• Search
  • Advanced Search

Search

  • HOME
  • Search
Medical Lecture Course
Endogenous Neurogenesis in Postnatal Brain
Yun Sil Chang
Clin Exp Pediatr. 2005;48(8):806-812.   Published online August 15, 2005
Repair mechanisms in the postnatal and mature central nervous system(CNS) have long been thought to be very limited. However recent works have shown that the mature CSN contains neural progenitors, precursors, and stem cells that are capable of generating new neurons, astrocytes, and oligodendrocytes especially in germinative areas such as the subventricular zone of the lateral ventricles, the dentate gyrus...
Original Article
Serum Nitric Oxide and Tumor Necrosis Factor-α Levels in Patients with Kawasaki Disease
Ji Hye Park, Jee Seon Shin, Young Mi Hong
Clin Exp Pediatr. 2005;48(7):772-778.   Published online July 15, 2005
Purpose : Kawasaki disease(KD) is a systemic panvasculitis that causes coronary artery lesions. KD is accompanied by immunoregulatory abnormalities. Nitric oxide(NO) can induce relaxation of blood vessels by activating guanylate cyclase in smooth muscle cells and high levels of NO may result in coronary artery lesions. We investigated tumor necrosis factor(TNF)-α and NO production before and after intravenous immunoglobulin(IVIG) therapy...
Antibiotic Sensitivity to the Major Causative Organisms of Acute Urinary Tract Infection in Children
Yung Kwun Lee, Hee Chul Lee, Jung Mi Chun, So Young Yoon, Woo Gill Lee, Son Moon Shin
Clin Exp Pediatr. 2005;48(7):760-765.   Published online July 15, 2005
Purpose : We studied the changes in antibiotic sensitivity to the causative organisms of urinary tract infection(UTI), in order to provide useful information on the choice of adequate drugs in the treatment of UTI. Methods : We retrospectively analyzed the major causative organisms and their antibiotic sensitivities in 69 patients diagnosed with UTI in the Department of Pediatrics, Samsung Cheil Hospital...
Etiology and Clinical Features of Viral Lower-respiratory Tract Infections in Children in Winter, 2003
Byung Ho Yun, Hee Chul Lee, Jung Mi Chun, So Young Yoon, Woo Gill Lee, Son Moon Shin
Clin Exp Pediatr. 2005;48(7):723-730.   Published online July 15, 2005
Purpose : This study was performed to characterize the etiology and clinical features of acute viral lower-respiratory tract infections(LRI). Methods : Etiologic agents and clinical features of acute viral LRI were studied from October. 2003 through March. 2004 in hospitalized children with LRI(253 cases) at Samsung Cheil Hospital. The viruses were identified by indirect immunofluorescent method. Medical records of patients with...
Etiology of Community-acquired Bacteremia in Healthy Children
Hyung Tae Kim, Hyun Oh Jang, Jin Soo Moon, Seung Yeon Nam, Dong Wook Kim, Chong Guk Lee, Chong Rae Cho
Clin Exp Pediatr. 2005;48(7):716-722.   Published online July 15, 2005
Purpose : A full view of the spectrum of all bacterial diseases in healthy children is essential to the establishment of public health priorities. Accurate information on the relative importance of the various pathogens in terms of the age of the affected patients, the site of infection and the case fatality rate are valuable to the clinician in choosing antimicrobial...
Validity of Bioelectrical Impedance Analysis(BIA) in Measurement of Human Body Composition
Hyung Suck Kim, Su Yung Kim
Clin Exp Pediatr. 2005;48(7):696-700.   Published online July 15, 2005
Propose : Body composition by bioelectrical impedance analysis(BIA) is a very useful method of analysing body composition. BIA is non-invasive, inexpensive, nonhazaedous and reproducible technique. The aim of this study was to determine the level of agreement between body composition measurement by BIA and dual-energy X-ray absorptiometry(DEXA). Methods : Data was examined in 100 children(male 58; female 42), who visited Pusan...
Case Report
A Case of Infantile Hemangioendothelioma of the Liver Treated with Hepatic Embolization and Lobectomy
Jae Seon Kim, Soo Kyung Moon, Hye Sun Yoon, Tae Seok Lee
Clin Exp Pediatr. 2005;48(6):660-664.   Published online June 15, 2005
Infantile hemangioendothelioma(IHE) of the liver is the most common vascular tumor in infants before the age of 6 months. It is a histologically benign tumor with potentially life-threatening complications. The clinical manifestations are variable, ranging from asymptomatic forms to intractable high-output heart failure. In addition, abdominal mass, intraperitoneal hemorrhage due to rupture of mass, respiratory distress, hematologic abnormalities and jaundice...
Original Article
Near-Infrared Spectroscopy for Monitoring Cerebral Hemodynamics in Hyperbilirubinemia-induced Newborn Piglets
Jong Hee Hwang, Chang Won Choi, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2005;48(6):649-654.   Published online June 15, 2005
Purpose : The present study examined how changes in cerebral hemodynamics in newborn piglets with bilirubin infusion can be evaluated by near infrared sepctroscopy(NIRS). Methods : Seventeen newborn piglets were randomly divided into the following three experimental groups : six in the control group(CG); seven in the bilirubin infusion group(BG), and four in the bilirubin infusion with 7-nitroindazole group(NG). To...
Bacteremia in Pediatric Cancer Patients : Causative Organisms and Antibiotic Sensitivities
Yong-Han Kim, Hyun-Dong Lee, Jeong-Ok Hah
Clin Exp Pediatr. 2005;48(6):619-623.   Published online June 15, 2005
Purpose : Bacteremia in immunocompromised pediatric cancer patients can lead to high morbidity and mortality, if not treated early and properly. The incidence and antibiotic sensitivities to common pathogens of bacteremia in pediatric cancer patients are liable to change, according to region and time. We investigated the causative organisms and antibiotic sensitivities of bacteremia in pediatric cancer patients to assess...
Clinical Outcome and Prognostic Factors of Acute Respiratory Distress Syndrome in Children
Jung-Min Ko, Eun-Ju Ha, Eun-Hee Lee, So-Youn Lee, Hyo-Bin Kim, Soo-Jong Hong, Seong-Jong Park
Clin Exp Pediatr. 2005;48(6):599-605.   Published online June 15, 2005
Purpose : The purpose of this study was to examine the causes, clinical courses and outcomes in children with acute respiratory distress syndrome(ARDS), and evaluate the physiologic variables as prognostic factors in the patients. Methods : Retrograde medical chart review was carried out in 24 patients who were diagnosed with ARDS at the pediatric intensive care unit(PICU) during 20-month period. Results...
Pulmonary Function Test and Body Composition Analysis in Obese Children
Jee Seon Shin, Ji Hye Park, Ji Young Kim, Su Jung Kim, Young Mi Hong
Clin Exp Pediatr. 2005;48(6):588-593.   Published online June 15, 2005
Purpose : Obesity is associated with disturbances of ventilatory functions in adults. But few studies have evaluated the pulmonary complications of obesity in the pediatric population. The purpose of this study is to clarify the effects of obesity on pulmonary function and body composition in obese children. Methods : Forty seven obese children whose ages ranged from nine to twelve...
Clinical Lecture
Common Urinary Symptoms in Outpatient Clinic - Voiding Dysfunction in Children -
Kee Hyuck Kim, Young Sig Kim
Clin Exp Pediatr. 2005;48(6):575-579.   Published online June 15, 2005
Urinary incontinence is the most common urinary symptom in children and causes considerable anxiety in children and parents. In most cases, there is no underlying organic pathology and the long- term prognosis is excellent. Despite these reassuring facts, children with wetting problems can be a challenge for primary pediatrician. This is probably because the problem is poorly understood, there is...
Case Report
Isolated 3-Methylcrotonyl CoA Carboxylase Deficiency Detected by Newborn Screening Program Using Tandem Mass Spectrometry
Ju Young Kwak, Jun Young Park, Kyung A Nam, Sang Hi Son, Son Sang Seo
Clin Exp Pediatr. 2005;48(5):561-564.   Published online May 15, 2005
Isolated deficiency of 3-methylcrotonyl CoA carboxylase is a rare disorder of the catabolic pathway for leucine and many patients have mild symptoms or no symptom. However, the introduction of tandem mass spectrometry in newborn screening has revealed an unexpectedly high incidence of this disorder. We report an asymptomatic premature infant with isolated 3-methylcrotonyl CoA carboxylase deficiency detected by newborn screening...
Original Article
The Change of Serum Soluble E-selectin in Kawasaki Disease
Jae-Ho Jeong, Eun-Young Cho, Jae-Woo Lim, Eun-Jeong Cheon, Kyong-Og Ko, Kyung-Il Lee
Clin Exp Pediatr. 2005;48(5):539-544.   Published online May 15, 2005
Purpose : The aim of this study was to investigate the pathophysiologic role of serum E-selectin, vascular endothelial growth factor(VEGF)-induced cell adhesion mollecule in Kawasaki disease(KD) and to look for the evidence of direct relationship between the plasma levels of soluble E-selectin and the incidence of coronary artery lesion(CAL). Methods : Changes in plasma levels of sE-selectin(n=98) over time were...
Airway Expandible Metallic Stent Implantation in Children with Tracheal or Bronchial Stenosis
Ju Young Jang, Hyo-Bin Kim, So Yeon Lee, Ja Hyung Kim, Seong Jong Park, Ji Hoon Shin, Soo-Jong Hong
Clin Exp Pediatr. 2005;48(5):512-517.   Published online May 15, 2005
Purpose : In adults, endoscopic tracheobronchial balloon dilatation and stenting have become valuable methods to establish and maintain an adequate airway lumen when tracheomalacia or neoplastic growth compromise the airways. But in children, only a few cases were reported due to technical problems. We report six children who were treated with stent implantation and describe the use and safety of...
Functional Immunity to Cross-Reactive Serotype 6A Induced by Serotype 6B in Pneumococcal Polysaccharide Vaccine
Kyung Hyo Kim
Clin Exp Pediatr. 2005;48(5):506-511.   Published online May 15, 2005
Purpose : Streptococcus pneumoniae serotype 6B and 6A are important pathogens in pneumococcal infections. It is commonly assumed that the 6B vaccines elicit antibodies cross-reacting with the 6A serotype and the cross-reactive antibodies protect against infections of 6A. To examine this assumption, we measured the opsonophagocytic capacity to serotype 6A and 6B in adults. Methods : Twenty-four adults were immunized...
Difference in the Transcriptional Activity of the Interleukin-4 Promoter Haplotypes
Eun Hwa Choi, Hee Sup Kim, Stephen J. Chanock, Hoan Jong Lee
Clin Exp Pediatr. 2005;48(5):495-499.   Published online May 15, 2005
Purpose : Interleukin-4(IL-4) is a critical component of the Th2 cytokine pathway and contributes to severity of respiratory syncytial virus(RSV) bronchiolitis. Previous studies observed an association between severe RSV bronchiolitis in Korean children with a common haplotype of the IL4 promoter. This study was performed to investigate functional differences of the variant IL4 promoter haplotypes. Methods : Genomic DNA was obtained...
Extubation Time by Birth Weight and the Predictors for Success/Failure at the First Extubation in Extremely Low Birth Weight Infants
Chang Won Choi, Sung Eun Park, Ga Won Jeon, Eun Jung Yoo, Jong Hee Hwang, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2005;48(5):488-494.   Published online May 15, 2005
Purpose : To outline the aspects of extubation by birth weight and find the predictors for success/ failure at the first extubation in extremely low birth weight infants. Methods : One hundred thirteen extremely low birth weight infants(<1,000 g) who were admitted to NICU at Samsung Seoul Hospital between Jan. 2000 and Jun. 2004 were enrolled. Clinical characteristics that are thought...
Serum Adiponectin Levels and Insulin Resistance in Obese Children
Hee-Sun Lee, Jin Lee, Min-Joo Kang, Byung-Min Choi, Kee-Hyoung Lee
Clin Exp Pediatr. 2005;48(5):481-487.   Published online May 15, 2005
Purpose : Adiponectin, adipose tissue-specific protein, has anti-inflammatory and anti-atherogenic properties. It has been found to have a negative correlation with obesity and to play a role in modulating glucose tolerance and insulin sensitivity. Serum adiponectin concentrations are decreased in adults with obesity and type 2 diabetes. We investigated the difference in adiponectin levels between obese and non-obese children, and...
Clinical Lecture
Approach to the Children with Recurrent Infections
Jae Ho Lee
Clin Exp Pediatr. 2005;48(5):461-468.   Published online May 15, 2005
The major function of immune system is to protect infections. The immune systems are composed of innate and adaptive immunity. In adaptive immunity, the cellular and humoral components interact each other. Neonates and infants are infected frequently, because immune systems are naive and easy to expose to infectious agents. The complete history and physical examination is essential to evaluate the...
Case Report
A Case of Neurofibromatosis Combined with Ectopic Kidney
Eugene Yang, Bo Hyun Kim, Joon Soo Lee
Clin Exp Pediatr. 2005;48(4):448-452.   Published online April 15, 2005
Neurofibromatosis(NF) is an autosomal dominant disorder, probably of neural crest origin that affects all three germinal layers. It is a group of heterogeneous multisystemic neurocutaneous disorders involving both neuroectodermal and mesenchymal derivatives. Type 1(von Recklinghausen disease) is the most common neurocutaneous disorder among the eight subtypes. Previous reports showed various involvements in the renal organ. Renovascular hypertension is the most...
Original Article
Expression of Expanded Polyglutamine Disease Proteins in Drosophila (Drosophila Polyglutamine Disease Models)
Sang Min Shin, Kyung Hoon Paik, Dong Kyu Jin
Clin Exp Pediatr. 2005;48(4):425-432.   Published online April 15, 2005
Purpose : Polyglutamine diseases are a group of diseases caused by the expansion of a polyglutamine tract in the protein. The present study was performed to verify if polyglutamine disease transgenic Drosophila models show similar dysfunctions as are seen in human patients. Methods : Polyglutamine disease transgenic Drosophila were tested for their climbing ability. And using genetic methods, the effects of...
Statistical Analysis of 1,000 Cases of Kawasaki Disease Patients Diagnosed at a Single Institute
Dae Hwan Hwang, Kyoung Mi Sin, Kyong Min Choi, Jae Young Choi, Jun Hee Sul, Dong Soo Kim
Clin Exp Pediatr. 2005;48(4):416-424.   Published online April 15, 2005
Purpose : To find the risk factors associated with coronory artery lesions, non-responsiveness to intravenous immunoglobulin(IVIG) treatment, and recurrences in Kawasaki disease patients. Methods : We retrospectively analyzed 1,000 Kawasaki disease patients who were admitted to Yonsei University Medical Center from September 1990 to December 2003. We compared between responder and non-responder groups to IVIG treatment as well as between relapsed...
Expression of Nerve Growth Factor during Urinary Bladder Development
Kyoung Eun Lee, Chang Hee Hong, Hee Jung Kang, Dug Ha Kim
Clin Exp Pediatr. 2005;48(4):411-415.   Published online April 15, 2005
Purpose : This study was performed to determine the developmental expression pattern of nerve growth factor(NGF) in the urine of healthy children. It was hypothesized that NGF may contribute to the development of the spinobulbospinal micturition reflex that represents the adult micturition pattern. Methods : Voided urine was collected in 60 healthy children during the first 5 years of life(0-1 month,...
Clinical Study of Children Using Home Mechanical Ventilation
Young Joon Ahn, Seung Hyeon Lee, Hyo-Bin Kim, Seong Jong Park, Tae Sung Ko, Soo-Jong Hong
Clin Exp Pediatr. 2005;48(4):401-405.   Published online April 15, 2005
Purpose : The use of mechanically-assisted ventilators at home reduces morbidity and improves the quality of life in children with chronic respiratory failure. But in Korea there is no clinical data of children with home mechanical ventilation. We investigated ventilator types, duration, the causes of failure or death, and the cost needed for care. Methods : We retrospectively analyzed the medical...
Risk Factors of Nosocomial Rotavirus Infections in Children
Sin Ae Park, Sun Hee Yu, Seon Woong Lim, Kyung Dan Choi
Clin Exp Pediatr. 2005;48(4):395-400.   Published online April 15, 2005
Purpose :Rotavirus is one of the most important causes of nosocomial infections among children. The aim of this study is to determine the risk of nosocomial rotavirus infections and to evaluate the effectiveness of breast-feeding and probiotics in the prevention of nosocomial rotavirus infections. Methods : This study was carried out on admitted children without diarrhea between March 1, 2003 and...
Human Surfactant Protein-A(SP-A) Gene Locus Associated with Mycoplasma pneumoniae Pneumonia in Korean Children
Seung Soo Kim, In Kyu Lee, Jung Ho Ko, Myung Ho Oh, Chong Woo Bae
Clin Exp Pediatr. 2005;48(4):376-379.   Published online April 15, 2005
Purpose : Mycoplasama pneumoniae is a leading cause of pneumonia and exacerbates other respiratory conditions such as asthma. Surfactant protein A(SP-A) is involved in surfactant physiology and surfactant structure, and plays a major role in innate host defense and inflammatory processes in the lung. In this study, SP-A mediated mycoplasma cidal activity. The candidate-gene approach was used to study the...
A Clinical Study on Relationship of Surgical Glove and Back Pain after Lumbar Puncture in Children
Sung Ryoung Han, Wan Suk Choi, Hae Jeong Lee, Hyun Seok Kim, Ju Suk Lee, Kyung Lae Cho
Clin Exp Pediatr. 2005;48(3):310-314.   Published online March 15, 2005
Propose : In this study, we evaluated whether powder on surgical gloves is a cause of postpuncture backpain in children. Mothods : In 164 children with meningitis between July and September 1997, we did not remove powder from surgical gloves. However, in 149 children with menigitis between May and October 2001 the powder was removed from the surgical gloves. Results : Out...
Evaluation of Serum Insulin-Like Growth Factor(IGF)-I, Insulin-Like Growth Factor Binding Protein(IGFBP)-2 and IGFBP-3 Levels in Healthy Korean Children
Gi Hoon Yang, Hye Lim Jung, Deok Soo Kim, Jae Won Shim, Jung Yeon Shim, Moon Soo Park
Clin Exp Pediatr. 2005;48(3):298-305.   Published online March 15, 2005
Purpose : We performed this study to evaluate the mean serum levels of insulin-like growth factor (IGF)-I, insulin-like growth factor binding protein(IGFBP)-2 and IGFBP-3 in healthy Korean children according to age and sex. Methods : Ninety two healthy children, consisting of 42 boys and 50 girls, were classified into five groups according to age : neonate; infancy; early childhood; late childhood;...
Clinical Significance of Immature Reticulocyte Fraction and Reticulocyte Cellular Indices in Pediatric Anemia Patients
Young Seo, Hye Lim Jung, Jae Won Shim, Deok Su Kim, Jeong Yeon Shim, Moon Soo Park
Clin Exp Pediatr. 2005;48(3):284-291.   Published online March 15, 2005
Purpose : Flow cytometric automated reticulocyte analysis is a superior method to manual reticulocyte counting, with respect to precision and sensitivity. Furthermore, flow cytometric analysis is able to measure immature reticulocyte fraction(IRF) and reticulocyte cellular indices(RCI : cell hemoglobin content : CHr, mean cell volume : MCVr, cell hemoglobin concentration mean : CHCMr, distribytion width : RDWr, HDWr, CHDWr). In...