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Original Article
A rise and fall in AST and ALT level in nonspecific reactive hepatitis
Tai Sung Kim, Tae Hyung Hur, Sun Jeong Lim, Joong Hyun Bin, Seung Hoon Hahn, So Young Kim, Hyun Hee Kim, Wonbae Lee
Clin Exp Pediatr. 2008;51(4):396-400.   Published online April 15, 2008
Purpose : The study was performed to assess the distribution of the diseases associated with nonspecific reactive hepatitis (NRH) for the past 10 years and to evaluate the change in the level of AST and ALT, and the difference by several variable factors. Methods : From January 1997 to December 2006, 646 patients had elevated liver enzymes among 22,763 patients admitted...
Normal antistreptolysin O titers of children by age group in the Gyeonggi-Incheon region
Jihun Lee, Yoo Jung Kim, Joong Hyun Bin, Ja Young Hwang, Seong Hoon Hahn, So Young Kim, Hyun Hee Kim, Wonbae Lee
Clin Exp Pediatr. 2007;50(10):965-969.   Published online October 15, 2007
Purpose : Measurement of antistreptolysin O (ASO) is often necessary to confirm a clinical diagnosis of recent streptococcal infection, especially in patients suspected of rheumatic fever and acute glomerulonephritis. Standard normal ranges for ASO should be established locally for each age group. We analyzed ASO to determine the upper limit of normal (ULN) ASO in children in the Gyeonggi-Incheon area. Methods...
Case Report
A case of multicystic dysplastic kidney and cystic adenomatoid malformation of the lung identified as incidental findings
Sun-Joo Lee, Ji-Hun Lee, Hyun-Hee Kim, So-Young Kim, Seung-Hoon Hahn, Ja-Young Hwang, Wonbae Lee
Clin Exp Pediatr. 2006;49(7):796-799.   Published online July 15, 2006
Multicystic dysplastic kidney and congenital cystic adenomatoid malformation of the lung are independent disorders, but both result from abnormal morphogenesis during embryogenesis. Congenital cystic adenomatoid malformation of the lung is associated with renal anomalies as well as other extrapulmonary anomalies and almost all cases with these anomalies are stillborn. We report a case of a 21-month-old male who was...
Original Article
The alteration of the positive rate of cytomegalovirus IgG antibody among preschool period children
Se-Young Seo, Sang-Jun Park, Ja-Young Hwang, Seong-Hoon Hahn, So-Young Kim, Hyun-Hee Kim, Wonbae Lee
Clin Exp Pediatr. 2006;49(1):51-55.   Published online January 15, 2006
Purpose : In order to evaluate the time of disappearance of cytomegalovirus(CMV) IgG antibodies from mothers, and the alteration of the positive rate of CMV IgG antibodies among preschool period children, we investigated the positive rate of CMV antibodies among preschool children. Methods : We studied 391 children who visited the Department of Pediatrics from March, 2001 to February, 2004. We...
Case Report
A Case of Young-Simpson Syndrome
Ja-Young Hwang, Se-Young Seo, Seong-Hoon Hahn, So-Young Kim, Hyun-Hee Kim, Wonbae Lee
Clin Exp Pediatr. 2005;48(9):1016-1018.   Published online September 15, 2005
Young Simpson syndrome is a rare malformation syndrome characterized by congenital hypothyroidism, dysmorphic face, mental retardation, severe postnatal growth retardation, hypotonia and congenital heart abnormalities. In the present study, we report a case of 4-year-old girl with Young Simpson syndrome for the first case in Korea.
Original Article
Comparison of Cytokine Expressions among Kawasaki Disease and Its Symptom-related Diseases
Ran Lee, So Hyun Park, Yu Jeong Kim, So Young Kim, Hyun Hee Kim, Wonbae Lee
Clin Exp Pediatr. 2004;47(5):567-573.   Published online May 15, 2004
Purpose : Kawasaki disease(KD) is an important acute febrile systemic vasculitis disease. Various cytokines have been studied to evaluate the pathogenesis of vascular injury. Some cytokines have been implicated for vascular injury, but there has been no direct evidence. We compared cytokine profiles of KD with Henoch-Sch nlein purpura(HSP), and febrile infections. Methods : We investigated the serum concentrations of...
Case Report
A Case of G-6-PD Guadalajara
Gi Bum Lee, Sun Ju Lee, Yoo Jung Kim, So Young Kim, Hyun Hee Kim, Bin Cho, Wonbae Lee
Clin Exp Pediatr. 2004;47(2):210-213.   Published online February 15, 2004
Glucose-6-phosphate dehydrogenase(G-6-PD) deficiency is a disease that shows hemolytic anemia and jaundice caused by injury of erythrocytes. The gene of G-6-PD has 13 exons and locates in Xq28, and over 150 mutations of this gene have been reported. We experienced a G-6-PD deficienct male patient who was suffering hemolytic anemia and jaundice confirmed by measuring low G-6-PD activity in the...
Clinical Lecture
Down Syndrome
Wonbae Lee
Clin Exp Pediatr. 2003;46(7):623-626.   Published online July 15, 2003
Original Article
Plasma G-CSF and GM-CSF Concentration and Amount of Their Receptors on the Granulocyte in Kawasaki Disease
Young-Kyoung Yoo, Gibum Lee, Hyun-Hee Kim, Soo-Young Kim, You-Jeong Kim, Wonbae Lee
Clin Exp Pediatr. 2003;46(4):376-381.   Published online April 15, 2003
Purpose : This study aimed to demonstrate the possible pathogenesis of granulopoiesis in patients of Kawasaki disease(KD) using quantitative analysis of G-CSF, GM-CSF and their CSFr. Methods : The plasma levels of G-CSF, GM-CSF, G-CSFr and GM-CSFr were studied in 14 patients in the acute phase of KD; 13 children with normal peripheral white blood cell counts were used as the...
Plasma G-CSF and GM-CSF Concentrations and Expression of their Receptors on the Granulocyte in Children with Leukocytosis
Won Seok Choi, Kyung Hwan Ryu, You Jeong Kim, So Young Kim, Hyun Hee Kim, Wonbae Lee
Clin Exp Pediatr. 2003;46(3):271-276.   Published online March 15, 2003
Purpose : Granulocyte-colony stimulating factor(G-CSF) and granulocyte macrophage-colony stimulating factor(GM-CSF) are principal cytokines in granulopoiesis and their physiologic effects are mediated through binding to specific cell surface receptors. Although it is known that the level of serum G-CSF and GM-CSF, and presentation of the receptors are increased in infectious diseases, there have been no studies to find the correlation between...
Detection Limit of Minimal Residual Disease in Leukemia Using Fluorescence in situ Hybridization
Jung Hyun Lee, So Young Kim, Hyun Hee Kim, Byung Kyu Suh, Wonbae Lee, Kyung Tai Whang
Clin Exp Pediatr. 2000;43(10):1364-1371.   Published online October 15, 2000
Purpose : The close relationship between the size of a tumor burden and the curability of acute leukemia is well established. Therefore, it is very important to detect residual leukemia accurately at low levels. Fluorescence in situ hybridization(FISH) techniques rely on chromosome-specific and gene specific DNA probes to identify numerical and structural chromosomal abnormalities. But the detection limit of FISH...
Antineutrophil Cytoplasmic Antibody in Kawasaki Disease
Soh-Yeon Kim, So Young Kim, Wonbae Lee, Kyong Su Lee, Ji-Min Kang
Clin Exp Pediatr. 1998;41(6):808-812.   Published online June 15, 1998
Purpose : Antineutrophil cytoplasmic antibody(ANCA) has been identified in various disorders including Wegener' s granulomatosis, microscopic polyarteritis and Kawasaki disease. Measuring this antibody has a diagnostic role. It facilitates monitoring disease activity and may also help understand the pathogenesis of the diseases in which it is found. We investigated the correlation between the hematologic findings and ANCA in acute Kawasaki disease and the diagnostic potential...
Use of Fluorescent in Situ Hybridization to Evaluate the Number of Chromosomes in Buccal Smear Cells in Normal Newborn Infants
Byoung Chan Lee, Jee Yeon Song, So Young Kim, Hyun Hee Kim, Seunghoon Han, Jong-In Byun, Wonbae Lee, Kyong Su Lee
Clin Exp Pediatr. 1995;38(11):1470-1475.   Published online November 15, 1995
Purpose : The diagnosis for chromosomal anomality has been made by obtaining cells in metaphase from peripheral blood and fresh tissue culture. But this method is difficult to perform because somewhat invasive and necessary time for cell culture and staining(48-72hr). Recently, the method to find numerical abnormalities in, autosome and sex chromosome of adult buccal mucosal smear by FISH was...
Case Report
A Case of Rhizomelic Chondrodysplasia Punctata
Yeon Dong Lee, Moon Young Song, Hyun Hi Kim, Seunghoon Han, Wonbae Lee
Clin Exp Pediatr. 1994;37(9):1312-1316.   Published online September 15, 1994
Chondrodysplasia punctata is a rare congenital disorder of bone, occuring in infants, which is characterized by raiographic manifestation of premature deposition of punctate calcific densitiy in epiphyseal areas, preformed in carilage. We experienced a case of rhizomelic type-chondrodysplsia punctata in a two day old female who showed short stature, symmetric shortening of proximal limbs, cataract, icthyositic skin lesion and characteristic coronal...