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Review Article
Evidence for adverse effect of perinatal glucocorticoid use on the developing brain
Young Pyo Chang
Clin Exp Pediatr. 2014;57(3):101-109.   Published online March 31, 2014

The use of glucocorticoids (GCs) in the perinatal period is suspected of being associated with adverse effects on long-term neurodevelopmental outcomes for preterm infants. Repeated administration of antenatal GCs to mothers at risk of preterm birth may adversely affect fetal growth and head circumference. Fetal exposure to excess GCs during critical periods of brain development may profoundly modify the limbic...

Original Article
The effects of shortened dexamethasone administration on remission rate and potential complications during remission induction treatment for pediatric acute lymphoblastic leukemia
Jae Wook Lee, Kwang Hee Lee, Young Joo Kwon, Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2007;50(12):1217-1224.   Published online December 15, 2007
Purpose : Due to its high potency against leukemic blasts, our institution has opted for the use of dexamethasone during acute lymphoblastic leukemia (ALL) remission induction, but in our most recent treatment protocol, CMCPL-2005, we shortened the length of steroid treatment from 4 to 3 weeks. We compared both the rates of remission induction and significant complications observed during induction...
A Study on the Effects of Early Surfactant Replacement and Gentle Ventilation in the Treatment of Respiratory Distress Syndrome
Yong Suk Lee, Ji Hye Lee, Sang Geel Lee
Clin Exp Pediatr. 2005;48(10):1096-1101.   Published online October 15, 2005
Purpose : Recently, early surfactant replacement and tidal volume based gentle ventilation has been a fundamental treatment of respiratory distress syndrome(RDS). The aims of this study were to survey the changes in ventilator care duration and rate of complication in RDS groups. Methods : We performed a retrospective study of 255 newborn infants less than 1,500 g admitted to the...
Prevention of Chronic Lung Disease with Early Dexamethasone Treatment in less than 32 Weeks Premature : Randomized Controlled Study
So Yun Shim, Su Jin Cho, Eun Ae Park
Clin Exp Pediatr. 2004;47(5):521-526.   Published online May 15, 2004
Purpose : The optimal timing and the consequences of dexamethasone therapy in chronic lung disease remain unknown. The purpose of this study was to determine whether early dexamethasone therapy would reduce the incidence of chronic lung disease and to determine the adverse effects and complications of prematurity associated with such therapy. Methods : Twenty neonates with hyaline membrane disease(dexamethasone n=10, placebo...
The Effect of Postnatal Dexamethasone Treatment on Hypoxic-Ischemic Brain Injury in Neonatal Rats
Chang Ro Park, Kyung Pil Park, Heng Mi Kim, Yoon Kyung Sohn
Clin Exp Pediatr. 2003;46(10):989-995.   Published online October 15, 2003
Purpose : Dexamethasone is frequently administered to prevent or treat chronic lung disease in human neonates who are also prone to hypoxic-ischemic(HI) insults. Recently, meta-analysis of the follow-up studies reveals a significantly increased odd ratio for the occurrence of cerebral palsy or an abnormal neurologic outcome, and there is conflicting evidence regarding the impact of dexamethasone exposure on HI brain...
Short-term Effects of Inhaled Corticosteroid Following Early Systemic Corticosteroid Administration in Premature Babies with Respiratory Distress Syndrome : A Preliminary Report
Hyeon-Soo Lee
Clin Exp Pediatr. 2000;43(11):1440-1445.   Published online November 15, 2000
Purpose : To asses the short-term effects of the topical corticosteroid, budesonide administered by metered dose inhaler(MDI) and spacer(Aerochamber MV 15) following systemic corticosteroid in premature babies with respiratory distress syndrome at birth. Methods : 19 premature babies <1800gm were randomly assigned to receive steroids(n=9) or not (n=10). The steroid group(n=9, GA[gestational age]=29.6¡¾2.9 weeks, BW[birth weight]=1.29¡¾0.35kg) received systemic dexamethasone for 48...
Comparison of Preventive Effect of RDS and Neonatal Morbidity between Antenatal Dexamethasone versus Ambroxol Administration
Eun Jeong, Kim, Seong Sook Jeon, Son Sang Seo
Clin Exp Pediatr. 2000;43(1):13-22.   Published online January 15, 2000
Purpose : Antenatal dexamethasone administration is associated with a significant lowering respiratory distress syndrome(RDS) incidence, but can increase neonatal infection. Ambroxol has been accepted as an alternative treatment to dexamethasone and is of at least equal efficacy but without adverse reaction. The aim of this study was to evaluate the effectiveness of ambroxol versus dexamethasone in RDS incidence and neonatal...
A Study of Factors Affecting Time of First Stool in Premature Infants
Hyeong Doo Cho, Je Woo Kim, Young Ah Lee, Hae Sun Yoon
Clin Exp Pediatr. 1999;42(12):1645-1650.   Published online December 15, 1999
Purpose : To assess the effect of gestational age and illness severity, and the effect of antenatal exposure to magnesium sulfate, glucocorticoids, and antibiotics, on the timing of the first stool in preterm infants. Methods : Medical records of all preterm infants admitted to the neonatal ward at Kangnam Sacred Heart Hospital between March 1998 and August 1998 were reviewed. We...
Effects of Growth Hormone Treatment on Alterations of Growth and Bone Metabolism in Rats Induced by Dexamethasone Administration
Woo Yeong Chung, Jeong Nyu Lee, Hye Kyoung Yoon
Clin Exp Pediatr. 1999;42(7):991-1002.   Published online July 15, 1999
Purpose : The aim of this study was to investigate the alterations of growth and bone metabolism in SDR induced by dexa administration and to evaluate the effects of GH treatment in dexamethasone(dexa) induced growth and bone metabolism in SDR. Methods : Forty-five female Sprague-Dawley rats(weight 150-170gm) were divided in 3 groups: Group 1(n=15) received normal saline as control, Group 2(n=15)...
Inhibitory Effects of Dexamethasone on Production IL-1α and TNF-α in Peripheral Blood Mononuclear Cells
Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1999;42(7):921-927.   Published online July 15, 1999
Purpose : IL-1α and TNF-α have a seminal role in the intial events of inflammation. An area of intense interest is the assessment of new therapeutic modalities that regulate inflammatory response in acute bacterial infection. We conducted this study to compare the inhibitory effects of dexamethasone on the secretion of proinflammatory cytokines, such as IL-lα and TNF-α from cord...
Effect of Dexamethasone on Preventing the Laryngeal Edema Following Extubation in Neonates
Joon Sung Kim, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
Clin Exp Pediatr. 1998;41(9):1180-1187.   Published online September 15, 1998
Purpose : We performed this study to evaluate the clinical efficacy and safety of dexamethasone in preventing laryngeal edema following exubation. Methods : We retrospectively reviewed the medical records of 100 neonates who underwent endotracheal intubation and mechanical ventilation. Subjects were divided into two groups; dexamethasone treated(60 cases, dexamethasone group) and non-treated(40 cases, control group). We examined the underlying diseases of...
Case Report
A Case of Dexamethasone induced Hypertrophic Cardiomyopathy in Neonate with Bronchopulmonary Dysplasia
Youn Jung Choi, Soon Mi Jung, Jae Kyun Yoon, Ki Hyeng Lee, Chang Sung Son, Chang Tocko
Clin Exp Pediatr. 1998;41(5):711-715.   Published online May 15, 1998
Although hypertrophic cardiomyopathy is uncommon in infant and children, we have experienced a case of dexamethasone induced hypertrophic cardiomyopathy in preterm baby who had bronchopulmonary dysplasia. This patient had hyaline membrane disease. Therefore, he received prolonged mechanical ventilation that resulted in bronchopulmonary dysplasia. After we carried out dexamethasone therapy for 7 days, hypertrophic cardiomyopathy appeared in his echocardiographic finding. We...
Original Article
The Treatment of Croup with Nebulized Budesonide and Intramuscular Dexamethasone
Jung Woo Lee, Young Ho Rah, Chong-Woo Bae, Sa Jun Chung, Yong Mook Choi
Clin Exp Pediatr. 1998;41(3):331-337.   Published online March 15, 1998
Purpose : Steroids have anti-inflammatory effects which reduces inflammation and edema of the tissue. Thus, corticosteroids have been used for treatment of croup. The aim this study is to compare and assess the effects of intramuscularly injected dexamethasone and nebulized budesonide in treatment of moderate or severe croup. Methods : Between July 1995 to June 1996, we have assessed 44 inpatients...
Effects of Early Dexamethasone Therapy in Neonatal Respiratory Distress Syndrome
Hyeon-Soo Lee
Clin Exp Pediatr. 1998;41(1):19-25.   Published online January 15, 1998
Purpose : To examine the clinical effects of early dexamethasone treatment from postnatal age of 1 week to ventilated preterm infants with respiratory distress syndrome. Methods : 14 one-week-old ventilator-dependent infants were enrolled. Seven received dexamethasone and another 7 did not receive. The doses of dexamethasone used were 0.25mg/kg twice daily for 3 days, 0.125mg/kg twice for 1 day, then 0.125mg/kg...
Effect of Nebulized Steroid(Budesonide) and Parenteral Steroid(Dexamethasone) on Children with Croup
Seon Mee Ahn, Jung Ae Sohn, Chul Zoo Jung, Dong Jin Lee, Young Hwan Lee, Yong Hoon Park
Clin Exp Pediatr. 1997;40(4):497-504.   Published online April 15, 1997
Purpose : This prospective study was conducted to evaulate the effect of nebulized steroid(budesonide) and parenteral steroid(dexamethasone) on chidren with croup. Methods : Twenty nine infants and children(6months-5years of age) admitted to hospital with croup were randomly assigned to receive either 1mg(4ml) of nebulized budesonide(17 patients) or 0.6mg/kg intramuscular injection of dexamethasone sodium phosphate(12 patients). Total croup score, heart rate...
The Therapeutic Effects of Dexamethasone Therapy in Neonate with Bacterial Meningitis
Eun Gyung Lee, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1995;38(5):602-611.   Published online May 15, 1995
Purpose : In experimental models of meningitis and in children with meningitis, dexametha-sone has been shown to reduce meningeal inflammation and to improve the outcome of disea-se. We studied the effects of dexamethasone administration in neonates(<2 month-old) with b-acterial meningitis. Methods : We retrospectively reviewed the medical records of 30 neonates admitted to the nursery, the Yonsei University College of Medicine...
Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(8):1035-1047.   Published online August 15, 1994
Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was...
The Therapeutic Effects of Dexamethasone in Bronchopulmonary Dysplasia
Min Joong Kwon, Kook In Park, Min Soo Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1993;36(12):1672-1680.   Published online December 15, 1993
We observed clinical features of 18 bronchopulmonary dysplasia (BPD) patients who were admitted to the neonatal intensive care unit in the Severance Hospital of Yonsei University College of Medicine from January 1. 1987 to June 30. 1991. Eight patients in whom ventilator settings were unchanged from for more than 5 days because of lack of improvement in pulmonary function. ...
Case Report
Cushing'S Syndrome In Childhood.
Duk Hi Kim, Nan Ae Kim, Do Kwang Yun, Duk Jin Yun, Eui Ho Hwang
Clin Exp Pediatr. 1983;26(6):593-597.   Published online June 30, 1983
There are little reports on Cushing’s syndrome in children. We have seen a case of Cushing’s syndrome due to left adrenal adenoma from 5 year 6 months old girl. She has been complained from obesity with, buffalo hump, hirsutism and vaginal spotting. Her blood cortisol levels were high and no diurnal variation. No suppression was occurred following dexamethasone 1 mg overnight or 4 mg...
Original Article
Clinical and Immunologic Studies on Epidemic Encephalitis.
Cheul Woo Park, Kwang Rhun Koo, Song Soo Moon, Ho Seung Yoo, Chang Soo Ra
Clin Exp Pediatr. 1983;26(6):545-552.   Published online June 30, 1983
Epidemic encephalitis in the Korea is caused by arbovirus (Japanese encephalitis virts). And this acute illness occurs annually during the late summer and early autumn months and is more prevalent among children under 15 years with high mortality. 130 cases of epidemic encephalitis were hospitalized at the Department of Pediatrics, Chosun University Hospital, during the period of August-October, 1982. Authors investigated hemaggulutination...