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Original Article
A PCR Assay of Gastric Biopsy Specimens for the Diagnosis of Helicobacter pylori Infection in Children
Jeong Wan Seo, Mi Ae Lee, Woon Sup Han
Clin Exp Pediatr. 1998;41(8):1084-1091.   Published online August 15, 1998
The Diagnostic Value of CSF Tumor Necrosis Factor-α for Early Diagnosis of Bacterial Meningitis
So Young Park, Soo Ja Hwang, Eun Ae Park, Jung Wan Seo, Seung Joo Lee
Clin Exp Pediatr. 1998;41(8):1078-1083.   Published online August 15, 1998
Purpose : During the course of bacterial meningitis, TNF-α produced by macrophages and monocytes in response to LPS and other inflammatory and immune stimulation, is now recognized as a primary mediator in the pathogenesis of infection, injury and inflammation and in the process of host defence. TNF-α was increased vascular permeability by inducing morphologic and structural changes of endothelial cells...
A Clinical Study on Acute Lower Respiratory Tract Infections by Adenovirus in Children
Ui Chong Chong, Mi Ran Kim, Dug Ha Kim, Hae Ran Lee, Chong Young Park, Han Sung Kim, Kyu Man Lee
Clin Exp Pediatr. 1998;41(8):1070-1077.   Published online August 15, 1998
Purpose : This study was performed to characterize the epidemiologic and clinical features of acute adenoviral lower respiratory tract infections. Methods : Culture and indirect immunofluorescence for adenovirus was done with nasopharyngeal aspirates from patients with acute lower respiratory tract infections from April to September, 1996. Cultured virus was serotyped for type 3, 4, and 7a by neutralization test, and medical...
Erratum
Perinatal Factors Influencing Clinical Response to Surfactant Replacement Therapy in Neonates with Respiratory Distress Syndrome
June Dong Park, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(8):1023-1032.   Published online August 15, 1998
Purpose : Surfactant replacement therapy significantly decreases neonatal complications and mortality in neonates with respiratory distress syndrome(RDS), but clinical responses to the treatment is not consistent. An analysis of the perinatal factors influencing the clinical response to the therapy is important for early detection of high risk and prognosis. The purpose of this study is to analyze the clinical...
Case Report
A Case of Superior Mesenteric Artery Aneurysm associated with Marfan Syndrome
Ick Ho Sung, Sang Hee Kim, Min Seop Song, Chul Ho Kim
Clin Exp Pediatr. 1998;41(7):984-988.   Published online July 15, 1998
Superior mesenteric artery aneurysm is very rare complication of Marfan syndrome, especially in children. A 11 years old male patient was admitted to the hospital because of fluctuating high fever and diagnosed as infective endocarditis and Marfan syndrome. During antibiotics therapy, fever was slowly decreased but abdominal pain was developed and pulsatile abdominal mass was palpable in the midline of...
Original Article
Clinical Studies of Intractable Diarrhea During Infancy
Jae Hong Park, Cheol Hong Kim, Eui Jun Yang, Sang Wook Park, Sang Wook Nam
Clin Exp Pediatr. 1998;41(7):923-930.   Published online July 15, 1998
Purpose : Intractable diarrhea during infancy is one of the major causes of infant mortality. But, its etiology, clinical courses, or methods of treatment are not well known. Therefore, we conducted a clinical approach to intractable diarrhea during infancy. Methods : We have retrospectively evaluated clinical characteristics, laboratory findings, methods of treatment, days required for recovery, in 23 infants who were...
C-Reactive Protein and Duration of Antibiotic Therapy in Neonatal Bacterial Infection
Jae Il Yoo, Jin Hwa Jeong, Jeong Ho Lee, Jong Dae Cho
Clin Exp Pediatr. 1998;41(7):901-908.   Published online July 15, 1998
Purpose : To determine whether C-reactive protein(CRP) can be used as a parameter to assess the safety of discontinuing antibiotic therapy and allows a shorter course of therapy in neonates treated for suspected bacterial infection. Methods : We have experienced 193 cases of suspected neonatal bacterial infection at Pusan Maryknoll Hospital. CRP levels were measured daily by immunonephelometry. Infants with initial...
Case Report
Reccurent Unilateral Lung Collapse in an Asthmatic Child
Yul-Yi Yeon, Kyung-Yil Lee, Dong-Jun Lee, Ji-Whan Han, Sung-Soo Hwang, Kyong-Su Lee
Clin Exp Pediatr. 1998;41(6):850-854.   Published online June 15, 1998
Abnomalities in the production and transport of airway secretions play an important role in the pathophysiology of asthma. Segmental atelectasis as a complication of asthma, is relatively common in children. On the other hand, massive atelectasis such as the collapse of one lung is a very rare occurence. We report a seven-year-old male asthmatic patient with right lung collapse caused by mucoid impaction. Fourteen...
Original Article
Immunologic Alterations of Peripheral Mononuclear Cells by Intravenous Immunoglobulin in the Acute Stage of Kawasaki disease
Ji-Whan Han, Kyung-Yil Lee, Kyong-Su Lee
Clin Exp Pediatr. 1998;41(6):813-824.   Published online June 15, 1998
Purpose : High dose intravenous immunoglobulin(IVIG) therapy is effective in reducing the incidence of coronary artery aneurysm in Kawasaki disease(KD) patients, however, the precise mechanisms by which IVIG reverses the immune activation is unknown. Methods : The sera and peripheral mononuclear cells(PBMCs) were obtained from 10 KD patients in the acute stage(24 hrs before) and 24 hrs after one dose of IVIG(2g/kg) treatment. We measured...
Effects of Patent Ductus Arteriosus on Right Ventricle in Premature Infants : by M-mode and Doppler Echocardiography
Eun Jeung Kim, Eun Sil Lee, Young Hwan Lee, Son Moon Shin, Jeong Ok Hah
Clin Exp Pediatr. 1998;41(6):734-740.   Published online June 15, 1998
Purpose : Patent ductus arteriosus, derived left to right shunt flows, elevate the pulmonary artery pressure in infants and children and may alter right ventricular afterload thereby right ventricular function. Therefore, we examined the effects of patent ductus arteriosus on the right ventricular systolic time interval in premature infants by non-invasive Doppler echocardiography. Methods : Tweleve premature infants with patent ductus arteriosus were studied...
Case Report
A Case of Pulmonary Lymphangiectasis
Cheol-Hong Kim, Seong-Hoon Kim, Soo-Eun Park, Jae-Hong Park
Clin Exp Pediatr. 1998;41(5):715-718.   Published online May 15, 1998
Pulmonary lymphangiectasis is relatively a rare disorder. This disorder can be divided into three groups. First, pulmonary abnormality is associated with lymphangiectasia in other viscera(especilly intestine) and extremities. In the second group, patients have a concomitant cardiac anomaly, which appears to be associated with obstructed pulmonary venous return. The third group comprises of patients whose lymphangicetasia is not associated with...
Original Article
A Clinical Study of Survival Rate and Prognostic Factors in Advanced Neurobalstoma in Children
Seung Yang, Ho Joon Im, Nam Su Kim, Hahng Lee
Clin Exp Pediatr. 1998;41(5):684-694.   Published online May 15, 1998
Purpose : Despite the use of improved therapeutic modalities, long-term survival remains poor in patients in stage Ⅲ or Ⅳ of neurobalstoma and for over 1 year olds at diagnosis. We evaluated the long-term survival rate and related prognostic factors in advanced neuroblastoma. Methods : Twenty-nine children diagnosed with stage Ⅲ or Ⅳ neuroblastoma after 1 year of age, between May...
The Risk Factor of Bacteremia in Children with Febrile Neutropenia due to Chemotherapy
Tae-Hong Kim, Young-Ho Lee
Clin Exp Pediatr. 1998;41(5):677-683.   Published online May 15, 1998
Purpose : We evaluated the easily-assessable risk factors to predict bacteremia in children with febrile neutropenia, who received anticancer chemotherapy. Methods : We retrospectively reviewed 46 children who had febrile neutropenia caused by anticancer chemotherapy between March, 1993 and February, 1997. The patients with localized infection on presentation were not eligible for this study. We evaluated the correlation between bacteremia and...
A Clinical Study on Lennox-Gastaut Syndrome
Yong Hun Choi, Gyo Dang Koo, Yeong Ho Rah, Sa Jun Chung
Clin Exp Pediatr. 1998;41(5):663-668.   Published online May 15, 1998
Purpose : Lennox-Gastaut syndrome is an intractable epilepsy which is comprised of several types of etiology and generalized seizures. It also combines with mental retardation. The present study was made to ascertain the clinical study on Lennox-Gastaut syndrome in Korea. Methods : From January, 1985 to December, 1995, 31 children, diagnosed with Lennox-Gastaut syndrome at Kyung Hee University Hospital, were analyzed...
Atrial Ectopic Tachycardia in Infant
Myung Ja Yoon, Chung Il Noh
Clin Exp Pediatr. 1998;41(5):646-653.   Published online May 15, 1998
Purpose : Atrial ectopic tachycardia(AET) in older children and adult is characterized by being chronic, incessant and intractable. However, the nature of infantile AET is not defined yet. The purpose of this study was to evaluate our experience of infantile AET. Methods : We retrospectively reviewed the medical records of 13 infants(mean onset age, 2.8±2.3 months) diagnosed at Seoul National University...
Relation of Postoperative Complication and Duration of Artificial Ventilation in Infants with Large Ventricular Septal Defect
Jeong-Yeol Song, Hyang-Suk Yoon, Hyun-Woong Yang, Jong-Bum Choi, Soon-Ho Choi
Clin Exp Pediatr. 1998;41(5):633-639.   Published online May 15, 1998
Purpose : The importance of postoperative management of those who have undergone intracardiac repair for congenital heart diseases has increased in recent years. In this study, we investigated postoperative complications and their relations to preoperative age or duration of the intubation and artificial ventilation in infants with large symptomatic ventricular septal defect. Methods : Between January, 1993 and December, 1996, sixty...
Prognosis of Bacterial Meningitis based on Cerebrospinal Fluid Culture
Yun Ju Lee, Won Sung Lee, Kyoung Sim Kim, Ki Bok Kim
Clin Exp Pediatr. 1998;41(5):614-621.   Published online May 15, 1998
Purpose : The present study was undertaken to assess whether the results of cerebrospinal fluid (CSF) culture are related to prognosis. Methods : Subjected to this study were 51 cases admitted to our department who had been diagnosed as bacterial meningitis. They were divided into two groups, Group Ⅰ(20) with positive CSF culture and Group Ⅱ(31) with negative outcome, then both...
Comparison of Continuous versus Intermittent Infusion of Indomethacin in PDA of Preterm Infants
Yun Kyoung Lee, Hee Seok Kim, Kyoung Ran Park, Chan Hu Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(5):599-605.   Published online May 15, 1998
Purpose : Patent ductus arteriosus(PDA) of prematurity is very important disease to study because it causes many cases of perinatal morbidity and its incidence is now increasing. Nowadays indomethacin is the drug of choice for PDA closure, but its use has been limited due to its side effects. Therefore, we compared the effect and side effects of indomethacin according to...
Case Report
A Case of Berry Syndrome associated with Syndactyly
Sang Chun Jung, Kyoung Sim Kim, Yong Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 1998;41(4):543-547.   Published online April 15, 1998
Berry syndrome is a rare association of congenital heart anomalies which consists of a distal aortopulmonary window with aortic origin of the right pulmonary artery and hypoplasia or interruption of the aortic arch. This defect can be corrected only by immediate surgical intervention, so accurate preoperative diagnosis and detailed anatomic depiction of this syndrome are important in prognosis. We experienced a case of Berry...
Original Article
A Clinical and Histological Study of Allergic Colitis in Infant
Jae Bok Kim, Kyung Mo Kim, Ki Soo Kim, Soo Young Pi, Yang Soon Park
Clin Exp Pediatr. 1998;41(4):521-528.   Published online April 15, 1998
Purpose : This study was done to evaluate the clinical and pathologic aspects of allergic colitis. Methods : This study evaluated 19 infants who presented with fresh blood mixed stools. Limited colonoscopy and biopsy were performed. Among the 19 infants, 13 infants were diagnosed as allergic colitis by histological findings. We analyzed the clinical and histological characteristics of 13 infants. Results : Male and female...
Milk Feeding Methods and the Changes of Serum Lactate Level in Infants with Iron Deficiency Anemia
Du Young Choi, Jong Duck Kim
Clin Exp Pediatr. 1998;41(4):514-520.   Published online April 15, 1998
Purpose : Infants undergo critical and rapid stages of growth. Optimal nutrition during this period is therefore essential. Iron deficiency is especially impotant and common. The aim of this study was to determine the present status and problems of milk feeding methods in infants with iron deficiency anemia and, futhermore, to develop appropriate feeding guidelines for adequate iron nutrition. Latate is the end product...
Phenotypic and Functional Differentiation of Promyelocytic Cell Line HL-60 by N-N-dimethylformamide
Kyung Hyo Kim, Ju Young Seoh
Clin Exp Pediatr. 1998;41(4):481-488.   Published online April 15, 1998
Purpose : HL-60 is a promyelocytic cell line. Fcγ receptors and complement receptor 3(CR3) play important role in the protective response of granulocytes and monocytes against microbial infection. We quantified the expression of FcγI, FcγII, FcγIII, and CD11b/CD18 during differentiation using HL-60 cells by N-N-dimethylformamide(DMF). Functional studies, such as phagocytic activity, respiratory burst and ADCC, were also performed. Methods : HL-60 cells were induced to...
Preparation and in vitro Physical Activities of Crude Natural Surfactant and Artificial Pulmonary Surfactant Containing Synthetic Peptide and Phospholipid Mixtures
Joo Hyun Kang, Song Yub Shin, Cheol-Young Maeng, Kil Lyong Kim, Chong-Woo Bae, Kyung-Soo Hahm
Clin Exp Pediatr. 1998;41(4):472-480.   Published online April 15, 1998
Purpose : In this study, natural pulmonary surfactant was extracted from bovine lung lavage and its surface activity was determined. To investigate the usefulness of synthetic peptides reconstituted with phospholipid as artificial surfactant, truncated peptides from surfactant protein (SP)-B were synthesized and restored the surface tension lowering activities when appropriately recombined with phospholipid. Methods : Crude natural surfactant(CNS) was isolated from lung lavage by centrifugation...
Retrospective 3-year Clinical Study of Enterobacter Bacteremia in Neonatal Intensive Care Unit
Kwang Ok Chung, Chun Hyuk Chang, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 1998;41(4):466-471.   Published online April 15, 1998
Purpose : Enterobacter is one of the important organisms in neonatal intensive care unit. We reviewed the clinical characteristics, underlying diseases, invasive procedures during admission, mortality and antibiotic sensitivity of Enterobacter infection in NICU. Methods : We retrospectively reviewed 21 neonatal patients whose blood cultures yielded Enterobacter between June 1994 and June 1997 at Dongguk University Hospital. Results : Blood cultures were positive in 62...
Comparison of Continuous Versus Intermittent Infusion of Indomethacin in PDA of Preterm Infants
Yun Kyoung Lee, Hee Seok Kim, Kyoung Ran Park, Chan Hu Park, June Dong Park, Beyong Il Kim, Woong Heum Kim, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(4):464-470.   Published online April 15, 1998
Purpose : Patent ductus arteriosus(PDA) of prematurity is very important disease to study because it causes many cases of perinatal morbidity and its incidence is now increasing. Nowadays indomethacin is the drug of choice for PDA closure, but its use has been limited due to its side effects. Therefore, we compared the effect and side effects of indomethacin according to the infusion method, continuous...
Case Report
Two Cases of Factor XI Deficiency in Sisters
Yun-Kyeong Cho, Jae-Young Lim, Yang-Suk Jung, Chan-Hoo Park, Hyang-Ok Woo, Byung-Kiu Park, Hee-Shang Youn
Clin Exp Pediatr. 1998;41(3):401-404.   Published online March 15, 1998
We experienced two cases of factor XI deficiency in a 5 yearr 7 month-old girl, whose chief complaint was coke-colored gross hematuria, and her 9-year-old elder sister. The laboratory findings were prolonged aPTT and prominent deficiency of factor XI. The gross hematuria of the index case was identified due to acute poststreptococcal glomerulonephritis. So we report two cases of factor...
Original Article
Percutaneous Closure of Patent Ductus Arteriosus Using Coil Embolization
Mi Jung Kang, Sejung Sohn, Eun Jung Bae, In Seng Park, Seong Ho Kim
Clin Exp Pediatr. 1998;41(3):369-377.   Published online March 15, 1998
Purpose : Percutaneous closure with occluding coils has been recently described as a method of nonsurgical treatment of the small patent ductus arteriosus(PDA). The snare-assisted technique or detachable coil has been newly developed, improving coil delivery and eliminating the incidence of coil embolization. This method is also applicable to residual PDA following surgical ligation or device implantation. The study purpose...
Normal Predicted Values of Pulmonary Function Test in Healthy Korean Children
Seung Yeon Nam, Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim
Clin Exp Pediatr. 1998;41(3):338-345.   Published online March 15, 1998
Purpose : We performed a pulmonary function test with simple, computerized spirometry composed of pneumotachometry and evaluated the predicted normal values of air flow rates and lung volumes in healthy Korean children. We calculated each of the simple and complex linear and logarithmic regression equations setting the predicted values. Methods : Four hundred and fifty-two healthy children were enrolled from December, 1994 to August, 1995....
Therapeutic Efficacy of Dual Therapy and Triple Therapy for Helicobacter pylori Infection in Children
Sun-Hwan Bae, Jae-Sung Koh, Jeong-Kee Seo
Clin Exp Pediatr. 1998;41(3):323-330.   Published online March 15, 1998
Purpose : An optimal treatment for Helicobacter pylori (H. pylori ) infection in children has not yet been established. In this study, the efficacy and the tolerability of triple therapy with colloidal bismuth subcitrate(CBS), amoxicillin and metronidazole, were evaluated in comparison with dual therapy with CBS and amoxicllin. Methods : Eighty-six children with H. pylori infection, aged 6 years to 14...
The Effect of Acanthopanax koreanum Extract on the Induction of Collagen Induced Arthritis for DBA/1J Mice
Dong Soo Kim, Chang Ho Song, Soo Kon Lee
Clin Exp Pediatr. 1998;41(2):247-254.   Published online February 15, 1998
Purpose : It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. We conducted this study to see whether the Acanthopanax koreanum extract has a preventive effect on the development of collagen induced arthritis in DBA/1J mice. Methods : Three groups of BDA/1J mice were immunized by intradermal injection of 2mg/kg bovine type...