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Original Article
Effect of Hypoxia-Ischemia on Striatal Monoamine Metabolism in Neonatal Rat Brains
Youn Hee Jee, Hyung Gun Kim, Woo Sung Park, Young Pyo Chang
Clin Exp Pediatr. 2003;46(8):789-794.   Published online August 15, 2003
Purpose : We intended to evaluate the effect of hypoxia-ischemia on extracellular striatal monoamine metabolism in neonatal rat brains by in vivo microdialysis. Methods : The right common carotid arteries of five or six-day old rats were surgically ligated, and the probes for microdialysis were inserted into the right striatum with stereotaxic instrument. After stabilization for two hours, artificial cerebrospinal fluid...
Case Report
A Case of Hemolytic Disease in a Newborn Due to Anti-Jkb
Dong-Kyun Park, Young-Min Kim, Chong-Woo Bae, Yong-Mook Choi, Woo-In Lee
Clin Exp Pediatr. 2003;46(7):718-721.   Published online July 15, 2003
The isoimmune hemolytic disease of newborn due to the incompatibility of minor blood groups is characterized by progressive neonatal hyperbilirubinemia and anemia caused by the IgG antibody transmitted from the mother to the fetus. Recently we had a case of hemolytic disease in a newborn due to anti-Jkb. There were no ABO and Rh(D) incompatibilities between mother and baby. The...
A Case of Netherton's Syndrome in a Newborn
Eun-Hee Lee, Ellen Ai-Rhan Kim, Ki-Soo Kim, Beom-Jin Cho, Jai-Kyoung Koh, Soo-Young Pi
Clin Exp Pediatr. 2003;46(4):389-392.   Published online April 15, 2003
Netherton's syndrome is an unusual disorder which consists of triad of ichtyosiform dermatosis, multiple defects of hair shaft and an atopic diathesis. The finding of bamboo hair is pathognomic in Netherton's syndrome and the ichthyosiform dermatosis may consist of either ichtyosis linearis circumflexa or congenital ichthyosiform erythroderma. Often, variability in the clinical features leads to a delay in diagnosis in...
A Case of Congenital Solitary Liver Abscess
Sang Hee Kim, So Young Kim, You Jeong Kim, Hyun Hee Kim, Won Bae Lee, Kyung Tai Whang
Clin Exp Pediatr. 2002;45(11):1426-1429.   Published online November 15, 2002
Congenital solitary liver abscess in newborns is an extremely rare and serious disease. Only one case was reported in the literature. Most a liver abscesses have a postnatal origin. We encountered a premature infant who had a low. Apgar score and an elevated right diaphragm at birth. Pyogenic solitary liver abscess was diagnosed by ultrasound and computed tomography. Staphylococcus aureus...
A Case of Klinefelter Syndrome associated with Unilateral Multicystic Dysplastic Kidney in a Newborn Infant
Kyung A Ha, Sun Mi Chung, Eun Jin Choi, Jin Kyung Kim, Un Seok Nho, Jae Shin Park, Woo Taek Kim, Young Dae Kwon
Clin Exp Pediatr. 2002;45(9):1141-1145.   Published online September 15, 2002
Klinefelter syndrome is the most common chromosomal abnormality, with a 47, XXY karyotype and typical clinical findings of infertility, hypogonadism, reduced body hair, gynecomastia, tall stature, and incresed gonadotropins and decreased testosterone levels. In addition to this classic description, several other diseases have been discribed in Klinefelter syndrome such as unilateral renal aplasia, autoimmune disease, diabetes mellitus, sexual precoxity, renal...
A Case of Hypernatremic Dehydration in an Exclusively Breast-Fed Newborn Infant
Kyung Pil Park, Jin Kyung Kim, Heng Mi Kim
Clin Exp Pediatr. 2002;45(6):790-795.   Published online June 15, 2002
Sporadic reports of hypernatremic dehydration in breastfed newborn infants have appeared in medical literature for at least 3 decades. We report the first case of hypernatremic dehydration resulting from inadequate breast-feeding in Korea. A 14-day old baby, born to a mentally retarded mother, was transferred to our hospital with a body weight loss of 460 g since birth(17%) and a...
Original Article
The Change of White Blood Cell Count Following Transfusion in Preterm Neonates
Soo Young Yoon, Gum Joo Lee, Gui Young Jung
Clin Exp Pediatr. 2002;45(3):325-330.   Published online March 15, 2002
Purpose : We intended to find out how the red cell transfusion would change the white cell count in preterm neonates under treatment in the intensive care unit. We also speculated whether the magnitude of such a change could indicate a potential neonatal infection. Methods : Total white blood cell count, total neutrophil count, and band count were compared and analyzed...
Effect of Resuscitation with High Concentration Oxygen on a Rat Model of Neonatal Hypoxic-Ischemic Brain Injury
Dong Seok Lee, Su-Hee Kwak, Heng-Mi Kim, Yoon Kyung Sohn
Clin Exp Pediatr. 2001;44(11):1278-1288.   Published online November 15, 2001
Purpose : This study was undertaken to determine whether any features of apoptosis would occur in the established model of cerebral hypoxia-ischemia in neonatal rats. It was also undertaken to evaluate the effect of post-insult hyperoxia on hypoxic ischemic cerebral injury. Methods : Seven-day-old neonatal rats underwent unilateral carotid artery dissection followed by 2 hours of hypoxia. To this end...
Case Report
A Neonatal Case of Symptomatic Congenital Cytomegalovirus Infection with Hearing Defect
Sung Jun Jang, Yoon Jung Cho, Sang Lak Lee, Joon Sik Kim, Tae Chan Kwon
Clin Exp Pediatr. 2001;44(2):205-210.   Published online February 15, 2001
Cytomegalovirus(CMV) is one of the leading cause of intrauterine infections of man with an incidence ranging from 0.48% to 2.2% of all live births. Although the majority of CMV-infected newborns are clinically asymptomatic at birth, some will have signs of congenital infection : Intrauterine growth retardation, petechial or purpuric rash, microcephaly, anemia, thrombocytopenia, jaundice, hepatosplenomegaly and intracranial calcification. We experienced...
Original Article
Organic Acid Analysis on Urine Samples Obtaine3d from Dried Filter Paper in Newborns : Development of Screening Method for Organic Aciduria in Newborns
Eun Ha Lee, Si Houn Hahn
Clin Exp Pediatr. 2000;43(10):1311-1317.   Published online October 15, 2000
Purpose : Neonatal screening for inherited metabolic disease is aimed at identifying affected infants early, thus permitting medical intervention to prevent or minimize the effect of the disease. However, organic aciduria, most of which causes severe disease and mental retardation, is not yet screened routinely because of the difficulty of tests, sample collection, and expenditure of time and financial resources....
Case Report
A Case of Neonatal Alloimmune Thrombocytopenia due to Anti-HLA A2
Sung Young Kim, Eun Ryoung Kim, Young Jin Kim, Myoung Hee Park, Eun Young Song, Kyou Sup Han
Clin Exp Pediatr. 2000;43(6):861-865.   Published online June 15, 2000
Neonatal alloimmune thrombocytopenia(NAIT) is a rare disease caused by maternal alloimmunization against fetal platelet surface antigen, which is mainly platelet specific alloantigen or human leukocyte antigen(HLA). During routine hemotology, we accidentally discovered thrombocytopenia in a female fullterm newborn admitted due to jaundice. We excluded NAIT due to human platelet alloantigen(HPA), because the HPA of the mother and baby were the...
Original Article
Change of Peripheral Blood CD5＋ B Lymphocytes in Early Neonatal Period
Ye Ho Lee, Bin Cho, Department of Pediatrics, College of Medicine, Cat , Kyung Tai Whang
Clin Exp Pediatr. 2000;43(5):674-678.   Published online May 15, 2000
Purpose : This study was aimed to investigate age-related changes of CD5＋ B lymphocytes in healthy Korean neonates. Methods : Sixty healthy neonatal infants were enrolled in this study; at birth(n=10), day 1(n=10), day 2(n=10), day 3(n=10), day 4(n=10) and day 5(n=10). Phenotypic analysis of CD5＋ B lymphocytes was performed on blood samples using standard flow-cytometric techniques. Results : The percentage of...
Oscillometric Blood Pressure of Upper and Lower Extremities and Aortic Blood Flow Velocity in Neonates
Sang Young Bae, Hae Soon Kim, Se Jung Sohn, Young Mi Hong
Clin Exp Pediatr. 2000;43(4):484-488.   Published online April 15, 2000
Purpose : We studied the blood pressure difference between the upper and lower extremities in healthy newborn infants and the effect of isthmic narrowing of the aorta on making a possible difference. Methods : The blood pressure was measured with an oscillometric blood pressure device from four extremities of 62 healthy infants aged 1-15 days. A Doppler echocardiography was performed for...
Effect of Hypoxia-ischemia on c-fos Expression in the Neonatal Rat Brain
Wang Bock Lee, Sun Hak Kwon, Heng Mi Kim
Clin Exp Pediatr. 2000;43(3):386-394.   Published online March 15, 2000
Purpose : Brain damage resulting from a combination of hypoxia and ischemia in the newborn infant remains a major cause of perinatal death, cerebral palsy, mental retardation and epilepsy. Metabolic stress, including ischemia, hypoxia and seizures, induces the expression of a variety of stress proteins including nuclear proto-oncogene c-fos. The induction of c-fos can be considered a biomarker of events...
Case Report
A Case of Tuberous Sclerosis with Hydrocephalus and Multiple Cardiac Tumors in Neonatal Period
Young Jun Song, Won Seop Kim, Beom Soo Park, Heon Seok Han
Clin Exp Pediatr. 2000;43(2):294-299.   Published online February 15, 2000
Several different tumors in different tissues(including the central nervous system, heart, kidney, liver, bone, and soft tissues) are found to be associated with tuberous sclerosis. In the brain, this tumor characteristically arises from the floor of the lateral ventricle and often occluded the foramen of Monro. Cardiac tumor is among the earliest signs of tuberous sclerosis and occurs in over...
Original Article
The Effect of Erythromycin on Gastric Antrum and Low Esophageal Sphincter in the Newborn Rabbit
Sung Dong Choi, Chung Sik Chun
Clin Exp Pediatr. 2000;43(1):34-42.   Published online January 15, 2000
Purpose : We studied smooth muscle strips from rabbit gastric antrum and low esophageal sphincter(LES) to explore the difference between newborn and adult rabbit on erythromycin(EM)- induced contractions. Another aim of this study was to determine the mechanism of LES contractile activities induced by erythromycin(EM). Methods : Muscle strips prepared from newborn and adult rabbits were stimulated with agonists such as KCl, motilin and EM,...
Follow up of Infants with Congenital Hypothyroidism Who were Detected by Newborn Screening Test
Kyung Ah Kim, Eun Sil Lee, Son Moon Shin, Han Ku Moon, Yong Hoon Park
Clin Exp Pediatr. 1999;42(8):1141-1148.   Published online August 15, 1999
Purpose : Developmental delay in congenital hypothyroidism can be prevented by early detection and treatment. We conducted a follow-up study to assess the growth and development of infants with congenital hypothyroidism who were detected by newborn screening test and received thyroid hormone therapy. Methods : Nineteen hypothyroid infants were detected by newborn screening test from April 1995 to May 1997. Measurements...
Effects of Angiotensin Converting Enzyme Inhibition into Apoptosis and Related Genes in the Neonatal Rat Kidney
Kee Hwan Yoo, Haewon Cheon, Byung Min Choi, Young Sook Hong, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1999;42(8):1086-1095.   Published online August 15, 1999
Purpose : The renin-angiotensin system plays an important role in renal growth and development. Exposuring the neonate to angiotensin converting enzyme(ACE) inhibitor increases mortality and results in growth retardation and abnormal renal development. ACE inhibition in the developing kidney reduces the renal expression of TGF-β1 and EGF, which may account for renal growth impairment. This study was designed to...
Comparison of Phototherapy Guidelines for Neonatal Jaundice in Healthy Term Newborns
Hyo-Jung Kim, Chang-Ryul Kim, Jae-Won Oh, Myung-Kul Yum, Soo-Jee Moon
Clin Exp Pediatr. 1999;41(5):606-613.   Published online May 15, 1999
Purpose : We hypothesized that phototherapy, if the total serum bilirubin(TSB) is ≥14mg/dl, would decrease not only in frequency and duration, but complications due to phototherapy, such as weight loss, rash, temperature instability, feeding intolerance, and diarrhea, would decrease when compared to phototherapy TSB ≥10mg/dl after 48 hours of life in healthy term newborns without hemolysis. Methods : Forty healthy newborns...
Anthropometric Measurement of Newborn in Women with Gestational Diabetes Mellitus
Kyung Hoon Kang, Seong Won Yang, Hye Kyung Han, Woo Gill Lee, Mi Na Lee, Hak Chul Jang, Il Soon Hwang, Eun Sung Kim
Clin Exp Pediatr. 1999;42(3):339-347.   Published online March 15, 1999
Purpose : To find the anthropometric characteristics of newborn in women with gestational diabetes mellitus(GDM), and the relationship between the birth weight and anthropometric measurements of newborn, maternal body habitus and glycemic control in GDM group. Methods : Maternal weight, height, and obstetric history of 82 women with GDM and 93 women with normal glucose tolerance were recorded at the...
Delayed Cerebral Energy Failure After Acute Hypoxia-Ischemia in Neworn Piglet Under 48hours of Continuous Monitoring Using Near-Infrared Spectroscopy
Yun Sil Chang, Won Soon Park, Munhyang Lee, Ki-Soo Kim, Jung-Hwan Choi, Son Moon Shin
Clin Exp Pediatr. 1998;41(9):1198-1210.   Published online September 15, 1998
Purpose : To test the hemodynamic and biochemical sequences of secondary cerebral energy failure after acute reversed hypoxic ischemic brain insult(HI) can be reproduced in newborn piglets. Methods : Fifteen anesthetized, ventilated newborn piglet(<3 day) were studied. Eight(HI) were induced transient HI by breathing 8% oxygen and complete occlusion of bilateral common carotid arteries for 30 minutes followed by reoxygenation...
Retrospective 3-year Clinical Study of Enterobacter Bacteremia in Neonatal Intensive Care Unit
Kwang Ok Chung, Chun Hyuk Chang, Sung Min Cho, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 1998;41(4):466-471.   Published online April 15, 1998
Purpose : Enterobacter is one of the important organisms in neonatal intensive care unit. We reviewed the clinical characteristics, underlying diseases, invasive procedures during admission, mortality and antibiotic sensitivity of Enterobacter infection in NICU. Methods : We retrospectively reviewed 21 neonatal patients whose blood cultures yielded Enterobacter between June 1994 and June 1997 at Dongguk University Hospital. Results : Blood cultures were positive in 62...
The Effect of Bundling on Neonatal Body Temperature
Ja Kyoung Lee, Eun Jung Kim, Hea Kyoung Lee, Young Hee Yu, Hyun Sook Lee
Clin Exp Pediatr. 1998;41(1):26-32.   Published online January 15, 1998
Purpose : Fever in newborn might be an indicator of serious bacterial infection. Differentiating environmental from disease-related temperature elevations in newborn is clinically important, because neonate with environment-related temperature elevation might be subjected to an unnecessary work-up to detect occult disease. But there are exists no consistent conclusions about environmental effect in previous literatures. We prospectively evaluated the effect of...
Neonatal Facial and Cry Responses to Invasive and Non-invasive Procedures
Seon Hwa Seo, Young Pyo Chang
Clin Exp Pediatr. 1997;40(11):1520-1528.   Published online November 15, 1997
Purpose : The evaluation of pain in neonates is difficult due to their limited means of communication. The aim of this study was to determine whether the behavioral reactions of facial action and cry provoked by an invasive pain-induced procedure could be discriminated from the reactions to a noninvasive pain-induced procedure in normal full-term neonates. Methods : Thirty-six healthy full-term neonates received three pain-induced...
Hemodynamic Effect of Nitric Oxide Inhalation in the Acute Hypoxic Pulmonary Hypertension Induced Newborn Piglet
Yun Cil Chang, Won Soon Park, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1997;40(10):1394-1409.   Published online October 15, 1997
Purposes : Nitric oxide(NO) is classified as toxic gas in native states, but in most biologic systems NO acts as a messenger molecule. NO is known as endothelium derived relaxing factor that modulates tone of vascular smooth muscle. Inhaled NO has been reported to act as a selective pulmonary vasodilator and we expect that NO inhalation can be used as a successful treatment modality...
Case Report
Gastric Duplication in the Newborn
Seong Jin Hong, Kyo Sun Kim, Hee Won Ham, Jeong Hee Park
Clin Exp Pediatr. 1996;39(11):1631-1635.   Published online November 15, 1996
Duplications of the stomach account for only 3.8% of gastrointestinal duplication, mainly discovered during first year of life. Etiopathogenesis is unknown. The most widely accepted theory is recannalization with fusion of longitudinal epithelial fold. The most frequent presented symptoms and signs include gastric outlet obstruction with vomiting, and palpable mass in the epigatric area. An upper gatrointestinal series usually reveals evidence of extrinsic mass...
Two Cases of Nitric Oxide Inhalation for Treatment of Severe Pulmonary Hypertension after Surgical Repair of Congenital Diaphragmatic Hernia
Yun Sil Chang, I-Seok Kang, Won Soon Park, Suk Koo Lee, Hun Hahk Kim, Heung Jae Lee
Clin Exp Pediatr. 1996;39(11):1611-1619.   Published online November 15, 1996
Nitric oxide, an endothelium-derived relaxing factor, is a selective pulmonary vasodilator. We have built and settled down the delivery system of nitirc oxide gas inhalation for the first time in Korea. Two newborn babies delvelped near fatal pulmonary hypertension after surgical repair of a congenital diaphragmatic hernia. All conventional therapeutic measures failed. So we decided to attempt to use of nitric oxide gas for...
A Case of Combined Congenital Deficiency of Factor V and Factor VIII
Kue Chang Cho, Soo Kyung Lee, Il Kyung Kim, Ho Sung, Chang Hee Choi
Clin Exp Pediatr. 1996;39(8):1162-1167.   Published online August 15, 1996
Hemorrhagic disease of newborn by combined blood clotting factor deficiencies is very rare. Combined deficiency of factor V and factor VIII is the most common form among these cases, and inherited by autosomal recessive trait. Clinical findings are easy bruising, posttraumatic bleeding and bleeding after tooth extractions, and the main laboratory findings are prolonged partial thromboplastin time (PTT) and prothrombin time (PT) that are...
Original Article
Comparison of The Efficacy of the Fiberoptic Phototherapy and Conventional Phototherapy for Neonatal Hyperbilirubinemia
Hye Jung Min, Gwi Sook Kim, Soo Kyung Lee, Il Kyung Kim, Ho Sung, Chang Hee Choi
Clin Exp Pediatr. 1996;39(8):1076-1083.   Published online August 15, 1996
Purpose : We performed this study in order to compare the feasibility and efficacy of the fiberoptic phototherapy with conventional phototherapy and double phototherapy with single phototherapy for the treatment of neonatal hyperbilirubinemia while watching for any possible side effects of the system. Methods : During the period of February 1994 till June 1995, randomized controlled study was performed. 130 healthy term infants with non-hemolytic...
Serial Changes of Doppler Echocardiographic Transvalvular Velocity during the Neonatal Period in Full Term Neonates
Woo Taek Kim, Myung Chul Hyun, Sang Bum Lee
Clin Exp Pediatr. 1996;39(7):977-986.   Published online July 15, 1996
Purpose : We performed this study to compare serial measurements which relate to both ventricular functions in full term neonates for the first three weeks after birth. Methods : Echocardiographic and pulsed Doppler studies were performed for 20 newborns during the first 36 hours of life, and subsequent serial studies in the second (n=13) and third(n=12) weeks of life. Evaluation included measurements of both...