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Original Article
Production and Characterization of Monoclonal Antibodies to Perchloric Acid Soluble Antigen of M. tuberculosis(TB-II)
Kyung Hyo Kim, Dong Soo Kim
Clin Exp Pediatr. 1993;36(8):1116-1123.   Published online August 15, 1993
Mycobacteria cause diseases which occur the world over and whoich carry a considerable burden in morbidity, mortality and social problems. A battery of monoclonal antibodies specific for mycobacterial antigens would provide a useful tool for rapid diagnosis of mycobacterial diseases. Fourtenn monoclonal antibodies to perchloric acid soluble antigne of M. tuberculosis were produced. Immunoglobulin isotypes of monoclonal antibodies were ten...
Production, Characterization, and Clinical Application of Perchloric Acid Soluble M. tuberculosis Antigen (TB-I)
Kyung Hyo Kim, John Linton, Yunsop Chong, Dong Soo Kim
Clin Exp Pediatr. 1993;36(8):1107-1115.   Published online August 15, 1993
The immune response to M. tuberculosis engages T-cell medicated reactions which determine the degree of resistance and also the clinical pattern of disease. Although antibodies produced by the infected host have yet no proven protection, they are appilicable for alternative diagnostic tests in tuberculosis. Preparation of purified antigens from Mycobacteria with specific antigenic determinants would improve serological diagnosis in tuberculosis. The...
Inteleukin-6 Level in Systemic Lupus Erythematosus
Young Nae Yim, Dong Soo Kim
Clin Exp Pediatr. 1993;36(3):386-393.   Published online March 15, 1993
Systemic lupus erythematousus(SLE) is a disease affecting blood vessels and connective tissue, which are damaged by deposition of pathogenic autoantibodies and immune complexes.Although a complex disease, SLE provides a number of insights into autoimmune pathogenesis. Autoimmune disease, in general, is characterized by B cell hyperactivity which results in hypergammaglobulinemia and production of a variety of autoantibodies reactive to organ-nonspecific antigens...
The Soluble Interleukin 2 Receptor Levels in Kawasaki Disease
Keum Chun Kim, Dong Soo Kim
Clin Exp Pediatr. 1992;35(12):1657-1666.   Published online December 15, 1992
Kawasaki disease has been known as an acute febrile mucocutaneous lymph node syndrome since 1967. But its definite pathophysiology still remains unclear. In order to study the immunologic basis for immunologic abnormalities in this disease, we studied the level of soluble interleukin-2 receptor (sIL-2R), interleukin-6 (IL-6) and C-reactive protein (CRP) at the acute and convalescent phases of the disease, comparing...
Case Report
Effect of Cultured Thymic Epithelium Transplantation in a Patients with Severe Combined Immunodeficiency
Soo Kyung Yun, Byoung Ho Cha, Woo Seung Jeoun, Dong Soo Kim
Clin Exp Pediatr. 1992;35(10):1443-1448.   Published online October 15, 1992
Severe combined immunodeficiency disease is caused by a group of genetic disease characterized by abnormal function of T and B lymphocytes. The treatment of choice for severe combined immunodeficiency disease is a HLA mached bone marrow transplant, but transplantation of cultured thymus epithelium was used to treat severe combined immunodeficiency disease in case of that mached, related bone...
Acquired Persistent Cytomegalovirus Infection : An Association with Common Variable Immunodeficiency
Min Hyea Kim, Young Mi Hong, Sung Joo Lee, Je Geun Chi, Dong Soo Kim
Clin Exp Pediatr. 1992;35(9):1272-1279.   Published online September 15, 1992
Acquired persistent cytomegalovirus infection was diagnosed by anti CMV antibody and lymph node biopsy and persisted in a 3-year-old boy with recurrent episode of high fever, lymphadenopathy hepatosplenomegaly and pneumonia. Initial immunologic abnormalities including low serum IgG, high IgM decreased T4 and T4/T8 ratio finally progressed to immunologic paralysis which was compatible to common variable immunodeficiency. This is the first case which...
Original Article
Clinical Features of Twelve Coxiellemia Pediatric Patients in Korea
Chuhl-Joo Lyu, Dong Soo Kim, Young Mo Sohn, Ki Sup Chung, Kir-Young Kim, Won Young Lee
Clin Exp Pediatr. 1992;35(9):1220-1225.   Published online September 15, 1992
Coxiella burnetii is a rickettsial organism and extremely infectious for humans animals. The infection caused by this organism is endemic throughout the world. Although it has not been reported in Korea because of the nonspecific clinical manifestations, the difficulties in diagnosis, and the underestimate of this disease. Update this infection has been misdiagnosed as other disease. We experienced twelve cases of...
Production and Characterization of Monoclonal Antibodies to Perchloric Acid Extract Antigen of M. bovis BCG(BCG Ⅱ)
Kyung Hyo Kim, Dong Soo Kim, Jeon Soo Shin
Clin Exp Pediatr. 1992;35(9):1183-1192.   Published online September 15, 1992
Mycobacteria causes disease which occur over the world. The development of reliable serological teset for the diagnosis of tuberculosis in humans has been complicated by the large degree of cross reactivitiy between antigens of Mycobacteria species can be used as a tool for serodiagnosis of tuberculosis. Fourteen monoclonal antibodies to perchloric acid extract antigen of M. bovis BCG were produced....
The Effects of RU 41.740, a Glycoprotein Extract from Klebsiella pneumoniae, on Peripheral Blood Mononuclear Cells
Moon Kyu Kim, Dong Soo Kim, Hyun Ok Kim
Clin Exp Pediatr. 1992;35(8):1066-1072.   Published online August 15, 1992
RU 41.740 is extract of Klebsiella pneumoniae K2O1 stain with immunomodulatory properties. It was composed of two glycoproteins, each being 31 KD and 33 KD in their molecular weight, on SDS-PAGE analysis. RU 41.740 was observed to augment cell mediated immunity of human peripheral blood mononulear cells measured by tritiated thymidine uptake method. Maximal augmentation was observed after 72 hours...
Production, Characterization, and Clinical Application of Perchloric Acid Extract of M. bovis BCG (BCG I)
Kyung Hyo Kim, Dong Soo Kim
Clin Exp Pediatr. 1992;35(8):1059-1065.   Published online August 15, 1992
Tuberculosis has been an important world-wide infectious disease. The prevalence of radiologically active tuberculosis was 1.8% of population in Korea. Probably the most important aspect of the pathogenesis of tuberculosis is the nature and specificity of the response of the immune system to the antigens of tubercle bacilli. Preparation of purified antigens from Mycobacteria with specific antigenic deterninants would improve...
In Vitro Immunization-IV: Antibody Response of Mouse Splenocytes Grown in a Mixture of Conditioned Media, Thymocytes, and Bone Marrow Cells
Dong Soo Kim, Geun Woong Noh
Clin Exp Pediatr. 1992;35(7):902-908.   Published online July 15, 1992
We have previously reported several methods of in vitro immunization using different conditioned media, and the highest antibody titer was observed when a mixture of three conditioned media[PHA-stimulated adherent splenocytes conditioned medium (ASM-P), ASM-p-stimulated non-adherent splenocyte conditioned medium (NASM-A), ASM-P-stimulated thymocyte conditioned medium (TM-A)] was used. In this experiment, thymocytes and/or bone marrow cells was added instead of above conditioned media...
The Interleukin-6 Level in Kawasak Disease
Moon Kyu Kim, Dong Soo Kim
Clin Exp Pediatr. 1992;35(4):515-526.   Published online April 15, 1992
Kawasaki disease is an acute multisystemic disease affecting infants and children with prominent vasculitic features. Although there has been considerable progress in understanding the pathogenesis of this disease, the inciting cause remains unclear. It has been noticed that there were many immunologic abnormalities during the acute stage of Kawasaki disease. In the pres-ent study, we studied serum interleukin-6(IL-6), C-reactive protein(CRP),...
The Effec of Conditiond Media Cultued from the Thymocytes and the Splenocytes on the Regulation of Antibody Isotypes; In Vitro Immunization-III
Dong Soo Kim, Geun Woong Noh, Soon Hwan Oh
Clin Exp Pediatr. 1992;35(3):306-314.   Published online March 15, 1992
We had developed a method of in-vitro immunization to increase antibody titer using several cnditioned media which were developed from mouse splenocyts and thymocytes. Using fetal calf serum, the splenocytes of the mouse were divided into two types; adherent cells and non-adherent cells. We used PHA to stimulate the adherent cells to produce PHA-stimulated adherent cell conditioned medium (ACSM-P). Non-adherent...
The effect of dietary fats of immune response in sublethally irradiated rats.
Soon Hwan Oh, Dong Soo Kim, Hae Won Nam, Juhn Kyu Loh
Clin Exp Pediatr. 1991;34(11):1494-1504.   Published online November 30, 1991
To investigate the effect of dietary fats on cellular immune response in the immunosuppressed rats, different compositions in the quality and quantity of dietary fats were fed to sublethally irradiated male rats. The results are as follows; 1) After 2 weeks of irradiation, the mean body weight of the fat free dietary group was significant- ly lower than the com oil group. The organ weight, especially...
Effect of dietary fats on immune response in rats.
Soon Hwan Oh, Dong Soo Kim, Hae Won Nam
Clin Exp Pediatr. 1991;34(10):1334-1345.   Published online October 31, 1991
To investigate the effect of dietary fats on the humoral and cellular immune response, different compositions in the quality and quantity of dietary fats were fed to male rats. The results are as follows; 1) The mean body weights of the rats which were fed the various dietary fats were not significant during the experimental period. The weights of the organs measured were the spleen,...
A case of neonatal herpes simplex virus encephalitis.
Kook In Park, Young Mo Sohn, Dong Soo Kim, Ran Namgung, Chul Lee, Dong Gwan Han, Won Young Lee, Ki Keun Oh, Myung Joon Kim
Clin Exp Pediatr. 1991;34(9):1276-1285.   Published online September 30, 1991
Neonatal herpes simplex virus infection still remains a life-threatening infection for the newborn. With an increasing incidence of genital herpes and an increase in the incidence of neonatal herpes simplex virus infections, it is important that pediatricians and neonatologists continue to maintain a high index of suspicion in infants whose symptoms may be compatible with herpes simplex virus infections so that early identification leads...
Study on the antibody formation in patinets treated with recombinant human growth hormone(rhGH).
Hye Jung Joo, Duk Hi Kim, Dong Soo Kim
Clin Exp Pediatr. 1991;34(9):1261-1268.   Published online September 30, 1991
Patients with short stature admitted to the Pediatrics Endocrinology Clinic, Yonsei University College of Medicine during a six-year period from August, 1983 to August, 1989 were divided into three groups. The group 1 received rhGH, group 2 received Oxandrolone and group 3 did not receive any treatment. These patients were tested for presence of antibodies to rhGH with ELISA and effect of rhGH was evaluated. 1) Among 53...
Prolonged Fever in Korean Children: Review of 120 Cases.
Ho Seong Kim, Dong Goo Lee, Dong Soo Kim
Clin Exp Pediatr. 1990;33(11):1516-1525.   Published online November 30, 1990
The authors reviewed the 120 patients with prolonged fever whose temperature was over 38.5°C and of undetermined etiology, who were admitted in Y야isei Medical Center from March 1982 to March 1989. The results were as follows; 1) The children admitted with prolonged fever were 0.3% of total in-patients at the same time. 2) 20 cases were less than 1 year of age on admission and 39...
Lipoid Pneumonia.
Chang Gee Kang, Ho Seong Kim, Jung Tak Kim, Dong Soo Kim, Eun Kyung Han, Kwang Gil Lee, In Joon Choi
Clin Exp Pediatr. 1990;33(3):393-397.   Published online March 31, 1990
Lipoid pneumonia is a chronic, interstitial, proliferative inflammation resulting from aspiration of lipoid material; it occurs principally in debilitated infants. Animal oils, owing to their high fatty acid content, are the most damaging. There are no characteristic signs or symptoms; cough is most common and in severe cases there may be dyspnea. We have experenced one case of lipoid pneumonia cause by an aspiration of...
A Case of Patient with Common Variable Immunodeficiency.
Keun Cheon Kim, Chang Gee Kang, Chang Hyun Yang, Dong Soo Kim, Kir Young Kim
Clin Exp Pediatr. 1989;32(8):1123-1127.   Published online August 31, 1989
Common variable immunodeficiency, as defined by World Health Organization classification of primary immunodeficiency, is a heterogenous group of disorders with hypogammaglobulinemia, decreased ability to produced antibody following antigenic challenge, and increased incidence of infections. The disorder was often familial, but no mode of inheritance has been discerned. Clinical fingings are recurrent bacterial infections, particularly respiratory infection. Laboratory evaluations in common variable immunodeficiency demonstrate decrease in...
Truncus Arteriosus Associated with Interrupted Aortic Arch.
Chang Hyun Yang, Jae Seung Yang, Jun Hee Sul, Dong Soo Kim, Sung Kyu Lee, Dong Shik Chin
Clin Exp Pediatr. 1988;31(6):779-783.   Published online June 30, 1988
We experienced a case of truncus arteriousus associated with interrupted aortic arch, ventricular septal defect and patent ductus arteriosus. A 5 month old boy had complained of rapid respiration and feeding difficulty since birth. There was no visible cyanosis or clubbing toes and nails. There was a grade 2 〜3 ejection systolic murmur with maximum intensity at the left lower sternal border. Diagnosis was...
Case Report
Coarctation of the Aorta : Unusual Type.
Jung Bae Lee, Dong Soo Kim, Chuhl Joo Ryu, Kwang Sin Cho, Jun Hee Sul, Sung Kyu Lee, Dong Shik Chin, Kyu Ok Choe, Bum Koo Cho
Clin Exp Pediatr. 1986;29(7):773-778.   Published online July 31, 1986
We experienced a case of coarctation of the aorta with aneurysmal dilatation which was located in aortic arch, who was a 13 year old male.On physical examination on admission, pulses were weak in right radial artery and in both femoral artery. Blood pressure measured 100/70 mmHg in right arm, 100/70 mmHg in left arm, 130/110 mmHg in right leg and 130/110...
A case of Unilateral Absence of Pulmonary Artery.
Kwang Sin Joh, Dong Soo Kim, Chul Joo Ryu, Shin Heh Kang, Sung Kyu Lee, Ki Young Lee, Dong Shik Chin
Clin Exp Pediatr. 1986;29(5):559-563.   Published online May 31, 1986
Unilateral Absence of Pulmonary Artery(UAPA) is a rare disease. It is characterized by no specfiic cardiopulmonary symptoms in general. We experienced a case of UAPA in a 9 year-old female patient with the chief complaint of abnormal chest Xray finding. Lung perfusion scan, cardiac catheterization with pulmonary and aortic angiography confirmed the diagnosis of right side UAPA.
Original Article
A Measurement of Measles Antibodies among the Age Between 6 to 15 Months
Ki Young Lee, Sang Woo Kim, Kyoung Tae Hwang, Kyu Chong Choi, Jong Soo Kim, Chang Ju Cho, Baek Keun Lim, Hyun Sook Kim, Dong Soo Kim
Clin Exp Pediatr. 1986;29(4):375-380.   Published online April 30, 1986
To determine the proper age of the measles vaccination, we must know the time when the passively transferred measles antibody from mother disappeared. Because it can be a major factor for vaccine failure to take the measles vaccine to the children who still have the passive immunity. We measured the degree of immunity of 50 children with the age between...
Case Report
Two cases of Vascular Ring.
Jun Chul Choi, Dong Soo Kim, Jun Hee Sul, SUng Kyu Lee, Dong Shik Chin
Clin Exp Pediatr. 1986;29(3):312-317.   Published online March 31, 1986
This study is a report of two cases of vascular ring that were experienced at Yonsei University in 1983 and 1985. The first case was a one-month-old female patient with a double aortic arch and PDA. The main pulmonary artery was connected to the anterior arch by PDA. The anterior arch was larger in diameter than the posterior arch and the descending...
A Case of Gastroenteritis Complicated with Empyema of Gall Bladder Caused by Salmonella Serogroup B.
Dong Soo Kim, Ki Sup Chung, Dong Shik Chin, Seung Hoon Choi, Eui Ho Hwang
Clin Exp Pediatr. 1986;29(2):221-224.   Published online February 28, 1986
There are four main groups of clinical manifestations in salmonellosis, gastroenteritis。 enteric fever, localized infection, and chronic carrier state, that may occur individually, simultaneously or consecutively in the course of an infection. The authors experienced a case of salmonella gastroenteritis complicated with empyema of gall bladder in a 12-year-old male patient. The clinical diagnosis was confirmed on the operating table and...
Original Article
Changing Pattern of Parasitic Infection by Year in Pediatric Age Group.
Dong Soo Kim, Ki Young Lee, Duk Jin Yun, Chin Thak Soh
Clin Exp Pediatr. 1981;24(6):567-576.   Published online June 15, 1981
To contract the parasitic infection, the environmental factor is more important although the host defense mechanism must be considered. Though it is important to consider the physical conditions, social and economic conditions are most important factors. Now it has been reported that the parasitic infection rate has been on the decrease along with improvement of social and economic conditions. Parasitologic...
Clinical Study on Foreign body Aspiration and Aspiration Pneumonia.
Dong Soo Kim, Ki Choon Kim, Ki Young Lee, Duck Jin Yun
Clin Exp Pediatr. 1981;24(4):343-351.   Published online April 15, 1981
A clinical study was done on 177 cases of inpatients, who had been admitted under the diagnosis of aspiration pneumonia and foreign body aspiration at the Department of Pedia-trics, Yonsei University College of Medicine from Jan. 1965 to Dec. 1977. The results were obtained as follows: 1)Children below 5 years old(59.3%) are prone to aspirate and it is more common in...
Case Report
Emergencies in Hemophilia.
Dong Soo Kim, Kwan Sub Chung, Kir Young Kim, Duk Jin Yun
Clin Exp Pediatr. 1980;23(10):809-814.   Published online October 15, 1980
9 classic hemophilacs in Severance Hospital, Yonsei University from Dec. '77 to Aug. '79 were reviewed and analysed and the following results were obtained. 1. Intracranial hemorrhage is required the most immediate emergent therapy in hemophiliacs and computerized transverse axial tomogarhy may be essential for the accurate and noninvasive diagnosis and for the effective emergency treatment. 2. To conserve supplies...
Original Article
A Case of Congenital Hypoplastic Anemia.
Dong Soo Kim, Chul Lee, Hong Kyu Lee, Kir Young Kim, Duk Jin Yun
Clin Exp Pediatr. 1980;23(9):771-775.   Published online September 15, 1980
Authours have observed a case of congenital hypoplastic anemia in 21 months old Korean male patient who was diagnosed through aspirations of bone marrow. His hematologic improvement was followed by administrations of prednisolone. A brief review of related literature was made.