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Original Article
Acoustic variations associated with congenital heart disease
Jung Eun Oh, Yoon Mi Choi, Sun Jun Kim, Chan Uhng Joo
Clin Exp Pediatr. 2010;53(2):190-194.   Published online February 15, 2010
Purpose : To investigate the nature of deviant voice physiology in preoperative children with congenital heart disease. Methods : Ninety-four children with congenital heart disease were enrolled. Their cries and related acoustic variables (fundamental frequency, duration, noise to harmonic ratio, jitter￠￢ and shimmer) were analyzed using a multi-dimensional voice program. Results : The average fundamental frequency showed a significant decrease in patent...
Effectiveness of head-up tilt test for the diagnosis of syncope in children and adolescents
Ka-Young Yu, Ji-Hye Choi, Chun Ja Yoo, Kyoung Suk Rhee, Chan Uhng Joo
Clin Exp Pediatr. 2009;52(7):798-803.   Published online July 15, 2009
Purpose : We aimed to examine the effectiveness of the head-up tilt test (HUT) for the diagnosis of syncope or presyncope in children and adolescents. Methods : HUT results and clinical features of 160 children and adolescents with syncope or presyncope were studied from May 2003 through March 2008 at the Chonbuk National University Hospital. The children and adolescents were subjected...
Results of radiofrequency catheter ablation in children and adolescent with tachyarrhythmia
Young Beom Chang, Seung Hyun Lee, Eun Young Kang, Kyoung-Suk Rhee, Chan Uhng Joo
Clin Exp Pediatr. 2007;50(11):1085-1090.   Published online November 15, 2007
Purpose : Radiofrequency catheter ablation (RFCA) has become an effective therapeutic modality for treating pediatric tachyarrhythmias. Using conventional RFCA catheters, ablation of parahisian accessory pathways may be difficult and have high risk for heart block. We reviewed the efficacy and complications of the RFCA in children and adolescent with arrhythmias including parahisian accessory pathways. Methods : We studied 48 patients...
Comparision of PCR-RFLP, PCR-SSCP, Amplication Refractory Mutation System(ARMS) in Leu72Met Polymorphism of Ghrelin Gene
Ju Sung Kang, Se Rim Kim, Sun Young Kim, Chan Uhng Joo, Soo Chul Cho, Pyoung Han Hwang
Clin Exp Pediatr. 2005;48(10):1068-1075.   Published online October 15, 2005
Purpose : The role of ghrelin, which promotes the secretion of growth hormone, was not well known until now. Recently it was found that the mutation of ghrelin gene is related to obesity and diabetes. This study is to find the screening method that can easily and effectively detect the polymorphism of Leu72Met in ghrelin gene of obesity patients and...
Case Report
Two Cases of Wolff-Parkinson-White Syndrome in a Family
Chan Uhng Joo, So Hee Lim, Pyung Han Hwang
Clin Exp Pediatr. 2002;45(9):1150-1154.   Published online September 15, 2002
Wolff-Parkinson-White(WPW) syndrome is characterized by electrographic evidence of ventricular preexcitation, which predisposes to supraventicular arrhythmias. Familial occurrence of WPW syndrome is uncommon. We observed two affected siblings in a family. Five members of the family underwent 12-lead electrocardiography and echocardiography. Although known genetic abnormality of the 7q34-q36(PRKAG2) for the familial WPW syndrome was evaluated, the mutation was not detected in...
Original Article
iption Factor NF-κB Caused by Acute Hypoxia in the Heart
Chan Uhng Joo, Woo Suk Juhng, Jae Cheol Kim, Ho Keun Yi
Clin Exp Pediatr. 2002;45(9):1106-1113.   Published online September 15, 2002
Purpose : Nuclear factor-κB(NF-κB) is now recognized as playing a potential role in programmed cell death and the adaptive response to various stress. Cellular hypoxia is a primary manifestation of many cardiovascular diseases. It seems that vascular endothelial growth factor (VEGF) and insulin like growth factor-I(IGF-I) have a function as a protective molecule in the heart against several stress including...
Electrocardiographic and Echocardiographic Characterisitics of Wolff-Parkinson-White Syndrome in Preschool Children
Jeoung Min Chu, Hyun Sup Sim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 2002;45(9):1097-1105.   Published online September 15, 2002
Purpose : This study was conducted to estabilish the prevalence, clinical features and relationship between ECG findings and echocardiographic findings of Wolff-Parkinsion-White(WPW) syndrome in asymptomatic preschool children. Methods : An electrocardiographic screening study was performed on 77,824 preschool children in Jeonbuk province from April, 1999 to August, 2001. Patients with WPW syndrome underwent echocardiographic study. Results : Twenty three patients with WPW...
Case Report
A Case of Constrictive Pericarditis with Purulent Effusion in an Infant
Kyoung Hee Kim, Yoon Ki Kang, Min Ho Kim, Chan Uhng Joo
Clin Exp Pediatr. 2000;43(9):1279-1284.   Published online September 15, 2000
Constrictive pericarditis is a rare disease of infancy and childhood, and is almost always caused by a tuberculosis or other infection. It is usually fatal, if untreated in acute phase. Early diagnosis of this condition is now facilitated by echocardiography and computerized tomography. Favorable outcome seems to depend on early diagnosis assured by echocardiography, early surgical treatment such as pericardiocentesis...
Original Article
Effect of Antiepileptic Drugs on Bone Metabolism and Growth in Epileptic Children
Woo Suk Juhng, Sun Jun Kim, Soo Chul Cho, Chan Uhng Joo
Clin Exp Pediatr. 1999;42(8):1078-1085.   Published online August 15, 1999
Purpose : Long-term administration of anticonvulsants for children with convulsive disorder may cause osteomalacia, depending on dosage, duration, types, and combination of anticonvulsants administered. This study was performed to examine the effect of anticonvulsant drugs on bone mineral density in epileptic children. Methods : Forty-eight epileptic children aged 3 to 15 years were enrolled in this study. They were treated with...
Effects of Cisapride on Action Potential Duration and on ATP-Sensitive K Channel in Guinea Pig Ventricular Muscles
Chan Uhng Joo, Young Jae Kim, Sung Ki Mun, Soo Wan Chae
Clin Exp Pediatr. 1999;42(7):953-958.   Published online July 15, 1999
Purpose : Cisapride(PrepulsidⓇ) has been recently associated with long QT syndrome. It has been reported to cause Torsades de Pointes and induce early afterdepolarization in rabbit Purkinje fibers. We investigated the electrophysiological effects of cisapride on cardiac action potential duration and ATP-sensitive K channel in papillary muscles. Methods : Cardiac action potentials in guinea pig papillary muscle were recorded with microelectrodes...
Case Report
Removal of a Displaced Catheter from Upper GI Tract of a Newborn Using a Goose Neck Snare
Chan Uhng Joo, Jae Ho Song, Soo Chul Cho
Clin Exp Pediatr. 1999;42(3):442-445.   Published online March 15, 1999
For the immediate proper respiratory care of a delivered newborn, the face is wiped immediately, and the mouth and nares should be suctioned. A soft rubber syringe or soft rubber catheter is suitable for suctioning. If respirations are infrequent, suction of the mouth and pharynx serves to stimulate breathing. We experienced a case of a foreign body in the distal...
A Case of Pulmonary Artery Sling Associated with Left Bronchial Stenosis and Patent Ductus Arteriosus
Woo Suk Juhng, Myung Hee Han, Chan Uhng Joo
Clin Exp Pediatr. 1998;41(10):1417-1423.   Published online October 15, 1998
Pulmonary artery sling is a rare and potentially lethal vascular anomaly wherein the anomalous left pulmonary artery arises from the posterior aspect of the right pulmonary artery and passing to the left lung between the trachea and the esophagus which causes respiratory distress in infants and children due to the extrinsic compression of the airway by the anomalous vessel. Associated...
Original Article
Echocardiographic Study of the Ventricular Septal Defect with Subaortic Ridge
Kyeung Hee Moon, Pyoung Han Hwang, Chan Uhng Joo
Clin Exp Pediatr. 1997;40(5):629-634.   Published online May 15, 1997
Purpose : The easy recognition and characterization of a discrete or fixed subaortic ridge by echocardiography provides a method for prospective study of the coexistence of ventricular septal defect(VSD) and subaortic ridge. In the presence of a VSD, a subaortic ridge may be clinically silent, but the obstruction can progress if the VSD is surgically or spontaneously closed. This study...
Case Report
A Case of Peripheral Pulmonary Artery Aneurysm without Pulmonary Hypertension
Kyeung Hee Moon, Woo Suk Juhng, Chan Uhng Joo
Clin Exp Pediatr. 1997;40(2):284-287.   Published online February 15, 1997
Aneurysm of the pulmonary artery is a rare entity. Aneurysm of the peripheral artery are even less common. An 14-year-old girl was admitted for the evaluation of cardiac murmur. There was a variable grade 2/6 systolic murmur along the left sternal border. The chest x-ray showed a round mass in the right perihilar region. Echocardiogram demonstrated a small muscular ventricular septal defect with mild...
Original Article
Effects of Cyclosporine on the Renal Sympathetic Nerve Activity and Baroreflex Function in Rabbits
Chan Uhng Joo, Tae Hee Park, Moon Hwan Lee, Jung Soo Kim
Clin Exp Pediatr. 1995;38(7):955-962.   Published online July 15, 1995
Purpose : The immunosuppresive drug cyclosporine(CS) is a novel agent that has greatly enhanced long-term survival after organ transplantation and has proved beneficial in the treat-ment of many autoimmune diseases. However, CS has emerged as a new cause of hypertens-ion. Although the causes of the hypertension are undoubtedly multifactorial, there are evidenc-es to suggest that sympathetic overactivity is involved. We...
Comparison of Graded and Bolus Infusion Methods in Baroreflex Measurements in Rabbits
Chan Uhng Joo
Clin Exp Pediatr. 1995;38(1):61-65.   Published online January 15, 1995
Graded infusion and bolus injection methods of vasoactive drugs have both been used to measure baroreflex sensitivity. To determine whether the two methods produce the same values of baroreceptor sensitivity, phenylephrine and nitroglycerin was administered intravenously by both graded infusion and bolus injection methods to 11 rabbits. To evaluate the baroreflex control of heart rate(HR), a logistic sigmoid function model...
Case Report
A Case of Congenital Tricuspid Stenosis
Chan Uhng Joo, Soo Young Cho, Soo Chul Cho
Clin Exp Pediatr. 1993;36(5):733-736.   Published online May 15, 1993
Congenital tricuspid stenosis is ancommon congenital heart anomaly. Tricuspid stenosis is usually associated with other anomalies, most commonly severe pulmonary stenosis or atresia with secondary hypoplasia of the right ventricle. Clinically it may be difficult to distinguish from tricuspid atresia. A case of congenital tricuspid stenosis in a 32 day-old-girl is presented. The patient had cyanosis and dyspnea. Echocardiographic study revealed...
Original Article
Systolic Pressure Amplification of the Aortic Pressure in Children with Congenital Heart Disease
Chan Uhng Joo, Byoung Geun Lee, Sun Jun Kim, Jung Soo Kim
Clin Exp Pediatr. 1993;36(2):232-238.   Published online February 15, 1993
Direct intraarterial measurement of blood pressure is an important diagnostic procedure in critical patients and premature baby care. Direct measurement was more accepted and confident method in physician than the indirect methods. But the presence of a significant amplification of systolic pressure in peripheral artery may lead to important error. So we have investigated the degree of the systolic pressure...
Case Report
A Case of Right Pulmonary Artery Arising from Ascending Aorta
Chan Uhng Joo, Nam Ki Kim, Ja Hong Kuk, Doing Geun Lee
Clin Exp Pediatr. 1992;35(9):1303-1306.   Published online September 15, 1992
The anomaly consisting of one pulmonary artery arising from the ascending aorta while the other originates normally from the right ventricle is a rare congenital malformation. Early surgery is desirable to prevent pulmonary vascular obstructive disease. The autoors experienced a patient of right pulmonary artery arising from ascending aorta who had severe respiratory distress. Echocardiographic study and autopsy findings showed anomalous...
Original Article
Effects of Adriamycin on Membrane Potential and Intracellular Sodium Activity in Canine Purkinje fibers
Chan Uhng Joo, Soo Wan Chae
Clin Exp Pediatr. 1992;35(8):1107-1112.   Published online August 15, 1992
Anthracycline antibiotic adriamycin (doxorubicin) is presently considered to be a very effective chemotherapeutic agent in the treatment of many human tumors. Adriamycin induced cardiomyopathy limits its clincal use. A number of hypotheses have been proposed to explain the mechanism of cardiotoxicity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on membrane potential and intracellular sodium ion...
A Clinical Study on Cardiovascular Disease of Children Taken Cardiac Catheterization and Cineangiography
Gi Yeon Song, Seog Beom Cho, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1992;35(7):949-956.   Published online July 15, 1992
A clinical study was made on 533 patients with cardiovascular disease who were admitted to pediatric department of Chonbuk National University Hospital and performed cardiac catheterization and cineangiography from February 1984 to August 1991. The results were as follows; 1) The ratio of male to female was about 0.81:1; among 533 cases, male 283cases, male 283cases, female 295cases. 2)The age distribution of the...
A case of hemiazygos continuation of a left inferior vena cava.
Soo Young Cho, Joseph Choi, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1991;34(10):1428-1432.   Published online October 31, 1991
Anomalies of the inferior vena cava (IVC) are often discovered incidentally during imaging studies performed for other reasons, since patients with these abnormalities are usually asymptomatic. Infrahepatic interruption of the IVC with azygos or hemiazygos continuation is an unusual anomaly of the IVC. We report a case of single left-sided IVC with hemiazygos continuation in associated with patent ductus arteriosus and left superior vena cava....
The effects of adriamycin on twitch force and membrane potential in an isolated Guinea-pig papillary muscle.
Chan Uhng Joo, Pyung Han Hwang, Jung Soo Kim, Hee Cheol Yu, Soo Wan Chae
Clin Exp Pediatr. 1991;34(5):677-681.   Published online May 31, 1991
The antiumor antibiotic adriamycin is presently considered to be a very effctive and useful chemotherapeutic agent in the treatment of many human tumors. Cardiotoxicity of adriamycin limits its clinical use. A number of hypotheses have been proposed to explain the mechanism of cardiotox- icity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on twitch force and membrane potential in an...
Changes of PPD-Specific Immunoglobulin in Pulmonary Tuberculosis After Treatment.
Ja Young Kim, Mun Hwan Lee, Pyoung Han Hwang, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1647-1655.   Published online December 31, 1990
The definite diagnosis and precise assessment of response to therapy is still a problem in childhood tuberculosis because these patients rarely produce sputum and if obtained it may be negative. For this reason, diagnosis rely largely on the clinical and X-ray examination, which have a low specificity and high proportion of false positive results. Recently immunologic diagnosis of tuberculosis using enzyme-linked immunosorbent assay (ELISA) was...
Percutaneous Balloon Valvuloplasty in Children with Pulmonary and Aortic Valvular Stenosis.
Chan Uhng Joo, Jung Soo Kim, Ho Yunh Song
Clin Exp Pediatr. 1989;32(9):1224-1231.   Published online September 30, 1989
Pulmonary and aortic valvular stenosis were relieved by percutaneous balloon valvuloplasty during cardiac catheterization on 14 children aged 22 months to 18 years. Before dilatation the transpulmonary systolic pressure gradients ranged from 43 mmHg (mean 87. 8 mmHg) in children with pulmonary valvular stenosis. There were significant reduction in the transpulmonary systolic pressure gradient (mean 33.1 mmHg) immediately after balloon valvuloplas- ty except one patient...
Changes of Plasma Atrial Natriuretic Peptide and Antidiuretic Hormone in Congenital Heart Disease.
Sun Jun Kim, Jong San Lee, Chan Uhng Joo, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1989;32(8):1106-1116.   Published online August 31, 1989
Human atrial myocytes secrete atrial natriuretic peptides (ANP) into the plasma, which causes rapid and marked natriuresis, diuresis and vasorelaxation. The releases of renin, aldosterone, and antidiuretic hormone are inhibited by ANP in vivo and in vitro experiments. Various atrial natriur- etic peptides were isolated and synthesized. Plasma ANP concentrations usually elevated in conges- tive heart failure, chronic renal failure, pulmonary arterial hypertension, tachyarrhythmia,...
A Case of Pulmonary Squestration.
Byung Sook Park, Jin Oh Kim, Beyong Sang Choi, Chan Uhng Joo, Dae Yeol Lee
Clin Exp Pediatr. 1988;31(10):1390-1393.   Published online October 31, 1988
Pulmonary sequestration is an uncommon congenital malformation charcterized by the presence of nonfunctioning lung tissue which usually has no communciation with the normal bronchial tree and which receives it's blood supply from an anomalous systemic artery instead of pulmonary arterial branch. We have experienced a case of pulmonary sequestration. The patient was 5 10/12 years old girl with the complaint of fever, cough, Chest films...
Case Report
A Case of Williams Elfin Facies Syndrome.
Kyung Jin Shin, Heon Seob Song, Byung Sook Park, In Soo Choi, Chan Uhng Joo, Jung Ku Jo
Clin Exp Pediatr. 1987;30(6):684-690.   Published online June 30, 1987
Williams elfin facies syndrome is a disorder which has previously designated as the pecular facies, mental retardation and supravalvular aortic stenosis. Supravalvular aortic stenosis is the least form of left ventricular outflow obstruction, originating at superior margin of sinuses of Valsalva just above the level of the coronary arteries. We had experienced a case of Williams elfin facies syndrome who had characteristic face, mental retardation...
Original Article
A Study of Radionuclide Angiocardiography in Congenital Heart Disease.
Beyong Sang Choi, Kyung Jin Shin, Beyong Sook Park, In Soo Choi, Chan Uhng Joo, Jung Soo Kim
Clin Exp Pediatr. 1986;29(9):964-968.   Published online September 30, 1986
In 101 heart disease patients, the radionuclide angiocardiography(RNA) were performed. Quantitation of left to right shunts were obtained by RNA and oximetry method in 41 patients simultaneously. A comparison of the values for Qp/Qs ratio obtained by RNA & oximetry in those patients revealed a good correlation coefficient of 0.87(P
Case Report
A Case of Scaphocephaly in a Newborn.
Chan Uhng Joo
Clin Exp Pediatr. 1985;28(3):297-300.   Published online March 31, 1985
Scaphocephaly is a kind of craniosynostosis. Because of premature closure of the sagittal suture in newborn with scaphocephaly, the lateral rgrowth of the head [is limited and the growth of the brain causes the head to expand in the occipitofrontal diameter. I have experienced a case of scaphocephaly in a newborn. A brief review of related literatures is included in...