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- Review Article
- Clinical utilization of cord blood over human health: experience of stem cell transplantation and cell therapy using cord blood in Korea
- Young-Ho Lee
- Clin Exp Pediatr. 2014;57(3):110-116. Published online March 31, 2014
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Cord blood (CB) has been used as an important and ethical source for hematopoietic stem cell transplantation (SCT) as well as cell therapy by manufacturing mesenchymal stem cell, induced pleuripotential stem cell or just isolating mononuclear cell from CB. Recently, the application of cell-based therapy using CB has expanded its clinical utility, particularly, by using autologous CB in children with...
- Original Article
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Youn Ho Shin, Jinho Yu, Kyung Won Kim, Kangmo Ahn, Seo-Ah Hong, Eun Lee, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Ji-Won Kwon, Byoung-Ju Kim, Hyo-Bin Kim, Jung Yeon Shim, Woo Kyung Kim, Dae Jin Song, So-Yeon Lee, Soo Young Lee, Gwang Cheon Jang, Dong In Suh, Hyeon-Jong Yang, Bong Sung Kim, Suk-Joo Choi, Soo-Young Oh, Ja-Young Kwon, Kyung-Ju Lee, Hee Jin Park, Pil Ryang Lee, Hye-Sung Won, Soo-Jong Hong
- Clin Exp Pediatr. 2013;56(10):439-445. Published online October 31, 2013
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Purpose Previous studies suggest that the concentration of 25-hydroxyvitamin D [25(OH)D] in cord blood may show an inverse association with respiratory tract infections (RTI) during childhood. The aim of the present study was to examine the influence of 25(OH)D concentrations in cord blood on infant RTI in a Korean birth cohort.
Methods The levels of 25(OH)D in cord blood obtained from 525 Korean...
- Review Article
- Umbilical cord blood transplantation
- Hong Hoe Koo, Hyo Seop Ahn
- Clin Exp Pediatr. 2012;55(7):219-223. Published online July 17, 2012
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Since the first umbilical cord blood transplantation (CBT) in 1998, cord blood (CB) has now become one of the most commonly used sources of hematopoietic stem cells for transplantation. CBT has advantages of easy procurement, no risk to donor, low risk of transmitting infections, immediate availability and immune tolerance allowing successful transplantation despite human leukocyte antigen disparity. Several studies have...
- Original Article
- Hematopoietic stem cell transplantation in children with acute leukemia: similar outcomes in recipients of umbilical cord blood versus marrow or peripheral blood stem cells from related or unrelated donors
- Eun Sang Yi, Soo Hyun Lee, Meong Hi Son, Ju Youn Kim, Eun Joo Cho, Su Jin Lim, Hee Won Cheuh, Keon Hee Yoo, Ki Woong Sung, Hong Hoe Koo
- Clin Exp Pediatr. 2012;55(3):93-99. Published online March 16, 2012
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Purpose This study compared outcomes in children with acute leukemia who underwent transplantations with umbilical cord blood (UCB), bone marrow, or peripheral blood stem cells from a human leukocyte antigen (HLA)-matched related donor (MRD) or an unrelated donor (URD).
Methods This retrospective study included consecutive acute leukemia patients who underwent their first allogeneic hematopoietic stem cell transplantation (HSCT) at Samsung Medical Center between...
- Relationship between cord blood level of IL-12 in preterm newborns and development of wheezing
- Hyo Jung Yu, Eun Ae Park, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye Sook Park, Eun Hee Ha
- Clin Exp Pediatr. 2008;51(7):754-759. Published online July 15, 2008
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Purpose : Abnormal activation patterns of Th1/Th2-cells have been suggested to increase the prevalence of allergic diseases. Prevention is regarded as an important corner stone in the management of allergic diseases. In this study, we have investigated the relationship between cord blood levels of IL-4, IL-10, and IL-12 in preterm newborns and the development of allergic respiratory diseases in infancy Methods... -
- A pilot study of neuroprotection with umbilical cord blood cell transplantation for preterm very low birth weight infants
- Kyu Young Chae, Kyu Hyung Lee, So-Hee Eun, Byung Min Choi, Baik-Lin Eun, Hoon-Chul Kang, Myung Jae Chey, Nam Keun Kim, Doyeun Oh
- Clin Exp Pediatr. 2007;50(9):882-890. Published online September 15, 2007
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Purpose : Preterm very low birth weight infant have high rate of adverse neurodevelopmental sequale. Recently, there have been lots of reports that human umbilical cord blood transplantation ameliorates functional deficits in animal models as hypoxic ischemic injury. This pilot study was undertaken to determine the clinical efficacy and safety of autologous umbilical cord blood cell transplantation for preventing neurodevelopmental... -
- Cord blood IL-10, IL-12 in preterm newborns as predictors of respiratory distress syndrome and bronchopulmonary dysplasia
- Jee Yoon Park,, Ji Young Kim, Soo Jin Cho, Young Ju Kim, Hye sook Park, Eun Hee Ha, Eun Ae Park
- Clin Exp Pediatr. 2007;50(3):248-254. Published online March 15, 2007
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Purpose : Inflammation plays a major role in the pathogenesis of RDS and BPD in the immature lung. We investigated the possible role of IL-10 and IL-12 in the cord blood of preterm newborns with RDS or BPD. Methods : Forty preterm newborns whose mothers received antenatal care at Ewha Womans University Mokdong Hospital between January 2003 to June 2005, and... -
- Ex vivo Expansion and Clonal Maintenance of CD34＋ Selected Cells from Cord Blood and Peripheral Blood
- Soon Ki Kim, Hye Yoon Ghil, Sun U. Song, Jong Weon Choi, Sang Kyu Park
- Clin Exp Pediatr. 2005;48(8):894-900. Published online August 15, 2005
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Purpose : Because of the unavailability of marrow transplantation, umbilical cord blood (CB) is increasingly being used. We evaluated the potential of ex vivo expansion and clonality in CD34＋ cells separated from cord blood source and mobilized peripheral blood (PB) in a serum-free media. Methods : The CD34＋ cells, selected from CB and mobilized PB, were expanded with hematopoietic growth... -
- Perinatal Factors Affecting Thyroid Stimulating Hormone(TSH) and Thyroid Hormone Levels in Cord Blood
- Eun Young Kim, Sang Kee Park, Chang Hun Song, Sung-Chul Lim
- Clin Exp Pediatr. 2005;48(2):143-147. Published online February 15, 2005
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Purpose : The aim of the this study was to evaluate the effect of various perinatal conditions on TSH and thyroid hormone levels in cord blood. Methods : Cord blood samples were collected from 130 neonates immediately after birth. TSH, T3, and free T4 levels were measured by the radioimmunoassay(RIA) method. The effects of gestational age, sex, birth weight, delivery method,... -
- Umbilical Cord Arterial Concentrations of Isoprostane(8-iso-PGF2α) in Newborn Infants
- Kun Song Lee, Yoon Hee Ji, Young Pyo Chang
- Clin Exp Pediatr. 2003;46(9):865-870. Published online September 15, 2003
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Purpose : We measured the umbilical cord arterial concentrations of isoprostane(8-iso-PGF2α) and intended to decide whether the umbilical cord arterial concentrations of isoprostane could be used as a useful parameter for lipid peroxidation in newborn infants. Methods : The isoprostane and malondialdehyde(MDA) concentrations of the umbilical cord were measured by enzyme immunoassay and TBARS(thiobarbituric acid reactive substance) assay in 33... -
- Case Report
- A Successful Transplant of HLA-3 Loci Mismatched Umbilical Cord Blood into a Patient with Acute Myeloid Leukemia from an Unrelated Donor
- Byoung Chul Kwon, Kyung Mi Shin, Sung Chul Won, Chuhl Joo Lyu, Chang Hyun Yang, Hyun Ok Kim
- Clin Exp Pediatr. 2002;45(7):912-916. Published online July 15, 2002
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Cord blood is a useful source of allogeneic hematopoietic stem cells for bone marrow reconstitution. The number of umbilical cord blood transplants is increasing worldwide. In this a case 15- month-old boy with acute myeloid leukemia was treated with umbilical cord blood transplant from an HLA-3 loci mismatched unrelated donor. Granulocyte recovery greater than 500/mm3 occurred at day 49, and... -
- Original Article
- The Relationship of Maternal Disorder with Neonatal Cord Blood Leptin - Preeclampsia, Diabetes Mellitus, Antenatal Steroid Treatment -
- Seon Mi Park, Eun Young Kim, Yeong Bong Park, Sang Kee Park
- Clin Exp Pediatr. 2001;44(10):1119-1126. Published online October 15, 2001
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Purpose : Leptin, the product of the ob gene is primarily by adipose tissue but also by the human placenta. Leptin may also have a role as a regulator of fetal growth and development during normal pregnancy as well as in pregnancies associated with anomalous fetal growth. Our study aimed to discover whether or not leptin concentration in neonatal cord... -
- Neonatal Cord Blood Leptin : Its Relationship to Birth Weight
- Byung Churl Lee, In Kyung Sung, Byung Kyu Suh, Moon Young Song
- Clin Exp Pediatr. 1999;42(5):637-643. Published online May 15, 1999
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Purpose : The purpose of this study was to correlate birth weight, skinfold thickness, gestational age, BMI and ponderal index of neonates and maternal status with cord serum leptin concentration. Methods : Sixty newborns were enrolled in this study. Standard growth curves were used to categorize infants as appropriate(AGA), large(LGA), or small for gestational age(SGA). Gestational age, birth weight, length, skinfold... -
- Inhibitory Effects of Actinomycin-D and Pentoxifylline on the Production of IL-1α and TNF-α by Human Cord and Adult Blood Mononuclear Cells
- Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
- Clin Exp Pediatr. 1998;41(12):1700-1708. Published online December 15, 1998
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Purpose : An area of intense intrest is assessment of new therapeutic modalities that regulate the inflammatory response in acute bacterial infection is proving to be an area of interest these days. So we conducted this study to compare the inhibitory effects of actinomycin-D and pentoxifylline on the production of IL-lα and TNF-α from cord blood mononuclear cells(MC) to those... -
- The Espression of Fcγ Receptors and Mac-1 in Cord and Adult Blood Monocytes and Lymphocytes and Production of Interleukin-8 by Cord and Adult Blood Mononeuclear Cells Stimulated by Lipopolysacchride
- Kyung Hyo Kim, Gyoung Hee Kim
- Clin Exp Pediatr. 1997;40(12):1660-1669. Published online December 15, 1997
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Purpose : The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fcmoiety of IgG(FcγR) are important in antibodymediated clearance of microbes by monocytes/macrophages and immune regulation in lymphocytes. As an approach to understanding their role in neonatal life, we have compared the constitutive expression of the three Fc receptors-FcγRI(CD64), FcγRII(CD32) and FcγRIII(CD16)-by neonatal and adult blood monocytes... -
- Immunophenotypic Analysis of Umbilical Cord Blood Stem Cells
- Won Ho Kang, Tai Ju Hwang, Hoon Kook, Byung Ju Kim
- Clin Exp Pediatr. 1997;40(11):1572-1581. Published online November 15, 1997
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Purpose : Since umbilical cord blood (UCB), which used to be discarded, was found to be a source of enriched hematopoietic stem and progenitor cells, basic research to elucidate characteristics of UCB hematopoietic stem cells (HSCs) and its clinical application to bedside transplantation have been attempted. Moreover, stem cell transplantation (SCT) has expanded its role, not only in hematopoietic reconstitution, but in cancer therapy,... -
- The Expression of Fcγ Receptors in Cord and Adult Blood Granulocytes
- Kyung Hyo Kim, Gyoung Hee Kim, Ju Young Seoh, Hae-Kyung Park
- Clin Exp Pediatr. 1997;40(6):794-800. Published online June 15, 1997
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Purpose : The immature neonatal immune system is thought to result in increased risk of infection. Receptors for the Fc moiety of IgG(FcγR) are important in antibody-mediated clearance of microbes by granulocytes and monocytes/macrophages. As an approach to understand their role in neonatal life, we compared the constitutive expression of the three Fc receptors-FcγRI(CD64), Fcγ RII(CD32) and FcγRIII(CD16)-of neonatal granulocytes with those of adult... -
- Production of Interleukin-1α and Tumor Necrosis Factor-α by Human Cord and Adult Blood Mononuclear Cells Stimulated by TSST-1 and LPS
- Eun Ae Park, Kyung Hyo Kim, Gyoung Hee Kim
- Clin Exp Pediatr. 1997;40(5):690-700. Published online May 15, 1997
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Purpose : Immature immunological defens mechanism in the neonate may contribute to the high susceptibility to overwhelming sepsis. S. aureus TSST-1 and E. coli LPS known as one of the important pathogens of septic shock or toxic shock induce massive release of various cytokines, such as tumor necrosis factor-alpha(TNF-α) and interleukin-1α(IL-1α) produced from peripheral blood mononuclear cells(PBMC). In contrast, limited... -
- The Correlation between CD34+ Cell and Nucleated RBC Counts in Human Cord Blood
- Seong Man Lee, Kyu Chan Kim, Sang Woo Kim
- Clin Exp Pediatr. 1996;39(10):1422-1428. Published online October 15, 1996
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Purpose : Human umbilical cord blood as a potential source of hematopoietic stem cell for stem cell transplantation in children has recently been advocated. Clinical application of cord blood transplantation, however, requires adequate blood volume and number of stem cells. Currently, the number of stem cells in the cord blood is usually measured by flowcytometry, which requires strict quality control and high costs. Here,... -
- Stem Cell Transplantation in Umbilical Cord Blood(I) Expansion Effects of Stem Cells in Umbilical Cord Blood with Various Hematopoietic Growth Factors
- Kyung Ha Ryu, Myung Hee Chung
- Clin Exp Pediatr. 1995;38(5):675-684. Published online May 15, 1995
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Stem cell transplantation is used for the patients lacking the capability of production of hem-atopoitic cells. Recently, there have been a few studies using the umbilical cord blood as a sou-rce of stem cells, however it remains unclear whether umhhilical cord blood contains sufficient amount to reconstitute the patient. Our study was designed to know that umbilical cord blood is proper... -
- A Study of Calcium and Inorganic Phosphorus Levels in Maternal and Cord Blood
- Woo Ha You, Seung Wan Lee, Jong Lin Rhi, Hyun Joo Jeong, Yong Joon Shin, Chung Hak Park
- Clin Exp Pediatr. 1992;35(4):492-498. Published online April 15, 1992
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A study of serum calcium, phosphorus levels in mother and umbilical cord was carried on 39 mother/baby pairs who were admitted to DAE HAN Hospital from Nov.1989 through Feb.1990. The results abstained were as follows: 1) The mean serum calcium levels of maternal and cord blood were 8.92¡¾10.59mg% and 9. 88¡¾10.74mg% repectively. The mean serum calcium of cord blood was statiscally higher than... -
- A study on Serum Calcium, Phosphorus, Magnesium and Parathyroid Hormone Levels of Cord Blood in Newborn.
- Kwang Rhun Koo, Chang Soo Ra
- Clin Exp Pediatr. 1986;29(2):163-169. Published online February 28, 1986
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A study of serum calcium, magnesium, phosphorus and PTH levels of cord blood in newborn infants and those of serum levels of maternal blood at parturition was carried on 38 mother/baby pairs who were admitted to Chosun University Hospital from November, 1982 throgh Desember, 1982. The following results were obtained; 1) The serum calcium levels of cord blood in 38 cases of the... -
- A Study of Calcium and Inorganic Phosphorus Levels in Umbilical Cord Blood.
- Woo Yoeng Chung
- Clin Exp Pediatr. 1983;26(9):850-856. Published online September 30, 1983
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The levels of serum calcium and inorganic phosphorus were studied in 50 pairs of umbilical cord and maternal blood at parturition and further more I try to compare statistically with each other. The reuslts obtained were summarized as follows: 1) The mean serum calcium levels of cord and maternal blood were 10.52±0.81 mg% and 9.23±1.16 mg% respectively. The mean serum calcium level of... -
- A Study on Serum Cortical and Glucose Levels of Cord Blood in Newborn.
- Ki Chang Song, Chang Soo Ra
- Clin Exp Pediatr. 1983;26(4):339-348. Published online April 30, 1983
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We have studied the serum cortisol levels of cord blood in newborn infants (40 cases) and. the serum cortisol levels of maternal blood at parturition (40 cases). And we also studied the serum glucose levels of cord blood in cases of newborn infant. For the purpose of analysis， the study objects were divided into two groups: normal vaginal delivery (35 cases) and cesarian... -
- A Study of Correlation between Bilirubin Leel of Cord Blood and Neonatal Hyperbilirubinemia.
- Hwan Sup Kang, Chang Il Ahn
- Clin Exp Pediatr. 1982;25(10):1039-1045. Published online October 31, 1982
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For adequate management and prevention of severe sequellae of neonatal hyperbilirubinemia^ such as kernicterus, early detection of its presence is very important in fields of neonatology. The author studied the correlation between bilirubin level of the cord blood and neonatal hyperbilirubinemia in random sampled 169 neonates of 729 deliveries during a period of five months since December 1981 at the Kyung Hee University Hospital.... -
- Study on cord blood hemoglobin and etiology of neonatal anemia.
- Chul Lee, Hae Jung Cho, Myung Ho Lee, Sook Ja Park, Young Hae Lee
- Clin Exp Pediatr. 1982;25(9):906-913. Published online September 30, 1982
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Capillary samples obtained by skin prick, generally from the heel or toe, have a higher hemoglobin Concentration than simultaneously collected venous samples. So, capillary values should not be compared to previously obtained cord venous blood values when one is looking for changes in hemoglobin, concentration during the first week of life. Cord venous blood hemoglobin and hemotocrit of 309 normal newborn infants have been... -
- Clinical Analysis of Cord Serum Immunoglobulin M.
- Duk Jin Yun, Kwang Ho Kim, Kwan Sub Chung, Gui Nyung Lee
- Clin Exp Pediatr. 1981;24(6):517-524. Published online June 15, 1981
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Determination of the immunoglobulin M(IgM) in umbilical cord sera has been advocated as a screening test for intrauterine infection, since the IgM is produced by the fetus and is not transported across the placenta from mother. The low level of IgM in normal neonate is thought to reflect the infrequent encounter of antigenic stimuli by the futus, upon exposure to... -
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