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Original Article
Postnatal Changes in Left Ventricular Performance in Early Neonatal Life
Sung Wook Yang, Chan Wook Woo, Jee Youn Lim, Jung Hwa Lee, Joo Won Lee, Chang Sung Son, Young Chang Tockgo, Young Yoo
Clin Exp Pediatr. 2000;43(9):1168-1173.   Published online September 15, 2000
Purpose : This study was undertaken to investigate changes in cardiac performance in early neonatal life by observing the changes of left ventricular(LV) function and volume according to the size of ductus arteriosus. Methods : The study group consisted of 21 full-term Cesarean section neonates who were admitted to the nursery of Korea University Hospital. We serially investigated the...
Neonatal Systemic Candidiasis : Comparison of Albicans and Parapsilosis Infection
Jung Mie Han, Ho Young Lee, Mi Jeong Kang, Sun Young Ko, Yun Sil Chang, Won Soon Park
Clin Exp Pediatr. 2000;43(8):1052-1058.   Published online August 15, 2000
Purpose : Systemic Candidiasis has become an increasingly important cause of morbidity and mortality in NICU infants. Severe infections caused by non-albicans Candida species have been increasingly reported in NICU infants. The purpose of the present study was to compare relative severity, mortality rates for C. albicans(CA) and C. parapsilosis(CP) infections in our NICU. Methods : This study included 16 infants...
The Utility of Serum Prealbumin as a Biochemical Marker for Nutritional Adequacy in Neonates
Ji A Jung, Eun Ae Park, Jeong Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 2000;43(5):605-610.   Published online May 15, 2000
Purpose : The purpose of this study was to determine the utility of serum prealbumin as a biochemical marker for nutritional adequacy in neonates. Methods : From March 1998 to May 1999, 71 fullterm(54 AGA, 9 LGA, 8 SGA) and 46 preterm neonates were enrolled. The correlations among prealbumin, albumin, birth weight and gestational age were obtained. Serum concentrations of albumin...
Clinical Evaluation of Diagnostic Criteria for Early Prediction of Bacterial Infection in Febrile Neonates
Jai Il Cho, Sang Chun Lee, Hwan Il Kim, Cheol Am Kim, Kil Seo Kim
Clin Exp Pediatr. 1999;42(12):1661-1667.   Published online December 15, 1999
Purpose : A retrospective study was undertaken to test the hypothesis that febrile neonates, who have bacterial infections, can be accurately predicted early by diagnostic criteria. Methods : We conducted a retrospective study of 152 infants, 28 days or less of age, whose rectal temperature was at least 38℃. Past history, family history, finding on physical examinations and results of CBC,...
Case Report
A Case of Parry-Romberg Syndrome in Neonate
Chun Hyuk Chang, Jin Hwa Jung, Sung Min Cho,, Dae Seop Choi
Clin Exp Pediatr. 1999;42(11):1589-1593.   Published online November 15, 1999
Parry-Romberg syndrome(Progressive hemifacial atrophy), described in the last century by Parry(1825) and Romberg(1846), is a very rare disorder characterized by a slowly progressive and self-limited unilateral(rarely bilateral) atrophy of the faces affecting variably the skin, subcutaneous fat tissues, musculature, connective tissue, cartilage and bones. And this disorder is usually accompanied by contralateral Jacksonian epilepsy, trigerminal neuralgia, and changes in the...
Original Article
Changes in Arterial Blood Gas in Crying Neonates
Yeo Hyang Kim, Heng Mi Kim
Clin Exp Pediatr. 1999;42(11):1496-1501.   Published online November 15, 1999
Purpose : Arterial blood gas and pH measurements are the standard by which adequacy of oxygenation and ventilation are assessed. The major problem with arterial punctures is that they can rarely be done without disturbing the neonates. Crying during arterial puncture usually results in change in respiratory patten and thus may result in significant changes in blood gas values Methods :...
Characteristics of Transient Hypothyroidism Detected by Neonatal Screening Test
Su-Yung Kim
Clin Exp Pediatr. 1999;42(11):1487-1495.   Published online November 15, 1999
Purpose : To help differentiate transient hypothyroidism from congenital hypothyroidism, both of which might be confused initially, the clinical characteristics of transient hypothyroidism were compared to those of permanent ones. Methods : An analysis of the clinical data, including perinatal history, TFT(thyroid function test), and radionuclide scanning, was performed. The outcome of 18 patients of transient hypothyroidism was also compared to...
Study of Nosocomial Infection of Rotavirus in Preterm and Full-term Neonates
Kwang Ok Chung, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim, Sun Hee Yu
Clin Exp Pediatr. 1999;42(3):332-338.   Published online March 15, 1999
Purpose : The present study was designed to investigate rotavirus infection by comparing clinical characteristics of the nosocomial infection of rotavirus between preterm and full-term neonates. Methods : The subjects were admitted from May to December, 1996. In 71 preterms, 44 were Rotazyme positive, 27 were negative, and in 321 full-terms, 64 were Rotazyme positive, 257 were negative. We studied the...
The Effect of Low-Dose Dopamine on the Renal Function of Asphyxiated Neonates
Seung Yeon Nam, Eun Ae Par, Seung Joo Lee
Clin Exp Pediatr. 1998;41(12):1685-1692.   Published online December 15, 1998
Purpose : Low-dose dopamine(0.5-3μg/kg/min) increases renal blood flow, glomerular filtration rate and natriuresis and has protective and therapeutic effects on oliguric renal failures. Asphyxia is the most common cause of acute renal failure in neonates. But the protective effects of dopamine have never been reported in asphyxiated neonates. So we reported the effects of low-dose dopamine on the renal function...
Study of a Comparison of Ultrasonography with Radiography to Localize the Umbilical Arterial Catheter
Byoung Min Choi, Young Kwan Park, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1998;41(12):1650-1659.   Published online December 15, 1998
Purpose : This study was performed to observe the utilization of ultrasonography in locating the position of UAC and to compare the position with anatomical landmarks seen on radiography. Methods : Optimal position is when the catheter tip is located between T6-T10 or L3-L5 by anteroposterior radiography(AP-R) and above the diaphragm by cross-table lateral radiography(CTL-R). Ultrasonographic studies used a Hewlett Packard...
Effect of Dexamethasone on Preventing the Laryngeal Edema Following Extubation in Neonates
Joon Sung Kim, Young Youn Choi, Jae Sook Ma, Tai Ju Hwang
Clin Exp Pediatr. 1998;41(9):1180-1187.   Published online September 15, 1998
Purpose : We performed this study to evaluate the clinical efficacy and safety of dexamethasone in preventing laryngeal edema following exubation. Methods : We retrospectively reviewed the medical records of 100 neonates who underwent endotracheal intubation and mechanical ventilation. Subjects were divided into two groups; dexamethasone treated(60 cases, dexamethasone group) and non-treated(40 cases, control group). We examined the underlying diseases of...
Case Report
A Case of Bilateral Vocal Cord Paralysis in Neonate
Young Kyoun Kim, Seung Cheol Lee, Se Wook Oh, Sang Woo Kim, Jae Hyung Park
Clin Exp Pediatr. 1998;41(4):558-561.   Published online April 15, 1998
Neonatal vocal cord paralysis is the second most common laryngeal anomaly, which accounts for approximately 10% of all congenital laryngeal lesions. Neonate with bilateral vocal cord paralysis are charactenzed with a glottic obstruction which usually shows dyspnea and inspiratory stridor. Treatment of bilateral vocal cord paralysis in neonate have two major goals : restore proper breathing and retain the voice. Tracheostomy is the best...
Original Article
Random Urine Ca/Cr Ratio in Healthy Neonates
Hea Young Lee, So Young Park, Eun Sun Yoo, Eun Ae Park, Seung Joo Lee
Clin Exp Pediatr. 1998;41(3):378-382.   Published online March 15, 1998
Purpose : Recently, in high risk preterm infants, we experienced high incidence of hypercalciuria, nephrolithiasis & nephrocalcinosis. To screen hypercalciuria, we need the normal value of random urine Ca/Cr ratio in healthy neonates according to gestational age, postnatal age, milk and calcium intake. Methods : Random urine Ca/Cr ratio was checked in 260 healthy full-term infants at the 2-7th day, and...
Incidence of Congenital Heart Disease in Neonate by Color Doppler Echocardiography
Tae Chan Kwon, Joon Sik Kim, Sang Lak Lee, Myung Sung Kim, Geun Soo Park, Chun Soo Kim, In Joo Kim, Bin Ahn
Clin Exp Pediatr. 1998;41(3):363-368.   Published online March 15, 1998
Purpose : Many reports exist about the frequency of congenital heart disease(CHD) in the world, but according to the definition of CHD and subjects of study group, many differences existed between the reports. We conducted this study to evaluate the incidence and frequency of CHD by color Doppler echocardiography in neonate, and to suggest a preliminary model of incidence of...
Mumps and Rubella-Specific IgG Levels of Term Pregnant W omen and Their Neonates
Young Kyoo Shin, Hae Won Cheon, Kee Hyoung Lee, Ji Tae Choung, Young Chang Tockgo
Clin Exp Pediatr. 1998;41(1):47-52.   Published online January 15, 1998
Purpose : This study was performed to evaluate seropositivities in term pregnant women and their neonates, and the transplacental transfer rate of maternal mumps and rubella- specific IgG from term pregnant women to their neonates. Methods : During Jun. 1, 1994 to Mar. 31. 1995, we collected 44 pairs of sera from pregnant women and their neonates in Anam Hospital of Korea University Medical...
Serum G-CSF Level Changes in Neonatal Sepsis
Kyung Ha Ryu, Eun Ae Park, Kyung Hyo Kim, Gyung Hee Kim
Clin Exp Pediatr. 1998;41(1):12-18.   Published online January 15, 1998
Purpose : The neonate is susceptible to severe and overwhelming bacterial infections. One of the most important deficiency in the neonatal host defense system seems to be quantitative and qualitative deficiency of the myeloid and the phagocytic system. Granulocyte colony-stimulating factor(G-CSF) has been shown to induce neutrophilia and enhance mature effector neutrophil function. We examined serum levels of G-CSF in...
Plasma Fibronectin Concentration in the Premature,Fullterm Neonates and Infants
Hyun Joo Lee, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(4):473-479.   Published online April 15, 1997
Purpose : Plasma fibronectin has important role in the inflammatory response as non-specific opsonin and host defense. Plasma fibronectin concentration is different according to age and presence of infection. We performed this study to evalulate plasma fibronectin concentration in the healthy preterm, term neonates and infants and how that correlate with gestational age and birth weight and increased CRP concentration....
Case Report
A CaseofAdrenal Aplasi
Yoon-Ok Kim, Myoung-Bum Choi, Yun-Kyeong Cho, Jae-Yong Lim, Yang-Suk Jung, Suong-Hwan Kim, Hyang-Ok Woo, Hee-Shang Youn
Clin Exp Pediatr. 1996;39(11):1627-1630.   Published online November 15, 1996
Major known causes of neonatal adrenal insufficiency are prolonged maternalsteroid use, adrenal hemorrhage from the perinatal stress and adrenogenital syndrome. Theoretically adrenal aplasia might be a cause of neonatal adrenal insufficiency but it has not been reported yet. We had experienced a case of adrenal aplasia in a 5 day-old male neonate whose chief complaint was hyperpigmentation. His laboratory findings were compatible...
Original Article
A Study for the Expression of the N-Methyl-D-Aspartate(NMDA) Subunit 2A(NR2A)and 2B(NR2B) of Rat Hippocampal Slices in the Hypoxic State
Hee Sin Go, Woo Taek Kim
Clin Exp Pediatr. 1996;39(9):1295-1308.   Published online September 15, 1996
Purpose : Excessive amounts of glutamate are released into the extracelluar space during hypoxia/ischemia and contribute to neuronal injury through overactivation of the NMDA receptors. It will be expected that the changes of the NMDA receptors to decrease the injury are developed as a kind of defense mechanism. The NMDA receptors are composed of NR1 and NR2, and there are four NR2 subunits; NR2A,...
Evaluation of Pulmonary Function Test by Pneumotachography and Passive Expiratory Flow-volume Technique in Newborns with Respiratory Diseases with Respiratory Diseases
Hye Jin Lee, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(4):482-490.   Published online April 15, 1996
Purpose : Pulmonary function test is an important diagnostic tool in neonatal intensive care. These tests provide a detailed assessment an infant's pulmonary status that can be used in several ways: to monitor the progression of lung disease, to streamline ventilator management, and to assess the infant's response to new treatments, such as surfactant replacement therapy or bronchodilator. The purpose...
Study on Platelet Countsand Indices in Neonates
Kyoung Hee Choi, Sung Soo Rim, Byung Min Moon, Ki Bok Kim
Clin Exp Pediatr. 1996;39(3):338-345.   Published online March 15, 1996
Purpose : The platelet number alone does not give a complete picture of platelet maturity and function, therefore, the platelet indices have been the subject of intensive study in recent years, but they have not been firmly established in the neonates. Methods : Blood samples collected in K2 EDTA bottle from femoral vein of 176 neonates (54 healthy fullterm, 96...
Plasma Fibronectin Concentration in the Neonate
Young Yoo, Kwang Chul Lee, Young Chang Tockgo
Clin Exp Pediatr. 1996;39(3):319-325.   Published online March 15, 1996
Purpose : Plasma fibronectin is thought to have important role in the inflammatory response and host defense. We performed this study to evaluate concentration in the full-term, healthy preterm, asphyxia and respiratory distress syndrome and how that correlated with gestational age and birth weight. Methods : We evaluate 51 neonates who were delivered at Korea University Hospital from Jan. 1992 to...
Pulmonary Function Test in Korean Neonates by Expiratory Flow-Volume Curve
So Young Park, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1996;39(1):53-62.   Published online January 15, 1996
Purpose : Neonatal pulmonary function test(PFT) adds a new dimension to the understanding and care of the infant at risk for lung dysfunction. PFT can be identified the risk for pulmonary problems and safely and effectively diagnosed, quantified, and qualified the dysfunction. So it is possible to early institution of prophylatic respiratory therapy in such neonates and it can improved...
Circumcision, Neonates, Pain sensation
In Rok Do, Jeong Ho Lee, Yong Sub Kim, Jong Dae Jo
Clin Exp Pediatr. 1995;38(10):1324-1328.   Published online October 15, 1995
Purpose : Routine neonatal circumcision has widely performed without anesthesia under the assumption that the penis of neonates does not yet have functioning pain sensory nerve endings at this early stage of development, and has decreased the incidence of neonatal urinary tract infection. This study was performed to evaluate whether neonates recognize pain during opertion of circumcision without anesthasia. Methods :...
Analysis of Auditory Brainstem Response in the Infants at High Risk for Hearing Disability
Kang Ho Cho, Myoung Jae Chey
Clin Exp Pediatr. 1995;38(10):1315-1323.   Published online October 15, 1995
Purpose : This study is performed to evaluate the clinical course, degree of hearing impairment and neurologic outcome of the infants at high risk for hearing disability. Methods : The 603 infants who had risk factors, such as severe birth asphyxia, hiperbilirubinemia requiring exchange transfusion, head and neck anomaly every low birthweight under 1500gm, family history of childhood hearing impairment, bacterial...
Diagnostic Value of Stable Microbubble Rating test and Efficacy of Surfactant Replacement Therapy in Neonates with Respiratory Distres syndroems
Jeong Hee Kim, Eun Ae Park, Kyung Hee Kim
Clin Exp Pediatr. 1995;38(6):760-770.   Published online June 15, 1995
Purpose : Stable microbubble rating test(SMR) plays an important role in the clinical course and the prognosis of respiratory distress syndrome(RDS) patients, because SMR can be easily performed and it can predict quickly the neonatal RDS. After the success of the pulmonary surfactant replacement therapy in RDS infants by Fujiwara and co-workers in 1980, many supporting studies were presented and...
The Therapeutic Effects of Dexamethasone Therapy in Neonate with Bacterial Meningitis
Eun Gyung Lee, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1995;38(5):602-611.   Published online May 15, 1995
Purpose : In experimental models of meningitis and in children with meningitis, dexametha-sone has been shown to reduce meningeal inflammation and to improve the outcome of disea-se. We studied the effects of dexamethasone administration in neonates(<2 month-old) with b-acterial meningitis. Methods : We retrospectively reviewed the medical records of 30 neonates admitted to the nursery, the Yonsei University College of Medicine...
Case Report
A Case of Hemimegalencephaly with Intraventricular Hemorrhage and Multifocal Intraparenchymal Hemorrage on Deep White Matter of Periventricular Area
Jin Sung Ko, Kook In Park, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwang Han, Choon Sik Yoon
Clin Exp Pediatr. 1995;38(4):561-566.   Published online April 15, 1995
Hemimegalencephaly is a rare congenital anomaly characterized by a intractable seizure an infantile death. This disease is a migrational disorder with enlargement of unilateral hemisphere, abnormal gyration of the cortex, the presence of large and atypical neuron, hetero trophic neuron at subcortical area and proliferation of astrocyte ect. We observed a neonate with neonatal seizure, and the radiological evaluation revealed abnormal...
Original Article
Outbreak of Non-typhoidal Salmonellosis in neonates
N.M. Park, M.J. Chey, M.J. Jeong, H.S. Kim, K.H. Kim, H.S. Lee
Clin Exp Pediatr. 1995;38(1):20-26.   Published online January 15, 1995
During the period from Jun. 24, 1991 to Aug. 31, 1991, we experienced 6 cases of non-typhoidal salmonella and 18 cases with symptoms suggesting salmonellosis. The results obtained were as follows; 1) Mean age on admission was 9¡¾6 days and mean body weight was 3.3¡¾0.3kg. All cases were fullterm neonate. 2) 12 pts were transferred from nursery becasuse of diarrhea (50.0%), 7 pts...
Intraventricular Hemorrhage in Full-Term Neonate
Myoung Bae Jeon, Kook In Park, Choon Sik Yoon, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(6):776-785.   Published online June 15, 1994
Intraventricular hemorrhage is a common hemorrhagic cerebral disorder in premature, but occurs much less frequently in the full-term newborn. In order to obtain documentation of clinical and ultrasonographic characteristics of intraventricular hemorrhage in full-term, we performed cerebral ultrasonography on 602 newborn infants who had been admitted to neonatal intensive care unit at the Deppartment of Pediatrics, Yonsei University College of...