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Original Article

Prednisolone impairs trabecular bone score changes in adolescents with 21-hydroxylase deficiency

Pattara Wiromrat, Yutapong Raruenrom, Phanpaphorn Namphaisan, Nantaporn Wongsurawat, Ouyporn Panamonta, Chatlert Pongchaiyakul

Background: Individuals with 21-hydroxylase deficiency (21OHD) require lifelong glucocorticoid (GC) therapy, which increases their risk of fragility fractures. However, fractures in GC-treated individuals can occur at normal bone mineral density (BMD) levels, suggesting an alteration in the bone microarchitecture.
Purpose: To evaluate trabecular bone microarchitecture and its changes in adolescents with 21OHD. Methods: We enrolled 38 adolescents with 21OHD for whom complete...

DOI: https://doi.org/10.3345/cep.2024.01060 [Epub ahead of print]

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