healthy children (17 boys, 14 girls) under evaluation for growth retardation. Height, weight, bone age, insulin like growth factor-1 (IGF-1), and insulin like growth factor binding protein 3 (IGF-BP3) were measured at baseline and after 6 months....
- Neurology
- Outcome of ultrasonographic imaging in infants with sacral dimple
- Jin Hyuk Choi, Taekwan Lee, Hyeok Hee Kwon, Sun Kyoung You, Joon Won Kang
- Clin Exp Pediatr. 2018;61(6):194-199. Published online June 25, 2018
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Purpose Sacral dimples are a common cutaneous anomaly in infants. Spine ultrasonography (USG) is an effective and safe screening tool for patients with a sacral dimple. The aim of this study was to determine the clinical manifestations in patients with an isolated sacral dimple and to review the management of spinal cord abnormalities identified with USG.
Methods We reviewed clinical records and collected...
- Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats
- Hyeok Hee Kwon, Taekwan Lee, Jinpyo Hong, Dong Woon Kim, Joon Won Kang
- Clin Exp Pediatr. 2018;61(5):150-155. Published online May 28, 2018
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Purpose Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms.
Methods We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their...
- Review Article
- General Pediatrics
- The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects
- Jae Hyun Kim, Sungha Yun, Seung-sik Hwang, Jung Ok Shim, Hyun Wook Chae, Yeoun Joo Lee, Ji Hyuk Lee, Soon Chul Kim, Dohee Lim, Sei Won Yang, Kyungwon Oh, Jin Soo Moon; for the Committee for the Development of Growth Standards for Korean Children and Adolescents, the Committee for School Health and Public Health Statistics; the Committee for School Health and Public Health Statistics; the Korean Pediatric Society, and Division of Health and Nutrition Survey; Korea Centers for Disease Control and Prevention
- Clin Exp Pediatr. 2018;61(5):135-149. Published online May 28, 2018
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Growth charts are curves or tables that facilitate the visualization of anthropometric parameters, and are widely used as an important indicator when evaluating the growth status of children and adolescents. The latest version of the Korean National Growth Charts released in 2007 has raised concerns regarding the inclusion of data from both breastfed and formula-fed infants, higher body mass index...
- Original Article
- Nephrology (Genitourinary)
- Hypercalciuria and febrile convulsion in children under 5 years old
- Vahid Seddighi Gorabi, Bahram Nikkhoo, Obeidollah Faraji, Mona Mohammadkhani, Sattar Mirzaee, Mohammad Aziz Rasouli, Abdorrahim Afkhamzadeh
- Clin Exp Pediatr. 2018;61(4):129-131. Published online April 23, 2018
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Purpose The association between hypercalciuria and febrile convulsion is controversial. The present study aimed to investigate the statistical association between hypercalciuria and childhood febrile convulsions.
Methods Overall, 160 children aged 6 months to 5 years, including 80 children with febrile convulsion and 80 febrile children without convulsion (comparison group), were recruited. All laboratory tests, including 24-hour urine calcium, were undertaken in an academic...
- Review Article
- Neurology
- Epilepsy syndromes during the first year of life and the usefulness of an epilepsy gene panel
- Eun Hye Lee
- Clin Exp Pediatr. 2018;61(4):101-107. Published online April 23, 2018
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Recent advances in genetics have determined that a number of epilepsy syndromes that occur in the first year of life are associated with genetic etiologies. These syndromes range from benign familial epilepsy syndromes to early-onset epileptic encephalopathies that lead to poor prognoses and severe psychomotor retardation. An early genetic diagnosis can save time and overall cost by reducing the amount...
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