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Original Article
The relationship between diuresis and pulmonary function in respira- tory distress syndrome of the newborn.
Eun Ae Park, Yung Sook Ko, Gyoung Hee Kim
Clin Exp Pediatr. 1991;34(8):1086-1092.   Published online August 31, 1991
The purpose of this study was to determine the relationship between improvement of pulmonary, function and diuresis in respiratory distress syndrome. This study was based on 24 cases of RDS infants admitted in NICU of Ewha Womans University from January 1988 to December 1990. The results were as follows. 1) Mean birth weight of study cases was 2.11 kg with gestational age between 29〜39 weeks. 2) Maximum...
Experimental study on the effect of phenobarbital on Na+, K+-activated adenosine triphosphatase in microsome fractions of mouse brain.
Seo Kyu Kim, Sa Jun Chung, Chang Il Ahn
Clin Exp Pediatr. 1991;34(7):959-970.   Published online July 31, 1991
Na+, K+-activated adenosine triphosphatase (Na+, K+-ATPase) is known to play a role as a trigger in neurotransmitter release and may also affect the transport of calcium ion (Ca++). By doing so, Na+, K+-ATPase, as an anticonvulsant, can modify the excitability level of cells in epilepsy. In order to elucidate the possible mechanisms of neuropharmacological interaction between Na+, K+.ATPase and phenobarbital, serial experimental studies were...
A study for mass screening of galactosemia using galactitol level by spot urine method among Korean infants.
Jin Tae Kim, Chong Won Bae, Sa Jun Chung, Chang Il Ahn, Suyama I , Isshiki G
Clin Exp Pediatr. 1991;34(7):949-958.   Published online July 31, 1991
For mass screening of the galactosemia, we used spot urine method using filter paper which was newly developed by Department of Pediatrics, Kyung Hee University Hospital and Department of Pediatrics, Osaka City University in Japan. We used control groups as followed, 7 of normal adults,- one patient of I, II, III types of galactosemia, respectively. The experimental groups were 62 infants of 0 to...
Acute renal failure with back pain after exercise.
Hae Jung Park, Mi Jung Kim, Dong Kyu Jin, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Jung Mi Park, Kyung Mo Yeun
Clin Exp Pediatr. 1991;34(6):863-868.   Published online June 30, 1991
We have experienced one case of acute renal failure without clinical rhabdomyolysis characterized by preceding exercise and back pain. This patient showed patch renal increased uptakes in bone scan with 99mTechnetium-methylene diphosphonate, and delayed wedge-shaped contrast enhancements in renal computed tomography. These findings can be explained by focal renal vasoconstriction of interlobar arteries or arcuate arteries, which may be considered as one of the...
A case of pancytopenia associated with mycoplasmal pneumonia.
Young Mee Yoo, Beom Soo Park, In Sang Jeon, Hee Young Shin, Hyo Seop Ahn, Se Jung Sohn
Clin Exp Pediatr. 1991;34(6):826-831.   Published online June 30, 1991
Mycoplasma pneumoniae infection is manifestated as pneumonia and extra-pulmonary symptoms such as hematologic, neurologic, gastrointestinal, musculoskeletal, dermatologic and cardiac manifes- tations. Among the hematologic changes, hemolytic anemia is most frequently seen. Throm- bocytopenic purpura, lymphocytosis or rarely lymphopenia, elevated erythrocyte sedimentation rate, positive direct Coombs test, reticulocytosis and DIC are known hematologic features. This 12 years old female patient was presented with pneumonia and pancytopenia....
The muscular ventricular septal defect and multiple ventricular septal defects in some congenital heart diseases.
Young Hwi Kim, Ki Soo Kim, Chung Il Noh, Jung Yun Choi, Yong Soo Yoon, In One Kim, Kyung Mo Yeon
Clin Exp Pediatr. 1991;34(6):779-786.   Published online June 30, 1991
In order to find out the incidences of muscular ventricular septal defect and multiple ventricular septal defects in cases with isolated ventricular septal defect, tetralogy of Fallot, complete endocar- dial cushion defect, complete transposition of the great arteries, corrected transposition of the great arteries and double outlet right ventricle, a retrospective analysis of 620 left ventriculograms were performed. The surgical and echocardiographic findings were...
Diagnosis and hydrostatic saline reduction of intussusception under ultrasonographic guidance.
Jong Yul Jeon, Jae Yun Kim, Chong Woo Bae, Sung Ho Cha, Chang Il Ahn, Sun Wha Lee, Jae Hoon Lim
Clin Exp Pediatr. 1991;34(6):771-778.   Published online June 30, 1991
Recently, a new technique of reduction for intussusception using saline solution and ultrasonogram instead of barium enema is being used in several centers. In order to evaluate its efficacy, we have conducted the clinical observation in 40 patients with intussusception who were treated by hydrostatic saline reduction under the ultrasonographic guidance in Kyung-Hee University Hospital from June 1989 to July 1990. We have observed...
A clinical study on neonatal bacterial meningitis.
Yong Won Park, Jung Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1991;34(6):763-770.   Published online June 30, 1991
Clinical courses of 12 neonates who were confirmed as neonatal bacterial meningitis by CSF culture or CSF latex agglutination test from January, 1986 to June, 1990, emphasizing on their complications and treatments, were evaluated. The results were summarized as follows; 1) The most common etiologic organism was E. coli (33.3%). 2) Two most common complications were ventriculitis (66.7%) and hydrocephalus (66.7%). 3) EVD with intraventricular antibiotics therapy was only...
Congenital bile duct cyst.
Myung Hee Yoon, Mi Sung Jeong, Hyung Ja Park, Shinna Kim, Doo Sun Lee
Clin Exp Pediatr. 1991;34(5):707-714.   Published online May 31, 1991
A case of congenital bile duct cyst in a 15-year-old female patient was diagnosed by clinical symptoms, laboratory data, ultrasonography, endoscopic retrograde cholangiopancreatography. Excision with Roux-en-Y choledochocystojejunostomy was performed with good result. We report one case of congenital bile duct cyst type IV-A (by Todani classification) with brief review of all 277 cases reported so far in Korean literature and present comparisons with Flanigan’ s...
Clinical analysis and prognostic factors in Henoch-Schonlein purpura .
Ha Young Lee, Chong Sung Chung, Kyu Chul Choeh, Byoung Soo Cho, Young Mook Choi, Chang Il Ahn
Clin Exp Pediatr. 1991;34(5):682-690.   Published online May 31, 1991
This study was undertaken to evaluate the prognostic factors of recurrence and renal involvement in Henoch-Sch公nlein purpura. Total 110 cases of anaphylactoid purpura below 15 years of age who admitted to Pediatric Departmen of Kyung Hee University for 8 years from January 1st 1979 to December 31st 1986 were analyzed clinically and statistically. The results were obtained as follows. 1) The peak incidence of age was 4...
The effects of adriamycin on twitch force and membrane potential in an isolated Guinea-pig papillary muscle.
Chan Uhng Joo, Pyung Han Hwang, Jung Soo Kim, Hee Cheol Yu, Soo Wan Chae
Clin Exp Pediatr. 1991;34(5):677-681.   Published online May 31, 1991
The antiumor antibiotic adriamycin is presently considered to be a very effctive and useful chemotherapeutic agent in the treatment of many human tumors. Cardiotoxicity of adriamycin limits its clinical use. A number of hypotheses have been proposed to explain the mechanism of cardiotox- icity with adriamycin, but none has yet been demonstrated. The effects of adriamycin on twitch force and membrane potential in an...
Accuracy of anorectal manometry in the diagnosis of congenital megacolon.
Jong Yul Jeon, Byeong Gie Yeo, Chong Woo Bae, Yong Mook Choi, Chang Il Ahn, Young Woon Chang
Clin Exp Pediatr. 1991;34(5):614-620.   Published online May 31, 1991
Thirty-seven patients with clinical impression of congenital megacolon were studied with anorectal manometry for the evaluation of its diagnostic accuracy. Including 12 neonates, their age ranged form 3 days to 8 years and barium enema was performed to all of them except one. The results of rectosphincteric reflex (RSR) of anorectal manometry was compared with the final diagnosis, which was obtained by clinical course,...
Predictors of neurologic handicap in hypoxic ischemic encephalopathy.
Seung Tae Kim, Gui Ran Kim, Byung Hak Lim, Sang Geel Lee, Im Ju Kang
Clin Exp Pediatr. 1991;34(4):473-479.   Published online April 30, 1991
Retrospective follow up studies were done in 52 term infants who were treated at the nursery in Taegu Fatima Hospital, for clinical evidence of Hypoxic ischemic enecphalopathy (stage II). All children were followed for a minimum of 6 months. Factors that significantly correlated with prognosis included 5-minute Apgar scores, the age at the onset of the seizures, the EEG and the initial brain CT. (1) Of...
Two cases of ectopic sublingual thyroid with hypothyroidism to be appeared in fetal life.
Dong Sik Kim, Mee Kyung Namgoong, Hae Yong Lee, Hwang Min Kim, Baek Keun Lim
Clin Exp Pediatr. 1991;34(3):426-434.   Published online March 31, 1991
Infants & children with hypothyrodism usually manifest variable skeletal abnormality. These features are the delay in longitudinal bone growth, the delay in epiphyseal maturation (=delay in bone age), the disturbances in bone mineralization and charateristic multiple stippled epiphysis (cretenoid epiphyseal dysgenesis). But many pediatrician have only concerned about the delay in epiphyseal maturation. Epiphyseal dysgenesis can be used a marker to find out the begining...
A case of citrobacter freundii osteomyelitis.
Hyung Goo Cho, Dong Sig Kim, Hwang Min Kim, Jae Seung Yang, Baek Keun Lim, Jong Soo Kim
Clin Exp Pediatr. 1991;34(3):408-412.   Published online March 31, 1991
Citrobacter although once regarded as nonpathogenic, has been responsible for many well- documented pathologic conditions, especially in compromised hosts. These include urinary tract, pulmonary and bone infections, gastroenteritis, gangrenous ulcer with septicemia, meningitis, and brain abscess. Citrobacter organisms have a mosaic of 0, K and H antigens that are found in the Enterobacter- iaceae. Cross reactions with antisera of other members of the Enterobacteriaceae suggest...
Effect of fluid restriction on postnatal weight and outcome in very low birth weight infants.
Chul Lee, Hyeon Soo Lee, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1991;34(3):348-354.   Published online March 31, 1991
We studied 45 very low birth weight infants for change in birth weight, urine output, serum Na level, ventilatory support and outcome between two groups after fluid restriction therapy. Group 1 (n=17) were infants whose weight loss were more than 5% of birth weight. Group 2 (n=17) were infants whose weight loss were more than 5% of birth weight. 1) Group 1 had more fluid...
A case of hyperimmunoglobulin E syndrome.
Myeong Cheol Shinn, Sung Dong Choi, Byung Gyu Suh, Jin Han Kang, Joon Sung Lee
Clin Exp Pediatr. 1991;34(2):292-298.   Published online February 28, 1991
The hyperimmunoglobulin E syndrome is a primary immunodeficiency disorder characterized by serious recurrent bacterial infections of the skin and respiratory system in early life, and markedly elevated serum IgE level. These recurrent infections are generally subcutaneous abscesses caused by Staphylococcus aureus. Also, additional characteristrics of this syndrome include coarse facial appearance, chronic pruritic dermatitis and eosinophilia. The baisic immunologic defect mechanism in hyperimmunoglobulin E syndrome is...
A case of congenital lactic acidosis.
Suk Min Choi, Myeong Ku Cho, Dong Hwan Lee, Sang Jhoo Lee, Kikumaro Aoki, Shuichi Yamaguchi
Clin Exp Pediatr. 1991;34(1):95-100.   Published online January 31, 1991
The congenital lactic acidosis represent a sizable group of metabolic disorders. They are in all likelihood genetically determined, and they are clearly heterogenous. They may be considered broadly as disorders of pyruvate metabolism in which there are two general categories: defects in gluconeogenesis and defects in pyruvate oxidation. We experienced a case of congenital lactic acidosis in neonate who was diagnosed by urinary organic acid...
A clinical and bacteriologic study of infants and children with urinary tract infection.
Jae In Roh, Yeong Su Kwon, Hung Kun Oh, Jin Hee Jeong, Man Chul Ha, Jin Yeong Jeong
Clin Exp Pediatr. 1991;34(1):57-65.   Published online January 31, 1991
Clinical, Bacteriologic and radiologic studies were performed in 321 infants and childen with urinary Tract Infection who were diagnosed at Department of pediatrics, Haesung Hospital from Jan. 1984 to Dec. 1988. The results were summarized as follows: 1) The incidence of urinary tract infection was highest in children below the age of one year, the rate then decreased with age. Among the total 321 cases,...
A Case of Hypohydrotic Ectodermal Dysplasia.
Chun Oh Lee, Byung Min Moon, Young Wook Kim, Ki Bok Kim
Clin Exp Pediatr. 1990;33(12):1718-1722.   Published online December 31, 1990
Hypohidrotic ectodermal dysplasia is a group of disorders characterized characterized by faulty development of ectodermal structures including the skin, teeth, skin appendages, resulting in hypohi- drosis, hypotrichosis, and abnormal dentition. Here, we report a case of typical hypohidrotic ectodermal dysplasia in a 16-month-old male who had unexplained recurring fever, hypohidrosis, hypotrichosis, anodontia, and characteristic facial features.
Prolapse of Ileal Mucosa Through the Patent Omphalomesenteric Duct.
Hwan Gyu Park, Ki Soo Pai, Jeong Wan Yoo, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han, Eui Ho Hwang, In Joon Choi
Clin Exp Pediatr. 1990;33(12):1713-1717.   Published online December 31, 1990
The omphalomesenteric duct in the embryo is a communication between the yolk sac and primitive gut. The duct closes by six to eight weeks of intrauterine life and disappears soon after. Patent omphalomesenteric duct is a congenital anomaly which occurs when there is incomplete closure of the duct during this period. The authors experienced a cases whereby a 29-day old male baby had patent...
Changes of beta-lactoglobulin Specific Immunoglobulins According to the Age and the Onset of Cow's Milk Feeding.
Jong San Lee, Soo Young Cho, Pyoung Han Hwang, Soo Cheol Cho, Jung Soo Kim
Clin Exp Pediatr. 1990;33(12):1639-1646.   Published online December 31, 1990
It is not yet possible to explain in detail the pathogenesis of the diverse types of food allergy encountered clinically. This generalization applies to milk allergy in spite of the large number of studies reporting the immune responses to cow’s milk proteins, both in healthy subjects and in milk sensitive patients. This study was performed to define the changes of circulating immunoglobulins against milk protein...
Echocardiographic Evaluation of Sequential Change of Cardiac Function in Normal Neonates.
Ji In Park, Chul Ha Kim, Byoung Hoon Yoo
Clin Exp Pediatr. 1990;33(11):1533-1539.   Published online November 30, 1990
Echocardigraphy was done on the first and the second day of life in 23 normal full term newborns to evaluate the sequential change of cardiac function of the normal neonates. The results were as follows. 1) On the first day of life, all of the measurements of diastolic filling except peak A velocity were significantly different when the right and left ventricle were compared. For...
A Case of Esophageal Variceal Bleeding in a Child Secondary to Portal Hypertension Associated with Cavernous Transformation of the Portal Vein Suggesting Extrahepatic Portal Obstruction.
Sun Yang Hong, Tae Won Oh, Jeong Kook Lee, Hahng Lee, Keun Soo Lee, Seok Chol Jeon, Heung Suk Seo
Clin Exp Pediatr. 1990;33(10):1406-1412.   Published online October 31, 1990
Esophageal variceal bleeding is a rare manifestation in childhood and it usually occurs secondary to portal hypertension. We experienced a case of esophageal variceal bleeding secondary to portal hypertension associated with portal obstruction but with no evidence of liver cirrhosis in a 4-year- and-10-month-old boy who was hospitalized due to hematemesis. He was a product of fullterm normal spontaneous delivery at home unattended by...
A case of Asphyxiating Thoracic Dystrophy.
Hyung Goo Cho, Hwang Min Kim, Jae Seung Yang, Jong Soo Kim, Whi Yul Cho, So Young Jin
Clin Exp Pediatr. 1990;33(9):1294-1300.   Published online September 30, 1990
Asphyxiating thoracic dystrophy, a rare form of bony dysplasia, is characterized by extreme constriction of thorax, short limbed dwarfism, abnormalities of pelvic bone in neonatal period, and progressive interstitial nephritis in childhood. The incidence of this syndrome has been estimated at 1 per 100,000 to 130,000 live births and more than 100 patients have been reported worldwide. Infants with asphyxiating thoracic dystrophy usually have...
Congenital Cytomegalovirus infection.
Kang Woo park, Ho Seek Ahn, Eui Bon Koo, Sung Won Kim, Kil Hyun Kim
Clin Exp Pediatr. 1990;33(9):1271-1275.   Published online September 30, 1990
We report a case of congenital cytomegalovirus infection that was associated with microcephaly, hydrocephalus and periventricular calcification. The male baby was born after 39wks gestation to 28 year-old mother who had no prenatel problem except for active pulmonary tuberculosis and pre- mature rupture of membrain. Hydrocephalus was recognized by antenatal ultrasonography at 8 weeks of geststional age and microcephaly was noted at birth. This enable...
Relationship between anaphylactoid purpura and Beta-Hemolytic Streptococcal Infection.
Ji Eun Lee, Young Sook Kang, Joon Sik Kim, Sung Ho Kim, Chin Moo Kang
Clin Exp Pediatr. 1990;33(9):1231-1236.   Published online September 30, 1990
Relationship between anaphylactoid purpura and beta-hemolytic streptococcal infection was obser- ved and analyzed through clinical manifestation and labortory findings in 146 cases of allergic purpura, hospitalized at Dongsan hospital, Keimyung University during the period from January, 1981 to May, 1987. The following results were obtained. 1) The age distribution of anaphylactoid purpura showed a peak incidence between 2 to 7 years of age and male preponderance was...
A Clinical Study on the Posterior Subcapsular Cataracts in Childhood Nephrotic Syndrome.
Dong Kyu Jin, Ja Wook Koo, Hae Il Cheong, Yong Choi, Kwang Wook Ko, Jong Hoon Lee, Young Suk Yu
Clin Exp Pediatr. 1990;33(8):1097-1103.   Published online August 31, 1990
A clinical study was carried out in 73 children with nephrotic syndrome who had had regular ophthalmologic examination annually at Seoul National University Children’s Hospital from March 1976 to February 1990 with the aim of finding the relationship between the posterior subcapsular cataract (PSC) and the effect of corticosteroids. The results were summarized as follows: 1) The number of patients with PSC were 23 cases...
Correlation among Electrocardiographic, Echocardigraphic and Hemodynamic Analysis in Atrial Septal Defect, Ostium Secundum type.
Soon Jung Lee, Chi Han Kwon, Joon Sik Kim, Tae Chan Kwon, Chin Moo Kang
Clin Exp Pediatr. 1990;33(7):946-951.   Published online July 31, 1990
The electrocardiographic, echocardiographic and hemodynamic analysis were made on 32 patients with atrial septal defect of ostium secundum type, who were diagnosed by echocardiography, right heart catheterization at Dong San Hospital, Keimyung University during the period of 5 years and 6 months from Jaunary 1982 to June 1987. Following results were obtained. Out of 32 patients, 14 were male and 18 were female. Their ages...
The Effect of Low-Dosage Alpha-Interferon Therapy in Children with Chronic Active Hepatitis B.
Hee Kyung Kim, Sung Min Choi, Cheol Woo Ko, Kun Soo Lee, Ja Hoon Koo, Doo Hong Ahn
Clin Exp Pediatr. 1990;33(7):915-922.   Published online July 31, 1990
A clinical trial was conducted to determine the effect of low-dosage recombinant a-interferon therapy in children with HBs Ag and HBe Ag positive chronic active hepatitis. Studied patients consist of 7 biopsy-proven children (aged 6.5-11.5 yr). After 16 weeks of therapy, following results were obtained. Out of 7 HBe Ag positive cases, 5 cases (71.4%) were converted to HBe Ag negative state. One of two...