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Original Article
A case of acute megakaryoblastic leukemia with Down syndrome.
Sung Jin Chang, Sung Min Sohn, Heung Sik Kim, Chin Moo Kang, Dong Seok Jeon
Clin Exp Pediatr. 1991;34(12):1730-1735.   Published online December 31, 1991
We experienced a case of acute megakaryoblastic leukemia (M7) with Down syndrome. The patient was admitted due to premature SGA, which revealed characteristic facial figure of Down syndrome. M7 was diagnosed with PB smear which showed abundant megakaryoblast and confirmed by using the monoclonal antiplatelet glycoprotein IIb/IIIa antibody (J 15). On 25th hospital day, the patient gained weight but discharged without further treatment of M7. Authors...
The effects of 1800 vGy cranial irradiation on intellectual function of children with acute lymphocytic leukemia.
Soo Ho Ahn, Jeong Ok Hah, Jung Hoon Lee
Clin Exp Pediatr. 1991;34(12):1683-1688.   Published online December 31, 1991
This study was conducted to investigate the effects of CNS prophylaxis with 1800 cGy cranial irradiation and intrathecal methotrexate (MTX) chemotherapy on intellectual function of the chil- dren with acute lymphocytic leukemia (ALL). Thirteen longterm survivors with ALL who were treated with 1800 cGy cranial irradiation and intrathecal MTX for CNS prophylaxis at pediatric department of Yeungnam University Hospital from May, 1983 to November, 1988...
Immune response induced by live attenuated varicella vaccine(Biken@) in children with acute lymphoblastic leukemia.
Hyo Seop Ahn, Joong Gon Kim
Clin Exp Pediatr. 1991;34(9):1255-1260.   Published online September 30, 1991
To determine the safety and efficacy of varicella vaccine, we studied 10 healthy children and 12 children in remission from acute lymphoblastic leukemia. They were immunized with the Oka strain of live attenuated varicella vaccine (Biken®). All the healthy children and 6 children with leukemia received the vaccine of 1,000 plaque-forming units (PFU), and 6 leukemic children received the vaccine of 500 PFU. The...
A case of bone marrow necrosis in acute lymphoblastic leukemia.
Mee Ran Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(8):1163-1168.   Published online August 31, 1991
Bone marrow necrosis is a rare complication most commonly encountered in patients with leuke- mia, metastatic tumor in marrow, sickle cell disease, DIC and severe infections. Recently it is regarded as a more common finding frequently overlooked and carrying not so poor prognosis. We reported here a boy with ALL who showed marrow necrosis on biopsy at the time of diagnosis and achieved complete...
A case of acute lymphoblastic leukemia complicating neuroblastoma in remission.
Dong Woo Son, Bum Soo Park, Jun Jae Kim, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(5):720-729.   Published online May 31, 1991
As childhood cancer survivors are now increasing in number owing to the improvements in diagnosis, staging, and treatment, concerns have been raised regarding the quality of survival of these patients. One of the limitation to quality and length of survival has been the development of second malignant neoplasm (SMN). In Korea, only one case of SMN has been reported. However, one can expect that...
Molecular analysis of childhood acute lekemia.
Hack Ki Kim, Kyong Su Lee, Sung Hoon Cho, Du Bong Lee
Clin Exp Pediatr. 1991;34(2):164-171.   Published online February 28, 1991
Immunoglobulin (Ig) and T cell receptor 0 chain (TcR分) gene rearrangements can be used as ”genetic marker” of lineage and clonality in the study of lymphoproliferative disease. We analyzed genomic DNA of the bone marrow mononuclear cells from twenty six patients with acute leukemia in children. The patients were seventeen cases of acute lymphocytic leukmia (ALL), seven cases of acute nonlymphocytic leukemia (ANL) and...
Two cases of hybrid leukemia.
Sung Dong Choi, Dae Chul Jung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee
Clin Exp Pediatr. 1991;34(1):130-136.   Published online January 31, 1991
The hybrid acute leukemia is defined as acute leukemia with both myeloid and lymphoid features. We experienced and report two cases of hybrid leukemia which were identified by morpholgy, cytochemical stain, reactivity with monoclonal antibody, analysis of immunoglobulin and T cell receptor genes rearrangement in 14 years old boy and 10 years old girl.
Clinical considerations of acute leukemia or transient myeloprolifo- rative disorder in Down syndrome.
Eun Sil Dong, Sung Hee Jang, Hong Hoe Koo, Hye Lim Jung, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(1):74-82.   Published online January 31, 1991
Children with Down syndrome have an increased incidence of acute leukemia. Infants with Down syndrome are also at risk of developing a transient myeloproliferative disorder indistinguishable from acute nonlymphocytic leukemia (ANLL) except by its eventual clinical recovery. We observed 11 patients with acute leukemia or transient myeloproliferative disorder in Down syndrome who had admitted to the Departmetn of Pediatrics, Seoul National University Children’s Hospital,...
A Case of Diabetic Ketoacidosis Associated with Acute Lymphocytic Leukemia during Remission Induction Chemotherapy.
Gyu Jin Oh, Hwa Jeong Lee, Heui Jeong Kwon, In Sil Lee
Clin Exp Pediatr. 1990;33(11):1598-1603.   Published online November 30, 1990
L-asparaginase is known as an effective anticancer drug in the induction chemotherapy of acute lymphocytic leukemia. The side effects or toxicities of L-asparaginase are hypersensitivity reaction, hepatotoxicity, pancreatitis, transient diabetes mellitus, CNS toxicity, disorders of coagulation system and mild cytotoxicity. We report a female patient with acute lymphocytic leukemia develop- ing diabetic ketoacidosis during induction chemotherapy with L-asparaginase, parednisolone, vincris- tine and intrathecal methotrexate, who...
A Case of Acute Megakaryoblastic Leukemia in infantwith down Syndrome.
Jang Sik Moon, Hae Young Hwang, Sejung Sohn, Hak Soo Lee, Heum Rye Park
Clin Exp Pediatr. 1990;33(10):1441-1446.   Published online October 31, 1990
Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have more than relationship to it. The authors report a case of acute megakaryoblastic leukemia in a 17 day-old male patient who was admitted for evaluation of high fever and dyspnea. The infiltration of atypical megakaryocytes...
A Case of Acute Mixed Lineage Leukemia (ANLL with TII) with neutropenic Enterocolitis.
Hyeon Joo Choi, Young Suk Koh, Young Mee Hong, Seung Joo Lee, Kee Suk Hong, Keum Ja Choi
Clin Exp Pediatr. 1990;33(9):1281-1287.   Published online September 30, 1990
We report a case of acute mixed lineage leukemia with both lymphoid and myeloid lineage characteristics (ANLL with Til) in a twelve-year-old girl who presented with fever and multiple petechiae. Bone marrow remission was obtained by treatment with acute lymphoid leukemia regiman (CCSG 106A). During induction chemotherapy, the patient was complicated by intestinal perforation due to neutropenic enterocolitis but recovered by surgical intervention and...
Serum Ribounclease Activity in Patients with Leukemia and Chromatographic Isolation of the Enzyme.
Young Suk Koh, Keun Lee
Clin Exp Pediatr. 1989;32(12):1715-1725.   Published online December 31, 1989
In order to find out the possibility for using serum ribonuclease (RNase) activity as diagnostic and therapeutic markers for leukemia, serum neutral, acid and alkaline RNase activities were determined in patients with acute lymphocytic leukemia (ALL) before and after anticancer therapy and in patients with acute myelogenous leukemia (AML). Also, serum RNases (neutral, acid and alkaline (RNase)and proteins were analyzed by column...
Three Cases of Typhlitis during Treatment for Acute Myelocytic Leukemia in Children.
Soon Mee Park, Il Soo Ha, Hoan Jong Lee, Jeong Kee Seo, Hyo Seop Ahn, Kyung Mo Yeon
Clin Exp Pediatr. 1989;32(10):1455-1462.   Published online October 31, 1989
Typhlitis is a rare necrotizing colitis in which inflammation is confined to cecum. It occurs during chemotherapy for malignancies, in terminal stage of aplastic anemia, in transplant patients. The pathogenesis of typhlitis has included leukemic infiltration of the bowel, thrombocytopenia, direct toxic effects of chemotherapy, steroid, bacterial invasion of the bowel wall secondary to neutropenia and alteration of the bowel flora by broad-spectrum antibiotics....
A Case of Myelodysplatic Syndrome.
Sun Bok Suh, Chang Ok Soh, Sang Hoon Lee, Chul Ho Kim, Soon Yong Lee
Clin Exp Pediatr. 1989;32(9):1314-1319.   Published online September 30, 1989
We have experienced a case of myelodysplastic syndrome (RAEB) in an 11-year-old boy with the complaints of pallor and petechiae for 1 month. After diagnosis, improvement was remarkable with chemotherapy of low dose cytosine arabinoside but the RAEB was transformed to acute myeloblastic leukemia 4 months after treatmemt. Anti-leukemic therapy was tried but induction of remission was failed and he was died of sepsis...
Cyclophosphamide-Induced Hemorrhagic Cystitis in Acute Lymphocytic Leukemia and Non-Hodgkin Lymphoma.
Young Seo Park, Il Soo Ha, Soon Ki Kim, Hae Il Jung, Yong Choi, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(5):665-669.   Published online May 31, 1989
We studied the cyclophosphamide-induced hemorrhagic cystitis in 72 cases of acute lymphocytic leukemia or Non-Hodgkin lymphoma, which had been treated at Seoul National University Children' s Hospital from June, 1985 to May, 1988 1) Among 72 cases treated with cyclophosphamide, 6 cases(12.8%) developed hemorrhagic cystitis in 47 cases of acute lymphocytic leukemia and 2 cases(8.0%) in 25 cases of Non-Hodgkin lymphoma. 2) The development of...
Infections in Childhood Leukemia.
Choong Won Lee, Young Sik Kim, Byung Kyu Park, Soon Ki Kim, Il Soo Ha, Hoan Jong Lee, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(5):659-664.   Published online May 31, 1989
A retrospective study was performed on twenty-nine children, who had experienced infection one or more times, among the thirty-eight children diagnosed as leukemia at the Department of Pediatrics, Seoul National University Hospital, between January, 1984 and June, 1985, and followed up for more than three years. The results were as follows; 1) The age of patients ranged from I year 5 months to 14 years...
A Case of Congenital Megakaryoblastic Leukemia Accompanied by Down Syndrome Which was Diagnosed by Autopsy Findings.
Il Kyung Kim, Dong Beom lee, Jung Sik Min, Chang Hee Choi, Je Geun Chi
Clin Exp Pediatr. 1989;32(2):262-269.   Published online February 28, 1989
Many cases of acute megakaryonlastic leukemia have been reported in childhood or adults, but congenital form or the cases occuring in neonatal period is very rare throughout the world. In Korea only one case was reported previously by Chung et al in 1987. The authors experienced a case of congenital megakaryoblastic leukemia accompanied by Down' s syndrome, which was confirmed by autopsy and positive...
High-Dose Cytosine Arabinoside (HD Ara-C) Therapy for Refractory Acute Leukemia in Children.
Il Soo Ha, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(10):1328-1337.   Published online October 31, 1988
Eleven children with refractory acute leukemia were treated with high dose cytosine arabinoside (HD Ara-C), given at a dosage of 3 gm/m2 intravenously over about one hour every 12 hours for four to eight doses. The antileukemic effects were evaluable in nine of the patients, two with ALL, seven with ANLL. Six of the seven patients with ANLL attained complete remission, while neither...
A Case of Acute Lymphocytic leukemia in a Newborn.
Young Jin Min, Myoung Hee Cha, Kyeng Sook Cho, Jong Dai Jo
Clin Exp Pediatr. 1988;31(9):1197-1201.   Published online September 30, 1988
The case of a 13 day-old baby is reported who satisfied the usual diagnostic criteria for congenital leukemia.
A Case of Acute Megakaryoblastic Leukemia in Infant with Down's Syndrome.
Jung Soon Whang, Soon hee Kim, Moon Ja Kim, Keun Lee, Je Geun Chi
Clin Exp Pediatr. 1988;31(8):1064-1070.   Published online August 31, 1988
Acute megakaryoblastic leukemia is an uncommonly recognized disorder that is characterized by rapidly progressive proliferation of atypical megakaryocytes and their precursor cells, and fatal course. Abnormalities in chromosome 21 may have a more than random relationship to acute megakaryoblastic leukemia. The authors reports a case of acute megakaryoblastic leukemia in a 2 month old female patient who was admitted for evaluation of hepatosplenomgaly. Multiple organ infiltration...
A Case of Cleidocranial Dysostosis with Leukemia.
Baik Lin eun, Si Hun Han, Young Sook Hong, Soon Kyum Kim
Clin Exp Pediatr. 1988;31(7):930-934.   Published online July 31, 1988
Cleidocranial dysostosis is a rare, inherited abnormality which affects the development of mem- bransous and cartilaginous bone. Authors report a case of cleidocranial dysostosis with leukemia in a 10 year old boy. The review of the literature was made briefly.
Treatment of Acute Myelogenous Leukemia in Children: Remission Induction with Adriamycin and Cytosine Arabinoside, and Postremission Maintenance Chemotherapy with Adriamycin, Cytosine Arabinoside and 6-thioguanine.
Soon Ki Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):850-862.   Published online July 31, 1988
The authers assessed the effectiveness of chemotherapy in 40 children with AML, experienced at Seoul National University Children’s Hospital during 8 years 5 months from April 1979 to August 1987. Remission induction treatment included adriamycin 30 mg/m2/day IV on days 1-3 and cytosine arabinoside 75 mg/m2/day continuous IV infusion on days 1-5. This regimen was repeated, if necessary, for one or two more courses. After...
A Clinical Observation on the Incidence of Childhood Leukemia.
Hyo Seop Ahn, Il Soo Ha, Soon Ki Kim, Hoan Jong Lee, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):841-849.   Published online July 31, 1988
We have analysed the type, age, sex, initial hematologic values and cell markers in 295 children, who had been diagnosed as leukemia at the department of pediatrics, Seoul National University Hospital, from Jan. 1983 to Dec. 1987. The patients were composed of 197 cases (66.8%) of ALL, 82 cases (27.7%) of ANLL and 16 cases (5.5%) of CML. FAB subclassification have been done in...
Clinical Characteristics and Pathogenesis of Typhlitis in Childhood Non-Lymphocytic Leukemia-Considerations on Clinical Mangement with Report of Two Cases and Literature Review.
Do Hyun Kim, Sung Oh Kim, Soo Yup Lee, In Joon Seol, Hahng Lee, Chong Moo Park, Poong Man Jung, Seok Chol Jeon, Young Hyeh Ko, Jung Dal Lee
Clin Exp Pediatr. 1988;31(5):607-620.   Published online May 31, 1988
The treatment of acute leukemia in childhood has been increasingly successful due to progression of chemotherapeutics and other supportive care. Improved survival rates in acute childhood leukemia have been associated with an increasing number of complications in the gastrointestinal tract. Typhlitis also known as ileocecal syndrome is a necrotizing inflammation of the cecum in leukemic patients on chemotherapy in the terminal stage of the...
A Case of Congenital Myeloblastic Leukemia Associated with Down's Syndrome.
Ho Jin Oh, Kee Hyoung Lee, Chang Sung Son, Hyun Keum Lee
Clin Exp Pediatr. 1987;30(12):1468-1474.   Published online December 31, 1987
A 4 day old male patient was admitted to our hospital due to jaundice, poor feeding and abdominal distention. His clinical features and peripheral blood smear revealed congenital myeloblastic leuke- mia which confirmed by autopsy. Chromosome study showed 47, XY, +21 in Karyotype. We report this case with review of literatures.
A Case of Juvenile Chronic Myelogenous Leukemia Associated with Juvenile Xanthogranuloma.
Eun Yong Lee, Jin Tae Kim, Young Sook Hong, Soon Kyun Kim, Hyun Keum Lee
Clin Exp Pediatr. 1987;30(11):1299-1304.   Published online November 30, 1987
We experienced a case of juvenile chronic myelogenous leukemia associated with juvenile xanthogranuloma and neurofibromatosis. This 1-year 6-month-old male patient had multipe cafg-au-lait spots, numerous nontender, yellowish, dome-shaped papules and nodules, hepatosplenomegaly, and pneumonia. Hematologic & bone marrow examinations, chromosomal study, and skin biopsy were performed for diagnosis. A brief review of the related literatures was added.
Clinical, Hematological and Cytogenetical Studies of Leukemia in Children.
Young Wook Kim, Chan Gyu Hwang, Ki Bok Kim
Clin Exp Pediatr. 1987;30(2):181-190.   Published online February 28, 1987
A review was made on the clinical, hematological and cytogenetical findings of 68 children diagnosed as leukemia at Pediatric Department, Kwangju Christian Hospital, during a period of 10 years from Jan. 1975 to Dec. 1985. The results were as follows: 1) The sex ratio of 68 children diagnosed as Leukemia was 1:1. The most common age group was 11-12 year(19.1%), followed by the group of 3-4...
Case Report
A Case of Chronic Myelogenous Leukemia in a Child Treated in a Interferon.
Ill Soo Ha, Jon Lin Rhi, Se Jung Sohn, Dug Ha Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1986;29(11):1232-1238.   Published online November 30, 1986
A child with Ph^positive chronic myelogenous leukemia was treated with human leukocyte interferon (Hu IFN-alpha). Hematologic remission was obtained in 16 weeks of treatment, and white blood cell count was decreased in number from 115,000 to 9,600. Platelet：count, spleen size, LDH and bone marrow M/E ratio were decreased in parallel, but there was no significant change in serum vitamin B12...
Original Article
A Clinical and Laboratory Study on Infection in Childhood Leukemia.
Jung Hee Lee, Kwang Hyun Kim, In Joon Seol, Heung Jae Lee, Hahng Lee, Chong Moo Park
Clin Exp Pediatr. 1986;29(7):699-709.   Published online July 31, 1986
Acute Leukemia is the most common among malignant disease in childhood, and the loss of normal hematopoiesis by proliferation of leukemic cells and the chemotherapy result in immunosuppression and the reduction of red blood cells, normal white blood cells and platelets. The children with acute leukemia may succumb to the disease due to infections, hemorrhage, other complications, or the progression...
A Study on Four Serum Enzymes in Acute Leukemia in Children.
In Joon Seol, Seung Jae Yang, Kyoo Hwan Rhee, Hahng Lee, Chong Moo Park, Jae Kyung Koh
Clin Exp Pediatr. 1986;29(2):130-142.   Published online February 28, 1986
In order to find out whether some of serum enzyme levels could be used as markers for acute leukemia in children, activities of amylase, alkaline phosphatase, 5 -nucleotidase and ribonuclease (RNase) and positive rates of these enzymes as markers for acute leukemia in children were determined in serum of patients with acute lymphocytic leukemia (ALL) and acute non-lymphocytic leukemia(ANLL). Since the...