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Original Article
Heart Rate Variability and Autonomic Activity in Patients Affected with Rett Syndrome
Deok Young Choi, Jin Ha Chang, Hee Jung Chung
Clin Exp Pediatr. 2003;46(10):996-1002.   Published online October 15, 2003
Purpose : In Rett syndrome patients, the incidence of sudden death is greater than that of the general population, and cardiac electrical instability including fatal cardiac arrhythmia is a main suspected cause. In this study, we are going to find out the possible cause of the higher risk of sudden death in Rett patients by the evaluation of heart rate...
Effects of Endothelin A Receptor Antagonist to Cellular Proliferation and Apoptosis in Neonatal Rat Heart
Byung Min Choi, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 2003;46(7):668-678.   Published online July 15, 2003
Purpose : In order to investigate the role of endothelins in the cardiac development, the present study was designed to examine the effects of endothelin A receptor(ETAR) antagonist to the cellular proliferation and apoptosis in the neonatal rat heart. In addition, the expression of various regulatory genes in protein and mRNA levels by ETAR antagonist were examined. Methods : Neonatal...
Screening Test for Heart Diseases in the First Grade Elementary School Children in Busan
Jae Min Oh, Hee Ju Park
Clin Exp Pediatr. 2003;46(5):490-494.   Published online May 15, 2003
Purpose : We'd like to determine the incidence of congenital heart disease and arrhythmia in elementary school children in Busan, and to provide adequate prevention and treatment. Methods : A total of 23,802(male 12,909, female 10,893) 1st grade elementary school children living in Busan were studied. All children were 7-8 years old. We obtained their medical history by questionnaire and checked...
Case Report
A False Diagnosis of Hypoplastic Left Heart Syndrome in a Fetus
Youn Jeong Shin, Sung Hee Jang, Jung Yun Choi, Eun Sook Han
Clin Exp Pediatr. 2002;45(2):267-272.   Published online February 15, 2002
Typical hypoplastic left heart syndrome(HLHS) is a distinct pathologic entity with aortic atresia, mitral atresia, very hypoplastic or absent left ventricle and thread like ascending aorta. Occasionally, the lesser degree of hypoplasia is found and is called hypoplastic left heart complex(HLHC) by some authors. This HLHC is often associated with critical aortic stenosis. Fetal echocardiography has enabled us to observe...
Original Article
Serial Changes of Cardiac Troponin I After Pediatric Open Heart Surgery
Yeo Hyang Kim, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 2002;45(2):208-213.   Published online February 15, 2002
Purpose : The major cause of cardiac dysfunction, after open heart surgery for congenital heart disease, is perioperative myocardial injury. Cardiac troponin I is found only within the myocardial cell, so it can be used as a biochemical marker of the myocardial injury. We performed this study to evaluate the worth of cardiac troponin I as a biochemical marker reflecting...
The Effectiveness of Propofol on Pediatric Cardiac Catheterization and Electrophysiologic Study
Woo Saeng Park, Myung Chul Hyun
Clin Exp Pediatr. 2001;44(7):773-777.   Published online July 15, 2001
Purpose : Our purpose was to evaluate the effectiveness of propofol on pediatric cardiac catheterization or radiofrequency catheter ablation. Methods : We measured the serial changes of arterial oxygen saturation, heart rate, systolic and diastolic blood pressure at 4 stages, a baseline(during normal sleep), stage 1(just after loading of propofol 2 mg/kg over 10 minutes), stage 2(10-15 minutes after propofol continuous...
Case Report
A Case of Protein-losing Enteropathy in Congestive Heart Failure : Resolution with Prednisolone
Jong-Woon Choi
Clin Exp Pediatr. 2001;44(5):587-591.   Published online May 15, 2001
Protein-losing enteropathy can result from primary or secondary intestinal lymphangiectasia. Secondary intestinal lymphangiectasia develops as a result of lymphatic obstruction or elevated lymphatic pressure. Cardiac lesions such as constrictive pericarditis, post-Fontan procedure state, and chronic congestive heart failure increase lymphatic pressure and may cause intestinal lymphangiectasia and protein-losing enteropathy. An 11-year-old girl who underwent corrective surgery for Tetralogy of Fallot...
Original Article
The Relationship between Change of Cardiac Function and Systemic Oxygen Consumption according to the Dose of Dopamine in the Rabbit
Hee Ju Park, Seok Ho Yoon, Bong Seok Choi, Jung Hwoi Cho, Ku Tae Kim, Sun Young K, Sang Ook Nam, Bok Luel Lee
Clin Exp Pediatr. 2001;44(2):177-184.   Published online February 15, 2001
Purpose : We'd like to know the relationship between the changes of cardiac function and systemic O2 consumption according to the increasing dose of dopamine. Methods : Ten rabbits(from 2kg to 2.8kg) were used in this experiment. Anesthesia was induced with intraperitoneal pentobarbital sodium(35mg/kg) and tracheostomy was done. It was maintained by ventilation with a mixture of 1-3% halothane and 67-69%...
Analysis of Malnutrition in Children with Congenital Heart Disease
Jeoung Eun Kim, Bo Hwa Choi, Kyung Mo Kim, Jae Kon Ko, Dong Man Seo
Clin Exp Pediatr. 2001;44(2):161-166.   Published online February 15, 2001
Purpose : Malnutrition and failure to thrive have long been recognized as common systemic consequences of congenital heart disease(CHD). But there is little data about the prevalence and severity of malnutrition with CHD in Korea. We designed this study to determine the prevalence of malnutrition among hospitalized children with CHD. Methods : We reviewed 100 hospitalized children with CHD who were...
Effect of Hypoxia on Antegrade and Retrograde Atrioventricular Conduction in Isolated Perfused Rabbit Heart
Heon-Seok Han, Young Jun Song, Miran Kang
Clin Exp Pediatr. 2000;43(9):1213-1223.   Published online September 15, 2000
Purpose : Cyanotic congenital heart diseases patients are in a state of hypoxia since birth. In general, hypoxia delays atrioventricular conduction. The atrioventricular node in such a hypoxic condition would have a different function, and some possibility for arrhythmia. The authors studied atrioventricular nodal function during hypoxia to elucidate the relationship between hypoxia and arrhythmia, including atrioventricular node in terms...
Significance of Postoperative Peritoneal Drainage and Peritoneal Dialys is in Infants with Congenital Heart Disease Who Underwent Open Heart Surgery
Ji-Hwan Choi, Jae-Hwa Oh, Hyang-Suk Yoon, Jong-Bum Choi, Soon-Ho Choi
Clin Exp Pediatr. 2000;43(9):1207-1212.   Published online September 15, 2000
Purpose : We reviewed 5 years worth of experience with peritoneal drainage and dialiysis in infants who underwent open heart surgery. The aim of this study was to investigate the effect of peritoneal drainage and peritoneal dialysis on fluid on balance and several paramenters od intensive care. Methods : Six(10%) of 60 consecutive infants who underwent open heart surgery required peritoneal...
Case Report
Two Cases of Left Ventricular Tumors Complicating Subaortic Stenosis in Newborn Infants
Ji Seon Kang, Mi Jung Hwang, Tae Hyoung Cho, Byung Ju Kim, Young Jong Woo, Jae Sook Ma
Clin Exp Pediatr. 2000;43(8):1122-1126.   Published online August 15, 2000
The most common obstruction of left ventricular outflow in childhood is produced either by a fibrous ring below the aortic valve, or by localized or diffuse muscular hypertrophy of the interventricular septum. Cardiac tumors causing subaortic stenosis in the newborn infant are extremely rare. This report describes two cases of subaortic stenosis caused by a tumor of the left ventricle...
Original Article
Teratogenic Effect of Dopamine on the Embryonic Chick Heart
Bon-Seok Koo, Nam Su Kim, Yong Joo Kim, Sung Yup Moon, Hang Lee
Clin Exp Pediatr. 2000;43(7):913-919.   Published online July 15, 2000
Purpose : To investigate the teratogenic potential of dopamine using a topical method of application to the developing Korean native chick embryo. Methods : A 5μg(0.05cc) of dopamine was applied to a 3-days-old chick embryo and the same amount of saline solution was applied as control. The embryo was then returned to the incubator and monitored. After 3 weeks the embryo was sacrificed and...
Identification of a Calcium-activated Potassium Channel Gene Expressed in Rat Cardiac Myocytes
In Seung Park, Hyun-Kyu Jeon, Nam Su Kim, Youn Mo Ahn, Chul-Seung Park, Ha Baik
Clin Exp Pediatr. 2000;43(7):905-912.   Published online July 15, 2000
Purpose : Calcium-activated potassium channels(KCa) may be involved in the transient outward current of the first phase of cardiac action potential. But it is still not clear whether cardiac myocytes express any KCa. We try to identify here the types of KCa expressed in rat caridac myocytes. Methods : We isolated total heart RNA from 50 rats(Spague-Dawley) and performed reverse transcription-polymerase chain reaction(RT-PCR) using specifically...
Congenital Heart Anomalies in Patients with Clefts of the Lip and/or Palate
Jin Ho Yu, Jeong Jin Yu, June Huh, Chung Il Noh, Jung Yun Choi, Yong Soo Yu
Clin Exp Pediatr. 2000;43(4):520-525.   Published online April 15, 2000
Purpose : The prevalence of congenital heart anomalies is known to be higher in patients with clefts of the lip and/or palate(CL/P). The purpose of this study was to determine the prevalence and type of congenital heart anomalies in patients with CL/P. Methods : We investigated congenital heart anomalies in 756 patients presented with CL/P from January 1986 to December...
Case Report
A Case of Isolated Right Ventricular Hypoplasia without Tricuspid Atresia or Pulmonary Atresia
Eui Jun Yang, Sun Young Kim, Sank Ook Nam, Hee Ju Park, Nam Hee Kwak
Clin Exp Pediatr. 1999;42(7):1026-1030.   Published online July 15, 1999
Isolated right ventricular hypoplasia, unassociated with severe pulmonary or tricuspid valvar malformations, is a rare primary congenital cardiac anomaly in which of the trabecular portion of right ventricle fails to develop. An atrial septal defect or a patent foramen ovale serves as an escape valve. We observed a 2-day-old neonate with this disorder who suffered from cyanosis. The diagnosis was...
Original Article
Assessment of Regional Wall Motion of the Left Ventricle in Children with Congenital Heart Disease
Chang Hee Han, Jun Ho Huh, Un Seok Nho, Byung Ho Choi, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 1999;42(6):807-816.   Published online June 15, 1999
Purpose : To assess wall motion of the left ventricle in the various forms of congenital heart disease and to select appropriate methods by which to gauge left ventricular wall motion. Methods : We evaluated left ventricular function, including volume, global ejection fraction, and regional wall motion(Centerline method, Local Ejection Fraction, Curved Perimeter method and Radial method). The evaluation was done...
Developmental Changes of Spectral and Chaotic Indexes of Heart Rate Variability in Normal Fetuses
Jee-Young Jung, Myung-Kul Yum, Nam-Su Ki, Jae-Won Oh, Chang-Ryul Kim, Jung Hye Hwang, Moon-Il Park
Clin Exp Pediatr. 1998;41(10):1380-1388.   Published online October 15, 1998
Purpose : The purposes of this study were to determine the normal values of spectral and chaotic indexes and to assess the maturational process of autonomic and chaotic control of fetal heart rate according to gestational age. Methods : Three hundred and thirty-seven mothers with normal singleton pregnancies, who were 23 weeks or more in gestational age, was randomly chosen. For...
The Assessment of Pulmonary Parenchymal Damage in Congenital Heart Disease using Lung Perfusion Scan
Hong Ryang Gil, Jae Goo Lee, Kang Uk Lee, Eun Ho Yi, Myung Ja Yun, Chung Il Noh, Jung Yeon Choi, Yong Soo Yun
Clin Exp Pediatr. 1998;41(5):640-645.   Published online May 15, 1998
Purpose : In acyanotic congenital heart disease of children with left to right shunt, 99mTc- Macroaggregate albumin(MAA) was employed to determine the scintigraphic severity of pulmonary parenchymal damage. Methods : These data of lung perfusion scan using 99mTc-MAA were compared with hemodynamic values obtained from cardiac catheterization. Results : The mean Pulmonary arterial pressure(≥30mmHg), total pulmonary resistance(≥2 Wood unit)...
Incidence of Congenital Heart Disease in Neonate by Color Doppler Echocardiography
Tae Chan Kwon, Joon Sik Kim, Sang Lak Lee, Myung Sung Kim, Geun Soo Park, Chun Soo Kim, In Joo Kim, Bin Ahn
Clin Exp Pediatr. 1998;41(3):363-368.   Published online March 15, 1998
Purpose : Many reports exist about the frequency of congenital heart disease(CHD) in the world, but according to the definition of CHD and subjects of study group, many differences existed between the reports. We conducted this study to evaluate the incidence and frequency of CHD by color Doppler echocardiography in neonate, and to suggest a preliminary model of incidence of...
Congenital Heart Disease and Associated Extracardiac Anomalies in Autopsies
Soon Seong Park, Myeong Ja Yoon, Jeong Sun Kim, Jeong Wook Seo, Chung Il Noh, Jung Yun Choi, Yong Soo Yoon, Byung Il Kim, Joong Hwan Choi, Chong Ku Yoon
Clin Exp Pediatr. 1998;41(3):354-362.   Published online March 15, 1998
Purpose : In order to find out how frequently and what kind of extra-cardiac anomalies (CAs) is associated with congenital heart disease(CHD) in general and in each CAs, autopsies with congenital cardiovascular malformations were studied. Methods : Autopsy files of Seoul National University Children' s Hospital from 1991 to 1995 were reviewed to find cases of CHDs. Other extra-CAs were tabulated from the records...
Recent Trend of Increasing Proportion of Interventional Catheterization in Congenital Heart Disease
Sang Yup Lee, Mi Jung Kang, Eun Jung Bae, In Seung Park, Woo Sup Kim, Se Jung Sohn, Seong Ho Kim
Clin Exp Pediatr. 1997;40(4):512-518.   Published online April 15, 1997
Purpose : The proportion of interventional catheterization in congenital heart disease is being increased in Korea, especially in Sejong Heart Institute, so we performed statistical analysis on the cardiac catheterization cases. Methods : Total 233 cases of congenital heart disease confirmed by cardiac catheterization at the Sejong Heart Institute between Jaunary 1995 and June 1995 were analyzed retrospectively. Results : 1) The...
Development of Approximate Entropy of Fetal Heart Rate Varibility during Normal Pregnancy
Myung Kul Yum, Jung Hye Hwang, Moon Il Park
Clin Exp Pediatr. 1997;40(4):464-472.   Published online April 15, 1997
Purpose : The approximate entropy of heart rate variability has recently been used as a tool in evaluating cardiovascular health and physiology and in diagnosing pertubated physiologic status, by quantifying the irregularity and the pattern of the heart rate variability. Therefore approximate entropy of the fetal heart rate variability will be used as an important tool in studying the fetal...
Diagnosis and Treatment of Fetal Cardiac Anomalies
Nam Su Kim, Myung Kul Yum, Hahng Lee, Sung Ro Jung, Jung Bae Yoo, Jae Ek Lee
Clin Exp Pediatr. 1996;39(10):1395-1404.   Published online October 15, 1996
Purpose : Fetal echocardiography is used for the prenatal diagnosis of congenital heart disease. Fetal echocardiography allows decisions to be made in advance where the fetal abnormality is not compatible with life after delivery or where early correction is required. Our fetal echocardiographic experience was analysed retrospectively to guide future clinical application. Methods : 138 mothers had fetal echocardiography from April 1992 to December...
The Effects of Lipo Prostaglandin E1(EglandinⓇ) in Patients with Ductus Dependent Congenital Heart Disease
Sejung Sohn, Seong Ho Kim, Eun Jung Bae, In Seung Park
Clin Exp Pediatr. 1996;39(8):1111-1121.   Published online August 15, 1996
Purpose : The adverse reactions of prostaglandin E1(PGE1) are troublesome in the preoperative management of critical patients with ductus dependent congenital heart disease, and a preparation with less adverse reactions is preferable. The effects of Lipo PGE1, a new preparation of PGE1 contained in lipid microspheres, were compared with those of conventional PGE1(PGE1-CD). Methods : Lipo PGE1 was infused at a rate of 5...
Correlation between Plasma Endothelin-1 Concentrations and Pulmonary Hypertension Associated with Congenital Heart Defects
Sang Ook Park, Su Eun Park, Hyang Jae Yoo, Young Tak Lim, Hee Ju Park
Clin Exp Pediatr. 1996;39(7):970-976.   Published online July 15, 1996
Purpose : Endothelin-1 is the most potent vasoconstrictor. This study was investigated the correlation of plasma endothelin-1 and pulmonary hypertension associated with congenital heart defect. Methods : We evaluated the concentration of ET-1 in 24 cases of congenital heart disease diagnosed at the Department of Pediatrics, Pusan National University, from December 1993 to September 1994. The patients were divided into 2 groups according to mean...
Case Report
An Autopsy Case of Double Aortic Arch
Ji Sook Kim, Yong Myung Jo, Kyung Hee Ko, Eun Ryoung Kim, Je Grun Chi
Clin Exp Pediatr. 1996;39(5):727-731.   Published online May 15, 1996
Double aortic arch is the most common type of symptomatic vascularring. In most patients, the symptoms are manifested at birth or in early infancy. Double aortic arch usually has more severe symptoms than other types of complete vascular rings. We experienced one case of complete duplicated double aortic arch with left descending aorta and left patent ductus arteriosus. A one-day-old female neonate was transferred...
Original Article
Changes of Clinical Patterns of the Acute Rheumatic Fever in Korea(Compared report of 1973-1985 with that of 1986-1992)
Hye Sun Yoon, Min Young Park, Wan Young Shin, Byong Soo Sco, Sung Ho Cho
Clin Exp Pediatr. 1995;38(4):470-481.   Published online April 15, 1995
Purpose : The annual incidence of acute rheumatic fever in Korea was not changing during 1980 to 1989 from Nationwide survey in 1991 in spite of talking about scanty outbreak among doctors in recent year.The proportion of patients with acute rheumatic fever among the entire pediatirc inpatients each year was approximately 0.3% and did not change significantly throughout the...
Case Report
A Case of Dandy-Walker Syndrome with Complex Cardiac Anomaly
Ssack Joong Yoon, Sung Jin Hong, Hyung Goo Cho, Dong Chul Park
Clin Exp Pediatr. 1995;38(1):110-116.   Published online January 15, 1995
The Dandy-Walker syndrome is a developmental disorder of the brain characterized by cystic dilatation of the fourth ventricle and agenesis or hypoplasia of the cerebellar vermis. We experinced a case of Dandy-Walker syndrome with complex cardiac anomaly in female newborn who presented with apnea at birth. Physical examination showed coloboma on left eye, low estting malformed ear, and high arched...
Original Article
Comparison of Graded and Bolus Infusion Methods in Baroreflex Measurements in Rabbits
Chan Uhng Joo
Clin Exp Pediatr. 1995;38(1):61-65.   Published online January 15, 1995
Graded infusion and bolus injection methods of vasoactive drugs have both been used to measure baroreflex sensitivity. To determine whether the two methods produce the same values of baroreceptor sensitivity, phenylephrine and nitroglycerin was administered intravenously by both graded infusion and bolus injection methods to 11 rabbits. To evaluate the baroreflex control of heart rate(HR), a logistic sigmoid function model...


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