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Original Article
Clinical significance of serum alanine aminotransferase and lifestyle intervention in children with nonalcoholic fatty liver disease
Kyoung Ah Kwon, Peter Chun, Jae Hong Park
Clin Exp Pediatr. 2016;59(9):362-367.   Published online September 21, 2016

This study aimed to investigate the clinical significance of serum alanine aminotransferase (ALT) levels in children with nonalcoholic fatty liver disease (NAFLD) and the effect of lifestyle intervention on NAFLD.


The clinical data of 86 children diagnosed with NAFLD were reviewed retrospectively. Forty-six patients belonged to the elevated ALT group and 40 to the normal ALT group. The clinical parameters of...

Review Article
Role of colonoscopy in the diagnosis and treatment of pediatric lower gastrointestinal disorders
Jae Hong Park
Clin Exp Pediatr. 2010;53(9):824-829.   Published online September 13, 2010

The safety and effectiveness of colonoscopy in the investigation of lower gastrointestinal tract pathology in children has been established for more than 2 decades in Korea. Skill and experience have since advanced to the point that both diagnostic and therapeutic colonoscopy are now routinely performed by most pediatric gastroenterologists. Pediatric colonoscopy differs significantly from its adult parallels in nearly every...

Case Report
A case of hepatopulmonary syndrome in a child with fatty liver disease secondary to hypopituitarism after craniopharyngioma resection
Sun Ju Im, Hyun Seok Park, Hyoung Doo Lee, Jae Hong Park, Hee Ju Park
Clin Exp Pediatr. 2007;50(8):794-798.   Published online August 15, 2007
Hepatopulmonary syndrome is a triad that includes: hepatic dysfunction, intrapulmonary vascular dilatation and abnormal arterial oxygenation. The incidence of intrapulmonary vascular dilatations, in adults with end-stage liver disease, has been reported to be 13% to 47%, however the incidence in children is unclear and the cases in Korean children have never been reported. The hepatopulmonary syndrome may occur as a...
A Case of Aplastic Anemia following Hepatic Failure by Acute Hepatitis
Hye Jin Ku, Young Tak Lim, Jae Hong Park
Clin Exp Pediatr. 2004;47(12):1356-1359.   Published online December 15, 2004
Aplastic anemia following acute hepatitis or acute hepatic failure is an uncommon disease and has a poor prognosis. We experienced a case of aplastic anemia following acute hepatic failure in a 10- year-old girl. She was admitted because of jaundice and lethargy for 8 days. Laboratory findings revealed marked elevated serum transaminases and bilirubin levels, prolonged prothrombin time and partial...
A Case of Intestinal Tuberculosis Concurring with Endobronchial and Laryngeal Tuberculosis
Su Jin Kim, Su Eun Park, Min Gi Lee, Gun Il Kim, Chang Hun Lee, Jae Hong Park
Clin Exp Pediatr. 2003;46(7):714-717.   Published online July 15, 2003
Although the incidence of tuberculosis has been reduced recently because of the advance of anti-tuberculosis chemotherapy, improvements of public health, and early diagnosis, it is still high in developing countries. Intestinal tuberculosis can occur at any age, but young adults and female are more affected. Early diagnosis of childhood intestinal tuberculosis is difficult, largely because of vague symptoms and nonspecific...
Original Article
Associated-Genes and Virulence Factors of Staphylococcus aureus Isolated from Nasal Cavity of Neonates
Yung Bu Kim, Ji Young Moon, Jae Hong Park
Clin Exp Pediatr. 2003;46(1):24-32.   Published online January 15, 2003
Purpose : Nosocomial infection with Staphylococcus aureus, especially methicillin resistant S. aureus, has become a serious concern in the neonatal intensive care unit. The aim of this study is to investigate the virulence factors, and the relationship between the antibiotic resistance and the associated genes of Staphylococcus aureus isolated from nasal cavity of neonates. Methods : Fifty one isolates of S....
Case Report
A Case of Stevens-Johnson Syndrome Plus Vanishing Bile Duct Syndrome Associated with Ibuprofen Use
Jee Yee Choi, Su Young Kim, Soon Ok Byun, Jae Hong Park
Clin Exp Pediatr. 2002;45(9):1146-1149.   Published online September 15, 2002
Acute vanishing bile syndrome is a cause of progressive cholestasis. It is most often drug or toxin related. It's pathogenesis is unknown. Stevens-Johnson syndorme is a well-recognized immune complex-mediated hypersensitivity reaction. It is induced by drug or infection. It has classic systemic, mucosal, and dermatologic manifestations. We report a case of a 14 years old female suffering from Stevens-Johnson syndrome...
A Case of Congenital Hepatic Fibrosis Accompanied by Renal Tubular Ectasia, Caroli Syndrome and Choledochal Cyst
Bong Seok Choi, Sang Nam Bae, Yong Tak Im, Jae Hong Park, Chang Hoon Lee, Jun Woo Lee
Clin Exp Pediatr. 2002;45(7):923-927.   Published online July 15, 2002
Congenital hepatic fibrosis is a relatively rare disease, characterized by bile ductular proliferation and prominent fibrosis in the portal area of liver resulting in portal hypertension. It is frequently associated with other abnormalities such as polycystic kidney, Caroli syndrome, cystic dysplasia of pancreas, intestinal lymphangiectasia, pulmonary emphysema, hemangioma, and cleft palate. We report here a case of congenital hepatic fibrosis...
A Case of Respiratory Difficulty Due to Congenital Tracheal Calcification and Nasal Pyriform Aperture Stenosis
Kyu Tae Kim, Young Mi Kim, Su Eun Park, Jae Hong Park, Hawn Jung Noh, Hak Jin Kim
Clin Exp Pediatr. 2002;45(5):669-672.   Published online May 15, 2002
Nasal obstruction is a cause of respiratory distress in newborns. The congenital nasal airway obstructive abnormalities are classified into three forms according to the location: posterior choanal atresia, nasal cavity stenosis and congenital nasal pyriform aperture stenosis(CNPAS). CNPAS is located at the anterior part of the nasal fossa. CT is the study of choice to make the diagnosis of CNPAS...
Medical Lecture Course
Ischemia-Reperfusion : Mechanism of Microvascular Dysfunction
Jae Hong Park
Clin Exp Pediatr. 2002;45(3):295-301.   Published online March 15, 2002
Case Report
Two Cases of Acute Form of Tyrosinemia Type I
Kyu Tae Kim, Young Mi Kim, Su Eun Park, Sang Ook Nam, Jae Hong Park
Clin Exp Pediatr. 2002;45(1):131-136.   Published online January 15, 2002
Tyrosinemia type I is an autosomal recessive disorder of amino acid metabolism and is caused by a deficiency of fumarylacetoacetate hydrolase(FAH), the last enzyme in the catabolic pathway of tyrosine. The disease is characterized by hepatic dysfunction, hepatocellular carcinomas, renal tubular dysfunction, rickets, and neurologic crises. We experienced 2 cases(a 4-day-old girl, a 7- month-old girl) of acute form of tyrosinemia type I. Case...
Original Article
Clinical Analysis of Atypical Kawasaki Disease : Comparison of Kawasaki Disease Between Typical and Atypical Types
Eun Ju Jeong, Jae Hong Park, Hee Ju Park
Clin Exp Pediatr. 2001;44(12):1448-1453.   Published online December 15, 2001
Purpose : Kawasaki disease(KD) is known as one of the most important causes of acquired heart disease in children. But the incidence of acquired heart disease can be reduced by early diagnosis and treatment with large amounts of intravenous γ-globulin(IVGG). For early diagnosis and treatment of atypical KD, we analyzed and compared the clinical features, laboratory findings and coronary lesions in patients with typical...
Case Report
A Case of VURD Syndrome
Sun Young Kim, Eu Jun Yang, Jae Hong Park, Su Young Kim, Sang Don Lee
Clin Exp Pediatr. 1998;41(12):1722-1725.   Published online December 15, 1998
VURD syndrome is a disorder characterized by a posterior urethral valve, unilateral reflux, and ipsilateral renal dysplasia. This syndrome is not uncommon, with an incidence in the range of 15 to 20% in patients with posterior urethral valve. Etiology is not clear, but there are a few reports that renal dysplasia is either a result of hydrostatic pressure transmitted to...
Original Article
Relationship of Recurrent Abdominal Pain Syndrome and Gastric Emptying Time
Eui Jun Yang, Jae Hong Park, In Ju Kim
Clin Exp Pediatr. 1998;41(11):1538-1548.   Published online November 15, 1998
Purpose : Recurrent abdominal pain syndrome(RAPS) is not uncommon in school-aged children, but the etiology and pathogenesis are not understood well. But recent studies suggest that motility disorder makes up a majority of the pathogenesis. The aim of this study was to investigate gastric emptying time(GET) which is a method to evaluate gastrointestinal motility in patients with recurrent abdominal pain...
Clinical and Pathological Comparison of Neonatal Hepatitis and Extrahepatic Biliary Atresia in Korean Children
Jae Hong Park, Ju Suk Lee, Su Eun Park, Chang Hun Lee
Clin Exp Pediatr. 1998;41(10):1372-1379.   Published online October 15, 1998
Purpose : Neonatal hepatitis and congenital extrahepatic biliary atresia are two major causes of neonatal cholestasis. But the method of therapeutic trials used for each disease is essentially different. Nonetheless, it is very difficult to differentiate these diseases clinically and histologically. This study is aimed to find out major differences between the two by clinical characteristics and scoring of various...
Case Report
A Case of Septic Pulmonary Embolism in Neonate
Sang Hee Lee, In Hoon Lee, Jin Kuk Kim, Byung Do Nam, Ju Seok Lee, Jae Hong Park
Clin Exp Pediatr. 1998;41(9):1304-1308.   Published online September 15, 1998
Septic pulmonary embolization is an uncommon condition in which the clot or fibrin matrix, contaminated with micro-organisms, lodge in the pulmonary arterial tree, leading to infarction, suppuration and other complications. The septic emboli reach the lung from a variety of sources, including acute suppurative pelvic thrombophlebitis, infective endocarditis involving tricuspid and pulmonary valve, osteomyelitis, suppurative lesions of the neck, infected...
A Case of Pancreatitis associated with Systemic Lupus Erythematosus
Su Eun Park, Ju Suk Lee, Sang Ook Park, Jae Hong Park, Su Young Kim
Clin Exp Pediatr. 1998;41(7):989-993.   Published online July 15, 1998
Systemic lupus erythematosus(SLE), an autoimmune disease with multisystemic involvement, has been reported to be associated with a number of gastrointestinal complications. But pancreatitis is an unusual complication of SLE, occuring in only 3-4% of lupus cohort. Multiple mechanisms contributing to pancreatitis associated with SLE have been demonstrated which include vasculitis, necrotizing pancreatitis, corticosteroid administration, and vascular thrombosis. We experienced a...
A Case of Type I Autoimmune Hepatitis in Children
Soeng Hun Kim, Su Eun Park, Jeong Hwa Choi, Jae Hong Park, Su Yung Kim
Clin Exp Pediatr. 1998;41(7):979-983.   Published online July 15, 1998
Autoimmune hepatitis is an inflammatory liver disease characterized histologically by a dense mononuclaear cell infiltration of the portal tract, serologically by the presence of non-organ and liver specific autoantibodies and increased concentrations of IgG in the absence of a known etiology. Two types of autoimmune hepatitis are classified in the peripheral blood of antinuclear antibody and/or in antismooth muscle antibody(ANA/ASMA)...
Original Article
Clinical Studies of Intractable Diarrhea During Infancy
Jae Hong Park, Cheol Hong Kim, Eui Jun Yang, Sang Wook Park, Sang Wook Nam
Clin Exp Pediatr. 1998;41(7):923-930.   Published online July 15, 1998
Purpose : Intractable diarrhea during infancy is one of the major causes of infant mortality. But, its etiology, clinical courses, or methods of treatment are not well known. Therefore, we conducted a clinical approach to intractable diarrhea during infancy. Methods : We have retrospectively evaluated clinical characteristics, laboratory findings, methods of treatment, days required for recovery, in 23 infants who were...
Case Report
A Case with Dysphagia Caused by Lower Esophageal Ring in Childhood
Su Eun Park, Hwang Jae Yoo, Cheol Hong Kim, Jae Hong Park
Clin Exp Pediatr. 1997;40(11):1616-1620.   Published online November 15, 1997
Lower esophageal ring is unique disorder of the esophagus. It is composed entirely of mucosal fold, containing no muscle or scar tissue. It is one of the most common causes of dysphagia of adults, but an unusual cause of dysphagia in pediatric age group. This 14-year old male patient experienced progressive dysphagia for several years. Approximately 15 months prior to this visit, he began...
A Case of Ischemic Colitis in Childhood
Hwang Jae Yoo, Su Eun Park, Sang Ook Park, Jae Hong Park, Su Yung Kim
Clin Exp Pediatr. 1997;40(6):867-871.   Published online June 15, 1997
Ischemic colitis is a common gastrointestinal disease not in childhood but in sixties decade. It' s developed due to ischemic injury of colon and classified to transient reversible form, chronic form and acute fulminant form. Uniquely Authors had experienced a case of ischemic colitis diagnosed as barium enema in childhood. This patient was brought to our hospital due to abdominal pain, abdominal distension and...
A Case of Spondyloepiphyseal Dysplasia Congenita
Hwang Jae Yoo, Su Eun Park, Sang Ook Park, Jae Hong Park, Su Yung Kim
Clin Exp Pediatr. 1997;40(5):716-720.   Published online May 15, 1997
Spondyloepiphyseal dysplasia congenita is one of the osteochondrodysplasia, used to be diagnosed by clinical symptoms and radiologic findings. Clinical findings are short-trunk dwarfism, oval face, hypertelorism, short neck, kyphosis, lordosis, joint instability, coxa vara, pectus excuvatum, cleft palate, severe myopia, retinal detachment, deafness, and radiologic findings are thoracic kyphosis, lumbar lordosis, platyspondyly, anterior flaring of ribs, delayed ossification of head...
Partial Monosomy 21 Associated with Unbalanced t(10p;21q)
Bon Su Koo, Sang Uk Park, Jae Hong Park, Su Yung Kim
Clin Exp Pediatr. 1995;38(8):1146-1150.   Published online August 15, 1995
We experienced a case of partial monosomy 21 ina 9 year and 8 month old boy. He showed mental and growth retardation, others normal appearance except for low set malformed ears. Chromosomal analysis on Giemsa banding with high resolution showed unbalnaced translocation between 10 and 21 chromosomes and the deletion of short arm and centromere of chromosome 21. His karyotype...
A Case of Hyperthyroidism Following Primary Hypotyroidism
Han Sung Cho, Hwang Jae Yoo, Sang Ook Park, Jae Hong Park, Su Young Kim
Clin Exp Pediatr. 1995;38(6):863-866.   Published online June 15, 1995
A 9-year-old girl presented with primary hypothroidism have been followed by the development of hyperthyroidism. The diagnosis of primary hypothyroidism had been made by clinical manifestation, elavated serum thyroid-stimulating hormone level, antithyroglobulin antibody and antimicrosome antibody. Five and a quarter years later, the diagnosis of hyperthyroidism had been made by clinical maifestation such as enlargemetn of thyroid gland, tahcycardia, increased...
Cystinuria 3 Cases
Ji Eun Choi, Bo Young Yun, Hae Won Park, Jae Hong Park, Il Sue Ha, Hae Il Jeong, Yong Choi, Hwang Choi, In Won Kim
Clin Exp Pediatr. 1995;38(2):245-251.   Published online February 15, 1995
We report three cases of cystinuria, presenting with urinary stones. A 2-year-old girl presented with urinary difficulty, hematuria, dysuria of sudden onset, and her 7-month-old younger brother also was presented with urinary difficulty, irritability on urination & stone passage. Other 6-month-old boy was admitted due to sudden onset anuria. They had radioopague renal & ureter stones and stone analysis revealed mixed...
Congenital Adrenal Hyperplasia with 21-hydroxylase Deficiencies in Twins
Young Don Kim, Jeong Hwa Choi, Jae Hong Park, Hee Ju Park, Seong Suk Jeon
Clin Exp Pediatr. 1994;37(10):1469-1473.   Published online October 15, 1994
Congenital adrenal hperplasia is inherited disorder of adrenal steroidogenesis. 21-hydroxylase deficiency is the most commone enzymatic defect and is divided into classic and late-onset or nonclassic forms. Both classic and non-classic 21-hydroxylase deficiencies are inherited in a recessive manner as allelic variants. But it is rare that happened in twin infants. Chief complaints of affected twins in our case were ambiguous...
Original Article
A Clinical Study of Childhood Systemic Lupus Erythematosus
Young-Jun Kim, Young Don Kim, Jae Hong Park, Su Young Kim, Hee-Ju Park
Clin Exp Pediatr. 1994;37(9):1235-1244.   Published online September 15, 1994
To Evaluate the clinical characteristics of childhood-onset systemic lupus erythemoatosus (SLE) and analyse the factors related to outcome of renal function in lupus nephritis, we reviewed medical records of 18 cases of SLE diagnosed at the Department of Pediatrics, Pusan Nationsl University Hospital from January 1981 to December 1990. The results were as was 1:2.6 1)Male...
Pheochromocytoma in Children
Tae Sue Ha, Jae Hong Park, Il Soo Ha, Hae Il Cheong, Yong Choi, Hyung Ro Moon, Gui Won Park
Clin Exp Pediatr. 1994;37(7):961-968.   Published online July 15, 1994
We Reviewed 10 hypertensive children with pheochromocytoma retrospectively and the following results were obtained. 1) Out of 10 patients, 7 were male and 3 female. Age ranged from 5.5 years to 13.8 years and their median age was 9.9 years. 2) They complained of sweating, lethargy, headache, or chest pain and so on, Hypertension were noticed in all patients. Heart murmurs were...
Analysis of Foreign Body in the Children's Airway and Follow-up Study
Jae Hong Park, Chan Yung Kim
Clin Exp Pediatr. 1993;36(2):169-178.   Published online February 15, 1993
The autor analysed foreign body in the airway, divided into two groups vegetable foreign body group(VFBG) and non-vegetable foreign body group(N-VFBG), according to the nature, in 88 patients aged from 5 months to 15years who were diagnosed and treated under ventilating bronchos copy at Department of Pediatrics and Otolaryngology, Pusan National University Hospital from 1980 to 1990. Of the 88...
Case Report
A Case of Distal Type of Renal Tubular Acidosis in a Neonate
Sung Sub Shim, Young Joon Kim, Jae Hong Park, Soo Yung Kim, Chan Yung Kim
Clin Exp Pediatr. 1992;35(7):1014-1018.   Published online July 15, 1992
A female infant at 38 days of age was admitted to pediatric department of Pusan National University hospital due to dehydration, weight loss, vomiting, polyuria. Physical exmination at the time of admission revealed a slightly anemic, moderately dehydrated, dwarfed female infant in no acute distress. Laboratory studies on admission revealed hypokalemic, hyperchloremic metablic acidosis with normal anion gap and persistent...
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