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Original Article
Growth Hormone Receptor Mutation and Partial Growth Hormone Insensitivity in Children with Idiopathic Short Stature
So Chung Chung, Ran Namgung, Duk Hee Kim
Clin Exp Pediatr. 2001;44(8):922-935.   Published online August 15, 2001
Purpose : Children with idiopathic short stature(ISS) are classified on the basis of exclusion criteria. Short stature with normal or increased circulating growth hormone(GH) and low IGF-I levels indicates that partial growth hormone insensitivity(GHI) may play a role in ISS. The present study was performed to investigate whether partial GHI is observed in children with idiopathic short stature and whether...
Evaluation of Health Status and Growth and Developmental Outcome of Intrauterine Growth-Retarded Infants
Il Tae Hwang, Eun Ae Park, Ho Seong Kim, Gyoung Hee Kim
Clin Exp Pediatr. 2001;44(6):635-641.   Published online June 15, 2001
Purpose : Although many children born with intrauterine growth retardation demonstrate significant catch-up growth in early childhood, substantial weight and height deficits remain in others. In addition, children with IUGR may demonstrate developmental deficits. The aims of this study are to evaluate the health status, growth and deveolpmental outcome of intrauterine growth retarded infants. Methods : Sixty five intrauterine growth retarded...
Case Report
A Case of Apert`s Syndrome(Acrocophalosyndactyly) with Fibroblast Growth Factor Receptor 2 Exon Ⅲa Mutation
Hyung Su K, Pyl Soon Yang, Jee Yeoun Kang, Ok Young Kim, Chul Hae Ku, Wha Mo Lee
Clin Exp Pediatr. 2000;43(7):1006-1011.   Published online July 15, 2000
Apert syndrome is an uncommon congenital disorder characterized by malformation of the skull in association with symmetrical syndactyly of both hands and feet. This syndrome is autosomal dominant. The original description was presented by Apert in 1906. Since then more than 200 cases have been reported in the world. Recently, we experienced a case of newhorn male infant with congenital...
Original Article
Insulin-like Growth Factor(IGF)-I and IGF-Binding Protein-3 in Relation to Hemoglobin Concentration in Healthy Infants
Yoon Ki Kang, Dae-Yeol Lee
Clin Exp Pediatr. 2000;43(7):967-973.   Published online July 15, 2000
Purpose : Insulin-like growth factor(IGF-I) and IGF binding protein(IGFBP)-3 is thought to play an important role in fetal erythropoiesis. The objective of this study was to establish a relation between IGF-I, free IGF-I, IGFBP-1, and -3 with hemoglobin level in healthy term, 3-month, and 12-month old infants. Methods : Healthy term infants(n=20) were enrolled at birth, as well as 3 months(n=30) and 12 months(n=30) of...
Effect of Growth Hormone Secretion on Serum Concentration of Leptin
Se-Eun Kim, Jeong-Nyeo Lee, Sang-Ook Nam, Woo-Yeong Chung
Clin Exp Pediatr. 2000;43(7):959-966.   Published online July 15, 2000
Purpose : To investigate the effect of growth hormone(GH) secretion on serum concentration of leptin, we evaluated the differences in serum concentration of leptin between patients with growth hormone deficiency(GHD) and GH normal short stature in prepubertal male children, and the relationship between GH and serum leptin level. Also, we analyzed the correlation between serum concentrations of leptin and insulin-like growth factor-I(IGF-I), insulin-like growth...
Changes in Fat Tissue and Growth Hormone Receptor mRNA after Growth Hormone Therapy
Hye Jung Shin, Duk Hee Kim, So Chung Chung, Kyungyoon Kam
Clin Exp Pediatr. 2000;43(2):247-252.   Published online February 15, 2000
Purpose : Growth hormone(GH) is a powerful inhibitor of lipoprotein lipase and is known to decrease fat cell mass. The lipolytic effect has more pronounced influence on visceral fat than subcutaneous fat. The effects of GH therapy on GH receptor in fat tissue are not clear. We investigated the changes in fat tissue and GH receptor mRNA in adipose tissue...
Effects of Growth Hormone Treatment on Alterations of Growth and Bone Metabolism in Rats Induced by Dexamethasone Administration
Woo Yeong Chung, Jeong Nyu Lee, Hye Kyoung Yoon
Clin Exp Pediatr. 1999;42(7):991-1002.   Published online July 15, 1999
Purpose : The aim of this study was to investigate the alterations of growth and bone metabolism in SDR induced by dexa administration and to evaluate the effects of GH treatment in dexamethasone(dexa) induced growth and bone metabolism in SDR. Methods : Forty-five female Sprague-Dawley rats(weight 150-170gm) were divided in 3 groups: Group 1(n=15) received normal saline as control, Group 2(n=15)...
Final Height in Idiopathic Growth Hormone(GH) Deficient Children Treated with GH
Byung Churl Lee
Clin Exp Pediatr. 1999;42(6):852-857.   Published online June 15, 1999
Purpose : Improved adult height is a major goal in the treatment of children with short stature due to GH deficiency(GHD). The purpose of this study was to evaluate final height in idiopathic GH deficient children after long-term GH treatment Methods : GHD was diagnosed in 9 male patients by at least two stimulation tests(maximum GH level≤5ng/ml). Other pituitary functions were...
Serum Levels of Insulin-Like Growth Factor-Ⅰ and Insulin-Like Growth Factor Binding Protein-3 between Short Children with or without Intrauterine Growth Retardation
Kye Shik Shim, Se Young Kim, Choong Ho Shin, Sei Won Yang
Clin Exp Pediatr. 1999;42(3):390-396.   Published online March 15, 1999
Purpose : Postnatally, 20% of children with intrauterine growth retardation(IUGR) has no catch- up growth, This might be dependent on the serum level of Insulin-like growth factor I(IGF-I), resulting in shortness. We measured serum levels of IGF-I and Insulin-like growth factor binding protein-3(IGFBP-3) in children with IUGR and normal short stature variants(NSSV) to observe whether they play a role in...
Case Report
A Case of Ulcerative Colitis with Growth Disturbance
Ki Hyun Jeon, Dong Hyun Choi, Eun Yung Seol, Kyung Eun Oh, Mun Ki Cho, Chul Son, Jong Soon Kim
Clin Exp Pediatr. 1999;42(2):289-295.   Published online February 15, 1999
Ulcerative colitis is a chronic relapsing inflammatory disease of the colonic and rectal mucosa, which affects children as well as adults. Inflammation caused by ulcerative colitis is limited to the colon and rectum, to the mucosa and submucosa, and is involved continuously, with varying degrees of ulceration, hemorrhage, edema, and regenerating epithelium. Ulcerative colitis most commonly presents with the onset...
A Case of FGFR2 Exon Ⅲc Mutation in Crouzon Syndrome
Seon Chan Bae, Eun Ha Lee, Moon Sung Park, Si Houn Hah, Chang Ho Hong
Clin Exp Pediatr. 1998;41(12):1717-1721.   Published online December 15, 1998
Crouzon syndrome, an autosomal dominant disorder, has characteristic features of craniosynostosis, hypertelorism, exophthalmos, maxillary hypoplasia and relative mandibular prognathism. Mutations of fibroblast growth factor receptor 2(FGFR2) gene are associated with craniosynostotic conditions, such as Crouzon syndrome, Jackson-Weiss syndrome, Pfeiffer syndrome, Apert syndrome and Beare-Stevenson cutis gyrata. We found one child with common morphological features of Crouzon syndrome. Interestingly, she...
Original Article
Profile of Insulin, Growth Hormone and Insulin-like Growth Factors in Human Cord Blood According to Birth Weight
Hye Young Kim, Dae Yeol Lee, Soo Chul Cho
Clin Exp Pediatr. 1998;41(11):1484-1490.   Published online November 15, 1998
Purpose : Insulin-like growth factors(IGFs) are mitogenic peptides that are essential for fetal and maternal tissue growth during pregnancy. They circulate primarily with serum IGF-binding protein(IGFBP) which regulates the availability of IGFs to their specific target tissue. This study was performed to examine the relationships between birth weight and IGFs, insulin and growth hormone in the sera of cord blood...
Short Term Effect of Recombinant Human Growth Hormone Therapy in Children with Chronic Renal Failure
Si-Whan Ko, Dong-Kyu Ji
Clin Exp Pediatr. 1998;41(9):1256-1261.   Published online September 15, 1998
Purpose : Growth retardation is one of the major side effects of chronic renal failure. In this study, the short-term growth promoting effect, effect on the chemical parameters, and probable side effects of growth hormone treatment to child patients with chronic renal failure were examined. Methods : The research sample was 5 child patients diagnosed with chronic renal failure and receiving...
Growth Status and Levels of Growth Factors in Children with Insulin-dependent Diabetes Mellitus
So Chung Chung, Duk Hee Kim
Clin Exp Pediatr. 1998;41(8):1102-1110.   Published online August 15, 1998
Purpose : It is well known that the linear growth velocity in children with insulin-dependent diabetes mellitus(type 1 DM) is closely related to metabolic control and onset age of the disease. Many studies have demonstrated growth impairment in children with type 1 DM, regardless of the degree of metabolic control, whereas other studies have found no growth retardation. Therefore, we...
Abnormalities of Hypothalamic-Pituitary MR Imaging and Pituitary Function in Patients with Growth Hormone Deficiency
Hun-Gy Kim, Han-Wook Yoo
Clin Exp Pediatr. 1998;41(6):791-798.   Published online June 15, 1998
Purpose : In this study, efforts have been made to evaluate the sella MRI in 14 patients with growth hormone deficiency to define more clearly the structural abnormalities of the hypothalamohypophyseal axis, examine frequency of these abnormalities, and determine whether a relationship exists between the sella MRI findings and types of endocrine dysfunction. Methods : Sella MRI was performed in 14 patients who were...
The Relationships of Pretreatment IGF-I SDS, Delay in Bone Age and Response to Recombinant Human Growth Hormone(rhGH) Therapy in Children with Growth Hormone Deficiency
Seon-Young You, Ki-Joong Kim, Jeh-Hoon Shin, Jin-Nyoung Park, Hee-Jeong Ahn, Yong-Joo Kim
Clin Exp Pediatr. 1998;41(1):90-98.   Published online January 15, 1998
Purpose : To assess whether pretreatment IGF-I SDS and pretreatmental bone age are useful indicators in the response of rhGH therapy in children with GH deficiency(GHD), the relationship between pretreatment IGF-I SDS, delay in bone age and the growth response during the first year of rhGH treatment was analyzed. Methods : This study included 12 children with GHD. We measured IGF-I levels by RIA...
Cardiovascular Effects of Growth Hormone Treatment in Idiopathic Short Stature
Hyang Ok Woo, Dong Wook Kim
Clin Exp Pediatr. 1997;40(8):1149-1155.   Published online August 15, 1997
Purpose : An excess of GH causes various problems within the cardiovascular system including cardiac hypertrophy and abnormalities of left ventricle(LV) function. To evaluate the cardiovascular effects due to GH treatment in idiopathic short stature (ISS), we measured the cardiovascular function. Methods : Twenty-two echocardiographic studies were performed in ISS who were admitted from Jan. 1994 through Jul. 1996, and they were divided into two...
Long-term Growth Response to Growth Hormone Therapy in Children with Growth Hormone Deficiency
Byung Churl Lee
Clin Exp Pediatr. 1997;40(5):672-679.   Published online May 15, 1997
Purpose : The aim of this study was to evaluate the long-term growth response to growth hormone therapy in 18 children with naive growth hormone deficiency. Methods : The subjects of this study were aged 3-13.5 years and each patient continuously received GH(EutropinⓇ) 0.45-0.7IU/kg/week, intramuscularly or subcutaneously in 3-7 divided dose for up to 7 years. Standard auxologic assessment was carried...
TheAnalytic Review of Standard Growth Valuein School-Age Children in Seoul
Joo Young An, Jin Seop Kang, Young Jin Hong, Don Hee Ahn, Sung Jae Suh
Clin Exp Pediatr. 1996;39(12):1669-1679.   Published online December 15, 1996
Purpose : It hasn't been developed a new standard growth value for children in Korea since 1985. This study was designed to compare the difference of standard growth value of height, weight and chest circumference for school-age children in Seoul between 1985 and 1994. Methods : Height, weight and chest circumference were measured in 6,308 students, aged 6-17 years, of 12...
The Characteristics of Insulin-like Growth Factor Binding Protein-3(IGFBP-3) in Serum; The Diagnostic Utility of IGFBP-3 in Growth Hormone Deficiency
Ki-Joong Kim, Jeh-Hoon Shin, Young-Ik Lee
Clin Exp Pediatr. 1996;39(11):1594-1599.   Published online November 15, 1996
Purpose : For diagnosis of growth hormone(GH) deficiency in short stature, peak growth hormone levels after pharmacologic stimulation are usually used. In this study, we measured serum IGFBP-3, which is a major binding protein in serum and is considered to be GH-IGF-I axis dependent, levels by radioimmuno assay(RIA) in sera from normal short stature(NSS) children, and patients with GH deficiency children to clarify the...
The Effect of Recombinant Human Growth Hormone on the Growth in the Children with Chronic Renal Failure
Sei Won Yang, Young Choi
Clin Exp Pediatr. 1996;39(7):997-1004.   Published online July 15, 1996
Purpose : We observed the effect of three year-administration of recombinant human growth hormone(rhGH) on the growth in the children with chronic renal failure(CRF). Methods : Five prepubertal children(three boys and two girls) with CRF, who had been managed by conservative methods, were given rhGH(1 U/kg/week) for three years. Growth parameters, such as growth velocity, height standard deviation score(SDS), and predicted final adult height, obtained...
Primary Distal Renal Tubular Acidosis in Children
Byoung Chul Kang, Hye Won Park, Il Soo Ha, Hae Il Cheong, Yong Choi
Clin Exp Pediatr. 1996;39(7):987-996.   Published online July 15, 1996
Purpose : This study was designed to examine the clinical characteristics and the effect of treatment in children with primary distal renal tubular acidosis (dRTA). Methods : Medical records of 4 children diagnosed as dRTA at Seoul National University Children's Hospital were reviewed, and the clinical manifestations, laboratory findings, diagnostic criteria and effects of treatments were investigated. Results : All cases presented with growth retardation....
The Concentration of Insulin Like Growth Factor-I(IGF-I) and IGF-Binding Protein-3 (IGFBP-3) in the Serum of Children with Growth Hormone Deficiency and the Alterations after Growth Hormone Treatment
Woo Yeong Chung, Dae-Yeol Lee
Clin Exp Pediatr. 1996;39(6):846-855.   Published online June 15, 1996
Purpose : The insulin like growth factors (IGFs) circulate complexed to IGF-binding proteins(IGFBPs). IGFBP-3 is the major circulating IGFBP and is found primarily as a 150 kDa complex which contains an acid labile subunit(ALS), IGFBP-3, and IGF-I or IGF-II and is considered to be growth hormone(GH) dependent. In this study, we measured serum IGF-I, IGFBP-3 and 150 kDa levels in sera of growth hormone...
The Changes of the Bone Mineral Density in the Girls with Turner Syndrome, using Recombinant Human Growth Hormone
Sei Won Yang
Clin Exp Pediatr. 1996;39(6):839-845.   Published online June 15, 1996
Purpose : Estrogen deficiency causes sexual infantilism in Turner syndrome, which could decrease the bone mineral density(BMD) since birth. This decreased BMD might be contributed by the decreased growth hormone(GH) secretion. To improve the decreased BMD, estrogen therapy is recommended, especially after the pubertal age, but estrogen therpay during childhood can accelerate the epiphyseal fusion, resulting in shorter final height. There is...
Relationship of Insulin-like Growth Factor-I with Pharmacologically Stimulated Growth Hormone secretion in Growth hormone Deficient Children
Phil-Soo Oh, Ki-Joong Kim, Young-Iee Yu, In-Joon Seol, Jeh-Hoon Shin
Clin Exp Pediatr. 1995;38(10):1394-1403.   Published online October 15, 1995
Purpose : At present, to determine growth hormone(GH) deficiency in short stature, many provocative tests using various pharmacologic agents such as clonodine, L-dopa, insulin should be done. These are not only complicated, but also misleading in some patients. And so, in search of a simple method of detecting GH deficiency that may replace the complicated stimulation test, we measured basal...
Diagnostic Significance of Urinary Growth Hormone Measurement in Patients with Growth Hormone Deficiency
No Hyun Kim, Woo Yeong Chung, Soon Yong Lee
Clin Exp Pediatr. 1995;38(8):1124-1131.   Published online August 15, 1995
Purpose : To investigate the diagnostic significance of urinary growth hormone measurement and compare with the urinary GH values in different methods of urine collection, this study was performed in patients with short stature. Methods : Measurement of urinary GH excretion was performed in 9 children with complete growth hormone deficiency (GCD), in 19 children with partial growth hormone deficiency (GPD)...
A Study on the Necessity to Revise the Present Growth Data for Height and Weight? -Base on Data from the Circumference and Triceps Thickness-
Gi Dong Hwang, Jae Kyung Choi, Jeh Hoon Shin, Nam Soo Kim, In Joon Seol, Hahng Lee
Clin Exp Pediatr. 1995;38(6):745-751.   Published online June 15, 1995
Purpose : Applying the present growth curve(established in 1985) in practice, we noticed some difference. And so, we performed this study to know that is it necessary to revise the present standard data in Korea. Methods : We checked the height and weight of 208 children of one primary school in Seoul. And also, we measured arm circumference and triceps thickness...
Characteristics of Insulin-Like Growth Factor I in Serum; Pattern of Insulin-Like Growth Factor Binding Protein (Large Complex) in Short Stature Patients with Complete Growth Hormone Deficiency
Jin Nyoung Park, Byung Deok Seo, Jeh Hoon Shin, Soo Ji Moon, Sung Yeoul Chang
Clin Exp Pediatr. 1994;37(11):1548-1559.   Published online November 15, 1994
To elucidate the complex of insulin-like growth factor binding proteins (IGF-BPs) in short stature patients, we carried out a prospective study on three patients who were diagnosed as complete GH deficiency at the department of pediatrics form July 1992 to June 1993. The results were summarized as follows: 1) Two circulating IGFs complexed to specific binding protein existed in normal serum. Binding...
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
The Effect of Cranial Irradiation on Growth of Children with Lymphatic Origin Tumors
Jin Seoup Jung, Yon Sook Rho, Sang Woo Kim
Clin Exp Pediatr. 1994;37(5):666-671.   Published online May 15, 1994
A retrospective study was conducted to investigate the effects of CNS prophylaxis with 1,800cGy cranial irradiation on standing height growth of children with acute lymphoblastic leukemia(ALL). Seventeen longterm survivors (DFS over 5 years) of ALL and Non-Hodgkins Lymphoma who had been admitted at pediatric department of Inje University Seoul Paik Hospital from January 1982 to September 1988 were studied. The long term...
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