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Case Report
A Case of Congenital Goiter with Congenital Hypothyroidism due to Organification Defect
Ik Hee Lee, Sung Yong Jung, Thi Hyung Park, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1993;36(7):1002-1008.   Published online July 15, 1993
We experienced a case of congenital goiter with congenital hypothyroidism in 45 dayold male, who complained of respiratory difficulty and anterior neck mass. After admission, he was diagnosed congenital hypothyroidism by the clinical manifestations and laboratory tests including biochemistry, radioimmunoassay, radioisotope study, perchlorate discharge test, and bone radiography. We obtained positive finding at the perchlorate discharge test and found that his...
Two Cases of Pseudolhypoparathyroidism in Sibling
Sun Whan Kwon, Hye Jin Lee, Seon Young Choi, Un Ki Yoon
Clin Exp Pediatr. 1993;36(6):882-887.   Published online June 15, 1993
Pseudohypoparathyroidism is a medical disorder characterized by a complex disorder of renal resistance to parathyroid hormone and the mechanism underlying the disease is still unclear. The autors described two cases of Pseudohypoparathyroidism in sibling, who had metabolic anomalies(hypocalcemia and hyperphosphatemia, high circulating immunoreactive PTH) and basal ganglia calcification. Bilateral basa ganglia calcifications, which was not visible on plain skull fim, was...
Original Article
Growth Outcome in Congenital Hypothyroidism
Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1993;36(5):713-720.   Published online May 15, 1993
Congenital hypothyroidism is one of the most common endocrine disease in childhood and it causes not only mental retardation but also growth retardation. There were many papers about evaluation of developmental outcome in congenital hypothyroidism, The aim of this study was to evaluate growth outcome in congenital hypothyroidism. We evaluated 65 patients with congenital hypothyroidism diagnosed at yonsei University College...
Case Report
A Case of Primary Hyperparathyroidism in Infancy
Mi Jung Park, Ho Seong Kim, Duk Hi Kim
Clin Exp Pediatr. 1992;35(7):1008-1013.   Published online July 15, 1992
Primary hyperparathyroidism is very rare and often fatal disease in childhood. We experienced a case in which a 4 months old male patient complaning of lethargy, hypotonia, respiratory difficulty showed typical laboratory and radiological findings compatible to primary hyperparathyroidism. He was successfully treated with total parathyroidectoimy with partial parathyroid autotrans-plantation. Thus the case of primary hyperparathyroidism in infancy is presented with...
A Case of Neonatal Hypothyroidism due to Maternal TSH-Binding Inhibitor Immunoglobulin
Myung Lye Kim, Rhie Choi, Dong Hwan Lee, Sang Jhoo Lee
Clin Exp Pediatr. 1992;35(6):804-808.   Published online June 15, 1992
Neonatal screening for congenital hypothroidism is important because of the possibility that mental retardation may be avoided if treatment started early. A 1 day old patient was admitted to our department of Pediatrics for congenital hypothyroidism screening. The mother was 33 years old and had been on thyroid replacement therapy since 32 years of age. During the pregnancy she was euthyroid...
Original Article
The Incidence of Hypothyroidism in Children with Down Syndrome
Seong Hyeon Jeon, Chun Ho Cho, Kyoung Sim Kim, Ki Bok Kim
Clin Exp Pediatr. 1992;35(4):534-538.   Published online April 15, 1992
A review of Thyroid function tests was performed on 32 children with Down syndrome confirmed by cytogenetic examination at the Dept. of Pediatrics, Kwangju Christian Hospital from Jan.1989 to Feb.1990. 1) Twenty among 32 children with Down syndrome were male, with the sex ratio being 1.7 : 1. Their ages ranged from 3 days to 5 years, with the mean age...
A clinical study on the thyroid nodule in childhood.
Yong Ju Kim, Ki Young Cheong, Jong Jin Seo, Young Hun Chung
Clin Exp Pediatr. 1991;34(8):1116-1122.   Published online August 31, 1991
A clinical study was carried out in 27 children with thyroid nodule who visited the Dept, of pediatrics, Chungnam National University Hospital during the 4 year period from March 1986 to February 1990. The results are as follows; 1) The most frequent age group was between 10 to 15 year, and the mean age was 10.65 ±3.19 year. The male to female ratio was 1:4.4 2) All patients...
Two cases of ectopic sublingual thyroid with hypothyroidism to be appeared in fetal life.
Dong Sik Kim, Mee Kyung Namgoong, Hae Yong Lee, Hwang Min Kim, Baek Keun Lim
Clin Exp Pediatr. 1991;34(3):426-434.   Published online March 31, 1991
Infants & children with hypothyrodism usually manifest variable skeletal abnormality. These features are the delay in longitudinal bone growth, the delay in epiphyseal maturation (=delay in bone age), the disturbances in bone mineralization and charateristic multiple stippled epiphysis (cretenoid epiphyseal dysgenesis). But many pediatrician have only concerned about the delay in epiphyseal maturation. Epiphyseal dysgenesis can be used a marker to find out the begining...
A case of IDDM associated with hypothyroidism.
Kyung Min Lee, Kuk Sin Jang, Mi Kyung Jang, Chul Zoo Jung
Clin Exp Pediatr. 1991;34(1):144-147.   Published online January 31, 1991
The authors experienced a case of insulin-dependent diabetes mellitus with hypothyroidism. We recommend that all patients with insulin-dependent diabetes mellitus be screened for thyroid mi- crosomal antibody and that those patients found to have thyroid microsomal antibody be followed annually for determination of free T4 and TSH values. We report this case with a review of related literatures.
Thyroid function Study in Respiratory distress Syndrome.
Sung Soo Kong, Mi Young Chung, Dong Hyunk Kum
Clin Exp Pediatr. 1990;33(10):1394-1398.   Published online October 31, 1990
It has been known that intrauterine thyroid hormone deficiency may be one of the factors predis- posing to RDS in premature infants. L-thyroxine has been shown to increase the production opf lung surfactant, widely accepted as deficient in RDS infants, as association between lung immaturity and fetal thyroid function is postulated. The authors investigated thyroid hormone concentration at birth and 5, 15 days of...
Clinical Observation on isolated TRH deficient Congenital Hypothyroidism.
Heon Seok Han, Hyung Ro Moon
Clin Exp Pediatr. 1990;33(10):1388-1393.   Published online October 31, 1990
Clinical features and endocrine function of 3 children with isolated TRH deficient congenital hypothyroidism followed at Seoul National University Children’s Hospital from Aug, 1986 to Aug. 1990 were reviewed. During above period 262 congenital hypothyroid patients were followed at endocrine clinic, number of congenital primary hypothyroidism was 218 cases (83.2%), and that of congenital secondary hypothyroidism was 44 cases (16.8%). Of the congenital primary hypothyroidism,...
A Case of Congenital Hypothyroidism.
Woo Hyon Kwon, Soon Young Song, Chang Ho Han, Hyae Ri Chung, Soo Yong Kim, Young Dae Kwon
Clin Exp Pediatr. 1990;33(5):708-713.   Published online May 31, 1990
Recently, we experienced a case of congenital hypothyroidism in 3month-old girl, who came with chief complaints of prolonged jaundice for 2 months after birth. After admission, she was diagnosed congenital hypothyroidism by the laboratory tests, including biochemistry, radioimmunoassay, radioisotope study, and bony radiography, and since then treated with sodium-L-thyroxine orally. The case was presented with brief review of literatures.
Prognosis according to Etiology and Age at Diagnosis in Congenital Hypothyroidism.
Myoung Sook Nam, Young Jong Oh, Byung Hee Kim, Young Jong Woo, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 1990;33(4):506-513.   Published online April 30, 1990
A retrospective study on patients with congenital hypothyroidism was undertaken. The following results were obtained from 17 patients, on whom follow up investigations were available. 1) Males outnumbered females. The etiologic classification revealed: thyroid agenesis (64.7%), dyshormonogenesis (23.5%), and ectopic thyroid (11.8%). 2) In two-thirds of cases the diagnosis were made under 1 year of age, with 23.5% of cases being diagnoses below 3 month and 41.2%...
A Case of Sexual Precocity with Congenital Hypothyroidism.
Wan Kyu Lee, Eun Jun Hyung, Duk Hi Kim
Clin Exp Pediatr. 1990;33(2):259-263.   Published online February 28, 1990
Sexual precocity in assocition with congenital hypothyroidism is a rare clinical entity. We experi- enced a case of sexual precocity, such as vaginal bleeding, breast development in a patient with congenital hypothyroidism' We present with the brief review of related literature.
Two Cases of Goitrous Hypothyroidism in Siblings.
Kwang Ok Lee, Hwa Il Kwag, Hoon Kook, Young Youn Choi, Tai Joo Hwang
Clin Exp Pediatr. 1990;33(1):129-134.   Published online January 31, 1990
The authors experienced two cases of goitrous hypothyroidism in siblings. The etiology was considered to be defect of iodide organification in steps of thyroxine synthesis. The diagnosis was made on the basis of history, clinical features, thyroid function test, thyroid scanning, ultrasonogram and perchlorate discharge test. We report these cases with a review of related literatres.
Effects of long-term anticonvulsant therapy of thyroid function.
Sei Joong Ko, Duk Hi Kim, Chang Jun Coe
Clin Exp Pediatr. 1989;32(11):1533-1539.   Published online November 30, 1989
Serum concentrations of total triiodothyronine (T3) and thyroxine (T4) as well as serum thyroid- stimulating hormone (TSH) were measured in 108 patients with childhood epilepsy taking anticonvul- sants and in 54 normal healthy children as control group. Of these 108 patients, 23 were treated with carbamazepine alone, 17 were phenytoin alone and the rest 68 were treated with combination of two or more drugs...
Study on Antithyroid Antibody and Thyroid Functional Status in Patients with Turner Syndrome.
Bo Young Lee, Duk Hi Kim, Kir Young Kim
Clin Exp Pediatr. 1989;32(10):1397-1401.   Published online October 31, 1989
This study is a systematic cytogenetic and clinico-hormonal analysis of 26 cases who were diagnosed as Turner syndrome at the Yonsei Medical Center from Jan. 1978 to Jan. 1988. Antithyroid antibody and thyroid function tests were performed in Turner syndrome(3 groups according to karyotypes) and control group. The results were as follows: 1) The incidence of positive antithyroid antibody in the 26 cases was 42.3% and...
Two Siblings of Congenital Hypothyroidsm due to Organification Defect.
Young Kie Park, Kwang Sun Park, Byung Churl Lee
Clin Exp Pediatr. 1989;32(4):582-588.   Published online April 30, 1989
Congenital hypothyroidism due to a variety of defects in the biosynthesis of thyroid hormone is detected in 1/30,000-50,000 live births. In the iodide organification defect which is one of defect in the biosynthesis of thyroid hormone, iodide is not organified and may be rapidly discharged from the thyroid by administration of perchlorate. We experienced two siblings who had short stature, goiter, mental retardation, constipation and other...
A Study on the Thyroin Function Test in Patients with Nonthyroidal Illness.
Mi Soo Ahn, Chan Young Kim
Clin Exp Pediatr. 1989;32(3):381-389.   Published online March 31, 1989
To evaluate the influence of nonthyroidal illnesses on the thyroid function in children, serum T₃ , T₄, rT₃ and TSH were measured using radioimmunoassay in 32 clinically euthyroid children with nonthyroidal illness who were admitted to Department of Pediatrics, Wallace Memorial Baptist Hospital from October, 1987 to April, 1988 Control group was 22 children in absence of thyroid diseases and systemic illnesses. The results of...
A Case of Primary Hyperparathyroidism in Childhood.
Dong Sung Kim, Soon Joo Lee, Kyung Il Lee, Byung Churl Lee
Clin Exp Pediatr. 1988;31(10):1350-1357.   Published online October 31, 1988
Primary hyerparathyrodism is rare in children under the age of sixteen and is characterized by conspicuous skeletal and renal changes. An 11 years old male patient who had complained of severe lower back pain, nausea and vomiting since last 3 months, showed typical laboratory and radiological findings of primary hyperparathy roidism. Confirmatory diagnosis was made by elevated serum parathyroid hormone concentration, imaging method by technetium-thallium subtraction...
Thyriod Function Studies in Children with Nephrotic Syndrome.
In Hoon Lee, Chan Yung Kim
Clin Exp Pediatr. 1988;31(8):1037-1047.   Published online August 31, 1988
To evaluate the influence of nephrotic syndrome on the thyroid function test in children, serum T3, T4, free T4, TSH, TBG and rT3 were measured using radioimmunoassay in 14 clinically euthyroid children with nephrotic syndrome who were admitted to Department of Pediatrics, Pusan National University Hospital from July, 1986 to August, 1987. Control group was 15 children who visit our outpatient department for minor...
Goiter in Children.
Young Wan Kim, Duk Hi Kim, Byeung Ju Jeoung
Clin Exp Pediatr. 1988;31(8):1028-1036.   Published online August 31, 1988
We studied 197 cases of patients with goiter who visited Department of Pediatrics, Yonsei University College of Medicine from January 1980 to June 1987. For each patient, serum T4, free T4, T3, TSH, antithyroid antibody, and antimicrosomal antibody were analyzed, thyroid scan was performed, and radioiodine uptake was measured. Following results were obtained: 1) Male to female ratio of 197 cases of goiter was 1:7.5, predominent...
Neurologic Outcome in Congenital Hypothyroidism.
Byeung Ju Jeoung, Duk Hi Kim, Chang Jun Coe, Hang Cho Kang
Clin Exp Pediatr. 1988;31(7):901-913.   Published online July 31, 1988
Congenital hypothyroidism is one of the most common endocrine disease in childhood and is a major cause of mental retardation. It is clear that the earlier treatment is started, the better intellec- tual potential and the likely absence of neurological sequellae. The present study was carried out to try to define the incidence and the nature of the neurologic disorders and to examine the...
Normal TSH Levels in Neonates by TSH Screening test.
Jae Won Song, Jong Lin Rhi, Sei Won Yang, Jung Hwan Choi, Chong Ku Yun, Hyung Ro Moon, Bo Youn Cho, Chang Soon Koh
Clin Exp Pediatr. 1988;31(6):754-761.   Published online June 30, 1988
In 110 term neonates without perinatal problems who were bom in SNUH, blood TSH levels were measured by TSH screening test for congenital hypothyroidism. The results are as follows 1) Normal TSH level was 14.8±7.8 µU/ml, 8.8±4.7 µU/ml, and 6.5±2.7 µU/ml in neonates of age 0 〜24 hours, 24—48 hours, and 48〜72 hours respectively, and all TSH values in neonates of age 48〜72 hours were...
The Prevalence of Antithyroid Autoantibodies in Korean Children.
Bung Hai Ahn, Sei Won Yang, Hyung Ro Moon
Clin Exp Pediatr. 1988;31(3):329-338.   Published online March 31, 1988
The prevalence of antithyroid autoantibodies and the relationship between the presence of autoantibodies and thyroid functions were studied in 752 Korean children of 10 to 15 years of age with normal thyroids. Antimicrosomal antibodies (AMA) were measured by the indirect agglutination technique using artificial gelatin particle carriers sensitized with thyroid microsomal antigen and antithyroglobulin antibodies (ATA) by the tanned red cell hemagglutination technique. Circulating AMA...
The Effect of Thyroid Hormone Deficiensy on Growth Hormone Levels.
Duk Hi Kim, Chan Il Park
Clin Exp Pediatr. 1988;31(1):64-71.   Published online January 31, 1988
Growth hormone and thyroid hormone are known to affect growth and development. The present experiment was undertaken to assess GH levels in the serum and pituitary gland of prophylthiouracil (PTU) treated rats. The serum concentration of T4 were decreased during PTU treatment. Serum GH concentration and pituitary GH content were decresed with severity of hypothyroid status. After withdrawl of PTU, their levels were recovered gradually. Acidophil...
Clinical Study of Congenital Hypothyroidism.
Byung Churl Lee, Soon Joo Lee, Sung Hoon Cho
Clin Exp Pediatr. 1987;30(12):1401-1408.   Published online December 31, 1987
We reviewed 24 patients with congenital hypothyroidism to observe the etiology, clinical symptoms and signs, bone age, height age, the degree of mental retardation and growth velocity after treatment form Jan. 1983 to June 1987. The results were as follows: 1) The male to female ratio was about 1:3.8. The cases diagnosed under 1 year old were only 12.5%. 2) In etiologic classification, thyroid dysgenesis...
Case Report
3 Cases of Congenital Hypothyroidism.
Chul Hwan Park, Moo Young Oh, Tae Gyu Hwang, Soon Yong Lee, Yeon Soon Kim
Clin Exp Pediatr. 1987;30(3):320-326.   Published online March 31, 1987
We observed 3 cases of congenital hypothyroidism. A 43-day-old girl, a 372-month-old boy and a 5-year-old girl were presented. The causes were thyroid agenesis of case I, defective TSH receptor (suspect) of case II and undetermined in case III respectively. The diagnosis was made by clinical manifestations, thyroid function test, A brief review of literatures was made.
Original Article
Juvenile Chronic Lymphocytic Thyroiditis.
Duk Hi Kim
Clin Exp Pediatr. 1987;30(1):71-79.   Published online January 31, 1987
A diagnosis of chronic lymphocytic thyroiditis(CLT) was made in 90 children & adolescents according to Fisher’s criteria. The age of the group ranged between 4 years & 16 years. On the basis of serum T4, T3 & TSH, three groups of patients were distinguished at the time of diagnosis.: euthyroid group (n=49), hyperthyroid group (n=7), hypothyroid group (n=34), where three subgroups were classified;...
Case Report
A Case Report of McCune Albright Syndrome.
Kei Hag Son, Un Ki Yoon, Soon Ok Byun, Ji Sub Oh
Clin Exp Pediatr. 1986;29(12):1366-1371.   Published online December 31, 1986
A case of McCune Albright syndrome in a 8 year old girl was presented. Examination revealed polyostotic fibrous dysplasia, cutaneous pigmentation, sexual precocity and hyperthyroidism. Recently, she has suffered from craniofacial deformity and thyroid gland enlargement. The diagnosis was confirmed by characteristic clinical feature, radiologic evidence,biochemical assay and radioisotopic assay. A review of the literature was made briefly.