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Original Article
Ultrasonographic Bladder Parameters for Successful Suprapubic Bladder Aspiration
Sung Chul Baek, Hoe Kyoung Koo, Cheol Hong Kim, Kyung Bum Kim, Hyun Hee Lee, Byung Min Choi, Kee Hwan Yoo, Young Suk Hong, Dong Gwan Han
Clin Exp Pediatr. 2004;47(2):187-192.   Published online February 15, 2004
Purpose : Suprapubic bladder aspiration(SBA) is a widely accepted method of obtaining sterile urine for culture in neonates but has a relatively low success rate and a few serious complications during SBA procedure. To improve the chance of obtaining urine, we determined the ultrasonographic bladder parameters(diameters and volume) to confirm that the bladder is adequately distended for successful aspiration of...
Physical and Biological Activity of Domestic Product of Modified Bovine Lung Surfactant
Chul Lee, Min Soo Park, Moon Sung Park, Jung Nyeon Kim, Jong Wook Lee, Kwang Hyun You, Won Jae Kwag, Kook In Park, Ran Nam gung, Dong Gwan Han
Clin Exp Pediatr. 1997;40(6):771-785.   Published online June 15, 1997
Purpose : Neonatal respiratory distress syndrome is caused by the deficiency of lung surfactant in premature babies. For the treatment of RDS at present surfactants such as Surfacten․ (Tokyo-Tanabe Co., Japan) and Exosurf․ (Wellcome Co., USA) are used. As awarded the grant from the Ministry of Science and Technology for a model research project of Medium-Technology program, we have modified (supplemented) the bovine lung...
Risk factors for Pulmonary Interstitial Emphysema(PIE) in Mechanically Ventilated Neonates with Hyaline Membrane Diseas
Shin Won Yoon, Chul Lee, Jeong Nyun Kim, Ran Namgung, Dong Gwan Han, Myung Joon Kim
Clin Exp Pediatr. 1997;40(3):318-326.   Published online March 15, 1997
Purpose : Pulmonary interstitial emphysema(PIE) is a common and serious complication of mechanical ventilation in infants with hyaline membrane disease. This abnormal collection of gases has two basic roentgenographic features; linear and cyst-like radiolucencies. High positive inspiratory pressure was found to be the most significant parameter associated with development of fatal pulmonary interstitial emphysema. Without prompt conservative management such as lowering peak inspiratory...
Case Report
A Case of Antley-Bixler Syndrome
Young Rae Kim, Kook In Park, Choon Sik Yoon, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1995;38(4):582-585.   Published online April 15, 1995
Antley-Bixler syndrome is a very rare disese of characteristic feature of craniosynostosis, brachycephaly, midface hypoplasia, depressed nasal bridge, radiohumeral synostosis and bowing femur. We presented a case of Antley-Bixtler syndrome with brief review of lituratures.
Original Article
Assessment of Infantile Mental and Motor Development Influenced by Breast Milk and Formula Feeding
Chul Lee, Min Soo Park, Young Mi Chung, Hye Jung Joo, Kwang-Moon Kim, Dong Gwan Han
Clin Exp Pediatr. 1995;38(3):289-296.   Published online March 15, 1995
Purpose : This study was undertaken to compare the mental and motor development, unsing Bayley Developmental Scale, during infancy(6-8 months of age) according to the choice of feeding, either breast milk of formula, as well as to evaluate its influence on physical growth. Methods : The study population was 43 normal infants between 6 and 8 months of age, of birth...
Evaluation of Development of Normal Infants Using Bayley Developmental Test
Young Mi Chung, Chul Lee, Kook In Park, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1994;37(11):1508-1518.   Published online November 15, 1994
From April to September 1992, 40 infants with age 6 months to 8 months who had been born in Yongdong Severanve Hospital were studied for evaluation of their development using Bayley developmental test. The result obtained were as follow: 1) Mean mental developmental index(MDI) is higher than mean psychomotor developmental index (PDI) and the values are 101.9¡¾8.2 and 105.5¡¾9.8 respectively. 2) As...
Clinical and Ultrasonographic Study on Prenatal Brain Damage in Newborn Infants
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee
Clin Exp Pediatr. 1994;37(10):1364-1375.   Published online October 15, 1994
To determine the incidence of prenatal brain damage, and evaluate the clinical and neurosonographical characteristics, we prospectively examined 508 newborn infants with intracranial ultrasound within the first day of life who admitted to the NICU of Severance Hospital from June 1990 to January 1992 and reviewed maternal or neonatal medical records. We found 12 cases(2.4%) of fetal brain...
Risk Factors of Bronchopulmonary Dysplasia in Premature Infants Treated with Mechanical Ventilation and Restrictive Fluid Therapy
Min Soo Park, Kook In Park, Hye Jung Choo, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(10):1357-1363.   Published online October 15, 1994
In addition to many of the widely accepted risk factors of bronchopulmonary dysplasia(BPD), such as prematurity, oxygen toxicity, barotrauma, and infection, the amount of fluid intake during the early phase of life has recently been reported to be an important factor, especially the amount of colloid. Forty-one premature infants who were admitted to the NICU of Severance Hospital, Yonsei University...
Case Report
A Case of Phakomatosis Pigmentovascularis
Seung Mo Park, Kook In Park, Hye Jung Joo, Ran Namgung, Chul Lee, Dong Gwan Han, Soo Il Chun
Clin Exp Pediatr. 1994;37(8):1156-1161.   Published online August 15, 1994
In 1947, Ota et al. First reported a case of phakomatosis pigmentovascularis and defined a subgroup of this disease having a congenital generalized hemangioma and pigmented lesions including anmongolian spot-like lesion, nevus pigmentosus and nevus of Ota. We experienced a case of phakomatosis pigmentovascularis type Iib in a 10-day old male baby, who since birth, had generalized nevus flammeus and...
Original Article
Effect of Glucocorticoid-Induced Hyperglycemia on Preventing Hypoxic-Ischemic Brain Damage by Dexamethasone in Neonatal Rat
Kook In Park, Tae Seung Kim, Min Soo Park, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(8):1035-1047.   Published online August 15, 1994
Purpose : We evaluated the protective effect of dexamethasone (DX) administration on brain damage produced in a perinatal model of cerebral hypoxia-ischemia in the rat. Since hyperglycemia has been shown to reduce hypoxic-ischemic brain injury (HI) in immature rat, we investigated the role of glucocorticoid-induced hyperglycemia in the neuroprotective mechanism of DX. Methods : Hypoxic-ischemic brain injury in 7-day-old rats was...
Intraventricular Hemorrhage in Full-Term Neonate
Myoung Bae Jeon, Kook In Park, Choon Sik Yoon, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(6):776-785.   Published online June 15, 1994
Intraventricular hemorrhage is a common hemorrhagic cerebral disorder in premature, but occurs much less frequently in the full-term newborn. In order to obtain documentation of clinical and ultrasonographic characteristics of intraventricular hemorrhage in full-term, we performed cerebral ultrasonography on 602 newborn infants who had been admitted to neonatal intensive care unit at the Deppartment of Pediatrics, Yonsei University College of...
Case Report
A Case of Brain Damage in Surviving Monozygotic Twin After Intrauterine Death of Co-Twin
Jae Young Choi, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han, Tae Sub Chung
Clin Exp Pediatr. 1994;37(5):701-706.   Published online May 15, 1994
Various anatomical defects have been described in the surviving twin who had a stillborn, macerated monozygotic co-twin Disseminated Intravascular Coargulation. The etiology is thought to be placental transfer of emboli or thromboplastic material through placental vascular anastomoses. We experienced a case of monozygotic twin with deceased co-twin at 30 weeks of gestation and confirmed to have antenatal periventricular germinal matrix and...
Original Article
Tc-99m HMPAO Brain SPECT in a Patient with Neonatal Seizure and Right Cerebral Hemiatrophy
Hye Young Kang, Kook In Park, Ran Namgung, Chul Lee, Chang Jun Coe, Dong Gwan Han, Tae Sub Chung, Woo Hee Jung
Clin Exp Pediatr. 1994;37(3):397-404.   Published online March 15, 1994
Functional brain imaging is very important in the diagnosis and evaluation of the various neurologic disorders. In addition to electroencephalography (EEG) and positron emission tomography (PET), single photon emission computed tomography (SPECT) have increasingly gained importance in determination of disturbances in regional brain functions. Both ictal and interictal Tc-99m hexamethyl-propyleneamine oxime single photon emission computed tomography (Tc-99m HMPAO SPECT) was done...
Case Report
A Case of Cerebrocostomandibular Syndrome with Congenital Heart Disease
Sang Heui Song, Kook In Park, Hye Jung Joo, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1993;36(4):574-578.   Published online April 15, 1993
Cerebrocostomandibular Syndrome is characterized by micrognathia, cleft palate, multiple thorax deformity and frequently, mental deficiency. Respiratory compromise is a common cause of death. We experienced a case of cerebrocostomandibular syndrome with congeniyal heart disease in a 2 day old female baby with the chief complaint of cyanosis and respiratory difficulty since birth, She was delivered by cesarian section due to delayed...
Measurement of Bone Mineral Density in Korean Newborns by Dual Photon Absorptiometry
Kook In Park, Chul Lee, Ran Namgung, Duk Hi Kim, Dong Gwan Han
Accepted January 1, 1970  
Bone mineral density (BMD), bone mineral content (BMC) and bone width (BW) of lumbar spine was measured in 37 term and 38 preterm appropriate-for-gestational-age (AGA) infants and 22 term small-for-gestational-age (SGA) infants who were delivered at Yonsei University Severance Hospital from January to September 1991 using dual photon absorptiometry (DPA). All of the infants were studied once within three days...
Original Article
Longitudinal Change of Cerebral Blood Flow Velocity in Neonates with the Doppler Technique
Kook In Park, Dong Gwan Han, Ran Namgung, Chul Lee, Jin Suk Suh, Myung Joon Kim
Clin Exp Pediatr. 1992;35(1):60-68.   Published online January 15, 1992
Eighty-one asymptomatic preterm, term-SGA, and full term infants who were delivered at Yonsei University Severance Hospital from January to July 1990 were studied with color duplex imaging doppler sonography to assess the postnatal changes of the cerebral blood flow velocity longitudinally. Pulsatility index (PI) and area under the velocity curve (AUVC) were calculated to quantitate changes in anterior cerbral artery blood...
A case of type VI Ehlers-Danlos syndrome.
Ki Soo Pai, Young Mi Chung, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1991;34(12):1717-1723.   Published online December 31, 1991
Ehlers-Danlos syndrome is an inherited hetergenous disorder of connective tissue with characteris- tic clinical manifestations. In this article, a case of Ehlers-Danlos syndrome is presented. A nine months old female was admitted due to developmental delay. On physical examination, she had soft velvety skin and corneal opacity. Both hip joints were positive for Barlow test. There was hyper- mobility of both knee and elbow...
A case of neonatal herpes simplex virus encephalitis.
Kook In Park, Young Mo Sohn, Dong Soo Kim, Ran Namgung, Chul Lee, Dong Gwan Han, Won Young Lee, Ki Keun Oh, Myung Joon Kim
Clin Exp Pediatr. 1991;34(9):1276-1285.   Published online September 30, 1991
Neonatal herpes simplex virus infection still remains a life-threatening infection for the newborn. With an increasing incidence of genital herpes and an increase in the incidence of neonatal herpes simplex virus infections, it is important that pediatricians and neonatologists continue to maintain a high index of suspicion in infants whose symptoms may be compatible with herpes simplex virus infections so that early identification leads...
Predictive factors and initial selection of antibiotics in neonatal sepsis.
Dong Chul Park, Chul Lee, Kook In Park, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1991;34(6):755-762.   Published online June 30, 1991
For simplifying and standardizing the interpretation of usual findings for neonatal sepsis, prenatal and perinatal factors, clinical symptoms and signs, method of management and hematologic findings were evaluated as a screening test. From the data obtained, a scoring system was formulated that assigns a score of 3 for diarrhea, 1. 5 for tachypnea, 1.5 for cyanosis, 1 for umbilical vessel catheterization, 1 for intravenous...
Effect of fluid restriction on postnatal weight and outcome in very low birth weight infants.
Chul Lee, Hyeon Soo Lee, Ran Namgung, Dong Gwan Han
Clin Exp Pediatr. 1991;34(3):348-354.   Published online March 31, 1991
We studied 45 very low birth weight infants for change in birth weight, urine output, serum Na level, ventilatory support and outcome between two groups after fluid restriction therapy. Group 1 (n=17) were infants whose weight loss were more than 5% of birth weight. Group 2 (n=17) were infants whose weight loss were more than 5% of birth weight. 1) Group 1 had more fluid...
Transplacental transmission of hepatitis B virus from carrier nothers to neonates.
Soh Yeon Kim, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1991;34(2):190-196.   Published online February 28, 1991
Neonates bom to hepatitis B carrier mothers at Yongdong Severance Hospital, Yonsei University College of Medicine were sampled for hepatitis B viral markers using venous blood drawn from external jugular vein within 3 hours after birth and the following results were obtained. Two thousand nine hundred and seventy two pregnant women who received prenatal care at Yongdong Severance Hospital, Yonsei University College of Medicine...
The role of exchange transfusion as a therapy for neonatal DIC.
Jung Tak Kim, Kook In Park, Ran Namgung, Dong Gwan Han, Kir Young Kim
Clin Exp Pediatr. 1991;34(1):31-40.   Published online January 31, 1991
A clinical study on the effects of exchange transfusion on disseminated intravascular coagulation was conducted on 32 patients with DIC who were admitted to the pediatric department of YUMC from January 1984 to June 1989. We diagnosed DIC when symptoms were compatible to the diagnosis and there were more than 3 abnormal laboratory findings out of the following 5, which were platelet count, PT,...
Prolapse of Ileal Mucosa Through the Patent Omphalomesenteric Duct.
Hwan Gyu Park, Ki Soo Pai, Jeong Wan Yoo, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han, Eui Ho Hwang, In Joon Choi
Clin Exp Pediatr. 1990;33(12):1713-1717.   Published online December 31, 1990
The omphalomesenteric duct in the embryo is a communication between the yolk sac and primitive gut. The duct closes by six to eight weeks of intrauterine life and disappears soon after. Patent omphalomesenteric duct is a congenital anomaly which occurs when there is incomplete closure of the duct during this period. The authors experienced a cases whereby a 29-day old male baby had patent...
Clinical Study of Umbilical Vessel Catheterization in Newborn Infants.
Dae Shik Kim, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1990;33(11):1503-1509.   Published online November 30, 1990
Umbilical vessel catheterization has become a common procedure in critically ill newborn infants. We studied the usefulness and complications of indwelling umbilical vessel catheters in 164 patients who were admitted to the neonatal intensive care unit of the Department of Pediatrics, Yonsei University Hospital from January 1985 to December 1988. The results were as follows: 1) Their birth weights ranged from 650 to 3,800 gm, and...
The Effect of Phototherapy on Serum bilirubin Binding Capacity and Affinity in the Neonate.
In Suck Ryu, Chul Lee, Ran Namkung, Dong Gwan Han
Clin Exp Pediatr. 1990;33(10):1319-1325.   Published online October 31, 1990
Since the effect of phototherapy in the treatment of neonatal hyperbilirubinemia has been reported 30 years ago, phototherapy has been used widely for neonatal hyperbilirubinemia, but the exact mechanism and the effect of light on the human body have not been fully determined. Free bilirubin level in the serum is an important indicator for kemicterus, a complication of neonatal hyperbilirubinemia. Free bilirubin level was...
Dubowitz Neurologic Examination in Normal Neonates.
Young Soo Lee, Soh Yeon Kim, Dong Chul Park, Kook In Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1990;33(7):977-988.   Published online July 31, 1990
With the improvement in survival rate in high risk infants in the neonatal intensive care unit, there is rising concern about the neurologic sequelae in these infants. In order to evaluate the neur- ologic examination in normal neonates, 400 normal newborns were evaluated for a duration of 6 months from Mach 1989 to August 1989. Neonates greater than 37 weeks gestational age, birth weight...
Exogenous Surfactant Replacement Therapy of Hyaline Membrane Disease: A controlled clinical trial.
Ran Namgung, Chul Lee, Kook In Park, Dong Gwan Han
Clin Exp Pediatr. 1990;33(1):22-34.   Published online January 31, 1990
We conducted a clinical controlled trial of exogenous surfactant replacement therapy in premature infants with hyaline membrane disease at the neonatal intensive care unit of Yonsei University Medical Center form Nov. 1987 to May 1988. Sixteen premature infants with severe HMD were randomly assigned to control group or surfactant-treated group. Eight infants (mean gestational age 29.9±2.8 week, mean birth weight 1, 425±308.9 gm) were given...
A case of congenital posterior choanal atresia.
Dae Shik Kim, Ran Namgung, Chul Lee, Dong Gwan Han, Seung Kyu Chung
Clin Exp Pediatr. 1989;32(11):1546-1552.   Published online November 30, 1989
The congenital posterior choanal atresia is an uncommon, but not rare, disorder that may threaten the newborn’s existence or give rise to chronic symptoms. As many as 50% of patients with choanal atresia have other associated anomalies. We experienced a case of congenital posterior choanal atresia without associated anomaly in 6 day old female baby. The patient was hospitalized due to the main symptoms...
A Study on Noninvasive Measurement of Blood Pressure in Normal Newborn.
Eun Hee Lee, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1989;32(9):1216-1223.   Published online September 30, 1989
Measurement of blood pressure in neonate is an important diagnostic procedure. But measurement of blood pressure were not performed routinely because of difficulty in measuring blood pressure and variable normal range according to measuring apparatus. Recently some accurate and convinient apparatuses of measuring blood pressure have been introduced in neonatal care, so normal blood pressure values of neonate are needed. In this study, we establish...
Ultrasonographic Diagnosis of Congenital Hypertrophic Pyloric Stenosis.
Shin Heh Kang, Chul Lee, Ran Namgung, Dong Gwan Han, Ki Keun Oh, Seung Hun Choi
Clin Exp Pediatr. 1989;32(6):756-764.   Published online June 30, 1989
The diagnosis of congenital hypertrophic pyloric stenosis has traditionally been made on the basis of history and physical examination in the majority of patients. Imaging procedures such as UGI series have been reserved for vomiting infats in whom the diagnosis was obscure. More recently ultrasonography with the lack of hazards associated with radiation provides an additional method of investigation which is accurate and diagnose...
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