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Original Article
Plasma Somatomedin C Levels in Normal Children
Bo Young Yun, Hoan Jong Lee
Clin Exp Pediatr. 1992;35(11):1493-1500.   Published online November 15, 1992
Somatomedin C, the insulin-like growth factor I is suggested to mediate the growth-promoting effect of growth hormone. Sm-C, mostly bound to plasma protein forming an IGF-I protein complex, is slowly cleared from plasma and thus its plasma concentration is quite constant. A single sampling of blood for Sm-C is sufficient for the measurement of its concentration. For the evaluation of...
A case of IDDM associated with hypothyroidism.
Kyung Min Lee, Kuk Sin Jang, Mi Kyung Jang, Chul Zoo Jung
Clin Exp Pediatr. 1991;34(1):144-147.   Published online January 31, 1991
The authors experienced a case of insulin-dependent diabetes mellitus with hypothyroidism. We recommend that all patients with insulin-dependent diabetes mellitus be screened for thyroid mi- crosomal antibody and that those patients found to have thyroid microsomal antibody be followed annually for determination of free T4 and TSH values. We report this case with a review of related literatures.
HLA Typing, Islet Cell Antibody and C-Peptide of Insulin Dependent Diabetes Mellitus in Children.
Hyeong Rae Cho, Sei Joong Ko, Duk Hi Kim, Hyun Chul Lee, Kap Bum Huh
Clin Exp Pediatr. 1990;33(12):1705-1712.   Published online December 31, 1990
35 childhood insulin-dependent (Typel) diabetes mellitus were typed for HLA and examined for presence of islet cell antibody and level of C-peptide. The following results were obtained: 1) HLA types were present as follows; HLA A24 (9) in 58%, DR3 in 38% and DR4 in 62%. This was slightly higher than the Korean population of 38%, 7% and 48% but there was no significant difference. 2) When...
The Findings of 2D and M-mode Echocardiography in Young Insulin-Dependent Diabetes Mellitus.
Byoung Rei Cho, Jae Wook Ko, Young Jin Hong, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1990;33(1):88-93.   Published online January 31, 1990
Twenty-one children and young adults with Insulin-dependent diatetes mellitus and 23 control underwent 2D and M-mode echocardiography. Following results were obtained: 1) LVESD, LVEDD, EF, FS, LAD/AOD ratio, Dm of IVS and Dm of PLVWT were not significantly different in diabetics compared to control subjects. 2) In IDDM PEP was slightly increased and LVET was slightly decreased, but there was not statistical significance between the two groups. But...
Cord Blood Insulin Concentration in Premature Neonates with Respiratory Distress Syndrome.
Soo Jung Keum, Rak Won Choi, Mi Youn Chung, Dong Hyuck Kum
Clin Exp Pediatr. 1989;32(10):1402-1407.   Published online October 31, 1989
Insulin seems to exert an inhibitory effect on lung maturation. The incidence of respiratory distress syndrome in neonates of diabetic mothers is significantly greater than that observed in age-and weight-matched controls. Thus hyperinsulinemia may be an important factor in the developemnt of RDS. We investigated the relationship between cord blood insulin concentration and subsequent develop- ment of RDS in 32 premature neonates born at Koryo...
The Effect of Pertussive Vaccine & Cyclosporin on Streptozotocin Induced Diabetic Rats.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(7):914-923.   Published online July 31, 1988
The injection of streptozotocin (STZ) at higher dose (60 mg/kg) to young male rats produce direct beta cell destruction and lead to insulin dependent diabetes (IDD). In contrast, the injection of multiple smaller dose of STZ (40 mg/kg/d for 5 days) produce IDD, which resembles type 1 diabetes in man. The protective effect of pertussis vaccine (PV) & cyclosporin (CA) against the develoment...
The Effects of Cyclosporin in Treatment of Insulin Dependent Diabetes Mellitus.
Duk Hi Kim
Clin Exp Pediatr. 1985;28(6):564-569.   Published online June 30, 1985
A 2 year 10 month old girl with 6 weeks duration and 13 year 4 month old boy with 8 weeks duration were given cyclosporin for 68 days. Therapy was initiated orally at the dosage of 10 mg per kg of body per day. Blood glucose, C-peptide, cyclosporin, creatinin, BUN and transaminase were checked regularly. Cyclosporin treatment allowed two patients to...
The Study on Residual Beta-cell Function in Children with Dibetes Mellitus.
Duk Hi Kim
Clin Exp Pediatr. 1985;28(5):492-498.   Published online May 31, 1985
C-peptide can be used as a measure of endogenous insulin secretion in insulin treated diabetes mellitus. Pancreatic p cell secretory activity was measured in 11 patients with insulin dependent and 2 patients with non insulin-dependent diabetes mellitus by means of serum C-peptide response to 1 mg of glucagon subcutaneously. Serum C-peptide was increased to near normal range in the remission phase and...
A Study on Serum Glucose, Insulin, and hGH Levels of Cord Blood in Newborn.
Cheol Won Park, Chang Soo Ra
Clin Exp Pediatr. 1984;27(10):945-957.   Published online October 31, 1984
We have studied the serum glucose, insulin and hGH levels of cord blood in newborn infants(38 cases) and the serum glucose, insulin and hGH levels of maternal blood at parturition (38 cases). For the purpose of analysis, the study objects were divided into two groups: normal infant group (32 cases) and premature infant group (6 cases). Serum glucose levels were...
A Clinical Study on Insulin Dependent Diabetes Mellitus.
H S Kim, Y K Suh, T W Paik, Y D Kwon, C M Kang
Clin Exp Pediatr. 1984;27(9):903-911.   Published online September 30, 1984
The authors studied twelve cases of insulin dependent diabetes mellitus who were admitted to Pediatric Department of Keimyung University, Dong San Hospital from February 1975 to January 1983. Disease was developed after puberty in eight cases and effected both sexes equally and had tendency, prevalent in winter season. There was no significant family history except one case who had diabetic...
Case Report
Three Cases of Insulin Dependent Diabetes Mellitus in Children.
Tae Hoon Lee, Sang Chul Park, Chang Hwi Kim, Sang Man Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1983;26(3):285-289.   Published online March 31, 1983
We experienced three cases of Insulin Dependent Diabetes Mellitus, which revealed fullfilling- all characteristics of clinical 技 laboratory finding during recent 3 years. Two diabetic children among three patients had developed diabetic ketoacidosis. The one of the two cases, 14 aged girl complained of dyspnea & severe emaciation. The another case, 11 year and 2 month-old boy who had cataract complained of severe epigastric pain,...
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