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Original Article
Association of CD4+CD25+FoxP3+ regulatory T cells with natural course of childhood chronic immune thrombocytopenic purpura
Bo Ra Son, Ji Yoon Kim
Clin Exp Pediatr. 2015;58(5):178-182.   Published online May 22, 2015
Purpose

The purpose of this study was to determine the frequency of CD4+CD25+FoxP3+ regulatory T cells (Treg) in the peripheral blood of patients with childhood chronic immune thrombocytopenic purpura (ITP) exhibiting thrombocytopenia and spontaneous remission. The findings of this study indicate the possibility of predicting spontaneous recovery and pathogenesis of childhood chronic ITP.

Methods

Eleven children with chronic ITP (seven thrombocytopenic and four...

Outcome of allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia in second complete remission: a single institution study
Eun-Jung Lee, Ji Yoon Han, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Dae-Chul Jeong, Bin Cho, Hack-Ki Kim
Clin Exp Pediatr. 2012;55(3):100-106.   Published online March 16, 2012
Purpose

The survival rate for childhood acute lymphoblastic leukemia (ALL) has improved significantly. However, overall prognosis for the 20 to 25% of patients who relapse is poor, and allogeneic hematopoietic stem cell transplantation (HSCT) offers the best chance for cure. In this study, we identified significant prognostic variables by analyzing the outcomes of allogeneic HSCT in ALL patients in second complete...

Case Report
A case of regression of atypical dense deposit disease without C3 deposition in a child
Min Sun Kim, Pyoung Han Hwang, Mung Jae Kang, Dae-Yeol Lee
Clin Exp Pediatr. 2010;53(7):766-769.   Published online July 31, 2010

Dense deposit disease (DDD) is a rare disorder characterized by the deposition of abnormal electron-dense material within the glomerular basement membrane of the kidneys. The diagnosis is made in most patients between 5 and 15 years of age, and within 10 years, approximately half of the affected patients progress to end-stage renal disease. We report a rare case of regressive...

Original Article
Remission rate and remission predictors of Graves disease in children and adolescents
Sun Hee Lee, Seong Yong Lee, Hye Rim Chung, Jae Hyun Kim, Ji Hyun Kim, Young Ah Lee, Sei Won Yang, Choong Ho Shin
Clin Exp Pediatr. 2009;52(9):1021-1028.   Published online September 15, 2009
Purpose : Medical therapy is the initial treatment for children with Graves disease to avoid complications of other treatments. However, optimal treatment for childhood Graves disease is controversial because most patients require relatively long periods of medical therapy and relapse is common after medication discontinuation. Therefore, this study aimed to search clinical or biochemical characteristics that could be used as...
The effects of shortened dexamethasone administration on remission rate and potential complications during remission induction treatment for pediatric acute lymphoblastic leukemia
Jae Wook Lee, Kwang Hee Lee, Young Joo Kwon, Dae Hyoung Lee, Nak Gyun Chung, Dae Chul Jeong, Bin Cho, Hack Ki Kim
Clin Exp Pediatr. 2007;50(12):1217-1224.   Published online December 15, 2007
Purpose : Due to its high potency against leukemic blasts, our institution has opted for the use of dexamethasone during acute lymphoblastic leukemia (ALL) remission induction, but in our most recent treatment protocol, CMCPL-2005, we shortened the length of steroid treatment from 4 to 3 weeks. We compared both the rates of remission induction and significant complications observed during induction...
Analysis of the association between bronchial hyperresponsiveness and genetic polymorphism of β2-adrenoceptor in adolescents with long-term asthma remission
Hee Kang, Young Yull Koh
Clin Exp Pediatr. 2007;50(6):556-564.   Published online June 15, 2007
Purpose : We hypothesized that the persisting bronchial hyperresponsiveness (BHR) of adolescents with asthma remission may be controlled mainly by genetic factors, and the BHR of symptomatic asthma by airway inflammation. β2-adrenoceptor gene is considered to be a candidate gene in the development of BHR. Thus, β2-adrenoceptor gene polymorphism may be associated with the BHR of adolescents with asthma remission,...
Peripheral Blood Eosinophil Counts and Serum ECP in Adolescents with Long-term Asthma Remission and Persistent Bronchial Hyperresponsiveness : Comparison with Adolescents with Symptomatic Asthma
Hee Kang, Young Yoo, Jinho Yu, Yang Park, Young Yull Koh
Clin Exp Pediatr. 2003;46(10):1013-1018.   Published online October 15, 2003
Purpose : Bronchial hyperresponsiveness(BHR) in asthma is thought to be a consequence of underlying airway inflammation. But the mechanism responsible for persistent BHR in adolescents with long-term asthma remission is poorly understood. The aim of this study was to examine whether BHR in adolescents with asthma remission is associated with peripheral blood eosinophilia and/or increased serum levels of eosinophil cationic...
Induction Chemotherapy with BH-AC, Idarubicin, and 6-Thioguanine in Childhood Acute Myelogenous Leukemia
Hyo Jeong Han, Hyoung Jin Kang, Jun Ah Lee, Hyoung Soo Choi, Hyeon Jin Park, Ki Woong Seong, Eun Sun Yoo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1998;41(2):209-215.   Published online February 15, 1998
Purpose : We have undertaken this study to evaluate the effects of induction chemotherapy involving BH-AC, idarubicin, and 6-thioguanine(6-TG). Methods : BH-AC 300mg/m2/day was administered intravenously over three hours for seven consecutive days. Idarubicin 12mg/m2/day was administered intravenously for three days. 6-TG 100 mg/m2/day was administered orally for seven days. Intrathecal ara-C was administered on the first day of treatment. Results...
Clinical Study of Graves` Diseasein Children : Remission and Relaps
Moon Young Song, Bin Cho, Byung Churl Lee
Clin Exp Pediatr. 1996;39(3):389-396.   Published online March 15, 1996
Purpose : This study was carried out to evaluate the age and sex distribution, clinical manifestation, presence of the antithyroid antibody, the clinical outcome following antithyroid drug treatment in children with Graves' disease. Methods : A total 45 children with Graves' disease were entered into the study. Diagnosis was based on clinical manifestation, elevated thyroid function and increased homogeneous 99mTc thyroid...
Case Report
A Case of Spontaneously Remitted Congenital Minimal Change Nephrotic Syndrome
Tae Sun Ha, Kyung Hee Lee, Beom Soo Park, Heon Seok Han
Clin Exp Pediatr. 1995;38(9):1288-1292.   Published online September 15, 1995
Nephrotic syndrome is a condition with severe proteinuria, hypoalbuminemia, and edema. When the syndrome develops within the first 3 months of life, it is generally considered as congenital and the overall outcome in this group seems to be worse than in miniaml change lesion that occurs at an older age regardless of the pathologic findings. A female infant with congenital nephrotic...
Original Article
A comparison between remission and nonremission groups of hepatitis B virus-associated membranous nephropathy in children.
Kang Yong Park, Hye Won Park, Yon Ho Choe, Tae Sun Ha, Il Soo Ha, Yong Choi, Kwang Wook Ko, Hyun Soon Lee, Yong Il Kim
Clin Exp Pediatr. 1991;34(11):1512-1518.   Published online November 30, 1991
We analyzed medical records of 35 patients with Hepatitis B virus-associated Membranous Nephropathy proven by kidney biopsy at SNUCH from Jan. 1975 to Jun. 1990. Clinical presentation, laboratory and pathologic findings were compared between remission group (who are free of proteinuria and edema in current status) and nonremission group (who have either proteinuria or edema). Age at onset was younger in remission group (4.51 ±2.93...