• Search
  • Advanced Search

Search

  • HOME
  • Search
Case Report
A case of regression of atypical dense deposit disease without C3 deposition in a child
Min Sun Kim, Pyoung Han Hwang, Mung Jae Kang, Dae-Yeol Lee
Clin Exp Pediatr. 2010;53(7):766-769.   Published online July 31, 2010

Dense deposit disease (DDD) is a rare disorder characterized by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidneys. The diagnosis is made in most patients between 5 and 15 years of age, and within 10 years, approximately half of the affected patients progress to end-stage renal disease. We report a rare case of regressive...

Original Article
Changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis
Dae Sun Jo, Ji Hye Han, Sun Young Kim, Min Sun Kim, Ho Keun Yi, Dae-Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2009;52(12):1348-1357.   Published online December 15, 2009
Purpose : The aims of this study were to identify the clinical characteristics and determine the changes in the expression of cytokines and apoptosis-related genes in children with infectious mononucleosis. Methods : Serological examinations of 15 pediatric patients diagnosed with infectious mononucleosis were performed prospectively. Peripheral blood from the patients was used to compare the composition of T cell subsets,...
Salmonellosis in children: Analysis of 72 Salmonella-positive culture cases during the last 10 years
Sung Hoon Noh, Ka Young Yu, Jung Soo Kim, Pyoung Han Hwang, Dae Sun Jo
Clin Exp Pediatr. 2009;52(7):791-797.   Published online July 15, 2009
Purpose : We aimed to investigate the clinical manifestations of and antibiotic resistance in culture-proven childhood salmonellosis. Methods : Clinical manifestations and laboratory data of and antibiotic use in subjects with culture-proven childhood salmonellosis, who were treated at the Chonbuk National University Hospital between September 1998 and August 2008, were analyzed retrospectively. Patients with underlying diseases or concomitant illnesses were excluded. Results...
Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
Eun Hye Park, Hyo Jung Lee, Soo Yeon Lee, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2009;52(2):213-219.   Published online February 15, 2009
Purpose : Iron is a critical nutritional element that is essential for a variety of important biological processes, including cell growth and differentiation, electron transfer reactions, and oxygen transport, activation, and detoxification. Iron is also required for neoplastic cell growth due to its catalytic effects on the formation of hydroxyl radicals, suppression of host defense cell activities, and promotion of...
Case Report
Hand-Foot syndrome induced by sorafenib, a multitargeted tyrosine kinase inhibitor, in a patient with advanced renal cell carcinoma
Seung Hyun Lee, Sung Hun Noh, Sun Young Kim, Kyu Yun Jang, Pyoung Han Hwang
Clin Exp Pediatr. 2009;52(1):119-123.   Published online January 15, 2009
Renal cell carcinoma (RCC) arising from epithelial cells of the renal tubules is a highly aggressive and malignant tumor in all ages; however, it rarely occurs in children. the standard treatment for RCC is radical nephrectomy with lymph node dissection when the tumor is localized and can be completely resected. Adjuvant chemotherapy, radiotherapy, and immunotherapy are used for pediatric patients...
Original Article
Capsaicin induced apoptosis and the enhanced anticancer effect of anticancer drugs in cancer cells
Sun Young Kim, You Jin Lee, Eun Hye Park, Ho Keun Yi, Dae Sun Jo, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2008;51(3):307-314.   Published online March 15, 2008
Purpose : Capsaicin, the major pungent ingredient in red pepper, has long been used in spices and food additives. It has been recently shown to induce apoptosis in several cell lines through a not well known mechanism. The aim of this study was to investigate the apoptosis-inducing effect of capsaicin on gastric cancer cells, and to provide valuable information concerning...
Case Report
Acute hemorrhagic edema in an infant mimicking Henoch-Sch nlein purpura: a case study
Hyang Mo Lee, Eun Young Kang, Han Uk Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2006;49(12):1354-1357.   Published online December 15, 2006
Acute hemorrhagic edema of infancy (AHEI) is an uncommon form of cutaneous leukocytoclastic vasculitis that occurs in infants and children younger than 2 years. AHEI is characterized clinically by marked peripheral edema and fever as well as large palpable purpuric and ecchymotic skin lesions in a target-like pattern, mainly on the face, ears and extremities, similar to the skin findings...
Original Article
The anti-tumor mechanisms of p53 through the regulation of expression and glycosylation of insulin-like growth factor binding protein-3
Sun Young Kim, Se Rim Kim, Jung Chang Lee, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2006;49(4):431-438.   Published online April 15, 2006
목 적 : 새로운 암억제 유전자로 알려진 IGFBP-3의 주요 기능은 IGF-I과 IGF-II와 결합을 하여 IGF의 기능을 조절하는 IGF dependent mechanism과 IGFBP-3 자체가 IGF와 결합과는 무관하게 세포의 apoptosis를 유도하는 IGF independent mechanism이 보고되었다. 암억제 유전자 p53의 대표적인 항암기전의 하나는 직접 IGFBP-3의 발현을 증가시키며, 발현된 IGFBP-3는 암세포의 apoptosis를 유도시킨다. IGFBP-3의 항암작용은 보고되었지만, IGFBP-3의 변역 후 변형에 의한 항암기전은 전혀 밝혀져 있지 않다....
Comparision of PCR-RFLP, PCR-SSCP, Amplication Refractory Mutation System(ARMS) in Leu72Met Polymorphism of Ghrelin Gene
Ju Sung Kang, Se Rim Kim, Sun Young Kim, Chan Uhng Joo, Soo Chul Cho, Pyoung Han Hwang
Clin Exp Pediatr. 2005;48(10):1068-1075.   Published online October 15, 2005
Purpose : The role of ghrelin, which promotes the secretion of growth hormone, was not well known until now. Recently it was found that the mutation of ghrelin gene is related to obesity and diabetes. This study is to find the screening method that can easily and effectively detect the polymorphism of Leu72Met in ghrelin gene of obesity patients and...
Case Report
A Case of Wiskott-Aldrich Syndrome with Novel Mutation in Exon 2 of the WASP Gene
Hyuk Lee, Jung In Park, Sun Young Kim,, Kyeung Hee Moon, Ho Keun Yi, Pyoung Han Hwang
Clin Exp Pediatr. 2005;48(5):551-556.   Published online May 15, 2005
Wiskott-Aldrich syndrome(WAS) is an X-linked recessive immunodeficiency characterized by thrombocytopenia with small platelet volume, eczema, and recurrent infections, and is also characterized by increased incidence of auto immune diseases and malignancies. The phenotype observed in this syndrome is caused by mutation in the Wiskott-Aldrich syndrome protein(WASP) gene localized to the proximal short arm of the X chromosome and recently isolated...
Original Article
The Tumor Suppressor Function of PTEN/MMAC1 through the Regulation of IGFs and IGFBPs
Ho Keun Yi, Dong Jin Hwang, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(8):884-891.   Published online August 15, 2004
Purpose : PTEN/MMAC1, a novel tumor suppressor gene, is mutated in a variety of advanced and metastatic cancers. It acts as a phosphatase, and thereby, regulates the PI-3 kinase/Akt pathway. In this study, we examined to evaluate the new function of anti-tumor effects of PTEN/MMAC1 through the regulation of the IGFs-IGFBPs in gastric cancer cells. Methods : PTEN/MMAC1 was expressed in...
Diagnostic Approach of Wiskott-Aldrich Syndrome
Dong Jin Hwang, Jun Won Yang, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(7):726-734.   Published online July 15, 2004
Objective : A probable diagnosis of Wiskott-Aldrich syndrome(WAS) should be considered in any boy presenting with unusual bleeding, congenital thrombocytopenia and small platelets. The definitive diagnosis of WAS is usually made by the detection of WASP gene mutation or a decrease or absence of the WAS protein(WASP) in blood cells using molecular genetic analysis. However, these methods are too time-consuming...
Case Report
A Case of Multiple Juvenile Xanthogranuloma Involving Skin and Systemic Organs
So Yeon Lee, Yong Seok Jang, Min Sun Kim, Yun Jeong Yang, Myoung Ja Jung, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(2):227-230.   Published online February 15, 2004
Juvenile xanthogranuloma(JXG) is one of the most common non-Langerhans cell histiocytosis, benign histiocytic proliferative disorder. It typically presents as a solitary, benign, rapidly growing cutaneous tumor that may regress spontaneously. Most cutaneous lesions of JXG occur in the head and neck region of infants and young children. This disease is usually present with cutaneous lesion only; visceral involvement including the...
Original Article
Pediatrician Perspectives on the Evaluation and Treatment of Acute Gastrointestinal Infections, Jeonbuk, South Korea, 2002
So Hee Lim, Yang Sim Koe, Dae Sun Jo, Sin Jae Lee, Pyoung Han Hwang, P. Kilgore, B. Nyhambat, Jung Soo Kim
Clin Exp Pediatr. 2003;46(12):1217-1223.   Published online December 15, 2003
Purpose : This study was conducted to assess clinical practices related to the evaluation and treatment of patients with acute gastrointestinal infection(AGI) in infants and children. This survey also evaluated the current opinion regarding the use of rotavirus vaccine. Methods : This survey was conducted using a self-administered questionnaire provided to 82 pediatricians in private clinics of Jeonbuk province. From April...
Alteration of Growth Factor Expression after Acute Ischemic Renal Injury
Yang Sim Koe, Soo Yeon Lee, Won Kim, Soo Chul Cho, Pyoung Han Hwang, Jung Soo Kim, Dae-Yeol Lee
Clin Exp Pediatr. 2003;46(7):687-694.   Published online July 15, 2003
Purpose : Regeneration and repair after ischemic renal injury appears to be modulated by circulating or locally produced growth factors. This study examined the changes of serum insulin like growth factor(IGF-I) and renal expression of IGF-I and II, vascular endothelial growth factor(VEGF), transforming growth factor-β(TGF-β), and connective tissue growth factor(CTGF) during the active regeneration period after acute ischemic injury. Methods :...
Apoptotic Pathway Induced by Dominant Negative ATM Gene in CT-26 Colon Cancer Cells
Jung Chang Lee, Ho Keun Yi, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang, Jin Woo Park
Clin Exp Pediatr. 2003;46(7):679-686.   Published online July 15, 2003
Purpose : Ataxia telangiectasia mutated(ATM) is involved in DNA damage responses at different cell cycle checkpoints, and signalling pathways associated with regulation of apoptosis in response to ionizing radiation(IR). However, the signaling pathway that underlies IR-induced apoptosis in ATM cells has remained unknown. The purpose of this study was, therefore, to investigate the apoptotic pathway that underlies IR-induced apoptosis in...
Novel Gap Junction Molecules, Connexin 37, Enhances the Bystander Effect in HSVtk/GCV Gene Therapy
Sun Young Kim, Ho Keun Yi, Jung Chang Lee, Dong Jin Hwang, Pyoung Han Hwang, Dae Yeol Lee, Soo Chul Cho
Clin Exp Pediatr. 2003;46(6):541-547.   Published online June 15, 2003
Purpose : Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro by exogenous overexpressing connexin 37(Cx37) in cells to increase GJIC. Methods : NIH3T3 cells were transfected with the Cx37 and HSVtk gene or the HSVtk gene alone by the calcium...
Case Report
A Case of Cerebral Vasculitis in Henoch-Shonlein Purpura
Soo Yeon Lee, Ju Mi Choung, Dong Jin Hwang, So Hee Eun, Pyoung Han Hwang
Clin Exp Pediatr. 2002;45(12):1601-1605.   Published online December 15, 2002
Henoch-Sh nlein Purpura(HSP) is an immuologically mediated systemic vasculitis of small blood vessels affecting predominantly the skin, gastrointestinal tract, joints, and kidneys. Clinical neurological manifestations such as headaches, behavioral changes, mental changes, seizures, and visual loss are described, but neurological complication are rare during the course of HSP. We experienced a case of an 8 year-old male with HSP who...
Original Article
Study on Vaccination State in Children : Jeonbuk Province, 2000
Ju Mi Choung, Jung Chul Kim, So Hee Eun, Pyoung Han Hwang, B. Nyhambat, P. Kilgore, Jung Soo Kim
Clin Exp Pediatr. 2002;45(10):1234-1240.   Published online October 15, 2002
Purpose : This study was carried out to obtain the vaccination rate and age appropriateness of vaccination in children under five years of age in Jeonbuk province. Methods : Eight hundred and fifty infants and children were enrolled in this study. Vaccination rate(Number of vaccinees/Number of subjects), places of vaccination, age appropriateness of vacination were examined by either vaccine record review or interview with...
Case Report
A Case of Central Nervous System Atypical Teratoid/Rhabdoid Tumor of The 4th Ventricle : A Highly Malignant Tumor in Infancy and Childhood Frequently Mistaken for Medulloblastoma
So Hee Eun, Sung Hee Jang, Myoung Hee Han, Myoung Ja Chung, Pyoung Han Hwang
Clin Exp Pediatr. 2001;44(12):1475-1479.   Published online December 15, 2001
Central nervous system atypical teratoid/rhabdoid tumor(CNS rhabdoid tumor) is a rare malignancy of uncertain origin. It typically occurs in infants and young children and comprises only a small fraction of pediatrics CNS malignancies. The tumor contains a large spindled cell component as classical rhabdoid morphology and focal areas resembling primitive neuroectodermal tumor. The tumor is defined histopathologically by the presence...
Original Article
Anti-angiogenesis and Anti-metastasis Characteristics of the Novel Tumor Suppressor Gene PTEN
Pyoung Han Hwang, Ho Keun Yi, Myoung Hee Han, Dae Yeol Lee, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2001;44(6):654-663.   Published online June 15, 2001
Purpose : The tumor suppressor gene PTEN/MMAC1 is mutated in a variety of advanced and metastatic cancers, strongly suggesting that PTEN/MMAC1 alterations may be involved in tumor progression and the formation of metastases. However, the roles of PTEN in tumor growth and metastasis and its functional mechanisms are not fully understood. We evaluated the tumor suppressor function of PTEN/MMAC1 gene...
Studies on Functional Differentiation of Small Intestinal Epithelial Cells
Ho Keun Yi, Su Mi Oh, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2001;44(5):523-532.   Published online May 15, 2001
Purpose : We investigated compounds from food sources given to children that may induce the differentiation of small intestinal epithelial cells in order to signal pathways that induce the proliferation and differentiation of small intestinal epithelial cells. Methods : We analyzed small intestinal epithelial cell differentiation using in vitro IEC-6 cells model. The growth curve of IEC-6 cells was obtained...
Effectiveness of Preoperative Transcatheter Arterial Chemoembolization in Hepatoblastoma
Pyoung Han Hwang, Dae Sun Jo, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2000;43(8):1098-1105.   Published online August 15, 2000
Purpose : To evaluate the effectiveness of transcatheter arterial chemoembolization(TACE) as a preoperative treatment for initially unresectable hepatoblastomas. Methods : From January 1995 to July 1999, we identified two boys and three girls(age range : 5- 27 months; mean age : 12 months) with pathologically-confirmed hepatoblastoma. To assess response to treatment, we utilized an identical TACE procedure for all the patients....
Induction of Apoptosis of Ewing`s Sarcoma Cells by Regulating Fusion Protein Expression
Ho Keun Yi, Ran Ju Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2000;43(7):942-951.   Published online July 15, 2000
Purpose : Fusion genes(EWS-Fli-1 and EWS-erg ) function as transcription activators and are essential for maintaining tumorigenic properties in Ewing`s sarcoma cells. Several reports have noted that Ets family transcription factors bind with CBP(CREB binding protein) in vitro. To understand the interaction of fusion proteins and CBP, we studied the CBP protein in TC135 cells expressing the EWS-Fli-1 gene. We...
Effects of Cefodizime on Phagocytosis of COS-1 Ccells
Pyoung Han Hwang, Sang Yun Nam, Ho Keun Yi, Min Ho Kim, Kong Soo Kim, Jung Soo Kim
Clin Exp Pediatr. 1998;41(12):1632-1638.   Published online December 15, 1998
Purpose : Cefodizime is a new third-generation cephalosporin which has a structure and immunomodutation properties similar to cefotaxime. Various studies on cefodizime have demonstrated the direct eradication of bacteria in cooperation with the host defense mechanism, particularly with phagocytosis. We evaluated the effects of cefodizime on the phagocytosis of COS-1 cells transfected with FcγRI/γγ or FcγRIIA cDNA. Methods : Phagocytosis was...
Echocardiographic Study of the Ventricular Septal Defect with Subaortic Ridge
Kyeung Hee Moon, Pyoung Han Hwang, Chan Uhng Joo
Clin Exp Pediatr. 1997;40(5):629-634.   Published online May 15, 1997
Purpose : The easy recognition and characterization of a discrete or fixed subaortic ridge by echocardiography provides a method for prospective study of the coexistence of ventricular septal defect(VSD) and subaortic ridge. In the presence of a VSD, a subaortic ridge may be clinically silent, but the obstruction can progress if the VSD is surgically or spontaneously closed. This study...
Placental Transfer of Anti-H. influenzae Type b Specific IgG and IgG Subclasses
Soo Hee Chang, Moon Hwan Lee, Pyoung Han Hwang, Soo Chul Cho, Jung Soo Kim
Clin Exp Pediatr. 1995;38(12):1638-1644.   Published online December 15, 1995
Purpose : Haemophilus injluenzae type b (Hib) is one of the most important causes of invasive bacterial diseases in infants and children. In Korea, however, the proportion occupied by Hib as a cause of pediatric pathogen seems to be less compared to those of western countries. This study was performed to provide the epidemiologic and immunologic basis of H influenzae type...
Case Report
A Case of Wiskott-Aldrich Syndrome
Byoung Geun Lee, Soo Hee Chang, Soo Young Cho, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1994;37(11):1615-1619.   Published online November 15, 1994
Wiskott-Aldrich Syndrome is an X-linked disorder characterized by recurrent infection, thrombocytopenia and eczema. Various defects in cell-mediated immunity and deficient antibody response to carbohydrate antigens have been described. We experienced a case of Wiskott-Aldrich Syndrome of 28 months old male patient. He has been suffered from multiple petechiae with bleeding, recurrent pyogenic infections and generalized eczema since 3 months of...
Original Article
Comparison of Anticancer Drug Efficacy Using the Short-Term Microplate Culture and MTT Dye Reduction Assa
Nam Ki Kim, Kwang Rae Lee, Pyoung Han Hwang, Jung Soo Kim
Clin Exp Pediatr. 1993;36(10):1426-1433.   Published online October 15, 1993
Individual tumors, even those of the same histologic type, show varying sensitivity to specific cytotoxic agent. Therefore, sensitivity testing assume an increasingly important as an orientational aid in planning chemotherapy. In the past decade there have been many attempts to develop a chemosensitivity test that would predict the clinical effectiveness of various chemosherapeutic agents against human neoplasms. In the United States...
Changes of IgG Subclasses in the Sera of the Children with Kawasaki Disease
Seog Beom Cho, Sun Kyu Park, Pyoung Han Hwang, Jung Soo Kim, Sa Hyoung Choi
Clin Exp Pediatr. 1993;36(9):1197-1202.   Published online September 15, 1993
Kawasaki disease is an acute vasculitis of infancy and early childhood characterized by high fever, rash, mucositis, lymphadenopathy and coronary artery damage. The failure to indentify a causative organism using convetional culture and serological techniques, and the lack of response to antibiotics indicate that the disorder is probably not due to any known bacterial or viral pathogens. During...